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Cited by 316

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

Open access
Ciardiello, Chiara, Cavallini, Lorenzo, Spinelli, Cristiana, Yang, Julie, Reis-Sobreiro, Mariana, De Candia, Paola, Minciacchi, Valentina, Di Vizio, Dolores·2016·International Journal of Molecular Sciences

Abstract

Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types.

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Crossref · 10.3390/ijms17020175

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Metadata

Authors
Ciardiello, C., Cavallini, L., Spinelli, C., Yang, J., Reis-Sobreiro, M., De Candia, P., Minciacchi, V., & Di Vizio, D.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2016-02-06
Volume
17
Issue
2
Pages
175
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2266388180
Cited by
316
References
8
FWCI
19.71
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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