Cited by 152T-cell and B-cell ImmunologyLymphatic System and DiseasesImmunotherapy and Immune Responses

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity

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Malhotra, Deepali, Fletcher, Anne L., Turley, Shannon J.·2013·Immunological Reviews

Abstract

Summary: Secondary lymphoid organs (SLO s), including lymph nodes, P eyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen‐presenting cells for cognate antigens, while moving along stromal networks. The cell‐cell interactions between stromal and hematopoietic cells in SLO s are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell‐ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD 8+ T‐cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal‐hematopoietic crosstalk has important consequences for regulating immune cell function within SLO s. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.

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  • Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.

    “These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”

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Authors
Malhotra, D., Fletcher, A. L., & Turley, S. J.
Affiliations
  • Harvard University (US)
  • Dana-Farber Cancer Institute (US)
Corresponding author
Turley, Shannon J.
Venue
Immunological Reviews
Publisher
Wiley
Published
2012-12-19
Volume
251
Issue
1
Pages
160-176
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2061753927
Cited by
152
References
122
Citations by year
2026: 1 · 2025: 1 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 21 · 2016: 18 · 2015: 25 · 2014: 12 · 2013: 8 · 2012: 1
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (P01AI045757)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074500)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
secondary lymphoid organs, stromal cells, hematopoietic cells, lymph node stroma, dendritic cells, lymphocyte migration, chemokines, CD8+ T cell tolerance, T cell proliferation, lymph node architecture, adaptive immune response
MeSH terms
Animals, Cell Communication, Cell Movement, Hematopoietic Stem Cells, Humans, Lymph Nodes, Lymphocyte Activation, Stromal Cells, Antigen Presentation, Chemokines, Adaptive Immunity

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