Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity
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Summary: Secondary lymphoid organs (SLO s), including lymph nodes, P eyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen‐presenting cells for cognate antigens, while moving along stromal networks. The cell‐cell interactions between stromal and hematopoietic cells in SLO s are therefore integral to the normal functioning of these tissues. Not only do stromal cells physically construct SLO architecture but they are essential for regulating hematopoietic populations within these domains. Stromal cells interact closely with lymphocytes and dendritic cells, providing scaffolds on which these cells migrate, and recruiting them into niches by secreting chemokines. Within lymph nodes, stromal cell‐ensheathed conduit networks transport small antigens deep into the SLO parenchyma. More recently, stromal cells have been found to induce peripheral CD 8+ T‐cell tolerance and control the extent to which newly activated T cells proliferate within lymph nodes. Thus, stromal‐hematopoietic crosstalk has important consequences for regulating immune cell function within SLO s. In addition, stromal cell interactions with hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal functions. Here, we examine ways in which these interactions within the lymph node environment influence the adaptive immune response.
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Structural cells (epithelium, endothelium, and fibroblasts) have been shown to contribute in important ways to mammalian immunity.
“These three cell types, which we refer to as “structural cells”, have been shown to contribute in important ways to mammalian immunity7–11.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [8]
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Immunological hallmarks of stromal cells in the tumour microenvironment
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Compartmentalized and systemic control of tissue immunity by commensals
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Mechanism of action of IL-7 and its potential applications and limitations in cancer immunotherapy
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- Authors
- Malhotra, D., Fletcher, A. L., & Turley, S. J.
- Affiliations
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Turley, Shannon J.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2012-12-19
- Volume
- 251
- Issue
- 1
- Pages
- 160-176
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3539229
- OpenAlex
- W2061753927
- Cited by
- 152
- References
- 122
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 13 · 2017: 21 · 2016: 18 · 2015: 25 · 2014: 12 · 2013: 8 · 2012: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (P01AI045757)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074500)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- secondary lymphoid organs, stromal cells, hematopoietic cells, lymph node stroma, dendritic cells, lymphocyte migration, chemokines, CD8+ T cell tolerance, T cell proliferation, lymph node architecture, adaptive immune response
- MeSH terms
- Animals, Cell Communication, Cell Movement, Hematopoietic Stem Cells, Humans, Lymph Nodes, Lymphocyte Activation, Stromal Cells, Antigen Presentation, Chemokines, Adaptive Immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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