Cited by 305Peroxisome Proliferator-Activated ReceptorsDiet and metabolism studiesCancer, Lipids, and Metabolism

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Regulation of Ketone Body Metabolism and the Role of PPARα

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Grabacka, Maja, Pierzchalska, Malgorzata, Dean, Matthew, Reiss, Krzysztof·2016·International Journal of Molecular Sciences

DOI 10.3390/ijms17122093PMC PMC5187893

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Abstract

Ketogenesis and ketolysis are central metabolic processes activated during the response to fasting. Ketogenesis is regulated in multiple stages, and a nuclear receptor peroxisome proliferator activated receptor α (PPARα) is one of the key transcription factors taking part in this regulation. PPARα is an important element in the metabolic network, where it participates in signaling driven by the main nutrient sensors, such as AMP-activated protein kinase (AMPK), PPARγ coactivator 1α (PGC-1α), and mammalian (mechanistic) target of rapamycin (mTOR) and induces hormonal mediators, such as fibroblast growth factor 21 (FGF21). This work describes the regulation of ketogenesis and ketolysis in normal and malignant cells and briefly summarizes the positive effects of ketone bodies in various neuropathologic conditions.

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395
Defining the role of mTOR in cancer
Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease
Youm, Y.-H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3804 · Cited by 2,172
The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations
Cleland, W. W. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)91800-6 · Cited by 2,092
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90211-6 · Cited by 1,915
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor
Shimazu, T., Hirschey, M. D., Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, C. A., Lim, H., Saunders, L. R., Stevens, R. D., et al. (2013) · Science · doi:10.1126/science.1227166 · Cited by 1,777
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687
Brain Metabolism during Fasting*
Owen, O. E., Morgan, A. P., Kemp, H. G., Sullivan, J. M., Herrera, M. G., & Cahill, G. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105650 · Cited by 1,662
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649
Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
Pawlak, M., Lefebvre, P., & Staels, B. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.10.039 · Cited by 1,578
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
Fuel Metabolism in Starvation
Cahill, G. F. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111258 · Cited by 1,360
The PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,138
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106
Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
Nguyen, L. N., Ma, D., Shui, G., Wong, P., Cazenave-Gassiot, A., Zhang, X., Wenk, M. R., Goh, E. L. K., & Silver, D. L. (2014) · Nature · doi:10.1038/nature13241 · Cited by 1,048
Hormone-fuel interrelationships during fasting.
Cahill, G. F., Herrera, M. G., Morgan, A. P., Soeldner, J. S., Steinke, J., Levy, P. L., Reichard, G. A., & Kipnis, D. M. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105481 · Cited by 1,036
Physiological roles of ketone bodies as substrates and signals in mammalian tissues.
Robinson, A. M., & Williamson, D. H. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.1.143 · Cited by 1,012
A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7473 · Cited by 943
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
Sibson, N. R., Dhankhar, A., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.316 · Cited by 897
The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
Veech, R. L. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.007 · Cited by 779
n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells
Riggs, M. G., WHITTAKER, R. G., Neumann, J. R., & Ingram, V. M. (1977) · Nature · doi:10.1038/268462a0 · Cited by 777
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Rardin, M. J., He, W., Nishida, Y., Newman, J. C., Carrico, C., Danielson, S. R., Guo, A., Gut, P., Sahu, A. K., Li, B., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.013 · Cited by 711
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704
Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., West, B. L., & Green, K. N. (2016) · Brain · doi:10.1093/brain/aww016 · Cited by 695
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif
Nojima, H., Tokunaga, C., Eguchi, S., Oshiro, N., Sujuti, H., Yoshino, K., Hara, K., Tanaka, N., Avruch, J., & Yonezawa, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200665200 · Cited by 678
(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G
Taggart, A. K. P., Kero, J. T., Gan, X., Cai, T., Cheng, K., Ippolito, M. C., Ren, N., Kaplan, R. A., Wu, K., Wu, T.-J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500213200 · Cited by 675
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010) · Nature · doi:10.1038/nature09584 · Cited by 646
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644
Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state
Yoshino, A., Hovda, D. A., Kawamata, T., Katayama, Y., & Becker, D. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90755-k · Cited by 592
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies
Maalouf, M., Rho, J. M., & Mattson, M. P. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.002 · Cited by 584
Branched-Chain Amino Acids: Enzyme and Substrate Regulation
Brosnan, J. T., & Brosnan, M. E. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.207s · Cited by 577
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
Rhee, J., Inoue, Y., Yoon, J. C., Puigserver, P., Fan, M., Gonzalez, F. J., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730870100 · Cited by 575
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
Koo, S.-H., Satoh, H., Herzig, S., Lee, C.-H., Hedrick, S., Kulkarni, R., Evans, R. M., Olefsky, J., & Montminy, M. (2004) · Nature Medicine · doi:10.1038/nm1044 · Cited by 550
Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
Henderson, S. T., Vogel, J. L., Barr, L. J., Garvin, F., Jones, J. J., & Costantini, L. C. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-31 · Cited by 548
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
Schalm, S. S., Fingar, D. C., Sabatini, D. M., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00329-4 · Cited by 528
The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
Gälman, C., Lundåsen, T., Kharitonenkov, A., Bina, H. A., Eriksson, M., Hafström, I., Dahlin, M., Åmark, P., Angelin, B., & Rudling, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.014 · Cited by 512
Effects of β-hydroxybutyrate on cognition in memory-impaired adults
Reger, M. A., Henderson, S. T., Hale, C. M., Cholerton, B., Baker, L. D., Watson, G. S., Hyde, K., Chapman, D., & Craft, S. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00087-3 · Cited by 510
A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier
Dehouck, B., Fenart, L., Dehouck, M.-P., Pierce, A., Torpier, G., & Cecchelli, R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.877 · Cited by 490
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
Gurvich, N., Tsygankova, O. M., Meinkoth, J. L., & Klein, P. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0799 · Cited by 470
Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids
Oldendorf, W. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.224.6.1450 · Cited by 463 · cited 2×
“The difficulties in crossing BBB are no concern for ketone bodies, which are efficiently absorbed through monocarboxylate transporters (MCT1, MCT2), the expression of which increases significantly during fasting [100,101].”
Background
Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain
Schönfeld, P., & Reiser, G. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.128 · Cited by 457
Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting
Hashimoto, T., Cook, W. S., Qi, C., Yeldandi, A. V., Reddy, J. K., & Rao, M. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910350199 · Cited by 450
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
Stafstrom, C. E., & Rho, J. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00059 · Cited by 448
Neuroprotective and disease-modifying effects of the ketogenic diet
Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200609000-00009 · Cited by 445
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Wolfrum, C., Asilmaz, E., Luca, E., Friedman, J. M., & Stoffel, M. (2004) · Nature · doi:10.1038/nature03047 · Cited by 442
The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages
Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller‐Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4944 · Cited by 441
Ketone Bodies, Potential Therapeutic Uses
Veech, R. L., Chance, B., Kashiwaya, Y., Lardy, H. A., & Cahill, G. F. (2001) · IUBMB Life · doi:10.1080/152165401753311780 · Cited by 427
Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by 13 C Nuclear Magnetic Resonance Spectroscopy
Ebert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427
Purification and characterization of the AMP‐activated protein kinase
Carling, D., Clarke, P. R., Zammit, V. A., & Hardie, D. G. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb15186.x · Cited by 418
Parkinson's disease: Autoimmunity and neuroinflammation
VIRGILIO, A. D., Greco, A., Fabbrini, G., Inghilleri, M., Rizzo, M. I., Gallo, A., Conte, M., Rosato, C., Appiani, M. C., & VINCENTIIS, M. D. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.07.022 · Cited by 397
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
Hegardt, F. G. (1999) · Biochemical Journal · doi:10.1042/bj3380569 · Cited by 375
Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
Edmond, J., Robbins, R., Bergstrom, J. D., Cole, R. A., & de Vellis, J. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180407 · Cited by 362
PPARα is a key regulator of hepatic FGF21
Lundåsen, T., Hunt, M., Nilsson, L.-M., Sanyal, S., Angelin, B., Alexson, S., & Rudling, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.068 · Cited by 361
Malonyl-CoA: the regulator of fatty acid synthesis and oxidation
Foster, D. W. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63967 · Cited by 358
Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
Mitchell, R. W., On, N. H., Del Bigio, M. R., Miller, D. W., & Hatch, G. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07245.x · Cited by 337
Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.
Nebeling, L. C., Miraldi, F. D., Shurin, S. B., & Lerner, E. (1995) · Journal of the American College of Nutrition · doi:10.1080/07315724.1995.10718495 · Cited by 312
Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study
VanItallie, T. B., Nonas, C., Rocco, A. D., Boyar, K. L., Hyams, K., & Heymsfield, S. B. (2005) · Neurology · doi:10.1212/01.wnl.0000152046.11390.45 · Cited by 300
The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer
Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-5 · Cited by 299
The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma
Abdelwahab, M. G., Fenton, K. E., Preul, M. C., Rho, J. M., Lynch, A., Stafford, P., & Scheck, A. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036197 · Cited by 289
Cellular and subcellular distribution of monocarboxylate transporters in cultured brain cells and in the adult brain
Pellerin, L., Halestrap, A. P., & Pierre, K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20307 · Cited by 269
Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report
Zuccoli, G., Marcello, N., Pisanello, A., Servadei, F., Vaccaro, S., Mukherjee, P., & Seyfried, T. N. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-33 · Cited by 266
Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1
Zupkovitz, G., Tischler, J., Posch, M., Sadzak, I., Ramsauer, K., Egger, G., Grausenburger, R., Schweifer, N., Chiocca, S., Decker, T., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01220-06 · Cited by 262
GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors
Ahmed, K., Tunaru, S., & Offermanns, S. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.001 · Cited by 260
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat
Croset, M., BROSSARD, N., POLETTE, A., & Lagarde, M. (1999) · Biochemical Journal · doi:10.1042/bj3450061 · Cited by 247
Fatty Acid Oxidation and Ketogenesis by Astrocytes in Primary Culture
Auestad, N., Korsak, R. A., Morrow, J. W., & Edmond, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb11435.x · Cited by 245
The Ketogenic Diet
Sinha, S. R., & Kossoff, E. H. (2005) · The Neurologist · doi:10.1097/01.nrl.0000160818.58821.d2 · Cited by 245
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy
Maurer, G. D., Brucker, D. P., Bähr, O., Harter, P. N., Hattingen, E., Walenta, S., Mueller‐Klieser, W., Steinbach, J. P., & Rieger, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-315 · Cited by 237
Energy Intake and Prostate Tumor Growth, Angiogenesis, and Vascular Endothelial Growth Factor Expression
Mukherjee, P., Sotnikov, A. V., Mangian, H. J., Zhou, J., Visek, W. J., & Clinton, S. K. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.6.512 · Cited by 237
Distribution of mRNAs Encoding the Peroxisome Proliferator‐Activated Receptor α, β, and γ and the Retinoid X Receptor α, β, and γ in Rat Central Nervous System
Cullingford, T. E., Bhakoo, K. K., Peuchen, S., Dolphin, C. T., Patel, R., & Clark, J. B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70041366.x · Cited by 234
Transcription coactivators for peroxisome proliferator-activated receptors
Yu, S., & Reddy, J. K. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.01.008 · Cited by 233
The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma
Stafford, P., Abdelwahab, M. G., ‍Kim, D. Y., Preul, M. C., Rho, J. M., & Scheck, A. C. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-74 · Cited by 228
Lysophosphatidylcholine as a Preferred Carrier Form of Docosahexaenoic Acid to the Brain
Lagarde, M., Bernoud‐Hubac, N., BROSSARD, N., Lemaitre-Delaunay, D., Thiès, F., Croset, M., & Lecerf, J. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:201 · Cited by 221
Peroxisome Proliferator-Activated Receptors, Coactivators, and Downstream Targets
Qi, C., Zhu, Y., & Reddy, J. K. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:187 · Cited by 220
Peroxisome Proliferator-Activated Receptor-α Activation as a Mechanism of Preventive Neuroprotection Induced by Chronic Fenofibrate Treatment
Deplanque, D., Gelé, P., Pétrault, O., Six, I., Furman, C., Bouly, M., Nion, S., Dupuis, B., Leys, D., Fruchart, J., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06264.2003 · Cited by 219
FGF21 and the late adaptive response to starvation in humans
Fazeli, P. K., Lun, M., Kim, S. M., Bredella, M. A., Wright, S., Zhang, Y., Lee, H., Catana, C., Klibanski, A., Patwari, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83349 · Cited by 214 · cited 2×
“In contrast to mice, in humans FGF21 does not regulate an immediate starvation response and its blood level does not rise until 7–10 days of fasting, when bHB plasma levels are already 70-fold higher than in fed state [53,54].”
Background
Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
Otto, C., Kaemmerer, U., Illert, B., Muehling, B., Pfetzer, N., Wittig, R., Voelker, H.-U., Thiede, A. H., & Coy, J. F. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-122 · Cited by 213
The Activity of Antiepileptic Drugs as Histone Deacetylase Inhibitors
Eyal, S., Yagen, B., Sobol, E., Altschuler, Y., Shmuel, M., & Bialer, M. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.00104.x · Cited by 207
The ketogenic diet and brain metabolism of amino acids: Relationship to the anticonvulsant effect
Yudkoff, M., Daikhin, Y., Melø, T. M., Nissim, I., Sonnewald, U., & Nissim, I. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093722 · Cited by 202
Ketoacids? Good medicine?
Cahill, G. F., & Veech, R. L. (2003) · PubMed Central · Cited by 201
Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein
Sato, T., Nakashima, A., Guo, L., & Tamanoi, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809207200 · Cited by 196
Age-dependent reduction of cortical contusion volume by ketones after traumatic brain injury
Prins, M. L., Fujima, L. S., & Hovda, D. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20633 · Cited by 194
Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3
Li, H., Gao, Z., Zhang, J., Ye, X., Xu, A., Ye, J., & Jia, W. (2012) · Diabetes · doi:10.2337/db11-0846 · Cited by 193
Oxidized Omega-3 Fatty Acids Inhibit NF-κB Activation Via a PPARα-Dependent Pathway
Mishra, A., Chaudhary, A. K., & Sethi, S. M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137191.02577.86 · Cited by 190
THE KETOGENIC DIET IN EPILEPSY
PETERMAN, M. G. (1925) · JAMA · doi:10.1001/jama.1925.02660520007003 · Cited by 184
Metabolic therapy: A new paradigm for managing malignant brain cancer
Seyfried, T. N., Flores, R. E., Poff, A. M., D’Agostino, D. P., & Mukherjee, P. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.07.015 · Cited by 183
Diabetes-associated nitration of tyrosine and inactivation of succinyl-CoA:3-oxoacid CoA-transferase
Turko, I. V., Marcondes, S., & Murad, F. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2289 · Cited by 182
Fatty acid transport into the brain: Of fatty acid fables and lipid tails
Mitchell, R. W., & Hatch, G. M. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.04.007 · Cited by 180
Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model
Mukherjee, P., El‐Abbadi, M. M., Kasperzyk, J. L., Ranes, M. K., & Seyfried, T. N. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600298 · Cited by 178
Clinical review: Ketones and brain injury
White, H. T., & Venkatesh, B. (2011) · Critical Care · doi:10.1186/cc10020 · Cited by 175
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
Huang, D., Li, T., Wang, L., Zhang, L., Yan, R., Li, K., Xing, S., Wu, G., Hu, L., Jia, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.109 · Cited by 175
Identification of a Peroxisome Proliferator-responsive Element Upstream of the Human Peroxisomal Fatty Acyl Coenzyme A Oxidase Gene
Varanasi, U., Chu, R., Huang, Q. M., Castellon, R., Yeldandi, A. V., & Reddy, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.2147 · Cited by 169
mTOR signaling in tumorigenesis
Xu, K. L., Liu, P., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.007 · Cited by 167
Medium‐chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte‐neuron lactate and ketone body shuttle systems
Thévenet, J., Marchi, U. D., Domingo, J. S., Christinat, N., Bultot, L., Lefebvre, G. C., Sakamoto, K., Descombes, P., Masoodi, M., & Wiederkehr, A. (2016) · The FASEB Journal · doi:10.1096/fj.201500182 · Cited by 167
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling
Kang, H., Fan, J., Lin, R., Elf, S., Ji, Q., Zhao, L., Jin, L., Seo, J. H., Shan, C., Arbiser, J. L., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.037 · Cited by 162
Effect of β-Hydroxybutyrate, a Cerebral Function Improving Agent, on Cerebral Hypoxia, Anoxia and Ischemia in Mice and Rats
Suzuki, M., Suzuki, M., Sato, K., Dohi, S., Sato, T., Matsuura, A., & Hiraide, A. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.87.143 · Cited by 160
Glucose and lactate supply to the synapse
Barros, L. F., & Deitmer, J. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.002 · Cited by 155
Ketone body synthesis in the brain: possible neuroprotective effects
Guzmán, M., & Blázquez, C. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.05.001 · Cited by 152
A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fastingPreprint
Hugo, S. E., Cruz-Garcia, L., Karanth, S., Anderson, R. M., Stainier, D. Y. R., & Schlegel, A. (2012) · Genes & Development · doi:10.1101/gad.180968.111 · Cited by 145
Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury
Robertson, C., Scafidi, S., McKenna, M. C., & Fiskum, G. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.030 · Cited by 143
Regulation of ketogenesis and clinical aspects of the ketotic state
McGarry, J. D., & Foster, D. W. (1972) · Metabolism · doi:10.1016/0026-0495(72)90059-5 · Cited by 143
Pekmeability Changes in the Blood-Brain Barrier: Causes and Consequences
Pardridge, W. M., Connor, J. D., Crawford, I. L., & Oldendorf, W. H. (1975) · Critical Reviews in Toxicology · doi:10.3109/10408447509079857 · Cited by 138
Metabolic and inflammatory adaptation of reactive astrocytes: role of PPARs
Iglesias, J., Morales, L., & Barreto, G. E. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-9833-2 · Cited by 137
Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
Cimini, A., Benedetti, E., Cristiano, L., Sebastiani, P., D’Amico, M. A., D’Angelo, B., & Loreto, S. D. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.043 · Cited by 129
The AMP‐Activated Protein Kinase Is Involved in the Regulation of Ketone Body Production by Astrocytes
Blázquez, C., Woods, A., CEBALLOS, M. L. D., Carling, D., & Guzmán, M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731674.x · Cited by 129
Leukotriene B4 Is a Physiologically Relevant Endogenous Peroxisome Proliferator-activated Receptor-α Agonist
Narala, V. R., Adapala, R. K., Suresh, M. V., Brock, T. G., Peters-Golden, M., & Reddy, R. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085118 · Cited by 126 · cited 1×
“Arachidonic acid derived inflammatory mediators, such as leukotrienes LTB4 and LTA4 are natural PPARα agonists [158].”
Background
Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells
Martinez‐Outschoorn, U., Zhao, L., Whitaker‐Menezes, D., Howell, A., Lisanti, M. P., & Sotgia, F. (2012) · Cell Cycle · doi:10.4161/cc.22136 · Cited by 125
Ketone bodies inhibit the viability of human neuroblastoma cells
SKINNER, R. S., Trujillo, A., Ma, X., & Beierle, E. A. (2009) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2008.10.042 · Cited by 119
Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinasePreprint
Lustig, Y., Ruas, J. L., Estall, J. L., Lo, J. C., Devarakonda, S., Laznik, D., Choi, J. H., Ono, H., Olsen, J. V., & Spiegelman, B. M. (2011) · Genes & Development · doi:10.1101/gad.2054711 · Cited by 118
The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders
Cullingford, T. E. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.09.008 · Cited by 116
DNA Binding-Independent Induction of I B Gene Transcription by PPAR
Delerive, P., Bosscher, K. D., Berghe, W. V., Fruchart, J., Haegeman, G., & Staels, B. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.5.0826 · Cited by 115
Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α
Scuderi, C., Valenza, M., Stecca, C., Esposito, G., Carratù, M. R., & Steardo, L. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-49 · Cited by 112
Quantitative Proteomics Reveals That Enzymes of the Ketogenic Pathway Are Associated with Prostate Cancer Progression
Saraon, P., Cretu, D., Musrap, N., Karagiannis, G. S., Batruch, I., Drabovich, A. P., van der Kwast, T., Mizokami, A., Morrissey, C. M., Jarvi, K. A., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.023887 · Cited by 112
Histone deacetylases: complex transducers of nuclear signals
Johnson, C. A., & Turner, B. M. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0299 · Cited by 110
The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury
Prins, M. L., & Matsumoto, J. H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046706 · Cited by 107
Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy
Chang, H. T., Olson, L. K., & Schwartz, K. A. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-47 · Cited by 107
Caloric restriction reduces growth of mammary tumors and metastases
Lorenzo, M. S. D., Baljinnyam, E., Vatner, D. E., Abarzúa, P., Vatner, S. F., & Rabson, A. B. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr107 · Cited by 107
Role of Carnitine Palmitoyltransferase I in the Control of Ketogenesis in Primary Cultures of Rat Astrocytes
Blázquez, C., Sánchez, C., Velasco, G., & Guzmán, M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71041597.x · Cited by 105
Cerebral Metabolic Response to Traumatic Brain Injury Sustained Early in Development: A 2-Deoxy-D-Glucose Autoradiographic Study
Thomas, S., Prins, M. L., Samii, M., & Hovda, D. A. (2000) · Journal of Neurotrauma · doi:10.1089/089771500415409 · Cited by 105
SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
Hirschey, M. D., Shimazu, T., Capra, J. A., Pollard, K. S., & Verdin, E. M. (2011) · Aging · doi:10.18632/aging.100339 · Cited by 105
Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. I. Regulation of branched chain alpha-ketoacid metabolism.
WILLIAMSON, J. R., Wałajtys-Rode, E., & Coll, K. E. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86514-6 · Cited by 104
THE INHIBITION OF MALIGNANT CELL GROWTH BY KETONE BODIES
Magee, B. A., Potezny, N., Rofe, A. M., & Conyers, R. A. J. (1979) · Immunology and Cell Biology · doi:10.1038/icb.1979.54 · Cited by 101
Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide
Scuderi, C., Esposito, G., Blasio, A., Valenza, M., Arietti, P., Steardo, L., Carnuccio, R., Filippis, D. D., Petrosino, S., Iuvone, T., et al. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01267.x · Cited by 100
A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth
Feyter, H. M. D., Behar, K. L., Rao, J. U., Madden-Hennessey, K., Ip, K. L., Hyder, F., Drewes, L. R., Geschwind, J.-F. H., de Graaf, R. A., & Rothman, D. L. (2016) · Neuro-Oncology · doi:10.1093/neuonc/now088 · Cited by 100
A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα
Meertens, L. M., Miyata, K., Cechetto, J. D., Rachubinski, R. A., & Capone, J. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6972 · Cited by 99
Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes
Xu, J., Chavis, J. A., Racke, M. K., & Drew, P. D. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.04.019 · Cited by 98
Peroxisome proliferator-activated receptor agonist regulation of glial activation: Relevance to CNS inflammatory disorders
Drew, P. D., Xu, J., Storer, P. D., Chavis, J. A., & Racke, M. K. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.04.003 · Cited by 97
EPILEPSY IN ADULTS
Barborka, C. J. (1930) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1930.02220110066004 · Cited by 96
The ketogenic diet for the treatment of malignant glioma
Woolf, E. C., & Scheck, A. C. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046797 · Cited by 96
Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy
Phoenix, K. N., Vumbaca, F., Fox, M. M., Evans, R., & Claffey, K. P. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0647-z · Cited by 94
The Role of Inflammation in Brain Cancer
Sowers, J. L., Johnson, K. M., Conrad, C. C., Patterson, J. T., & Sowers, L. C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-0348-0837-8_4 · Cited by 93
Loss of acetoacetate coenzyme A transferase activity in tumours of peripheral tissues
Tisdale, M. J., & Brennan, R. A. (1983) · British Journal of Cancer · doi:10.1038/bjc.1983.38 · Cited by 91
Implementing A Ketogenic Diet Based on Medium-chain Triglyceride Oil in Pediatric Patients with Cancer
Nebeling, L. C., & Lerner, E. (1995) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(95)00189-1 · Cited by 89
Glucagon activates mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase in vivo by decreasing the extent of succinylation of the enzyme
Quant, P. A., Tubbs, P. K., & Brand, M. D. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15291.x · Cited by 87
Ten-Year Single-Center Experience of the Ketogenic Diet: Factors Influencing Efficacy, Tolerability, and Compliance
Wibisono, C., Rowe, N., Beavis, E., Kepreotes, H., Mackie, F., Lawson, J. A., & Cardamone, M. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.12.018 · Cited by 86
New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae
Pohl, J., Ring, A., Herrmann, T. R. W., & Stremmel, W. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2004341 · Cited by 86
Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE
Kostiuk, M. A., Keller, B. O., & Berthiaume, L. G. (2010) · The FASEB Journal · doi:10.1096/fj.09-149765 · Cited by 85
Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes
Cristiano, L., Bernardo, A., & Ceru`, M. P. (2001) · Journal of Neurocytology · doi:10.1023/a:1016525716209 · Cited by 81
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration
Marcondes, S., Turko, I. V., & Murad, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141222598 · Cited by 78
Hydroxycarboxylic and oxocarboxylic acids in urine:products from branched-chain amino acid degradation and from ketogenesis
Liebich, H. M., & Först, C. (1984) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(84)80031-6 · Cited by 77
Peroxisome proliferator‐activated receptor‐α agonist fenofibrate regulates IL‐12 family cytokine expression in the CNS: relevance to multiple sclerosis
Xu, J., Racke, M. K., & Drew, P. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04875.x · Cited by 76
Regulation of P450 4A expression by peroxisome proliferator activated receptors
Johnson, E. F., Hsu, M., Savas, Ü., & Griffin, K. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00282-2 · Cited by 74
Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases
Van, A. L., Sakayori, N., Hachem, M., Belkouch, M., Picq, M., Lagarde, M., Osumi, N., & Bernoud‐Hubac, N. (2016) · Biochimie · doi:10.1016/j.biochi.2016.07.011 · Cited by 73
Ketogenesis in isolated rat liver mitochondria I. Relationships with the citric acid cycle and with the mitochondrial energy state
Lopes-Cardozo, M., & van den Bergh, S. G. (1972) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(72)90092-8 · Cited by 71
Relationship between central and peripheral fatty acids in humans
Guest, J., Garg, M. L., BILGIN, A. A. B., & Grant, R. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-79 · Cited by 69
Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: the role of the forkhead transcription factor FKHRL1
Nadal, A., Marrero, P. F., & Haro, D. (2002) · Biochemical Journal · doi:10.1042/bj20020598 · Cited by 65
Succinylation and inactivation of 3-hydroxy-3-methylglutaryl-CoA synthase by succinyl-CoA and its possible relevance to the control of ketogenesis
Lowe, D. M., & Tubbs, P. K. (1985) · Biochemical Journal · doi:10.1042/bj2320037 · Cited by 63
PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings
Puligheddu, M., Pillolla, G., Melis, M., Lecca, S., Marrosu, F., Demontis, M., Scheggi, S., Carta, G., Murru, E., Aroni, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064541 · Cited by 61
3‐Oxo acid coenzyme A transferase activity in brain and tumors of the nervous system1
Fredericks, M. R., & Ramsey, R. B. (1978) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1978.tb06581.x · Cited by 60
Peroxisome Proliferator-Activated Receptor-α Contributes to the Anti-Inflammatory Activity of Glucocorticoids
Cuzzocrea, S., Bruscoli, S., Mazzon, E., Crisafulli, C., Donato, V., Paola, R. D., Velardi, E., Esposito, E., Nocentini, G., & Riccardi, C. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.041475 · Cited by 60
Hormonal regulation of ketone-body metabolism in man.
Alberti, K. G. M. M., Johnston, D. G., Gill, A., Barnes, A., & Ørskov, H. (1978) · PubMed · Cited by 59
Differential effects of PPARα activators on induction of ectopic expression of tissue-specific fatty acid binding protein genes in the mouse liver
Motojima, K. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00046-7 · Cited by 55
The peroxisome proliferator-activated receptor α-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain
Cullingford, T. E., Dolphin, C. T., & Sato, H. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00014-x · Cited by 54
Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism
Sánchez‐Alvarez, R., Martinez‐Outschoorn, U., Zhao, L., Lamb, R., Hulit, J., Howell, A., Sotgia, F., Rubin, E., & Lisanti, M. P. (2013) · Cell Cycle · doi:10.4161/cc.23109 · Cited by 54
Peroxisome proliferator-activated receptor δ is a specific sensor for teratogenic valproic acid derivatives
Lampen, A., Carlberg, C., & Nau, H. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01423-6 · Cited by 53
The regulation of FGF21 gene expression by metabolic factors and nutrients
Erickson, A., & Moreau, R. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0016 · Cited by 53
Mapping Cerebral Glucose Metabolism During Spatial Learning: Interactions of Development and Traumatic Brain Injury
Prins, M. L., & Hovda, D. A. (2001) · Journal of Neurotrauma · doi:10.1089/089771501750055758 · Cited by 52
Increase in antiepileptic efficacy during prolonged treatment with valproic acid: Role of inhibition of histone deacetylases?
Hoffmann, K., Czapp, M., & Löscher, W. (2008) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.04.019 · Cited by 52
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism
Rando, G., Tan, C. K., Khaled, N., Montagner, A., Leuenberger, N., Bertrand‐Michel, J., Paramalingam, E., Guillou, H., & Wahli, W. (2016) · eLife · doi:10.7554/elife.11853 · Cited by 52
Metabolic and Regulatory Roles of Leucine in Neural Cells
Murín, R., & Hamprecht, B. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9444-4 · Cited by 51
Peroxisome Proliferator-Activated Receptor-α Activation Inhibits Langerhans Cell Function
Dubrac, S., Stoitzner, P., Pirkebner, D., Elentner, A., Schoonjans, K., Auwerx, J. H., Saeland, S., Hengster, P., Fritsch, P. O., Romani, N., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4362 · Cited by 50
On the Mechanism of Ketogenesis and Its Control
Huth, W., Jonas, R., WUNDERLICH, I., & Seubert, W. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02476.x · Cited by 49
Skeletal muscle PGC‐1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice
Svensson, K., Albert, V., Cardel, B., Salatino, S., & Handschin, C. (2016) · The FASEB Journal · doi:10.1096/fj.201500128 · Cited by 49
Human Mitochondrial NAD(P)+–Dependent Malic Enzyme Participates in Cutaneous Melanoma Progression and Invasion
Chang, Y., Gao, H., Chiang, C., Wang, W., Huang, S., Ku, C.-F., Liu, G., & Hung, H. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.385 · Cited by 48
Control of Ketogenesis from Amino Acids. IV. Tissue Specificity in Oxidation of Leucine, Tyrosine, and Lysine1
Noda, C., & Ichihara, A. (1976) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131371 · Cited by 46
Effect of Dietary Energy Restriction on Vascular Density during Mammary Carcinogenesis
Thompson, H. J., McGinley, J. N., Spoelstra, N. S., Jiang, W., Zhu, Z., & Wolfe, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0787 · Cited by 46
Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα
König, B., Koch, A. H., Giggel, K., Dordschbal, B., Eder, K., & Stangl, G. I. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.03.002 · Cited by 46
PPARα Agonist Fenofibrate Ameliorates Learning and Memory Deficits in Rats Following Global Cerebral Ischemia
Xuan, A., Chen, Y., Long, D., Zhang, M., Ji, W., Zhang, W., Liu, J., Hong, L.-P., He, X., & Chen, W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8882-7 · Cited by 45
PPARα agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS‐treated macrophages
Paukkeri, E., Leppänen, T., Sareila, O., Vuolteenaho, K., Kankaanranta, H., & Moilanen, E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707477 · Cited by 44
FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
Stemmer, K., Zani, F., Habegger, K. M., Neff, C., Kotzbeck, P., Bauer, M., Yalamanchilli, S., Azad, A., Lehti, M., Martins, P. J. F., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3668-7 · Cited by 44
Role of neuron-glia interaction in the regulation of brain glucose utilization.
Pellerin, L., Bonvento, G., Chatton, J., Pierre, K., & Magistretti, P. J. (2002) · PubMed · Cited by 43
Mechanisms of catecholamine effects on ketogenesis
Bahnsen, M. K., Burrin, J. M., Johnston, D. G., Pernet, A., Walker, M., & Alberti, K. G. M. M. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.2.e173 · Cited by 42
Gene expression of fatty acid transport and binding proteins in the blood–brain barrier and the cerebral cortex of the rat: Differences across development and with different DHA brain status
Pélerin, H., Jouin, M., Lallemand, M.-S., Alessandri, J., Cunnane, S. C., Goustard, B., & Guesnet, P. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.07.004 · Cited by 41
Anticonvulsant Effect of Time-Restricted Feeding in a Pilocarpine-Induced Seizure Model: Metabolic and Epigenetic Implications
Landgrave-Gómez, J., Mercado-Gómez, O. F., Vázquez-García, M., Molina, V., Córdova-Dávalos, L. E., Arriaga-Ávila, V. S., Miranda-Martínez, A., & Guevara‐Guzmán, R. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00007 · Cited by 40
The role of leucine in ketogenesis in starved rats
Thomas, L. K., Ittmann, M., & Cooper, C. (1982) · Biochemical Journal · doi:10.1042/bj2040399 · Cited by 40
Fenofibrate Induces Ketone Body Production in Melanoma and Glioblastoma Cells
Grabacka, M., Wilk, A. M., Antończyk, A., Banks, P., Walczyk-Tytko, E., Dean, M. J., Pierzchalska, M., & Krzysztof Reiss, F. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00005 · Cited by 39
Self-citation
Human ketone body production and utilization studied using tracer techniques: Regulation by free fatty acids, insulin, catecholamines, and thyroid hormones
Keller, U. B., Lustenberger, M., Müller‐Brand, J., Gerber, P. P. G., & Stauffacher, W. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050306 · Cited by 38
Effect of PPARα activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes
Murakami, K., Bujo, H., Unoki‐Kubota, H., & Saitō, Y. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.037 · Cited by 38
Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist
Januszewicz, E., Pająk, B., Gajkowska, B., Samluk, Ł., Djavadian, R. L., Hinton, B. T., & Nałęcz, K. A. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.08.020 · Cited by 38
Utilization and preferred metabolic pathway of ketone bodies for lipid synthesis by isolated rat hepatoma cells
Hildebrandt, L. A., Spennetta, T. L., Elson, C. E., & Shrago, E. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.269.1.c22 · Cited by 38
Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate
Dueregger, A., Schöpf, B., Eder, T., Hoefer, J., Gnaiger, E., Aufinger, A., Kenner, L., Perktold, B., Ramoner, R. E., Klocker, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135704 · Cited by 36
KTX 0101: A Potential Metabolic Approach to Cytoprotection in Major Surgery and Neurological Disorders
Smith, S. L., Heal, D. J., & Martin, K. F. (2005) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00265.x · Cited by 36
β‐Hydroxybutyric Acid Inhibits Growth Hormone‐Releasing Hormone Synthesis and Secretion Through the GPR 109A/Extracellular Signal‐Regulated 1/2 Signalling Pathway in the Hypothalamus
Fu, S., Liu, B., Wang, J. ‐., Xue, W., Liu, H. ‐., Zeng, Y., Huang, B., Li, S. ‐., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12256 · Cited by 35
Ketone-body metabolism in glioma and neuroblastoma cells.
Patel, M. S., Russell, J. J., & Gershman, H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7214 · Cited by 34
Utilization of ketone bodies and glucose by established neural cell lines
Roeder, L. M., Poduslo, S. E., & Tildón, J. T. (1982) · Journal of Neuroscience Research · doi:10.1002/jnr.490080412 · Cited by 33
The Hepatocyte Nuclear Factor 4 (HNF-4) Represses the Mitochondrial HMG-CoA Synthase Gene
guez, J. C. R. X., Ortiz, J. A., Hegardt, F. G., & Haro, D. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.8032 · Cited by 32
Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene
Rodríguez, J. C., Ortiz, J. A., Hegardt, F. G., & Haro, D. (1997) · Biochemical Journal · doi:10.1042/bj3260587 · Cited by 32
Modulation of Fatty Acid Metabolism by Glucagon in Man: II. Effects in Insulin-deficient Diabetics
Schade, D. S., & Eaton, R. P. (1975) · Diabetes · doi:10.2337/diab.24.5.510 · Cited by 30
[2,4-13C]β-hydroxybutyrate Metabolism in Astrocytes and C6 Glioblastoma Cells
Eloqayli, H., Melø, T. M., Haukvik, A., & Sonnewald, U. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0485-3 · Cited by 24
Very Long Chain Fatty Acid β-Oxidation in Astrocytes: Contribution of the ABCD1-Dependent and -Independent Pathways
Morita, M., Shinbo, S., 朝日彰子, & Imanaka, T. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00411 · Cited by 22

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Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 981
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation
Schiliro, C., & Firestein, B. L. (2021) · Cells · doi:10.3390/cells10051056 · Cited by 659
Very-Low-Calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases: Systematic Review and Consensus Statement from the Italian Society of Endocrinology (SIE)
Caprio, M., Infante, M., Moriconi, E., Armani, A., Fabbri, A., Mantovani, G., Mariani, S., Lubrano, C., Poggiogalle, E., Migliaccio, S., et al. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01061-2 · Cited by 283
Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer
Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 299
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease
Torres, J. A., Kruger, S. L., Broderick, C., Amarlkhagva, T., Agrawal, S., Dodam, J. R., Mrug, M. M., Lyons, L. A., & Weimbs, T. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.012 · Cited by 223

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Authors: Grabacka, M., Pierzchalska, M., Dean, M., & Reiss, K.
Affiliations: University of Agriculture in Krakow (PL)
Department of Food Biotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Kraków, Poland
Louisiana State University (US)
Neurological Cancer Research, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, 1700 Tulane Ave, New Orleans, LA 70112, USA
Corresponding author: Grabacka, Maja
ORCID: Grabacka, Maja
Dean, Matthew
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2016-12-13
Volume: 17
Issue: 12
Pages: 2093
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms17122093
PMC: PMC5187893
OpenAlex: W2562858475
Cited by: 305
References: 209
Citations by year: 2026: 19 · 2025: 34 · 2024: 26 · 2023: 22 · 2022: 54 · 2021: 42 · 2020: 44 · 2019: 34 · 2018: 25 · 2017: 4
FWCI: 1.90
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health, USA (P20-GM103501)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: ketone body metabolism, ketogenesis, ketolysis, PPARα, fasting, AMPK, PGC-1α, mTOR, FGF21, cancer metabolism, neuropathology, nuclear receptors
MeSH terms: Animals, Brain, Humans, Ketone Bodies, Neoplasms, Signal Transduction, Neuroprotective Agents, PPAR alpha

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Regulation of Ketone Body Metabolism and the Role of PPARα

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