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Dietary Strategies Implicated in the Prevention and Treatment of Metabolic Syndrome
Open accessAbstract
Metabolic syndrome (MetS) is established as the combination of central obesity and different metabolic disturbances, such as insulin resistance, hypertension and dyslipidemia. This cluster of factors affects approximately 10%-50% of adults worldwide and the prevalence has been increasing in epidemic proportions over the last years. Thus, dietary strategies to treat this heterogenic disease are under continuous study. In this sense, diets based on negative-energy-balance, the Mediterranean dietary pattern, n-3 fatty acids, total antioxidant capacity and meal frequency have been suggested as effective approaches to treat MetS. Furthermore, the type and percentage of carbohydrates, the glycemic index or glycemic load, and dietary fiber content are some of the most relevant aspects related to insulin resistance and impaired glucose tolerance, which are important co-morbidities of MetS. Finally, new studies focused on the molecular action of specific nutritional bioactive compounds with positive effects on the MetS are currently an objective of scientific research worldwide. The present review summarizes some of the most relevant dietary approaches and bioactive compounds employed in the treatment of the MetS to date.
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“Generally, energy-restricting diets are aimed at inducing a state of negative energy balance so that stored lipids inside adipocytes are used as alternative substrates (233).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [233]
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Metadata
- Authors
- De la Iglesia, R., Loria-Kohen, V., Zulet, M., Martinez, J., Reglero, G., & Ramirez de Molina, A.
- Affiliations
- GENYAL Platform on Nutrition and Health, IMDEA Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Department of Nutrition, Food Science and Physiology, University of Navarra, 31008 Pamplona, Spain
- Madrid Institute for Advanced Studies (ES)
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-11-10
- Volume
- 17
- Issue
- 11
- Pages
- 1877
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5133877
- OpenAlex
- W2553075863
- Cited by
- 168
- References
- 188
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 25 · 2021: 25 · 2020: 19 · 2019: 16 · 2018: 25 · 2017: 11
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metabolic syndrome, dietary intervention, Mediterranean diet, omega-3 fatty acids, negative energy balance, meal frequency, total antioxidant capacity, insulin resistance, impaired glucose tolerance, glycemic index, glycemic load, dietary fiber, carbohydrate quality, abdominal obesity, dyslipidemia, hypertension
- MeSH terms
- Diet, Dietary Fiber, Energy Metabolism, Feeding Behavior, Humans, Nutritional Physiological Phenomena, Fatty Acids, Omega-3, Metabolic Syndrome, Glycemic Index, Diet, Mediterranean
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