The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Iron Homeostasis in Health and Disease
Open accessAbstract
Iron is required for the survival of most organisms, including bacteria, plants, and humans. Its homeostasis in mammals must be fine-tuned to avoid iron deficiency with a reduced oxygen transport and diminished activity of Fe-dependent enzymes, and also iron excess that may catalyze the formation of highly reactive hydroxyl radicals, oxidative stress, and programmed cell death. The advance in understanding the main players and mechanisms involved in iron regulation significantly improved since the discovery of genes responsible for hemochromatosis, the IRE/IRPs machinery, and the hepcidin-ferroportin axis. This review provides an update on the molecular mechanisms regulating cellular and systemic Fe homeostasis and their roles in pathophysiologic conditions that involve alterations of iron metabolism, and provides novel therapeutic strategies to prevent the deleterious effect of its deficiency/overload.
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Cites
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Advances in pathogenesis and therapeutic strategies for osteoporosis
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Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis
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Metadata
- Authors
- Gozzelino, R., & Arosio, P.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-01-20
- Volume
- 17
- Issue
- 1
- Pages
- 130
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2275619434
- Cited by
- 359
- References
- 124
- FWCI
- 27.65
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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