Cited by 122T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Mechanism of action of IL-7 and its potential applications and limitations in cancer immunotherapy

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Gao, Jianbao, Zhao, Lintao, Wan, Yisong, Zhu, Bo·2015·International Journal of Molecular Sciences

Abstract

Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of naive and memory T cell homeostasis in the periphery. Moreover, it is important for the organogenesis of lymph nodes (LN) and for the maintenance of activated T cells recruited into the secondary lymphoid organs (SLOs). The immune capacity of cancer patients is suppressed that is characterized by lower T cell counts, less effector immune cells infiltration, higher levels of exhausted effector cells and higher levels of immunosuppressive cytokines, such as transforming growth factor β (TGF-β). Recombinant human IL-7 (rhIL-7) is an ideal solution for the immune reconstitution of lymphopenia patients by promoting peripheral T cell expansion. Furthermore, it can antagonize the immunosuppressive network. In animal models, IL-7 has been proven to prolong the survival of tumor-bearing hosts. In this review, we will focus on the mechanism of action and applications of IL-7 in cancer immunotherapy and the potential restrictions for its usage.

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Authors
Gao, J., Zhao, L., Wan, Y., & Zhu, B.
Affiliations
  • Army Medical University (CN)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
  • Wan, Yisong
  • Zhu, Bo
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2015-05-06
Volume
16
Issue
5
Pages
10267-10280
ISSN
1422-0067 (ISSN-L)
OpenAlex
W1595607998
Cited by
122
References
80
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 2 · 2014: 1
FWCI
1.00
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UNC Libraries
Funders
  • National Natural Science Foundation of China (81222031, 81071772, 81070018)
  • Chongqing Science and Technology Commission
  • National Key Research and Development Program of China
  • National Institute of Allergy and Infectious Diseases (R01AI097392)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
IL-7, cancer immunotherapy, T cell homeostasis, lymphocyte development, secondary lymphoid organs, T cell exhaustion, immunosuppression, TGF-beta, lymphopenia, immune reconstitution
MeSH terms
Animals, Humans, Immunotherapy, Neoplasms, T-Lymphocytes, Signal Transduction, Interleukin-7

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