The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Molecular, Cellular and Functional Effects of Radiation-Induced Brain Injury: A Review
Open accessAbstract
Radiation therapy is the most effective non-surgical treatment of primary brain tumors and metastases. Preclinical studies have provided valuable insights into pathogenesis of radiation-induced injury to the central nervous system. Radiation-induced brain injury can damage neuronal, glial and vascular compartments of the brain and may lead to molecular, cellular and functional changes. Given its central role in memory and adult neurogenesis, the majority of studies have focused on the hippocampus. These findings suggested that hippocampal avoidance in cranial radiotherapy prevents radiation-induced cognitive impairment of patients. However, multiple rodent studies have shown that this problem is more complex. As the radiation-induced cognitive impairment reflects hippocampal and non-hippocampal compartments, it is of critical importance to investigate molecular, cellular and functional modifications in various brain regions as well as their integration at clinically relevant doses and schedules. We here provide a literature overview, including our previously published results, in order to support the translation of preclinical findings to clinical practice, and improve the physical and mental status of patients with brain tumors.
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Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Irradiation induces neural precursor-cell dysfunction
Monje, M. L., Mizumatsu, S., Fike, J. R., & Palmer, T. D. (2002) · Nature Medicine · doi:10.1038/nm749 · Cited by 1,271
Why new neurons? Possible functions for adult hippocampal neurogenesis
Kempermann, G. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00635.2002 · Cited by 469
The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells
Lewis, C.-A., Manning, J., Rossi, F., & Krieger, C. (2012) · Neurology Research International · doi:10.1155/2012/803701 · Cited by 76 · cited 10×
“Astrocytes are the most numerous nonneuronal cell types in the CNS and represent about 50% of human brain volume.”
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Late side effects of radiation treatment for head and neck cancer
Brook, I. (2020) · Radiation Oncology Journal · doi:10.3857/roj.2020.00213 · Cited by 319
Sex-specific cognitive deficits following space radiation exposure
Parihar, V. K., Angulo, M. C., Allen, B. D., Syage, A., Usmani, M. T., Passerat de la Chapelle, E., Amin, A. N., Flores, L., Lin, X., Giedzinski, E., et al. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.535885 · Cited by 67
Hohsfield, L. A., Najafi, A. R., Ghorbanian, Y., Soni, N., Hingco, E. E., Kim, S. J., Jue, A. D., Swarup, V., Inlay, M. A., & Green, K. N. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01931-0 · Cited by 66
Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis
Sabirzhanov, B., Makarevich, O., Barrett, J., Jackson, I. L., Faden, A. I., & Stoica, B. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103695 · Cited by 31
Metadata
- Authors
- Balentova, S., & Adamkov, M.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-11-24
- Volume
- 16
- Issue
- 11
- Pages
- 27796-27815
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2173225193
- Cited by
- 175
- References
- 6
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
