Regulation of Ketone Body Metabolism and the Role of PPARα

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

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Defining the role of mTOR in cancer

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations

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Roles of PPARs in health and disease

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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The kinetics of enzyme-catalyzed reactions with two or more substrates or products

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Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

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Targeting Metabolic Cross Talk Between Cancer Cells and Cancer-Associated Fibroblasts

Jung, J. G., & Le, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65768-0_15 · Cited by 24

Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models

Ari, C., Murdun, C., Goldhagen, C. R., Koutnik, A. P., Bharwani, S., Diamond, D. M., Kindy, M. S., D’Agostino, D. P., & Kovács, Z. (2020) · Nutrients · doi:10.3390/nu12082459 · Cited by 23

Ketogenic diet: a tool for the management of neuroendocrine neoplasms?

Muscogiuri, G., Barrea, L., Campolo, F., Sbardella, E., Sciammarella, C., Tarsitano, M. G., Bottiglieri, F., Colao, A., & Faggiano, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1832955 · Cited by 23

Transcriptomic and metabolomic characterization of post-hatch metabolic reprogramming during hepatic development in the chicken

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Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm

Cooper, I. D., Brookler, K. H., Kyriakidou, Y., Elliott, B., & Crofts, C. A. P. (2021) · Biomedicines · doi:10.3390/biomedicines9070800 · Cited by 24

Is there a relationship between the ketogenic diet and sleep disorders?

Barrea, L., Pugliese, G., Frías-Toral, E., Napolitano, B., Laudisio, D., Aprano, S., Ceriani, F., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1993154 · Cited by 23

Aerobic exercise for eight weeks provides protective effects towards liver and cardiometabolic health and adipose tissue remodeling under metabolic stress for one week: A study in mice

Kim, Y. J., Kim, H. J., Lee, S. G., Kim, D. H., Jang, S., Go, H. S., Lee, W. J., & Seong, J. K. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155178 · Cited by 23

Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Ursino, G., Ramadori, G., Höfler, A., Odouard, S., Teixeira, P. D. S., Visentin, F., Veyrat‐Durebex, C., Lucibello, G., Firnkes, R., Ricci, S., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31803-5 · Cited by 24

Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms

Sridharan, B., & Lee, M. (2021) · Current Molecular Medicine · doi:10.2174/1566524021666211004104703 · Cited by 22

Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention

Li, B., Liao, Z., Mo, Y., Zhao, W., Zhou, X., Xiao, X., Cui, W., Feng, G., Zhong, S., Liang, Y., et al. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0638-8 · Cited by 22

α-Lactalbumin ameliorates hepatic lipid metabolism in high-fat-diet induced obese C57BL/6J mice

Chen, H., Guan, K., Qi, X., Wang, R., & Ma, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104253 · Cited by 25

Quantitation of Reactive Acyl-CoA Species Mediated Protein Acylation by HPLC–MS/MS

Baldensperger, T., Sanzo, S. D., Ori‬‬, A., & Glomb, M. A. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02656 · Cited by 21

Biophysical characterization of melanoma cell phenotype markers during metastatic progression

Sobiepanek, A., Paone, A., Cutruzzolà, F., & Kobiela, T. (2021) · European Biophysics Journal · doi:10.1007/s00249-021-01514-8 · Cited by 21

Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease

Pickel, L., Iliuta, I.-A., Scholey, J. W., Pei, Y., & Sung, H. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab131 · Cited by 21

Analyses of lung cancer-derived volatiles in exhaled breath and in vitro models

Choueiry, F., Barham, A., & Zhu, J. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221082634 · Cited by 21

β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis

Jiang, H., Bai, Z., Ou, Y., Liu, H., Si, Z.-L., Liu, Y., Liu, X., Liu, X., Zhang, Z., & Tan, N. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.116013 · Cited by 21

The proteomic effects of ketone bodies: implications for proteostasis and brain proteinopathies

García‐Velázquez, L., & Massieu, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1214092 · Cited by 21

Two-dimensional LC-MS/MS and three-dimensional LC analysis of chiral amino acids and related compounds in real-world matrices

Ishii, C., & Hamase, K. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115627 · Cited by 22

Therapies for Alzheimer’s disease: a metabolic perspective

Domingues, R., Pereira, C., Cruz, M. T., & Silva, A. (2021) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2021.01.011 · Cited by 21

The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome

Gilbert‐Jaramillo, J., Garcez, P. P., James, W., Molnár, Z., & Clarke, K. (2019) · Journal of Anatomy · doi:10.1111/joa.12959 · Cited by 20

Inuit metabolism revisited: what drove the selective sweep of CPT1a L479?

Hale, N. (2020) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2020.01.010 · Cited by 20

Ketogenic diet alleviates renal fibrosis in mice by enhancing fatty acid oxidation through the free fatty acid receptor 3 pathway

Qiu, Y., Hu, X.-F., Xu, C., Lu, C., Cao, R., Xie, Y., & Yang, J. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1127845 · Cited by 20

Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females

Cooper, I. D., Kyriakidou, Y., Edwards, K., Petagine, L., Seyfried, T. N., Duraj, T., Soto-Mota, A., Scarborough, A., Jacome, S. L., Brookler, K. H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115621 · Cited by 20

Unveiling the role of interleukin-6 in pancreatic cancer occurrence and progression

Song, M., Tang, Y., Cao, K., Qi, L., & Xie, K. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1408312 · Cited by 22

Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals

Guo, M., Jiang, X., Ouyang, H., Zhang, X., Zhang, S., Wang, P., Bi, G., Wu, T., Zhou, W., Liang, F., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.01.024 · Cited by 19

Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bodies and Relevance of HMGCS2 to Health and Disease

Suresh, V. V., Sivaprakasam, S., Bhutia, Y. D., Prasad, P. D., Thangaraju, M., & Ganapathy, V. (2025) · Biomolecules · doi:10.3390/biom15040580 · Cited by 19

PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα

Lin, Y., Chen, L., You, X., Li, Z., Li, C., & Chen, Y. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101331 · Cited by 19

Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension

Reyes-García, J., Carbajal-García, A., Mise, A. D., Zheng, Y., Wang, X., & Wang, Y.-X. (2022) · Antioxidants · doi:10.3390/antiox11030473 · Cited by 20

Reprogramming of glucocorticoid receptor function by hypoxia

Vanderhaeghen, T., Timmermans, S., Watts, D., Paakinaho, V., Eggermont, M., Vandewalle, J., Wallaeys, C., Wyngene, L. V., Looveren, K. V., Nuyttens, L., et al. (2021) · EMBO Reports · doi:10.15252/embr.202153083 · Cited by 17

Ketogenic Diet and Ketone Bodies as Clinical Support for the Treatment of SARS-CoV-2—Review of the Evidence

Bolesławska, I., Kowalówka, M., Bolesławska-Król, N., & Przysławski, J. (2023) · Viruses · doi:10.3390/v15061262 · Cited by 18

Various types of fasting diet and possible benefits in nonalcoholic fatty liver: Mechanism of actions and literature update

Mirrazavi, Z. S., & Behrouz, V. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.005 · Cited by 20

The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

Xie, J., Chen, X., Zheng, M., Zhu, J., & Mao, H. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2904143 · Cited by 18

Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase

MAZZIO, E. A., Badisa, R. B., Mack, N., Cassim, S., Ždralević, M., Pouysségur, J., & Soliman, K. F. A. (2020) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20205 · Cited by 17

Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model

Delaye, J.-B., Lanznaster, D., Veyrat‐Durebex, C., Fontaine, A., Bacle, G., Lefèvre, A., Hergesheimer, R., Lecron, J., Vourc’h, P., Andres, C. R., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00933-3 · Cited by 17

Functional Characterization of the Lin28/let-7 Circuit During Forelimb Regeneration in Ambystoma mexicanum and Its Influence on Metabolic Reprogramming

Varela-Rodríguez, H., Abella-Quintana, D. G., Espinal‐Centeno, A., Varela-Rodríguez, L., Gomez‐Zepeda, D., Caballero-Pérez, J., García‐Medel, P. L., Brieba, L. G., Ordaz-Ortíz, J. J., & Cruz‐Ramírez, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.562940 · Cited by 18

Effect of Nardostachys jatamansi DC. on Apoptosis, Inflammation and Oxidative Stress Induced by Doxorubicin in Wistar Rats

Singh, M., Khan, M. A., Kamal, Y. T., Ahmad, J., Fahmy, U. A., Kotta, S., Alhakamy, N. A., & Ahmad, S. (2020) · Plants · doi:10.3390/plants9111579 · Cited by 16

Zishen Qingre Tongluo Formula Improves Renal Fatty Acid Oxidation and Alleviated Fibrosis via the Regulation of the TGF‐ β 1/Smad3 Signaling Pathway in Hyperuricemic Nephrology Rats

Liu, P., Wang, C., Wang, Y., Zhang, H., Liu, B., & Qiu, X. (2021) · BioMed Research International · doi:10.1155/2021/2793823 · Cited by 16

Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models

Cui, H., Hu, D., Liu, Y., & Zhao, J. (2023) · Gene · doi:10.1016/j.gene.2023.148053 · Cited by 16

Glucose and Fatty Acid Metabolism of Dairy Cows in a Total Mixed Ration or Pasture-Based System During Lactation

García-Roche, M., Cañibe, G., Casal, A., Mattiauda, D. A., Ceriani, M., Jasinsky, A., Cassina, A., Quijano, C., & Carriquiry, M. (2021) · Frontiers in Animal Science · doi:10.3389/fanim.2021.622500 · Cited by 16

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

D’Imperio, S., Monasky, M. M., Micaglio, E., Negro, G., & Pappone, C. (2021) · Nutrients · doi:10.3390/nu13082482 · Cited by 16

Identification of Novel Key Molecular Signatures in the Pathogenesis of Experimental Diabetic Kidney Disease

Diao, M., Wu, Y., Yang, J., Liu, C., Xu, J., Jin, H., Wang, J., Zhang, J., Gao, F., Jin, C., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.843721 · Cited by 16

Potential for Ketotherapies as Amyloid-Regulating Treatment in Individuals at Risk for Alzheimer’s Disease

Taylor, M., Sullivan, D. K., Keller, J. E., Burns, J. M., & Swerdlow, R. H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.899612 · Cited by 17

Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing

Zhang, Y., Tu, S., Shao, X., Meng, J., Zhang, Z., Wei, W., Jing, X., Qin, Z., Wu, J., Xu, W., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69341-z · Cited by 18

Plasma and urine metabolite profiling reveals the protective effect of Clinacanthus nutans in an ovalbumin-induced anaphylaxis model: 1H-NMR metabolomics approach

Khoo, L. W., Kow, A. S. F., Maulidiani, M., Lee, M. T., Tan, C. P., Shaari, K., Tham, C. L., & Abas, F. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.06.038 · Cited by 15

Alterations in plasma concentrations of energy-balance-related metabolites in patients with lung, or head & neck, cancers: Effects of radiotherapy

Rodríguez‐Tomàs, E., Arguís, M., Arenas, M., Fernández‐Arroyo, S., Murcia, M., Sabater, S., Torres, L., Baiges‐Gayà, G., Hernández‐Aguilera, A., Camps, J., et al. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103605 · Cited by 15

Dietary Copper Deficiency Leads to Changes in Gene Expression Indicating an Increased Demand for NADH in the Prefrontal Cortex of the Rat’s Brain

Cendrowska‐Pinkosz, M., Ostrowska-Leśko, M., Ognik, K., Krauze, M., Juśkiewicz, J., Dąbrowska, A. M., Szponar, J., & Mańdziuk, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126706 · Cited by 15

Ketone bodies in exercise, health and disease: Metabolic mechanisms, pathophysiology, and therapeutic implications

Yin, L., Liu, Q., Jia, Z., & Guo, B. (2025) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2025.05.004 · Cited by 17

The enedioic acid analog 326E alleviates metabolic dysfunction-associated steatohepatitis via dual targeting at ACLY and PPARα

Xie, Z., Cheng, L., Hu, Y. H., Song, G., Wang, F., Zhang, M., Zhang, Y., Zhang, X., Zhou, C., Zhu, X., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.011 · Cited by 14

Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation

Lu, D., Liu, Y., Luo, Y., Zhao, J., Feng, C., Xue, L., Xu, J., Wang, Q., Yan, T., Xiao, P., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159089 · Cited by 14

Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism

Pan, L., Xu, Z., Wen, M., Li, M., Lyu, D., Xiao, H., Li, Z., Xiao, J., Cheng, Y., & Huang, H. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00959-1 · Cited by 15

Role of OXCT1 in ovine adipose and preadipocyte differentiation

Zeng, J., Zhou, S., Zhao, J., Jin, M., Kang, D., Yang, Y., Wang, X., & Chen, Y.-L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.128 · Cited by 14

Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue

Park, S., Song, J., Baek, I., Jang, K. Y., Han, C. Y., Jun, D. W., Kim, P. K., Raught, B., & Jin, E. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00648-1 · Cited by 14

Heme Oxygenase-1 and Blood Bilirubin Are Gradually Activated by Oral D-Glyceric Acid

Hirvonen, O. P., Lehti, M., Kyröläinen, H., & Kainulainen, H. (2022) · Antioxidants · doi:10.3390/antiox11122319 · Cited by 14

Is Fasting Good When One Is at Risk of Liver Cancer?

Minciună, I., van Kleef, L. A., Ştefănescu, H., & Procopeț, B. (2022) · Cancers · doi:10.3390/cancers14205084 · Cited by 13

Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress

Catapano, J., Luty, M., Wróbel, T., Pudełek, M., Piwowarczyk, K., Kędracka–Krok, S., Siedlar, M., Madeja, Z., & Czyż, J. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00400-1 · Cited by 13

Perfluorooctanesulfonic acid exposure leads to downregulation of 3-hydroxy-3-methylglutaryl-CoA synthase 2 expression and upregulation of markers associated with intestinal carcinogenesis in mouse intestinal tissues

Tessmann, J. W., Deng, P., Durham, J., Li, C., Banerjee, M., Wang, Q., Goettl, R. A., He, D., Wang, C., Lee, E. Y., et al. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142332 · Cited by 13

Functionalized Graphene-Based Biosensors for Early Detection of Subclinical Ketosis in Dairy Cows

Chick, S., Kachouei, M. A., Knowlton, K. F., & Ali, M. A. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c07715 · Cited by 13

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism

Blankestijn, M., Bloks, V. W., Struik, D., Huijkman, N., Kloosterhuis, N., Wolters, J. C., Wanders, R. J. A., Vaz, F. M., Islinger, M., Kuipers, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-06479-y · Cited by 13

Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells

Qiao, X., Li, Y., Mai, J., Ji, X., & Li, Q. (2018) · Molecules · doi:10.3390/molecules23071654 · Cited by 13

Development of a selective three-dimensional HPLC system for enantiomer discriminated analysis of lactate and 3-hydroxybutyrate in human plasma and urine

Hsieh, C.-L., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113871 · Cited by 13

Signal integration in the (m)TORC1 growth pathway

Ramlaul, K., & Aylett, C. H. S. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1501-7 · Cited by 12

Metabolic regulation of interferon-mediated innate antiviral immunity

Tian, Z., Cao, Q., Ma, Z., & Jiang, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680688 · Cited by 13

Low-Carbohydrate Ketogenic Diet for Improvement of Glycemic Control: Mechanism of Action of Ketosis and Beneficial Effects

Das, S., Sakr, H. F., Sirasanagandla, S. R., Bima, A. I. H., & Elsamanoudy, A. Z. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220511121629 · Cited by 13

Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease

Roberts, C.-T., Raabe, N., Wiegand, L., Shahib, A. K., & Rastegar, M. (2024) · Pharmaceuticals · doi:10.3390/ph17121601 · Cited by 13

Comprehensive Overview of Ketone Bodies in Cancer Metabolism: Mechanisms and Application

Liang, Z., Deng, L., Zhou, X., Zhang, Z., & Zhao, W. (2025) · Biomedicines · doi:10.3390/biomedicines13010210 · Cited by 12

Is Breath Best? A Systematic Review on the Accuracy and Utility of Nanotechnology Based Breath Analysis of Ketones in Type 1 Diabetes

Marfatia, K., Ni, H., Preda, V. A., & Nasiri, N. (2025) · Biosensors · doi:10.3390/bios15010062 · Cited by 12

Sleep profile during fasting in PPAR-alpha knockout mice

Kondo, Y., Chikahisa, S., Shiuchi, T., Shimizu, N., Tanioka, D., Uguisu, H., & Séi, H. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112760 · Cited by 12

Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells

Hu, T., Huang, W., Li, Z., Kane, M. A., Zhang, L., Huang, S. M., & Wang, H. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115117 · Cited by 12

Pan-Cancer Analysis of Glycolytic and Ketone Bodies Metabolic Genes: Implications for Response to Ketogenic Dietary Therapy

Qian, L., Li, Y., Cao, Y., Meng, G., Peng, J., Li, H., Wang, Y., Xu, T., Zhang, L., Sun, B., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.689068 · Cited by 15

Lipid exposure activates gene expression changes associated with estrogen receptor negative breast cancer

Yadav, S., Virk, R. K. A., Chung, C. H., Eduardo, M. B., VanDerway, D., Chen, D., Burdett, K. B., Gao, H., Zeng, Z., Ranjan, M., et al. (2022) · npj Breast Cancer · doi:10.1038/s41523-022-00422-0 · Cited by 11

Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)

Tada, A., Misawa, E., Tanaka, M., Saito, M., Nabeshima, K., Yamauchi, K., Abe, F., Goto, T., & Kawada, T. (2020) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.66.176 · Cited by 12

Royaume du Maroc

Benhima (1962) · Présence Africaine · doi:10.3917/presa.042.0147 · Cited by 13

Regulation of adult stem cell function by ketone bodies

Andersen, O. E., Poulsen, J. V., Farup, J., & de Morrée, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1246998 · Cited by 13

Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach

Mir, R., Javid, J., Ullah, M. F., Alrdahe, S. S., Albalawi, I. A., Mustafa, S. K., Jalal, M. M., Altayar, M. A., Albalawi, A. D., Abunab, M. K., et al. (2025) · Medical Oncology · doi:10.1007/s12032-025-02945-5 · Cited by 12

Energy Crisis Links to Autophagy and Ferroptosis in Alzheimer’s Disease: Current Evidence and Future Avenues

Fan, Y., Wang, Z., & He, D. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220817140737 · Cited by 11

Exploring the impacts of ketogenic diet on reversible hepatic steatosis: initial analysis in male mice

Ravaut, G., Carneiro, A., & Mounier, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1290540 · Cited by 12

Comparative study on different field tests of ketosis using blood, milk, and urine in dairy cattle

Faruk, M. S. A., Park, B., Ha, S., Lee, S., Mamuad, L. L., & Cho, Y. (2020) · Veterinární Medicína · doi:10.17221/69/2019-vetmed · Cited by 12

The Effect of Nutritional Ketosis on Aquaporin Expression in Apolipoprotein E-Deficient Mice: Potential Implications for Energy Homeostasis

da Silva, I. V., Gullette, S., Florindo, C., Huang, N. K., Neuberger, T., Ross, A., Soveral, G., & Castro, R. (2022) · Biomedicines · doi:10.3390/biomedicines10051159 · Cited by 10

HMGCS2 Mediation of Ketone Levels Affects Sorafenib Treatment Efficacy in Liver Cancer Cells

Suk, F., Wu, C.-Y., Chiu, W., Chien, C.-Y., Chen, T.-L., & Liao, Y. (2022) · Molecules · doi:10.3390/molecules27228015 · Cited by 10

Development of a Three-Dimensional HPLC System for the Simultaneous Determination of Lactate and 3-Hydroxybutyrate Enantiomers in Mammalian Urine

HSIEH, C.-L., Lin, P.-Y., Akita, T., Mita, M., Ide, T., Lee, J., & Hamase, K. (2018) · Chromatography · doi:10.15583/jpchrom.2018.021 · Cited by 10

Intermittent cold stimulation affects energy metabolism and improves stress resistance in broiler heart

Li, T., Wei, H., Zhang, S., Liu, X. K., Lu, X., Liu, Y., Gong, R., & Li, J. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103190 · Cited by 9

Mildly elevated serum bilirubin and its correlations with lipid levels among male patients undergoing health checkups

Bai, X., Qiao, J., & Zhang, H. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01979-w · Cited by 9

Adaptive metabolic response to short-term intensive fasting

Zhang, S., Lv, Y., Qian, J., Wei, W., Zhu, Y., Liu, Y., Li, L., Zhao, C., Gao, X., Yang, Y., et al. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.12.020 · Cited by 9

Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity

Chen, X., Wang, L., Denning, K. L., Mazur, A., Xu, Y., Wang, K., Lawrence, L. M., Wang, X., & Lu, Y. (2024) · Biomedicines · doi:10.3390/biomedicines12050988 · Cited by 9

Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase

Schlicker, L., Zhao, G., Dudek, C.-A., Boers, H. M., Meyer‐Hermann, M., Jacobs, D. M., & Hiller, K. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.785999 · Cited by 12

Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer

Langer, H. T., Ramsamooj, S., Liang, R. J., Grover, R., Hwang, S., & Goncalves, M. D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.903157 · Cited by 9

Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice

Iso, T., Haruyama, H., Sunaga, H., Matsui, M., Matsui, H., Tanaka, R., Umbarawan, Y., Syamsunarno, M. R. A. A., Yokoyama, T., & Kurabayashi, M. (2019) · BMC Physiology · doi:10.1186/s12899-019-0038-6 · Cited by 9

The physiology of ketosis and the ketogenic diet

Leonard, T. G. A. (2020) · Southern African Journal of Anaesthesia and Analgesia · doi:10.36303/sajaa.2020.26.6.s3.2547 · Cited by 9

Anti‐aging effects of intermittent fasting: a potential alternative to calorie restriction?

Bhoumik, S., & Rizvi, S. I. (2021) · Biologia · doi:10.1007/s11756-021-00770-5 · Cited by 10

Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease

Berndt, N., Hudert, C. A., Eckstein, J., Loddenkemper, C., Henning, S., Bufler, P., Meierhofer, D., Sack, I., Wiegand, S., Wallach, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911072 · Cited by 9

Network pharmacology approach to bioactive chemical compounds identified from Lespedeza bicolor lignum methanol extract by GC–MS for amelioration of hepatitis

Oh, K., Adnan, M., & Cho, D. H. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100851 · Cited by 9

Comparative Effects of Efavirenz and Dolutegravir on Metabolomic and Inflammatory Profiles, and Platelet Activation of People Living with HIV: A Pilot Study

Roux, C., Mason, S., du Toit, L. D. V., Nel, J. G., Rossouw, T. M., & Steel, H. C. (2024) · Viruses · doi:10.3390/v16091462 · Cited by 8

Maladaptive Peripheral Ketogenesis in Schwann Cells Mediated by CB 1 R Contributes to Diabetic Neuropathy

Li, W., Yang, T., Wang, N., Li, B., Meng, C., Yu, K., Zhou, X., Cao, R., & Cui, S. (2025) · Advanced Science · doi:10.1002/advs.202414547 · Cited by 9

NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2

Suo, D., Wang, L., Zeng, T., Zhang, H., Li, L., Liu, J., Yun, J., Guan, X., & Li, Y. (2020) · Oncogenesis · doi:10.1038/s41389-020-00260-4 · Cited by 9

1,25(OH)2D3 alleviates oxidative stress and inflammation through up-regulating HMGCS2 in DSS-induced colitis

Wang, H., Zhao, M., Hong, S., He, X., Li, T., Tong, C.-C., Guan, J. Z., Xu, D., & Chen, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111131 · Cited by 9

Systems-wide effects of short-term feed deprivation in obese mice

Andersen, D., Roager, H. M., Zhang, L., Moll, J. M., Frandsen, H. L., Danneskiold‐Samsøe, N. B., Hansen, A. K., Kristiansen, K., Licht, T. R., & Brix, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-85020-z · Cited by 8

The Effects of Nettle Extract Consumption on Liver PPARs, SIRT1, ACOX1 and Blood Lipid Levels in Male and Female C57Bl6 Mice

Drozdek, S. D., Odeh, D., Đikić, D., Gračan, R., Oršolić, N., Dragović‐Uzelac, V., Turković, L. F., Dragičević, P., & Jurčević, I. L. (2022) · Nutrients · doi:10.3390/nu14214469 · Cited by 8

Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets

Dey, A. D., Mannan, A., Dhiman, S., & Singh, T. G. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06617-6 · Cited by 8

Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats

Vukšić, A., Lovrić, J., Konjevoda, P., Blažević, N., Bilušić, M., & Bradamante, V. (2019) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/aiht-2019-70-3215 · Cited by 7

Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential

Stalińska, J., Houser, L., Rak, M., Colley, S. B., Krzysztof Reiss, F., & Jursic, B. S. (2019) · Scientific Reports · doi:10.1038/s41598-019-53207-0 · Cited by 7

Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting

Fougerat, A., Bruse, J., Polizzi, A., Montagner, A., Guillou, H., & Wahli, W. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101303 · Cited by 56

Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man

Christodoulides, C., Dyson, P., Sprecher, D., Tsintzas, K., & Karpe, F. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0111 · Cited by 153

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Shi, M. Y., Yu, H. C., Han, C. Y., Bang, I. H., Park, H. S., Jang, K. Y., Lee, S., Son, J. B., Kim, N. D., Park, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40597-z · Cited by 30

mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis

Alpergin, E. S. S., & Wolfgang, M. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100884 · Cited by 15

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495