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Cited by 301Extracellular vesicles in diseaseCellular transport and secretionCaveolin-1 and cellular processes

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

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Iraci, Nunzio, Leonardi, Tommaso, Gessler, Florian, Vega, Beatriz, Pluchino, Stefano·2016·International Journal of Molecular Sciences
DOI 10.3390/ijms17020171PMC PMC4783905
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Abstract

Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane vesicles, with distinct biogenesis routes, biophysical properties and different functions both in physiological conditions and in disease. The release of EVs is a widespread biological process, which is conserved across species. In recent years, numerous studies have demonstrated that several bioactive molecules are trafficked with(in) EVs, such as microRNAs, mRNAs, proteins and lipids. The understanding of their final impact on the biology of specific target cells remains matter of intense debate in the field. Also, EVs have attracted great interest as potential novel cell-free therapeutics. Here we describe the proposed physiological and pathological functions of EVs, with a particular focus on their molecular content. Also, we discuss the advances in the knowledge of the mechanisms regulating the secretion of EV-associated molecules and the specific pathways activated upon interaction with the target cell, highlighting the role of EVs in the context of the immune system and as mediators of the intercellular signalling in the brain.

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200 of 259 shown

Authors
Iraci, N., Leonardi, T., Gessler, F., Vega, B., & Pluchino, S.
Affiliations
  • Wellcome/MRC Cambridge Stem Cell Institute (GB)
  • European Bioinformatics Institute (GB)
Corresponding author
Pluchino, Stefano
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2016-02-06
Volume
17
Issue
2
Pages
171
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms17020171
PMC
PMC4783905
OpenAlex
W2269341591
Cited by
301
References
279
Citations by year
2026: 13 · 2025: 17 · 2024: 31 · 2023: 26 · 2022: 30 · 2021: 48 · 2020: 41 · 2019: 34 · 2018: 24 · 2017: 23 · 2016: 14
FWCI
2.86
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Multiple Sclerosis Society (RG-4001-A1)
  • Fondazione Italiana Sclerosi Multipla (RG 2010/R/31)
  • Wellcome Trust (FP7/2007–2013)
  • Multiple Sclerosis Society
  • Ministero della Salute
  • Cambridge Trust
  • Evelyn Trust (RG69865, 69865)
  • Gates Cambridge Trust
  • Institute on the Environment, University of Minnesota
  • Medical Research Council (MC_PC_12009)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
extracellular vesicles, membrane vesicles, vesicle biogenesis, microRNA, mRNA, proteins, lipids, intercellular communication, immune system, brain
MeSH terms
Extracellular Vesicles, Animals, Biological Transport, Cell Communication, Cell Transformation, Neoplastic, Disease Susceptibility, Humans, Proteins, RNA, Signal Transduction, Drug Delivery Systems, Exosomes, Immunomodulation

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