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Cited by 1,141

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles

Open access
Abdal Dayem, Ahmed, Hossain, Mohammed, Lee, Soo, Kim, Kyeongseok, Saha, Subbroto, Yang, Gwang-Mo, Choi, Hye, Cho, Ssang-Goo·2017·International Journal of Molecular Sciences
DOI 10.3390/ijms18010120
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Abstract

Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices.

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Metadata

Authors
Abdal Dayem, A., Hossain, M., Lee, S., Kim, K., Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-01-10
Volume
18
Issue
1
Pages
120
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms18010120
OpenAlex
W2570849890
Cited by
1,141
References
14
FWCI
31.05
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles. https://app.cochat.ai/papers/10.3390/ijms18010120
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Abdal Dayem, A., Hossain, M., Lee, S., Kim, K., Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2017). The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18010120

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.