Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin
Open accessAbstract
Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging. UV-induced oxidative damage and induction of matrix metalloproteinases (MMP) have been implicated in this process. Because polyphenols from green tea (GTP) prevent other cutaneous adverse effects of UV radiation we hypothesized that UV irradiation-induced oxidative damage and induction of MMP might be prevented in vivo in mouse skin by oral administration of GTP. GTP was administered in drinking water (0.2%, wt/vol) to SKH-1 hairless mice, which were then exposed to multiple doses of UVB (90 mJ per cm2, for 2 mo on alternate days) following in vivo photoaging animal protocol. Treatment of GTP resulted in inhibition of UVB-induced protein oxidation in vivo in mouse skin, a hallmark of photoaging, when analyzed biochemically, by immunoblotting, and immunohistochemistry. GTP treatment also inhibited UVB-induced protein oxidation in vitro in human skin fibroblast HS68 cells, which supports in vivo observations. Moreover, oral administration of GTP also resulted in inhibition of UVB-induced expression of matrix degrading MMP, such as MMP-2 (67%), MMP-3 (63%), MMP-7 (62%), and MMP-9 (60%) in hairless mouse skin. These data suggest that GTP as a dietary supplement could be useful to attenuate solar UVB light-induced premature skin aging.
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Green tea polyphenols in drinking water (0.2%, w/v) inhibited UVB-induced oxidative stress in the skin of SKH-1 hairless mice exposed to multiple doses of UVB light (90 mJ/cm2) for two months.
“A study by Vayalil et al. demonstrated the inhibition of oxidative stress induced by UVB radiation in the skin of SKH-1 hairless mice that received GTPs in their drinking water (0.2%, w/v) and were then exposed to multiple doses of UVB light (90 mJ/cm2) for two months.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [213]
Green tea polyphenols inhibited the UVB-induced expression of matrix-degrading MMPs, such as MMP-2 (67%), MMP-3 (63%), MMP-7 (62%) and MMP-9 (60%).
“The inhibition of protein oxidation was observed, as was the inhibition of the UVB-induced expression of matrix-degrading MMPs, such as MMP-2 (67%), MMP-3 (63%), MMP-7 (62%) and MMP-9 (60%) [213].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [213]
Research indicates that green tea polyphenols can alleviate the symptoms of premature skin ageing induced by UVB radiation.
“Research also indicates that GTPs can alleviate the symptoms of premature skin ageing induced by UVB radiation [213].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [213]
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- Authors
- Vayalil, P. K., Mittal, A., Hara, Y., Elmets, C. A., & Katiyar, S. K.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Katiyar, Santosh K.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2004-06
- Volume
- 122
- Issue
- 6
- Pages
- 1480-1487
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1984055188
- Cited by
- 262
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 14 · 2016: 21 · 2015: 18 · 2014: 15 · 2013: 14 · 2012: 17
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03ca094593-01, 5r03es011421-02, 5r01ca079820-05)
- National Cancer Institute (CA 79820, CA94593)
- National Institute of Environmental Health Sciences (ES11421)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- green tea polyphenols, photoaging, UV-B radiation, oxidative damage, matrix metalloproteinases, MMP-2, MMP-3, MMP-7, MMP-9, protein oxidation, dermal fibroblasts, dietary supplements, SKH-1 mice
- MeSH terms
- Administration, Oral, Animals, Cells, Cultured, Female, Fibroblasts, Flavonoids, Humans, Mice, Hairless, Phenols, Skin, Specific Pathogen-Free Organisms, Tea, Ultraviolet Rays, Oxidative Stress, Matrix Metalloproteinase 3, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Matrix Metalloproteinases, Matrix Metalloproteinase 7, Collagen Type IV, Mice, Polyphenols
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