The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Antimicrobial Activity of Chitosan Derivatives Containing N-Quaternized Moieties in Its Backbone: A Review
Open accessAbstract
Chitosan, which is derived from a deacetylation reaction of chitin, has attractive antimicrobial activity. However, chitosan applications as a biocide are only effective in acidic medium due to its low solubility in neutral and basic conditions. Also, the positive charges carried by the protonated amine groups of chitosan (in acidic conditions) that are the driving force for its solubilization are also associated with its antimicrobial activity. Therefore, chemical modifications of chitosan are required to enhance its solubility and broaden the spectrum of its applications, including as biocide. Quaternization on the nitrogen atom of chitosan is the most used route to render water-soluble chitosan-derivatives, especially at physiological pH conditions. Recent reports in the literature demonstrate that such chitosan-derivatives present excellent antimicrobial activity due to permanent positive charge on nitrogen atoms side-bonded to the polymer backbone. This review presents some relevant work regarding the use of quaternized chitosan-derivatives obtained by different synthetic paths in applications as antimicrobial agents.
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Cites
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Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing
Pourshahrestani, S., Zeimaran, E., Kadri, N. A., Mutlu, N., & Boccaccini, A. R. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000905 · Cited by 448
New antimicrobial chitosan derivatives for wound dressing applications
Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., Ghetu, N., Danciu, M., Dubruel, P., Pieptu, D., et al. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.12.078 · Cited by 194
The antioxidant and antimicrobial activities of different phenolic acids grafted onto chitosan
Wang, Y., Xie, M., Ma, G., Fang, Y., Yang, W., Ma, N., Fang, D., Hu, Q., & Pei, F. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115238 · Cited by 183
Metadata
- Authors
- Martins, A., Facchi, S., Follmann, H., Pereira, A., Rubira, A., & Muniz, E.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2014-11-13
- Volume
- 15
- Issue
- 11
- Pages
- 20800-20832
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2016049568
- Cited by
- 289
- References
- 86
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Martins, A., Facchi, S., Follmann, H., Pereira, A., Rubira, A., & Muniz, E. (2014). Antimicrobial Activity of Chitosan Derivatives Containing N-Quaternized Moieties in Its Backbone: A Review. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms151120800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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