The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Interleukin 12 a Key Immunoregulatory Cytokine in Infection Applications
Open accessAbstract
Interleukin 12 (termed IL-12p70 and commonly designated IL-12) is an important immunoregulatory cytokine that is produced mainly by antigen-presenting cells. The expression of IL-12 during infection regulates innate responses and determines the type of adaptive immune responses. IL-12 induces interferon-γ (IFN-γ) production and triggers CD4+ T cells to differentiate into type 1 T helper (Th1) cells. Studies have suggested that IL-12 could play a vital role in treating many diseases, such as viral and bacterial infections and cancers. The unique heterodimeric structure, which IL-12 shares with its family members including IL-23, IL-27, and IL-35, has recently brought more attention to understanding the mechanisms that regulate the functions of IL-12. This article describes the structure and biological activities of IL-12 in both the innate and adaptive arms of the immune system, and discusses the applications of IL-12 in treating and preventing infections.
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Cites
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Cited by
Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., Queiroz, M. G. L., Cruz, A. C. R., Vasconcelos, B. H. B., Chiang, J. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17765-5 · Cited by 3,478
Interleukin 12: still a promising candidate for tumor immunotherapy?
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The group 2 innate lymphoid cell ( ILC 2) regulatory network and its underlying mechanisms
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Metadata
- Authors
- Hamza, T., Barnett, J. B., & Li, B.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2010-02-26
- Volume
- 11
- Issue
- 3
- Pages
- 789-806
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2063871323
- Cited by
- 383
- References
- 76
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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