The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis
Open accessAbstract
The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has been extensively investigated in cancer research because it is involved in the regulation of mRNA stability and translation in many cell types. HuR activity and function is associated with its subcellular distribution, transcriptional regulation, translational and post-translational modifications. HuR regulation of target mRNAs is based on the interaction between the three specific domains of HuR protein and one or several U- or AU-rich elements (AREs) in the untranslated region of target mRNAs. A number of cancer-related transcripts containing AREs, including mRNAs for proto-oncogenes, cytokines, growth factors, and invasion factors, have been characterized as HuR targets. It has been proposed that HuR has a central tumorigenic activity by enabling multiple cancer phenotypes. In this review, we comprehensively survey the existing evidence with regard to the diverse functions of HuR in caner development and progression. The current data also suggest that HuR might be a novel and promising therapeutic target and a marker for treatment response and prognostic evaluation.
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Cites
1 retracted
Jiang, W. G. (2011) · Oncology Reports · doi:10.3892/or.2011.1271 · Cited by 30
RetractedRelief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress
Bhattacharyya, S. N., Habermacher, R., Martine, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332
Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR
Lebedeva, S., Jens, M., Theil, K., Schwanhäusser, B., Selbach, M., Landthaler, M., & Rajewsky, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.008 · Cited by 716
Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein
Ma, W.-J., Cheng, S., Campbell, C., Wright, A., & Furneaux, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8144 · Cited by 667
Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR
Levy, N. S., Chung, S., Furneaux, H., & Levy, A. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6417 · Cited by 663
Mukherjee, N., Corcoran, D. L., Nusbaum, J. D., Reid, D. W., Georgiev, S., Hafner, M., Ascano, M., Tuschl, T., Ohler, U., & Keene, J. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.007 · Cited by 654
HuR recruits let-7/RISC to repress c-Myc expression
Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 543
HuR Regulates p21 mRNA Stabilization by UV Light
Wang, W., Furneaux, H., Cheng, H., Caldwell, M. C., Hutter, D., Liu, Y., Holbrook, N., & Gorospe, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.760-769.2000 · Cited by 539
Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
Abdelmohsen, K., Pullmann, R., Lal, A., Kim, H. H., Galban, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.011 · Cited by 527
Identification of a target RNA motif for RNA-binding protein HuR
de Silanes, I. L., Zhan, M., Lal, A., Yang, X., & Gorospe, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306453101 · Cited by 502
Cited by
Zhang, Z., Yao, Z., Wang, L., Ding, H., Shao, J., Chen, A., Zhang, F., & Zheng, S. (2018) · Autophagy · doi:10.1080/15548627.2018.1503146 · Cited by 474
Lai, K. K. Y., Kweon, S.-M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.021 · Cited by 165
Self-citationWolfe, M. B., Schagat, T. L., Paulsen, M. T., Magnuson, B., Ljungman, M., Park, D., Zhang, C., Campbell, Z. T., Goldstrohm, A. C., & Freddolino, P. L. (2020) · RNA · doi:10.1261/rna.077362.120 · Cited by 22
Metadata
- Authors
- Wang, J., Guo, Y., Chu, H., Guan, Y., Bi, J., & Wang, B.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-05-10
- Volume
- 14
- Issue
- 5
- Pages
- 10015-10041
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W1982443445
- Cited by
- 290
- References
- 164
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, J., Guo, Y., Chu, H., Guan, Y., Bi, J., & Wang, B. (2013). Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms140510015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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