The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
The group 2 innate lymphoid cell ( ILC 2) regulatory network and its underlying mechanisms
Abstract
Summary: Group 2 innate lymphoid cells ( ILC 2s) play critical roles in the induction of type 2 inflammation, response to parasite infection, metabolic homeostasis, and tissue repair. These multifunctional roles of ILC 2s are tightly controlled by complex regulatory systems in the local microenvironment, the disruption of which may cause various health problems. This review summarizes up‐to‐date knowledge regarding positive and negative regulators for ILC 2s based on their function and signaling pathways, including activating cytokines ( IL ‐33, IL ‐25; MAPK , NF ‐κB pathways), co‐stimulatory cytokines ( IL ‐2, IL ‐7, IL ‐9, TSLP ; STAT 5, IL ‐4; STAT 6, TNF superfamily; MAPK , NF ‐κB pathways), suppressive cytokines (type1 IFN s, IFN ‐γ, IL ‐27; STAT 1, IL ‐10, TGF ‐β), transdifferentiation cytokines ( IL ‐12; STAT 4, IL ‐1β, IL ‐18), lipid mediators ( LTC 4, LTD 4, LTE 4, PGD 2; Ca 2+ ‐ NFAT pathways, PGE 2, PGI 2; AC / cAMP / PKA pathways, LXA 4, LTB 4), neuropeptides ( NMU ; Ca 2+ ‐ NFAT , MAPK pathways, VIP , CGRP , catecholamine, acetylcholine), sex hormones (androgen, estrogen), nutrients (butyrate; HDAC inhibitors, vitamins), and cell‐to‐cell interactions ( ICOSL ‐ ICOS ; STAT 5, B7‐H6‐ NK p30, E‐cadherin‐ KLRG 1). This comprehensive review affords a better understanding of the regulatory network system for ILC 2s, providing impetus to develop new treatment strategies for ILC 2‐related health problems.
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Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
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Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
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Self-citationNuocytes represent a new innate effector leukocyte that mediates type-2 immunity
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Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
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IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo
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Cited by
Type 2 immunity in the skin and lungs
Akdis, C. A., Arkwright, P. D., Brüggen, M.-C., Busse, W., Gadina, M., Guttman‐Yassky, E., Kabashima, K., Mitamura, Y., Vian, L., Wu, J., et al. (2020) · Allergy · doi:10.1111/all.14318 · Cited by 560
Recent advances in understanding the role of IL-4 signaling
Keegan, A. D., Leonard, W. J., & Zhu, J. (2021) · Faculty Reviews · doi:10.12703/r/10-71 · Cited by 154
Jiang, Z., Li, J., Kong, N., Kim, J.-H., Kim, B.-S., Lee, M.-J., Park, Y. M., Lee, S.-Y., Hong, S.-J., & Sul, J. H. (2022) · Scientific Reports · doi:10.1038/s41598-021-04373-7 · Cited by 54
Metadata
- Authors
- Kabata, H., Moro, K., & Koyasu, S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2018-10-07
- Volume
- 286
- Issue
- 1
- Pages
- 37-52
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2896586246
- Cited by
- 293
- References
- 137
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- closed
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