The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Cancer Development, Progression, and Therapy: An Epigenetic Overview
Open accessAbstract
Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of cell adhesion receptors necessary for tissue-specific, cell–cell attachment, as well as up-regulation of receptors that enhance cell motility. Epigenetic changes, including histone modifications, DNA methylation, and DNA hydroxymethylation, can modify these characteristics. Targets for these epigenetic changes include signaling pathways that regulate apoptosis and autophagy, as well as microRNA. We propose that predisposed normal cells convert to cancer progenitor cells that, after growing, undergo an epithelial-mesenchymal transition. This process, which is partially under epigenetic control, can create a metastatic form of both progenitor and full-fledged cancer cells, after which metastasis to a distant location may occur. Identification of epigenetic regulatory mechanisms has provided potential therapeutic avenues. In particular, epigenetic drugs appear to potentiate the action of traditional therapeutics, often by demethylating and re-expressing tumor suppressor genes to inhibit tumorigenesis. Epigenetic drugs may inhibit both the formation and growth of cancer progenitor cells, thus reducing the recurrence of cancer. Adopting epigenetic alteration as a new hallmark of cancer is a logical and necessary step that will further encourage the development of novel epigenetic biomarkers and therapeutics.
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Cites
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Cited by
Drug resistance in cancer: An overview
Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., Snyder, N., & Sarkar, S. (2014) · Cancers · doi:10.3390/cancers6031769 · Cited by 2,463
Self-citationEpigenetic drivers of tumourigenesis and cancer metastasis
Chatterjee, A., Rodger, E. J., & Eccles, M. R. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.004 · Cited by 328
Use of Epigenetic Drugs in Disease: An Overview
Heerboth, S., Lapinska, K., Snyder, N., Leary, M., Rollinson, S., & Sarkar, S. (2014) · Genetics & Epigenetics · doi:10.4137/geg.s12270 · Cited by 326
Self-citationAn Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy
Aziz, B., Aziz, I., Khurshid, A., Raoufi, E., Esfahani, F. N., Jalilian, Z., Mozafari, M. R., Taghavi, E., & Ikram, M. (2023) · Biomedicines · doi:10.3390/biomedicines11010224 · Cited by 70
“Abnormal cell growth due to genetic mutation causes the development of a tumor that is either benign, malignant or non-malignant [2].”
BackgroundAlzoubi, S., Brody, L., Rahman, S., Mahul-Mellier, A.-L., Mercado, N., Ito, K., El-Bahrawy, M., Silver, A., Boobis, A., Bell, J. D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9887 · Cited by 37
Metadata
- Authors
- Sarkar, S., Horn, G., Moulton, K., Oza, A., Byler, S., Kokolus, S., & Longacre, M.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-10-21
- Volume
- 14
- Issue
- 10
- Pages
- 21087-21113
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2068164877
- Cited by
- 386
- References
- 152
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sarkar, S., Horn, G., Moulton, K., Oza, A., Byler, S., Kokolus, S., & Longacre, M. (2013). Cancer Development, Progression, and Therapy: An Epigenetic Overview. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms141021087
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