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Cited by 1,099Protease and Inhibitor MechanismsSkin Protection and AgingTGF-β signaling in diseases

Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis

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Pittayapruek, Pavida, Meephansan, Jitlada, Prapapan, Ornicha, Komine, Mayumi, Ohtsuki, Mamitaro·2016·International Journal of Molecular Sciences
DOI 10.3390/ijms17060868PMC PMC4926402
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Abstract

Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16). The alterations made to the ECM by MMPs might contribute in skin wrinkling, a characteristic of premature skin aging. In photocarcinogenesis, degradation of ECM is the initial step towards tumor cell invasion, to invade both the basement membrane and the surrounding stroma that mainly comprises fibrillar collagens. Additionally, MMPs are involved in angiogenesis, which promotes cancer cell growth and migration. In this review, we focus on the present knowledge about premature skin aging and skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, with our main focus on members of the MMP family and their functions.

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Authors
Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., & Ohtsuki, M.
Affiliations
  • Thammasat University (TH)
  • Jichi Medical University (JP)
Corresponding author
Komine, Mayumi
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2016-06-02
Volume
17
Issue
6
Pages
868
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms17060868
PMC
PMC4926402
OpenAlex
W2409710963
Cited by
1,099
References
101
Citations by year
2026: 99 · 2025: 116 · 2024: 143 · 2023: 158 · 2022: 181 · 2021: 130 · 2020: 105 · 2019: 87 · 2018: 47 · 2017: 30 · 2016: 3
FWCI
5.06
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Thailand Research Fund (TRG5780230)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
matrix metalloproteinases, photoaging, photocarcinogenesis, extracellular matrix degradation, collagenase, gelatinase, stromelysin, matrilysin, membrane-type MMPs, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, tumor invasion, angiogenesis, skin wrinkling
MeSH terms
Aging, Animals, Cell Transformation, Neoplastic, Humans, Neoplasms, Ultraviolet Rays, Reactive Oxygen Species, Matrix Metalloproteinases

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