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Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease
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γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain. In the past, there has been a major research drive focused on the dysfunction of the glutamatergic and cholinergic neurotransmitter systems in Alzheimer’s disease (AD). However, there is now growing evidence in support of a GABAergic contribution to the pathogenesis of this neurodegenerative disease. Previous studies paint a complex, convoluted and often inconsistent picture of AD-associated GABAergic remodeling. Given the importance of the GABAergic system in neuronal function and homeostasis, in the maintenance of the excitatory/inhibitory balance, and in the processes of learning and memory, such changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis. Given the limited scope of currently available therapies in modifying the course of the disease, a better understanding of GABAergic remodeling in AD could open up innovative and novel therapeutic opportunities.
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“Loss of GABA, the primary inhibitory neurotransmitter in the brain, is a key component of AD.”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [84]
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Self-citation
Metadata
- Authors
- Govindpani, K., Calvo-Flores Guzmán, B., Vinnakota, C., Waldvogel, H., Faull, R., & Kwakowsky, A.
- Affiliations
- University of Auckland (NZ)
- Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand
- Corresponding author
- Kwakowsky, Andrea
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-08-21
- Volume
- 18
- Issue
- 8
- Pages
- 1813
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5578199
- OpenAlex
- W2746415584
- Cited by
- 208
- References
- 353
- Citations by year
- 2026: 20 · 2025: 14 · 2024: 25 · 2023: 26 · 2022: 16 · 2021: 41 · 2020: 29 · 2019: 29 · 2018: 5 · 2017: 2
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Funders
- Aotearoa Foundation (3705579)
- Brain Research New Zealand (3710638)
- Health Research Council of New Zealand (3627373)
- Maurice and Phyllis Paykel Trust (3713650)
- Auckland Medical Research Foundation (3712563)
- University of Otago (110089.01)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, GABAergic system, inhibitory neurotransmission, excitation-inhibition balance, neurodegeneration, AD pathogenesis, therapeutic target
- MeSH terms
- Alzheimer Disease, Brain, gamma-Aminobutyric Acid, Humans, Neurotransmitter Agents, GABAergic Neurons
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