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Cited by 109PI3K/AKT/mTOR signaling in cancerRedox biology and oxidative stressAutophagy in Disease and Therapy

Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade

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Maiese, Kenneth, Chong, Zhao Zhong, Wang, Shaohui, Shang, Yan Chen·2012·International Journal of Molecular Sciences
DOI 10.3390/ijms131113830PMC PMC3509553
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Abstract

Oxidative stress impacts multiple systems of the body and can lead to some of the most devastating consequences in the nervous system especially during aging. Both acute and chronic neurodegenerative disorders such as diabetes mellitus, cerebral ischemia, trauma, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and tuberous sclerosis through programmed cell death pathways of apoptosis and autophagy can be the result of oxidant stress. Novel therapeutic avenues that focus upon the phosphoinositide 3-kinase (PI 3-K), Akt (protein kinase B), and the mammalian target of rapamycin (mTOR) cascade and related pathways offer exciting prospects to address the onset and potential reversal of neurodegenerative disorders. Effective clinical translation of these pathways into robust therapeutic strategies requires intimate knowledge of the complexity of these pathways and the ability of this cascade to influence biological outcome that can vary among disorders of the nervous system.

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Authors
Maiese, K., Chong, Z. Z., Wang, S., & Shang, Y. C.
Affiliations
  • Rutgers Cancer Institute (US)
  • Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA
Corresponding author
Maiese, Kenneth
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2012-10-26
Volume
13
Issue
11
Pages
13830-13866
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms131113830
PMC
PMC3509553
OpenAlex
W2002440118
Cited by
109
References
15
Citations by year
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FWCI
0.85
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
oxidative stress, neurodegenerative diseases, PI3K/AKT/mTOR pathway, signal transduction, nervous system aging, apoptosis, autophagy, Alzheimer's disease, Parkinson's disease, Huntington's disease, tuberous sclerosis complex, cerebral ischemia, diabetes mellitus, therapeutic target
MeSH terms
Animals, Cell Survival, Humans, Nervous System, Signal Transduction, Cell Death, Oxidative Stress, Neurodegenerative Diseases, Phosphatidylinositol 3-Kinases, Diabetes Complications, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases

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