The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide
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Abstract
Cell-penetrating peptides (CPPs), which can facilitate the transport of molecular cargo across the plasma membrane, have become important tools in promoting the cellular delivery of macromolecules. GV1001, a peptide derived from a reverse-transcriptase subunit of telomerase (hTERT) and developed as a vaccine against various cancers, reportedly has unexpected CPP properties. Unlike typical CPPs, such as the HIV-1 TAT peptide, GV1001 enabled the cytosolic delivery of macromolecules such as proteins, DNA and siRNA via extracellular heat shock protein 90 (eHSP90) and 70 (eHSP70) complexes. The eHSP-GV1001 interaction may have biological effects in addition to its cytosolic delivery function. GV1001 was originally designed as a major histocompatibility complex (MHC) class II-binding cancer epitope, but its CPP properties may contribute to its strong anti-cancer immune response relative to other telomerase peptide-based vaccines. Cell signaling via eHSP-GV1001 binding may lead to unexpected biological effects, such as direct anticancer or antiviral effects. In this review, we focus on the CPP effects of GV1001 bound to eHSP90 and eHSP70.
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Six active immunotherapy agents are currently studied in phase 1, 2, and 3 clinical trials: CAD106, ABvac40, GV1001, ACC-001, UB-311, and Lu AF20513.
“Six active immunotherapy agents are currently studied in phase 1, 2, and 3 clinical trials:”
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Karpov, O., Lahav, M., Wolach, O., Raanani, P., Peer, D., Kaplan, T., & Uziel, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112872 · Cited by 1 · see citing works
A Significance Correlation between Malignant Tumors and Telomerase
AL-Khafaf, M. N., Abubaker, S. R., & Ahmed, A. (2021) · Annals of the Romanian Society for Cell Biology
Langel, Ü. (2019) · Springer eBooks · doi:10.1007/978-981-13-8747-0_1
Langel, Ü. (2023) · Springer eBooks · doi:10.1007/978-3-031-38731-9_1
Langel, Ü. (2023) · Springer eBooks · doi:10.1007/978-3-031-38731-9_13
Age-related disease: Effective intervention
Fossel, M., & Cooke, J. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00013-x
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Singh, A., Misra, A., & Zaheer, S. (2026) · Aging and Cancer · doi:10.1002/aac2.70027
Felicidade, J., Blandón‐Cumbreras, F. G., Arteaga, J. F., Remón, P., Fernandes, A. M. A., Salluce, G., Gasser, G., Nájera, F., Santos, F. M. F., Pischel, U., et al. (2026) · ChemistryEurope · doi:10.1002/ceur.70362
- Authors
- Kim, H., Seo, E.-H., Lee, S.-H., & Kim, B.-J.
- Affiliations
- Seoul National University (KR)
- Konkuk University (KR)
- Corresponding author
- Kim, Bum-Joon
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-12-07
- Volume
- 17
- Issue
- 12
- Pages
- 2054
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5187854
- OpenAlex
- W2560252815
- Cited by
- 48
- References
- 59
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 1 · 2016: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Research Foundation (NRF) grant of Ministry of Science, ICT and Future Planning, South Korea (NRF-2015R1C1A1A02037267)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- GV1001, cell-penetrating peptides, telomerase reverse transcriptase, hTERT, cancer vaccines, siRNA delivery, antitumor immunity, antiviral activity
- MeSH terms
- Animals, Heat-Shock Proteins, Humans, Peptide Fragments, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Telomerase, Vaccines, Subunit, Cell-Penetrating Peptides
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