Mechanism of action of IL-7 and its potential applications and limitations in cancer immunotherapy
Open accessAbstract
Interleukin-7 (IL-7) is a non-hematopoietic cell-derived cytokine with a central role in the adaptive immune system. It promotes lymphocyte development in the thymus and maintains survival of naive and memory T cell homeostasis in the periphery. Moreover, it is important for the organogenesis of lymph nodes (LN) and for the maintenance of activated T cells recruited into the secondary lymphoid organs (SLOs). The immune capacity of cancer patients is suppressed that is characterized by lower T cell counts, less effector immune cells infiltration, higher levels of exhausted effector cells and higher levels of immunosuppressive cytokines, such as transforming growth factor β (TGF-β). Recombinant human IL-7 (rhIL-7) is an ideal solution for the immune reconstitution of lymphopenia patients by promoting peripheral T cell expansion. Furthermore, it can antagonize the immunosuppressive network. In animal models, IL-7 has been proven to prolong the survival of tumor-bearing hosts. In this review, we will focus on the mechanism of action and applications of IL-7 in cancer immunotherapy and the potential restrictions for its usage.
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IL-7R down-regulation guarantees an efficient use of the limited amount of IL-7 to naïve T cells that need it, driving their proliferation and preserving their phenotype.
“IL-7R down-regulation guarantees an efficient use of the limited amount of IL-7 to naïve T cells that need it, driving their proliferation and preserving their phenotype (160).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [160]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
IL-2: The First Effective Immunotherapy for Human Cancer
Rosenberg, S. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1490019 · Cited by 1,297 · see citing works
Homeostasis of Naive and Memory T Cells
Surh, C. D., & Sprent, J. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.002 · Cited by 1,193 · see citing works
Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.
Bajénoff, M., Egen, J., Koo, L. Y., Laugier, J., Brau, F., Glaichenhaus, N., & Germain, R. N. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.011 · Cited by 1,022 · see citing works
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells
Link, A., Vogt, T. K., Favre, S., Britschgi, M. R., Acha‐Orbea, H., Hinz, B., Cyster, J. G., & Luther, S. A. (2007) · Nature Immunology · doi:10.1038/ni1513 · Cited by 934 · see citing works
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813 · see citing works
Ray-Coquard, I. L., Cropet, C., Glabbeke, M. M. V., Sebban, C., Cesne, A. L., Judson, I. R., Trédan, O., Verweij, J., Biron, P., Labidi‐Galy, S. I., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3845 · Cited by 783 · see citing works
Interleukin-7 receptor expression: intelligent design
Mazzucchelli, R. I., & Durum, S. K. (2007) · Nature reviews. Immunology · doi:10.1038/nri2023 · Cited by 649 · see citing works
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
Cieri, N., Camisa, B., Cocchiarella, F., Forcato, M., Oliveira, G., Provasi, E., Bondanza, A., Bordignon, C., Peccatori, J., Ciceri, F., et al. (2013) · Blood · doi:10.1182/blood-2012-05-431718 · Cited by 611 · see citing works
Maintaining the norm: T-cell homeostasis
Jameson, S. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri853 · Cited by 599 · see citing works
Kerdiles, Y. M., Beisner, D. R., Tinoco, R., Dejean, A. S., Castrillón, D. H., DePinho, R. A., & Hedrick, S. Μ. (2009) · Nature Immunology · doi:10.1038/ni.1689 · Cited by 541 · see citing works
Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines
Park, J., Yu, Q., Erman, B., Appelbaum, J., Montoya-Durango, D. E., Grimes, H. L., & Singer, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.016 · Cited by 487 · see citing works
Sportès, C., Hakim, F. T., Memon, S. A., Zhang, H., Chua, K., Brown, M. R., Fleisher, T. A., Krumlauf, M., Babb, R. R., Chow, C. K., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071681 · Cited by 476 · see citing works
Rosenberg, S. A., Sportès, C., Ahmadzadeh, M., Fry, T. J., Ngo, L. T., Schwarz, S. L., Stetler-Stevenson, M., Morton, K. E., Mavroukakis, S. A., Morre, M., et al. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000210386.55951.c2 · Cited by 443 · see citing works
Interleukin-15 biology and its therapeutic implications in cancer
Steel, J. C., Waldmann, T. A., & Morris, J. C. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.004 · Cited by 361 · see citing works
Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization
Fujita, N., Sato, S., Katayama, K., & Tsuruo, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203668200 · Cited by 360 · see citing works
Cell biology of IL-7, a key lymphotrophin
Jiang, Q., Li, W., Aiello, F. B., Mazzucchelli, R. I., Asefa, B., Khaled, A. R., & Durum, S. K. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.05.004 · Cited by 341 · see citing works
Lund, A. W., Durães, F. V., Hirosue, S., Raghavan, V. R., Nembrini, C., Thomas, S. N., Issa, A., Hugues, S., & Swartz, M. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.01.005 · Cited by 341 · see citing works
Ouyang, W., Beckett, O., Flavell, R., & Li, M. O. (2009) · Immunity · doi:10.1016/j.immuni.2009.02.003 · Cited by 318 · see citing works
Barata, J. T., da Silva, A. B. G., Brandão, J. G., Nadler, L. M., Cardoso, A. A., & Boussiotis, V. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040789 · Cited by 283 · see citing works
Waldmann, T. A. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0009 · Cited by 239 · see citing works
Pellegrini, M., Calzascia, T., Elford, A. R., Shahinian, A., Lin, A. E., Dissanayake, D., Dhanji, S., Nguyen, L. T., Gronski, M. A., Morre, M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1953 · Cited by 228 · see citing works
Sportès, C., Babb, R. R., Krumlauf, M., Hakim, F. T., Steinberg, S. M., Chow, C. K., Brown, M. R., Fleisher, T. A., Noël, P., Marić, I., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1303 · Cited by 227 · see citing works
Guimond, M., Veenstra, R. G., Grindler, D. J., Zhang, H., Cui, Y., Murphy, R. D., Kim, S. Y., Na, R., Hennighausen, L. G., Kurtuluş, S., et al. (2009) · Nature Immunology · doi:10.1038/ni.1695 · Cited by 218 · see citing works
Bolotin, E., Annett, G., Parkman, R., & Weinberg, K. I. (1999) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701655 · Cited by 217 · see citing works
Suzuki, K., Kadota, K., Sima, C. S., Nitadori, J., Rusch, V. W., Travis, W. D., Sadelain, M., & Adusumilli, P. S. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2052 · Cited by 207 · see citing works
Hepatic interleukin-7 expression regulates T cell responses.
Sawa, Y., Arima, Y., Ogura, H., Kitabayashi, C., Jiang, J.-J., Fukushima, T., Kamimura, D., Hirano, T., & Murakami, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.007 · Cited by 203 · see citing works
IL-7–producing stromal cells are critical for lymph node remodeling
Onder, L., Narang, P., Scandella, E., Chai, Q., Iolyeva, M. E., Hoorweg, K., Halin, C., Richie, E. R., Kaye, P. M., Westermann, J., et al. (2012) · Blood · doi:10.1182/blood-2012-03-416859 · Cited by 169 · see citing works
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs
Turley, S. J., Fletcher, A. L., & Elpek, K. G. (2010) · Nature reviews. Immunology · doi:10.1038/nri2886 · Cited by 165 · see citing works
Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity
Malhotra, D., Fletcher, A. L., & Turley, S. J. (2013) · Immunological Reviews · doi:10.1111/imr.12023 · Cited by 152 · see citing works
Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity
Lundström, W., Highfill, S. L., Walsh, S. T. R., Beq, S., Morse, E., Kockum, I. S., Alfredsson, L. S., Olsson, T. P., Hillert, J. A., & Mackall, C. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222303110 · Cited by 150 · see citing works
IL-7 in human health and disease
Lundström, W., Fewkes, N. M., & Mackall, C. L. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.02.005 · Cited by 150 · see citing works
Kimura, M. Y., Pobezinsky, L. A., Guinter, T. I., Thomas, J., Adams, A., Park, J., Tai, X., & Singer, A. (2012) · Nature Immunology · doi:10.1038/ni.2494 · Cited by 143 · see citing works
IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
Silva, A., Laranjeira, A. B. A., Martins, L. R., Cardoso, B. A., Demengeot, J., Yunes, J. A., Seddon, B. P., & Barata, J. T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3606 · Cited by 143 · see citing works
Effects of exogenous interleukin-7 on human thymus function
Okamoto, Y., Douek, D. C., McFarland, R., & Koup, R. A. (2002) · Blood · doi:10.1182/blood.v99.8.2851 · Cited by 140 · see citing works
GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
Xue, H., Bollenbacher, J., Rovella, V., Tripuraneni, R., Du, Y., Liu, C., Williams, A., McCoy, J. P., & Leonard, W. J. (2004) · Nature Immunology · doi:10.1038/ni1117 · Cited by 140 · see citing works
Miller, P. W., Sharma, S. P., Stolina, M., Butterfield, L. H., Luo, J., Lin, Y., Dohadwala, M., Batra, R. K., Wu, L., Economou, J. S., et al. (2000) · Human Gene Therapy · doi:10.1089/10430340050016157 · Cited by 130 · see citing works
Lymph node stroma broaden the peripheral tolerance paradigm
Fletcher, A. L., Malhotra, D., & Turley, S. J. (2011) · Trends in Immunology · doi:10.1016/j.it.2010.11.002 · Cited by 120 · see citing works
Visualization and Identification of IL-7 Producing Cells in Reporter Mice
Mazzucchelli, R. I., Warming, S., Lawrence, S. M., Ishii, M., Abshari, M., Washington, A. V., Feigenbaum, L., Warner, A., Sims, D. J., Li, W., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007637 · Cited by 117 · see citing works
IL-7–induced proliferation of recent thymic emigrants requires activation of the PI3K pathway
Swainson, L. A., Kinet, S., Mongellaz, C., Sourisseau, M., Henriques, T., & Taylor, N. N. (2006) · Blood · doi:10.1182/blood-2006-06-027912 · Cited by 116 · see citing works
An overview of IL-7 biology and its use in immunotherapy
El-Kassar, N., & Gress, R. E. (2009) · Journal of Immunotoxicology · doi:10.3109/15476910903453296 · Cited by 110 · see citing works
IL-7 Promotes CXCR3 Ligand-Dependent T Cell Antitumor Reactivity in Lung Cancer
Andersson, Å., Yang, S.-C., Huang, M., Zhu, L. X., Kar, U. K., Batra, R. K., Elashoff, D. A., Strieter, R. M., Dubinett, S. M., & Sharma, S. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803340 · Cited by 106 · see citing works
Cattaruzza, L., Gloghini, A., Olivo, K., Francia, R. D., Lorenzon, D., Filippi, R. D., Carbone, A., Colombatti, A., Pinto, A., & Aldinucci, D. (2009) · International Journal of Cancer · doi:10.1002/ijc.24389 · Cited by 104 · see citing works
Schlissel, M. S., Durum, S. K., & Muegge, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.1045 · Cited by 104 · see citing works
Lambeck, A. J. A., Crijns, A. P. G., Leffers, N., Sluiter, W. J., ten Hoor, K. A., Braid, M., van der Zee, A. G. J., Daemen, T., Nijman, H. W., & Kast, W. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1828 · Cited by 101 · see citing works
Modulating T‐cell homeostasis with IL‐7: preclinical and clinical studies
Capitini, C. M., Chisti, A. A., & Mackall, C. L. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02085.x · Cited by 98 · see citing works
Kittipatarin, C., & Khaled, A. R. (2007) · Cytokine · doi:10.1016/j.cyto.2007.07.183 · Cited by 96 · see citing works
Heninger, A., Theil, A., Wilhelm, C., Petzold, C., Huebel, N., Kretschmer, K., Bonifacio, E. E., & Monti, P. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201286 · Cited by 87 · see citing works
Osteoclasts Are Active in Bone Forming Metastases of Prostate Cancer Patients
Roato, I., D’Amelio, P., Gorassini, E., Grimaldi, A., Bonello, L., Fiori, C., Delsedime, L., Tizzani, A., Libero, A. D., Isaia, G., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003627 · Cited by 85 · see citing works
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development
Patra, A. K., Avots, A., Zahedi, R. P., Schüler, T., Sickmann, A., Bommhardt, U., & Serfling, E. (2012) · Nature Immunology · doi:10.1038/ni.2507 · Cited by 78 · see citing works
Bream, J. H., Hodge, D. L., Gonsky, R., Spolski, R. J., Leonard, W. J., Krebs, S., Targan, S. R., Morinobu, A., O’Shea, J. J., & Young, H. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401168200 · Cited by 75 · see citing works
Functional cleavage of the common cytokine receptor γ chain (γ c ) by calpain
Noguchi, M., Sarin, A., Aman, M. J., Nakajima, H., Shores, E. W., Henkart, P. A., & Leonard, W. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11534 · Cited by 74 · see citing works
The lymph as a pool of self-antigens
Clement, C. C., Rötzschke, O., & Santambrogio, L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.10.004 · Cited by 74 · see citing works
Yamanaka, K., Clark, R. A., Rich, B. E., Dowgiert, R. K., Hirahara, K., Hurwitz, D., Shibata, M., Mirchandani, N., Jones, D. A., Goddard, D. S., et al. (2005) · Blood · doi:10.1182/blood-2005-03-1139 · Cited by 73 · see citing works
Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?
Barata, J. T., Cardoso, A. A., & Boussiotis, V. A. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190400027852 · Cited by 70 · see citing works
Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer
Mengus, C., Magnen, C. L., Trella, E., Yousef, K., Bubendorf, L., Provenzano, M., Bachmann, A., Heberer, M., Spagnoli, G. C., & Wyler, S. F. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-162 · Cited by 70 · see citing works
Colombetti, S., Lévy, F., & Chapatte, L. (2009) · Blood · doi:10.1182/blood-2008-05-155309 · Cited by 69 · see citing works
Beq, S., Rozlan, S., Gautier, D., Parker, R., Fabre-Mersseman, V., Schilte, C., Assouline, B., Rancé, I., Lavedan, P., Morre, M., et al. (2009) · Blood · doi:10.1182/blood-2008-11-191288 · Cited by 68 · see citing works
Habibi, M., Kmieciak, M., Graham, L., Morales, J. K., Bear, H. D., & Manjili, M. H. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0024-3 · Cited by 68 · see citing works
Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines
Cosenza, L., Görgün, G., Urbano, A., & Foss, F. M. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00245-5 · Cited by 62 · see citing works
Cha, E., Graham, L., Manjili, M. H., & Bear, H. D. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0573-0 · Cited by 62 · see citing works
Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours.
Al-Rawi, M. A. A., Mansel, R. E., & Jiang, W. G. (2003) · PubMed · doi:10.14670/hh-18.911 · Cited by 61 · see citing works
Role of CXCR3 Ligands in IL-7/IL-7Rα-Fc mediated antitumor activity in Lung Cancer
Andersson, Å., Srivastava, M., Harris-White, M., Huang, M., Zhu, L. X., Elashoff, D., Strieter, R., Dubinett, S., & Sharma, S. P. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3346 · Cited by 57 · see citing works
Golden‐Mason, L., Kelly, A. M., Traynor, O., McEntee, G., Kelly, J., Hegarty, J. E., & O’Farrelly, C. (2001) · Cytokine · doi:10.1006/cyto.2001.0852 · Cited by 53 · see citing works
Interleukin-7 and Interleukin-15 for Cancer
Zarogoulidis, P., Lampaki, S., Yarmus, L. B., Kioumis, I. P., Pitsiou, G., Katsikogiannis, N., Hohenforst‐Schmidt, W., Li, Q., Huang, H., Sakkas, A., et al. (2014) · Journal of Cancer · doi:10.7150/jca.10471 · Cited by 46 · see citing works
Bone invading NSCLC cells produce IL-7: mice model and human histologic data
Roato, I., Caldo, D., Godio, L., D’Amico, L., Giannoni, P., Morello, E. M., Quarto, R., Molfetta, L., Buracco, P., Mussa, A., et al. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-12 · Cited by 45 · see citing works
Ouyang, W., Oh, S. A., Ma, Q., Bivona, M. R., Zhu, J., & Li, M. O. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.016 · Cited by 43 · see citing works
IL-7: The global builder of the innate lymphoid network and beyond, one niche at a time
Kang, J., & Coles, M. C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.02.003 · Cited by 40 · see citing works
Le, H. K., Graham, L., Miller, C. H. T., Kmieciak, M., Manjili, M. H., & Bear, H. D. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0666-y · Cited by 39 · see citing works
Katz, G., Pobezinsky, L. A., Jeurling, S., Shinzawa, M., Laethem, F. V., & Singer, A. (2014) · Science Signaling · doi:10.1126/scisignal.2005221 · Cited by 36 · see citing works
Carlo, E. D., D’Antuono, T., Pompa, P., Giuliani, R., Rosini, S., Stuppia, L., Musiani, P., & Sorrentino, C. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1951 · Cited by 33 · see citing works
The additional value of TGFβ1 and IL-7 to predict the course of prostate cancer progression
Schroten, C., Dits, N. F. J., Steyerberg, E. W., Ries Kranse, C., van Leenders, A. G. J. L. H., Bangma, C. H., & Kraaij, R. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1159-3 · Cited by 32 · see citing works
Zhao, L., Mei, Y., Sun, Q., Guo, L., Wu, Y., Xiao, Y., Hu, B., Liu, X., & Liu, H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400004 · Cited by 31 · see citing works
Self-citationInterleukin-7 improves reconstitution of antiviral CD4 T cells
Lu, H., Zhao, Z., Kalina, T., Gillespy, T., Liggitt, D., Andrews, R. G., Maloney, D. G., Kiem, H., & Storek, J. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.08.008 · Cited by 25 · see citing works
T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B
Zhao, L., Liu, L., Gao, J., Yang, Y., Hu, C., Guo, B., & Zhu, B. (2014) · BMC Immunology · doi:10.1186/s12865-014-0033-4 · Cited by 19 · see citing works
Self-citationIn vivoAntitumor Activity of a Recombinant IL-7/HGFβ Hybrid Cytokine in Mice
Lai, L., Jin, J., & Goldschneider, I. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-3198 · Cited by 17 · see citing works
Essential role of TNF-alpha in development of spleen fibroblastic reticular cells
Zhao, L., Chen, J., Liu, L., Gao, J., Guo, B., & Zhu, B. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.01.006 · Cited by 15 · see citing works
Self-citationYuan, C., Yang, X., Zhu, C., Liu, S., Wang, B., & Wang, X. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.1.265 · Cited by 15 · see citing works
Schroten, C., de Ridder, C. M. A., Reneman, S., Crezee, M., Dalgleish, A. G., Todryk, S. M., Bangma, C. H., & Kraaij, R. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0560-z · Cited by 12 · see citing works
Tumor Protection by IL-7 Secreting Whole Cell Vaccine is Merely Mediated by NK1.1-positive Cells
Schroten, C., Scheffer, R., Boon, L., de Ridder, C. M. A., Bangma, C. H., & Kraaij, R. (2012) · Journal of Immunotherapy · doi:10.1097/cji.0b013e318242514b · Cited by 4 · see citing works
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Hirayama, A. V., Gauthier, J., Hay, K. A., Voutsinas, J. M., Wu, Q., Gooley, T., Li, D., Cherian, S., Chen, X., Pender, B. S., et al. (2019) · Blood · doi:10.1182/blood-2018-11-887067 · Cited by 355 · see citing works
Nakao, S., Arai, Y., Tasaki, M., YAMASHITA, M., Murakami, R., Kawase, T., Amino, N., Nakatake, M., Kurosaki, H., Mori, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax7992 · Cited by 191 · see citing works
An overview of JAK/STAT pathways and JAK inhibition in alopecia areata
Lensing, M., & Jabbari, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955035 · Cited by 182 · see citing works
Ayeka, P. A., Bian, Y., Githaiga, P. M., & Zhao, Y. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2030-7 · Cited by 138 · see citing works
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Zhao, J., Huang, W., Wu, Y., Luo, Y., Wu, B., Cheng, J., Chen, J., Liu, D., & Li, C. (2020) · Cancer Cell International · doi:10.1186/s12935-020-1094-5 · Cited by 116 · see citing works
The Role of IL-7 and IL-7R in Cancer Pathophysiology and Immunotherapy
Wang, C., Kong, L.-Z., Kim, S., Lee, S., Oh, S., Jo, S., Jang, I.-H., & Kim, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810412 · Cited by 112 · see citing works
Borowczak, J., Szczerbowski, K., Maniewski, M., Kowalewski, A., Janiczek-Polewska, M., Szylberg, A., Marszałek, A., & Szylberg, Ł. (2022) · Biomedicines · doi:10.3390/biomedicines10071670 · Cited by 86 · see citing works
Re-evaluation of epidermodysplasia verruciformis: Reconciling more than 90 years of debate
Przybyszewska, J., Zlotogorski, A., & Ramot, Y. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.12.035 · Cited by 76 · see citing works
The Cytokine Network in Colorectal Cancer: Implications for New Treatment Strategies
Braumüller, H., Mauerer, B., Andris, J., Berlin, C., Wieder, T., & Kesselring, R. (2022) · Cells · doi:10.3390/cells12010138 · Cited by 74 · see citing works
Zhao, Y., Wei, K., Chi, H., Xia, Z., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1022808 · Cited by 71 · see citing works
Cytokines in oncolytic virotherapy
Pol, J. G., Workenhe, S. T., Konda, P., Gujar, S. A., & Kroemer, G. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.10.007 · Cited by 68 · see citing works
The role of CD27 in anti-viral T-cell immunity
Grant, E. J., Nüssing, S., Sant, S. A., Clemens, E. B., & Kedzierska, K. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.12.001 · Cited by 64 · see citing works
Joseph, N., Dovedi, S. J., Thompson, C., Lyons, J., Kennedy, J., Elliott, T., West, C., & Choudhury, A. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv546 · Cited by 67 · see citing works
Theivendren, P., Kunjiappan, S., Pavadai, P., Ravi, K., Murugavel, A., Dayalan, A., & Kumar, A. S. K. (2024) · ACS Measurement Science Au · doi:10.1021/acsmeasuresciau.4c00062 · Cited by 55 · see citing works
The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases
Chou, C., Chang, Y., Kořínek, M., Chen, Y., Yang, Y.-T., Leu, S., Lin, I., Tang, C.-J., & Chiu, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030483 · Cited by 51 · see citing works
Shekhar, S., Yadav, A. K., Khosla, A., & Solanki, P. R. (2022) · ECS Sensors Plus · doi:10.1149/2754-2726/ac9227 · Cited by 49 · see citing works
Krzystek‐Korpacka, M., Zawadzki, M., Neubauer, K., Bednarz-Misa, I. S., Górska, S., Wiśniewski, J. Ł., Witkiewicz, W., & Gamian, A. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1933-3 · Cited by 47 · see citing works
Zhang, M. M., Beno, B. R., Huang, R. Y. ‐., Adhikari, J., Deyanova, E. G., Li, J., Chen, G., & Gross, M. L. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03879 · Cited by 46 · see citing works
Mohme, M., Maire, C. L., Geumann, U., Schliffke, S., Dührsen, L., Fita, K. D., Akyüz, N., Binder, M., Westphal, M., Guenther, C., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0803 · Cited by 45 · see citing works
IL-7/IL-7 receptor axis stimulates prostate cancer cell invasion and migration via AKT/NF-κB pathway
Qu, H., Zou, Z., Pan, Z., Zhang, T., Deng, N., Chen, G., & Wang, Z. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.017 · Cited by 43 · see citing works
Hassane, M., Jouan, Y., Creusat, F., Soulard, D., Boisseau, C., Gonzalez, L., Patin, E. C., Heuzé‐Vourc'h, N., Sirard, J., Faveeuw, C., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0212-y · Cited by 42 · see citing works
Seol, M. A., Kim, J. H., Oh, K., Kim, G., Seo, M. W., Shin, Y., Sim, J. H., Shin, H. M., Seo, B. Y., Lee, D., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43294-4 · Cited by 41 · see citing works
Patin, E. C., Soulard, D., Fleury, S., Hassane, M., Dombrowicz, D., Faveeuw, C., Trottein, F., & Paget, C. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1416 · Cited by 38 · see citing works
Toker, A., & Ohashi, P. S. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.05.001 · Cited by 37 · see citing works
The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines
Huang, J., Long, Z., Jia, R., Wang, M., Zhu, D., Liu, M., Chen, S., Zhao, X., Yang, Q., Wu, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680442 · Cited by 36 · see citing works
Calorie Restriction Attenuates Terminal Differentiation of Immune Cells
White, M. J., Beaver, C., Goodier, M. R., Bottomley, C., Nielsen, C. M., Wolf, A., Boldrin, L., Whitmore, C. L., Morgan, J. E., Pearce, D. J., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00667 · Cited by 34 · see citing works
Ding, Z., Habtetsion, T. G., Cao, Y., Li, T., Liu, C., Kuczma, M., Chen, T., Hao, Z., Bryan, L. J., Munn, D. H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12488-z · Cited by 33 · see citing works
Epigenetic Maintenance of Acquired Gene Expression Programs during Memory CD8 T Cell Homeostasis
Abdelsamed, H. A., Zebley, C. C., & Youngblood, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00006 · Cited by 33 · see citing works
Local and Systemic IL-7 Concentration in Gastrointestinal-Tract Cancers
Bednarz-Misa, I. S., Diakowska, D., & Krzystek‐Korpacka, M. (2019) · Medicina · doi:10.3390/medicina55060262 · Cited by 33 · see citing works
Aparicio, M., Alba, C., Proctocolitis Study Group of CAM Public Health Area 6, Rodríguez, J. M., & Fernández, L. (2020) · Nutrients · doi:10.3390/nu12030634 · Cited by 32 · see citing works
Current annotation strategies for T cell phenotyping of single-cell RNA-seq data
Mullan, K. A., de Vrij, N., Valkiers, S., & Meysman, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1306169 · Cited by 31 · see citing works
Vertebrate Cytokines and Their Evolution
Secombes, C. J., Wang, T., & Bird, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801975-7.00005-0 · Cited by 31 · see citing works
Dar, M. A., Ahmad, S. M., Bhat, B. A., Dar, T. A., Haq, Z. U., Wani, B. A., Shabir, N., Kashoo, Z. A., Shah, R. A., Ganai, N. A., et al. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110475 · Cited by 28 · see citing works
Cancer immunotherapy from biology to nanomedicine
Abdelbaky, S. B., Ibrahim, M. T., Samy, H., Mohamed, M., Mohamed, H., Mustafa, M., Abdelaziz, M. M., Forrest, M. L., & Khalil, I. A. H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.025 · Cited by 27 · see citing works
Chronic activation profile of circulating CD8+ T cells in Sézary syndrome
Torrealba, M. P., Manfrere, K. C. G., Miyashiro, D., de Lima, J. F., Oliveira, L. D. M., Pereira, N. Z., Cury‐Martins, J., Pereira, J. C., Duarte, A. J. S., Sato, M. N., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23334 · Cited by 26 · see citing works
Tasaki, M., YAMASHITA, M., Arai, Y., Nakamura, T., & Nakao, S. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-02947-y · Cited by 25 · see citing works
The role of the common gamma-chain family cytokines in γδ T cell-based anti-cancer immunotherapy
Acker, H. H. V., Campillo-Davó, D., Roex, G., Versteven, M., Smits, E., & Tendeloo, V. F. V. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.05.002 · Cited by 25 · see citing works
Pediatric Burn Survivors Have Long-Term Immune Dysfunction With Diminished Vaccine Response
Johnson, B. Z., McAlister, S. M., McGuire, H. M., Palanivelu, V. T., Stevenson, A. W., Richmond, P., Palmer, D. J., Metcalfe, J. R., Prescott, S. L., Wood, F. M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01481 · Cited by 25 · see citing works
Haneef, K., Ali, A., Khan, I., Naeem, N., Jamall, S., & Salim, A. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12479 · Cited by 25 · see citing works
Lee, K.-J., Choi, D., Tae, N., Song, H. W., Kang, Y., Lee, M., Moon, D., Oh, Y., Park, S., Kim, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101567 · Cited by 24 · see citing works
Lee, Y., Park, I., Wickramasuriya, S. S., Arous, J. B., Koziol, M.-E., & Lillehoj, H. S. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102013 · Cited by 24 · see citing works
Eftimie, R., & Hassanein, E. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1432-8 · Cited by 24 · see citing works
Gauthaman, K., Sait, K., Anfinan, N. M., Kadam, R. A., Ahmed, F., Rasool, M., Naseer, M. I., Pushparaj, P. N., & Al-Qahtani, M. H. (2019) · Oncology Letters · doi:10.3892/ol.2019.10094 · Cited by 23 · see citing works
Chemotherapy and immunotherapy: A close interplay to fight cancer?
Hanoteau, A., & Moser, M. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1190061 · Cited by 21 · see citing works
Group 2 ILC s: A way of enhancing immune protection against human helminths?
Nausch, N., & Mutapi, F. (2017) · Parasite Immunology · doi:10.1111/pim.12450 · Cited by 20 · see citing works
Kemmerer, C. L., Schittenhelm, J., Dubois, E., Neumann, L., Häsler, L. M., Lambert, M., Renovanz, M., Kaeser, S. A., Tabatabai, G., Ziemann, U., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08825-1 · Cited by 20 · see citing works
Disrupted fibroblastic reticular cells and interleukin-7 expression in tumor draining lymph nodes
Gao, J., Zhao, L., Liu, L., Yang, Y., Guo, B., & Zhu, B. (2017) · Oncology Letters · doi:10.3892/ol.2017.6537 · Cited by 19 · see citing works
Self-citationGenotoxicity induced by monomethylarsonous acid (MMA +3 ) in mouse thymic developing T cells
Xu, H., Medina, S., Lauer, F. T., Douillet, C., Liu, K. J., Stýblo, M., & Burchiel, S. W. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.07.897 · Cited by 19 · see citing works
Ahn, S., Park, J., Kim, H., Heo, M., Sung, Y. C., & Jeun, S. (2022) · Cancer Medicine · doi:10.1002/cam4.5467 · Cited by 18 · see citing works
Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer
Paller, C. J., Wang, L., Fu, W., Kumar, R., Durham, J. N., Azad, N. S., Laheru, D. A., Browner, I. S., Kachhap, S. K., Boyapati, K., et al. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0002 · Cited by 17 · see citing works
Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
Yu, F., Tian, T., Deng, B., Wang, T., Qi, Q., Zhu, M., Yan, C., Ding, H., Wang, J., Dai, J., et al. (2018) · Gastric Cancer · doi:10.1007/s10120-018-0841-y · Cited by 17 · see citing works
Ke, B., Wu, X., Yang, Q., Huang, Y., Wang, F., Gong, Y., Liu, J., & Shi, L. (2019) · Bioscience Reports · doi:10.1042/bsr20190052 · Cited by 15 · see citing works
Devi, N., Adivitiya, & Khasa, Y. P. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7683-5 · Cited by 15 · see citing works
Interleukin (IL)-7 Signaling in the Tumor Microenvironment
Bednarz-Misa, I. S., Bromke, M. A., & Krzystek‐Korpacka, M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55617-4_2 · Cited by 15 · see citing works
YAMASHITA, M., Tasaki, M., Murakami, R., Arai, Y., Nakamura, T., & Nakao, S. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.01.016 · Cited by 13 · see citing works
Hervás-Salcedo, R., & Martín-Antonio, B. (2022) · Cancers · doi:10.3390/cancers14153796 · Cited by 13 · see citing works
Innate Immunity and Tertiary Lymphoid Structures
Zhao, R., & Gao, D. (2025) · Immunological Reviews · doi:10.1111/imr.70052 · Cited by 12 · see citing works
Mahmoud, M. H., Badr, G., Badr, B. M., Kassem, A. U., & Mohamed, M. S. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.07.005 · Cited by 12 · see citing works
Marton, C., Mercier‐Letondal, P., Galaine, J., & Godet, Y. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104314 · Cited by 12 · see citing works
Foldi, J., Blenman, K., Marczyk, M., Gunasekharan, V., Polanska, A., Gee, R. J., Davis, M., Kahn, A. M., Silber, A. L. M., & Pusztai, L. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07426-3 · Cited by 11 · see citing works
Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue
Gholiha, A. R., Hollander, P., Löf, L., Larsson, A. O., Hashemi, J., Mattsson, J. U., Molin, D. L., Amini, R., Freyhult, E., Kamali‐Moghaddam, M., et al. (2021) · Cancers · doi:10.3390/cancers14010009 · Cited by 11 · see citing works
Li, S., Wang, Z., Zhang, G., Fu, J., & Zhang, X. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.022 · Cited by 11 · see citing works
Tumor Microenvironment Onmyoji: Cytokines with Dual Protumor and Antitumor Roles
Wang, Y., Lin, A., Liu, Z., Cheng, Q., Zhang, J., & Luo, P. (2026) · 癌症:英文版 · doi:10.34133/cancomm.0008 · Cited by 10 · see citing works
The perioperative dynamics of IL-7 following robot-assisted and open colorectal surgery
Krzystek‐Korpacka, M., Zawadzki, M., Szufnarowski, K., Bednarz-Misa, I. S., Górska, S., Witkiewicz, W., & Gamian, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-27245-z · Cited by 10 · see citing works
Cary, L. H., Noutai, D., Salber, R. E., Fadiyimu, O., Gross, A., Almeida-Porada, G. D., Kidane, Y., & Whitnall, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071795 · Cited by 10 · see citing works
Nitto, C. D., Ravazza, D., Gilardoni, E., Look, T., Sun, M., Prodi, E., Moisoiu, V., Pellegrino, C. E., Manz, M. G., Puca, E., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-008504 · Cited by 9 · see citing works
Sermaxhaj, F., Plavetić, N. D., Gözalan, U., Kulić, A., Varga, L. R., Popović, M., Sović, S., Mijatović, D., Sermaxhaj, B., & Sopjani, M. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02646-7 · Cited by 9 · see citing works
Effect of cellular aging on memory T-cell homeostasis
Swain, A. C., Borghans, J. A. M., & de Boer, R. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.947242 · Cited by 9 · see citing works
Kong, W. Y., Soderholm, A. T., Brooks, A. J., Cruz, J. L. G., & Wells, J. W. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.102937 · Cited by 9 · see citing works
Jiang, B., Zhou, L., Lu, J., Wang, Y., Liu, C., Liang, Z., Zhou, W., You, L., & Guo, J. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15244 · Cited by 9 · see citing works
Modular Lentiviral Vectors for Highly Efficient Transgene Expression in Resting Immune Cells
Fichter, C., Aggarwal, A., Wong, A. K. H., McAllery, S., Mathivanan, V., Hao, B., MacRae, H. H., Churchill, M. J., Gorry, P. R., Roche, M., et al. (2021) · Viruses · doi:10.3390/v13061170 · Cited by 9 · see citing works
circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR ‐338‐5p/ IL ‐7 pathway
Zhang, S., Ma, J., Yu, T., Song, Z., Lau, W. Y., & Zha, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18137 · Cited by 8 · see citing works
From lymphopenia to restoration: IL-7 immunotherapy for lymphocyte recovery in glioblastoma
Kim, J., Choi, H., Jeun, S., & Ahn, S. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216714 · Cited by 8 · see citing works
Gallbladder Interleukins in Children with Calculous Cholecystitis
Deņisova, A., Pilmane, M., Eņģelis, A., & Pētersons, A. (2021) · Pediatric Reports · doi:10.3390/pediatric13030054 · Cited by 7 · see citing works
Marton, C., Minaud, A., Coupet, C., Chauvin, M., Dhiab, J., Vallet, H., Boddaert, J., Kehrer, N., Bastien, B., Inchauspé, G., et al. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2232247 · Cited by 7 · see citing works
Dower, W. J., Park, A. I., Bakker, A. V., Cwirla, S. E., Pongtornpipat, P., Williams, B. M., Joshi, P., Baxter, B. A., Needels, M. C., & Barrett, R. W. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286834 · Cited by 7 · see citing works
Visioni, A., & Skitzki, J. J. (2016) · Cancers · doi:10.3390/cancers8090086 · Cited by 7 · see citing works
Hiza, H. C., Fenner, L., Hella, J., Kuchaka, D. J., Sasamalo, M., Blauenfeldt, T., Kibiki, G. S., Kavishe, R. A., Mhimbira, F., & Rühwald, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202525 · Cited by 7 · see citing works
Meta-analysis of commonly mutated genes in leptomeningeal carcinomatosis
Congur, I., Koni, E., Onat, O. E., & Keskin, Z. T. (2023) · PeerJ · doi:10.7717/peerj.15250 · Cited by 6 · see citing works
Disrupted Homeostatic Cytokines Expression in Secondary Lymph Organs during HIV Infection
Zhao, L., Gao, J., Li, Y., Liu, L., Yang, Y., Guo, B., & Zhu, B. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030413 · Cited by 6 · see citing works
Self-citationRestoring thymic function: Then and now
El-Kadiry, A. E.-H., & Rafei, M. (2019) · Cytokine · doi:10.1016/j.cyto.2019.05.009 · Cited by 6 · see citing works
Cho, Y. S., Kim, B., Sim, C. K., Kim, I., & Lee, M. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161899 · Cited by 5 · see citing works
Cloning and Expression of Recombinant Human Interleukin-7 in Chinese Hamster Ovary (CHO) Cells.
Toghraie, F. S., Sharifzadeh, S. M., Ramezani, A., Maymand, E. M., Yazdanpanah‐Samani, M., & Ghaderi, A. A. (2017) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Daghestani, M. H., Hakami, H. H., Ambreen, K., Saleem, A., Aleisa, N. A., Alneghery, L. M., & Amin, M. H. (2020) · Toxin Reviews · doi:10.1080/15569543.2020.1818107 · Cited by 3 · see citing works
Yoon, T., Pyo, J. Y., Ahn, S. S., Song, J. J., Park, Y., & Lee, S. (2022) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/xi77r8 · Cited by 3 · see citing works
Transcriptional Inflammatory Signature in Healthy Donors and Different Radiotherapy Cancer Patients
O’Brien, G., Kamuda, M., Cruz-Garcia, L., Polozova, M. V., Tichý, A., Marková, M., Sirák, I., Zahradníček, O., Widłak, P., Ponge, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021080 · Cited by 3 · see citing works
Inflammatory status and prognosis of locally advanced non-small cell lung cancer
Galván‐Román, J. M., Curbelo, J., & Aspa, J. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.08.27 · Cited by 2 · see citing works
Reiser, S. C., Tellermann, J., Akota, I., & Pilmane, M. (2021) · Life · doi:10.3390/life11060556 · Cited by 3 · see citing works
Kim, M.-A., Nam, J., Shin, H., Kim, J. Y., Jun, A., Cho, H., Han, M.-R., & Kim, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020948 · Cited by 2 · see citing works
Identification of new IL-7Rα small-molecule agonists: a multi-computational approach
Lee, J., Lee, K., & Koh, B. (2021) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2021.1969684 · Cited by 2 · see citing works
Wadapurkar, R. M., Sivaram, A., & Vyas, R. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1987326 · Cited by 2 · see citing works
Cytokines in Cancer Immunotherapy
Sudan, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-3350-1_10 · Cited by 2 · see citing works
The role of miR-3188-mediated transcriptional activation of IL-7Rα in tumor immunotherapy research
Wan, D., Liang, X., Liang, F., Zhu, M., Zhang, C., & Zhang, S. (2025) · Molecular Immunology · doi:10.1016/j.molimm.2025.12.007 · Cited by 1 · see citing works
Strategies to Target Tumor Immunosuppression
Draghiciu, O., Nijman, H. W., & Daemen, T. (2014) · Springer eBooks · doi:10.1007/978-3-662-44946-2_5 · Cited by 1 · see citing works
The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review
Hesari, M., Attar, Z., Soltani-Shirazi, S., Keshavarzian, O., Taheri, R., Tabrizi, R., & Fouladseresht, H. (2023) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2023.0050 · Cited by 1 · see citing works
Exploitation of Cell Mediated Immune Responses to Cancer Immunotherapy
ASHINE, T. A. (2019) · Journal of Medicine, Physiology and Biophysics · doi:10.7176/jmpb/59-03 · Cited by 1 · see citing works
Abudulai, L. N., Fernández, S., Corscadden, K. J., Kirkham, L. S., Hunter, M., Post, J. J., & French, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00839
- Authors
- Gao, J., Zhao, L., Wan, Y., & Zhu, B.
- Affiliations
- Army Medical University (CN)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Wan, Yisong
- Zhu, Bo
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-05-06
- Volume
- 16
- Issue
- 5
- Pages
- 10267-10280
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4463645
- OpenAlex
- W1595607998
- Cited by
- 122
- References
- 80
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 12 · 2022: 15 · 2021: 15 · 2020: 15 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 2 · 2014: 1
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Natural Science Foundation of China (81222031, 81071772, 81070018)
- Chongqing Science and Technology Commission
- National Key Research and Development Program of China
- National Institute of Allergy and Infectious Diseases (R01AI097392)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- IL-7, cancer immunotherapy, T cell homeostasis, lymphocyte development, secondary lymphoid organs, T cell exhaustion, immunosuppression, TGF-beta, lymphopenia, immune reconstitution
- MeSH terms
- Animals, Humans, Immunotherapy, Neoplasms, T-Lymphocytes, Signal Transduction, Interleukin-7
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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