Epigenetic Modifications in Essential Hypertension
Open accessAbstract
Essential hypertension (EH) is a complex, polygenic condition with no single causative agent. Despite advances in our understanding of the pathophysiology of EH, hypertension remains one of the world’s leading public health problems. Furthermore, there is increasing evidence that epigenetic modifications are as important as genetic predisposition in the development of EH. Indeed, a complex and interactive genetic and environmental system exists to determine an individual’s risk of EH. Epigenetics refers to all heritable changes to the regulation of gene expression as well as chromatin remodelling, without involvement of nucleotide sequence changes. Epigenetic modification is recognized as an essential process in biology, but is now being investigated for its role in the development of specific pathologic conditions, including EH. Epigenetic research will provide insights into the pathogenesis of blood pressure regulation that cannot be explained by classic Mendelian inheritance. This review concentrates on epigenetic modifications to DNA structure, including the influence of non-coding RNAs on hypertension development.
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Notable changes in epigenetic modifications have been reported in hypertension and chronic kidney disease.
“and notable changes in epigenetic modifications have been reported in hyper-tension and CKD85,195.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [85]
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- Authors
- Wise, I., & Charchar, F.
- Affiliations
- Federation University (AU)
- Corresponding author
- Charchar, Fadi
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-03-25
- Volume
- 17
- Issue
- 4
- Pages
- 451
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC4848907
- OpenAlex
- W2302794419
- Cited by
- 113
- References
- 69
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 8 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 10 · 2019: 13 · 2018: 22 · 2017: 6 · 2016: 2 · 2013: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- FedUni ResearchOnline (Federation University Australia) (submittedVersion, cc-by)
- FedUni ResearchOnline (Federation University Australia) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- essential hypertension, epigenetic modifications, DNA methylation, non-coding RNA, gene expression regulation, chromatin remodeling, blood pressure regulation, polygenic hypertension, genetic and environmental risk factors
- MeSH terms
- Essential Hypertension, Histones, Humans, Hypertension, DNA Methylation, RNA, Untranslated, MicroRNAs, Epigenesis, Genetic
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