Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,372

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577

Excitatory actions of gaba during development: the nature of the nurture

Ben-Ari, Y. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn920 · Cited by 2,448

Cortical inhibitory neurons and schizophrenia

Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297

Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

Perry, E., Tomlinson, B. E., Blessed, G., Bergmann, K., Gibson, P., & Perry, R. H. (1978) · British medical journal · doi:10.1136/bmj.2.6150.1457 · Cited by 2,043

GABAA Receptor Channels

Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975

Ionic dependence of glutamate neurotoxicity

Choi, D. W. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00369.1987 · Cited by 1,854

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of alzheimer’s disease.

Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

Schofield, P. R., Darlison, M. G., Fujita, N., Burt, D. R., Stephenson, F. A., Rodriguez, H., Rhee, L. M., Ramachandran, J., Reale, V., Glencorse, T. A., et al. (1987) · Nature · doi:10.1038/328221a0 · Cited by 1,622

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592

A review on Alzheimer's disease pathophysiology and its management: an update

Kumar, A., Singh, A., & Ekavali (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.09.004 · Cited by 1,578

Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons

Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498

Fine structural localization of glutamine synthetase in astrocytes of rat brain

Norenberg, M. D., & Martinez-Hernandez, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90071-4 · Cited by 1,349

NEUROTRANSMITTER-RELATED ENZYMES AND INDICES OF HYPOXIA IN SENILE DEMENTIA AND OTHER ABIOTROPHIES

Bowen, D. M., Smith, C. B., White, P., & DAVISON, A. N. (1976) · Brain · doi:10.1093/brain/99.3.459 · Cited by 1,313

Amyloid-β and tau--a toxic pas de deux in Alzheimer’s disease

Ittner, L. M., & Götz, J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2967 · Cited by 1,269

GABA A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216

International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · PubMed · Cited by 1,204

Interneuron dysfunction in psychiatric disorders

Marín, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3155 · Cited by 1,190

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

Sperling, R. A., LaViolette, P. S., O'Keefe, K., O'Brien, J., Rentz, D. M., Pihlajamaki, M., Marshall, G., Hyman, B. T., Selkoe, D. J., Hedden, T., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.003 · Cited by 1,027

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S. F., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W., et al. (1997) · Nature · doi:10.1038/386239a0 · Cited by 1,023

Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures

Izquierdo, I., & Medina, J. H. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3799 · Cited by 959

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

Chishti, M. A., Yang, D.-S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100710200 · Cited by 955

Molecular Structure and Physiological Functions of GABA B Receptors

Bettler, B., Kaupmann, K., Mosbacher, J., & Gassmann, M. (2004) · Physiological Reviews · doi:10.1152/physrev.00036.2003 · Cited by 943

The GABAergic deficit hypothesis of major depressive disorder

Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934

Defined types of cortical interneurone structure space and spike timing in the hippocampus

Somogyi, P., & Klausberger, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.078915 · Cited by 927

Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

Levey, A. I., Kitt, C. A., Wf, S., Price, D., & Brann, M. R. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03218.1991 · Cited by 920

Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes

Sieghart, W., & Sperk, G. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023393507 · Cited by 914

Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910

Identification and characterization of the vesicular GABA transporter

McIntire, S. L., Reimer, R. J., Schuske, K., Edwards, R. H., & Jørgensen, E. M. (1997) · Nature · doi:10.1038/39908 · Cited by 887

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882

Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study

Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1737 · Cited by 806

Two Forms of the γ‐Aminobutyric Acid Synthetic Enzyme Glutamate Decarboxylase Have Distinct Intraneuronal Distributions and Cofactor Interactions

Kaufman, D. L., Houser, C. R., & Tobin, A. J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08211.x · Cited by 789

P1‐146: Chlamydia Pneumoniae‐Infected Astrocytes Alter Their Expression of Adam10, Bace1, and Presenilin‐1 Proteases

Al-Atrache, Z., Cader, A., & Appelt, D. M. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.894 · Cited by 765

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755 · cited 3×

Calcium and neurodegeneration

Mattson, M. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00275.x · Cited by 751

A new benzodiazepine pharmacology

Möhler, H., Fritschy, J. M., & Rudolph, U. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.2 · Cited by 716

Relative Frequencies of Alzheimer Disease, Lewy Body, Vascular and Frontotemporal Dementia, and Hippocampal Sclerosis in the State of Florida Brain Bank

Barker, W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., Waters, C., Jimison, P., Shepherd, E., Sevush, S., et al. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200210000-00001 · Cited by 714

International Union of Pharmacology. XV. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function

Barnard, E. A., Skolnick, P., Olsen, R. W., Möhler, H., Sieghart, W., Biggio, G., Bræstrup, C., Bateson, A. N., & Langer, S. Z. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01363-2 · Cited by 711

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

Vossel, K. A., Beagle, A. J., Rabinovici, G., Shu, H., Lee, S. E., Naasan, G., Hegde, M., Cornes, S., Henry, M., Nelson, A. B., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.136 · Cited by 709

γ-AMINOBUTYRIC ACID IN BRAIN: ITS FORMATION FROM GLUTAMIC ACID

Roberts, E., & Frankel, S. (1950) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50929-2 · Cited by 708

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier

McEnery, M. W., Snowman, A. M., Trifiletti, R. R., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3170 · Cited by 708

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

Brickley, S. G., & Módy, I. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.012 · Cited by 695

Epilepsy and Cognitive Impairments in Alzheimer Disease

Palop, J. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.15 · Cited by 684

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

Margeta, M., Jan, Y. N., & Jan, L. Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00012-x · Cited by 680

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

Lee, G. S., Cowan, N. J., & Kirschner, M. W. (1988) · Science · doi:10.1126/science.3122323 · Cited by 680

Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons

Tamás, G., Buhl, E. H., Lörincz, A., & Somogyi, P. (2000) · Nature Neuroscience · doi:10.1038/73936 · Cited by 648

Two isoforms of glutamate decarboxylase: why?

Soghomonian, J., & Martin, D. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01270-x · Cited by 643

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

Davies, P. (1979) · Brain Research · doi:10.1016/0006-8993(79)90336-6 · Cited by 634

The GABA system in anxiety and depression and its therapeutic potential

Möhler, H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.040 · Cited by 627

The Role of GABA in Human Motor Learning

Stagg, C. J., Bachtiar, V., & Johansen‐Berg, H. (2011) · Current Biology · doi:10.1016/j.cub.2011.01.069 · Cited by 625

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

Lüscher, C., & Slesinger, P. A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2834 · Cited by 617

Regulation of γ‐Aminobutyric Acid Synthesis in the Brain

Martin, D. L., & Rimvall, K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03165.x · Cited by 615

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms

Esclapez, M., Tillakaratne, N. J. K., Kaufman, D. L., Tobin, A., & Houser, C. R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01834.1994 · Cited by 614

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

Mufson, E. J., Counts, S., Perez, S. E., & Ginsberg, S. D. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.11.1703 · Cited by 602

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Talantova, M., Sanz-Blasco, S., Zhang, X., Xia, P., Akhtar, M. W., Okamoto, S.-I., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306832110 · Cited by 600

Benzodiazepine use and risk of Alzheimer's disease: case-control study

de Gage, S. B., Moride, Y., Ducruet, T., Kurth, T., Verdoux, H., Tournier, M., Pariente, A., & Bégaud, B. (2014) · BMJ · doi:10.1136/bmj.g5205 · Cited by 560

GABA as an inhibitory neurotransmitter in human cerebral cortex

McCormick, D. A. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.62.5.1018 · Cited by 557

GABA is the principal neurotransmitter of the circadian system

Moore, R. Y., & Speh, J. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90120-a · Cited by 555

Functional properties of recombinant rat GABAA receptors depend upon subunit composition

Verdoorn, T. A., Draguhn, A., Ymer, S., Seeburg, P. H., & Sakmann, B. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90145-6 · Cited by 545

THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEX

Iversen, L. L., & Neal, M. J. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb06831.x · Cited by 542

Analysis of GABA A Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics

Rudolph, U., & Möhler, H. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121429 · Cited by 528

The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity

DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527

GABAergic interneuron origin of schizophrenia pathophysiology

Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498

Functional domains of GABAA receptors

Smith, G. B., & Olsen, R. W. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89009-4 · Cited by 491

Stoichiometry and Assembly of a Recombinant GABAAReceptor Subtype

Tretter, V. E., Ehya, N., Fuchs, K., & Sieghart, W. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02728.1997 · Cited by 484

A POST-MORTEM STUDY OF THE CHOLINERGIC AND GABA SYSTEMS IN SENILE DEMENTIA

Rossor, M. N., Garrett, N., Johnson, A. L., Mountjoy, C. Q., Roth, M., & Iversen, L. L. (1982) · Brain · doi:10.1093/brain/105.2.313 · Cited by 460

GABA system dysfunction in autism and related disorders: From synapse to symptoms

Coghlan, S., Horder, J., Inkster, B., Méndez, M. A., Murphy, D., & Nutt, D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.005 · Cited by 459

Glial Cell Function: Uptake of Transmitter Substances

Henn, F. A., & Hamberger, A. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.11.2686 · Cited by 459

Trophic actions of GABA on neuronal development

Represa, A., & Ben‐Ari, Y. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.010 · Cited by 456

Clinical features of Alzheimer's disease

Förstl, H., & Kurz, A. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050101 · Cited by 444

Quaternary Structure of the Native GABAA Receptor Determined by Electron Microscopic Image Analysis

Nayeem, N., Green, T. P., Martin, I. L., & Barnard, E. A. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62020815.x · Cited by 436

Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site.

Whiting, P. J., McKernan, R. M., & Iversen, L. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9966 · Cited by 432

GABA uptake regulates cortical excitability via cell type–specific tonic inhibition

Semyanov, A. V., Walker, M. C., & Kullmann, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn1043 · Cited by 431

Glutamate and GABA receptor signalling in the developing brain

Luján, R., Shigemoto, R., & López‐Bendito, G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.042 · Cited by 429

Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors.

Günther, U., Benson, J. A., Benke, D., Fritschy, J., Reyes, G., Knoflach, F., Crestani, F., Aguzzi, A., Arigoni, M., Lang, Y., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7749 · Cited by 423

Presynaptic Cholinergic Dysfunction in Patients with Dementia

Sims, N. R., Bowen, D. M., Allen, S. J., Smith, C., Neary, D., Thomas, D. J., & DAVISON, A. N. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb11311.x · Cited by 421

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

Levey, A. I., Edmunds, S. M., Koliatsos, V. E., Wiley, R. G., & Heilman, C. J. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-04077.1995 · Cited by 421

Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].

Liu, Q., López‐Corcuera, B., Mandiyan, S., Nelson, H. R., & Nelson, N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53968-5 · Cited by 417

Neurochemical characteristics of early and late onset types of Alzheimer's disease.

Rossor, M. N., Iversen, L. L., Reynolds, G. P., Mountjoy, C. Q., & Roth, M. (1984) · BMJ · doi:10.1136/bmj.288.6422.961 · Cited by 415

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABAB receptor function

Galvez, T., Duthey, B., Kniazeff, J., Blahoš, J., Rovelli, G., Bettler, B., Prézeau, L., & Pin, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2152 · Cited by 383

GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity

Wagner, S., Castel, M., Gainer, H., & Yarom, Y. (1997) · Nature · doi:10.1038/42468 · Cited by 370

GABA sets the tempo for activity-dependent adult neurogenesis

Ge, S., Pradhan, D. A., Ming, G., & Song, H. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.11.001 · Cited by 369

GABAA receptor diversity and pharmacology

Möhler, H. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0284-3 · Cited by 368

GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications

Conti, F., Minelli, A., & Melone, M. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.03.003 · Cited by 362

Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies

Cossart, R., Bernard, C., & Ben‐Ari, Y. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.011 · Cited by 351

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease

Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348

A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity

Paulsen, O., & Moser, E. I. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01205-8 · Cited by 345

GABAB receptors – the first 7TM heterodimers

Marshall, F. H., JONES, K. A., Kaupmann, K., & Bettler, B. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01383-8 · Cited by 345

The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins

Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12102-a · Cited by 342

Alterations of GABAergic Signaling in Autism Spectrum Disorders

Pizzarelli, R., & Cherubini, E. (2011) · Neural Plasticity · doi:10.1155/2011/297153 · Cited by 338

GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex

Minelli, A., Brecha, N., Karschin, C., Debiasi, S., & Conti, F. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07734.1995 · Cited by 333

Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain

Tomita, H., Vawter, M. P., Walsh, D. M., Evans, S. J., Choudary, P. V., Li, J., Overman, K. M., Atz, M. E., Myers, R. M., Jones, E. G., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.013 · Cited by 331

Structure, Pharmacology, and Function of GABAA Receptor Subtypes

Sieghart, W. (2006) · Advances in pharmacology · doi:10.1016/s1054-3589(06)54010-4 · Cited by 321

Molecular heterogeneity of the gamma-aminobutyric acid (GABA) transport system. Cloning of two novel high affinity GABA transporters from rat brain.

Borden, L. A., Smith, K. E., Hartig, P. R., Branchek, T. A., & Weinshank, R. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36802-4 · Cited by 318

The Revitalized Tau Hypothesis on Alzheimer's Disease

Maccioni, R. B., Farias, G. A., Morales, I., & Navarrete, L. P. (2010) · Archives of Medical Research · doi:10.1016/j.arcmed.2010.03.007 · Cited by 316

Purification and Characterization of Glutamate Decarboxylase from Mouse Brain

Wu, J., Matsuda, T., & Roberts, E. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44004-0 · Cited by 312

Selective Alterations in GABA A Receptor Subtypes in Human Temporal Lobe Epilepsy

Loup, F., Wieser, H. G., Yonekawa, Y., Aguzzi, A., & Fritschy, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05401.2000 · Cited by 308

Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

Wu, Z., Guo, Z., Gearing, M., & Chen, G. (2014) · Nature Communications · doi:10.1038/ncomms5159 · Cited by 306

GABAB‐receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization

Fritschy, J., Meskenaïte, V., Weinmann, O., Honer, M., Benke, D., & Möhler, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00481.x · Cited by 305

θ, a novel γ-aminobutyric acid type A receptor subunit

Bonnert, T. P., McKernan, R. M., Farrar, S. J., Bourdellès, B. L., HEAVENS, R. P., Smith, D. W., Hewson, L., Rigby, M. R., SIRINATHSINGHJI, D. J. S., Brown, N. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9891 · Cited by 303

GAT-3, a High-Affinity GABA Plasma Membrane Transporter, Is Localized to Astrocytic Processes, and It Is Not Confined to the Vicinity of GABAergic Synapses in the Cerebral Cortex

Minelli, A., Debiasi, S., Brecha, N. C., Vitellaro‐Zuccarello, L., & Conti, F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06255.1996 · Cited by 295

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

Li, G., Bien-Ly, N., Andrews-Zwilling, Y., Xu, Q., Bernardo, A., Ring, K., Halabisky, B., Deng, C., Mahley, R. W., & Huang, Y. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.10.015 · Cited by 288

Soluble β-Amyloid1-40Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses

Roselli, F., Tirard, M., Lu, J., Hutzler, P., Lamberti, P., Livrea, P., Morabito, M. A., & Almeida, O. F. X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-05.2005 · Cited by 283

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

Li, Y., Sun, H., Chen, Z., Xu, H., Bu, G., & Zheng, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00031 · Cited by 282

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[ 3 H]Glutamate Binding

Greenamyre, J. T., Penney, J. B., D’Amato, C. J., & Young, A. B. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb04127.x · Cited by 278

Loss of functional GABA A receptors in the Alzheimer diseased brain

Limón, A., Reyes‐Ruiz, J. M., & Miledi, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204606109 · Cited by 275

Mutations in GABAAreceptor subunits associated with genetic epilepsies

Macdonald, R. L., Kang, J., & Gallagher, M. J. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.186999 · Cited by 272

Stoichiometry of a Ligand-gated Ion Channel Determined by Fluorescence Energy Transfer

Farrar, S. J., Whiting, P. J., Bonnert, T. P., & McKernan, R. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10100 · Cited by 269

The Role of GABA in the Pathophysiology and Treatment of Anxiety Disorders

Nemeroff, C. B., MD, & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4169 · Cited by 263

GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon

Guidotti, A., Auta, J., Davis, J. M., Dong, E., Grayson, D. R., Veldic, M., Zhang, X., & Costa, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2212-8 · Cited by 262

The GABAB1b Isoform Mediates Long-Lasting Inhibition of Dendritic Ca2+ Spikes in Layer 5 Somatosensory Pyramidal Neurons

Pérez‐Garci, E., Gassmann, M., Bettler, B., & Larkum, M. E. (2006) · Neuron · doi:10.1016/j.neuron.2006.04.019 · Cited by 262

Zinc-mediated inhibition of GABAA receptors: discrete binding sites underlie subtype specificity

Hosie, A. M., Dunne, E. L., Harvey, R. J., & Smart, T. G. (2003) · Nature Neuroscience · doi:10.1038/nn1030 · Cited by 256

Glutamatergic systems in Alzheimer's disease

Francis, P. T. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.934 · Cited by 254

Analysis of the set of GABAA receptor genes in the human genome

Simon, J., Wakimoto, H., Fujita, N., Lalande, M., & Barnard, E. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401354200 · Cited by 253

Structure, function, and plasticity of GABA transporters

Scimemi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00161 · Cited by 248

gamma-Aminobutyric acid is an inhibitory neurotransmitter restricting the release of luteinizing hormone-releasing hormone before the onset of puberty.

Mitsushima, D., HEI, D. L., & Terasawa, E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.395 · Cited by 246

17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease

Massone, S., Vassallo, I., Fiorino, G., Castelnuovo, M., Barbieri, F., Borghi, R., Tabaton, M., Robello, M., Gatta, E., Russo, C., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.019 · Cited by 245

Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles

Jin, H., Wu, H., Osterhaus, G., Wei, J., Davis, K., Sha, D., Floor, E., Hsu, C.-C., Kopke, R. D., & Wu, J.-Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730698100 · Cited by 243

Emerging Concepts in Alzheimer's Disease

Vinters, H. V. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163927 · Cited by 242

GABAB Receptor Coupling to G-proteins and Ion Channels

Padgett, C. L., & Slesinger, P. A. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)58006-2 · Cited by 241

Taurine prevents the neurotoxicity of β‐amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders

Louzada, P., Lima, A. C. P., Mendonça-Silva, D., Noël, F., de Mello, F. G., & Ferreira, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0739com · Cited by 239

Biochemical and molecular studies using human autopsy brain tissue

Hynd, M. R., Lewohl, J. M., Scott, H. L., & Dodd, P. R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01747.x · Cited by 238

Postmortem Changes of Amino Compounds in Human and Rat Brain

Perry, T. L., Hansen, S., & Gandham, S. S. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb01608.x · Cited by 238

Excitatory and inhibitory neurotransmitters in the generation and degeneration of hippocampal neuroarchitecture

Mattson, M. P., & Kater, S. B. (1989) · Brain Research · doi:10.1016/0006-8993(89)91514-x · Cited by 231

Dementia

Burns, A. S., & Iliffe, S. (2009) · BMJ · doi:10.1136/bmj.b75 · Cited by 230

The role of GABAergic modulation in motor function related neuronal network activity

Hall, S. D., Stanford, I. M., Yamawaki, N., McAllister, C. J., Rönnqvist, K. C., Woodhall, G. L., & Furlong, P. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.025 · Cited by 229

GABA B2 Is Essential for G-Protein Coupling of the GABA B Receptor Heterodimer

Robbins, M. J., Calver, A. R., Filippov, A. K., Hirst, W. D., Russell, R. B., Wood, M. D., Nasir, S., Couve, A., Brown, D. A., Moss, S. J., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08043.2001 · Cited by 221

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

Guidotti, A., Auta, J., Chen, Y., Davis, J. M., Dong, E., Gavin, D. P., Grayson, D. R., Matrisciano, F., Pinna, G., Satta, R., et al. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.021 · Cited by 221

Impaired and repaired inhibitory circuits in the epileptic human hippocampus

Maglóczky, Z., & Freund, T. F. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.04.002 · Cited by 217

Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding

Galvez, T., Parmentier, M., Joly, C., Malitschek, B., Kaupmann, K., Kuhn, R. R., Bittiger, H., Froestl, W., Bettler, B., & Pin, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13362 · Cited by 217

GABAA receptors display association of γ2-subunit with α1- and β2/3-subunits

Benke, D., Mertens, S., Trzeciak, A. M., Gillessen, D., & Möhler, H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64347-2 · Cited by 216

REVIEW: tau protein pathology in Alzheimer’s disease and related disorders

Tolnay, M., & Probst (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00182.x · Cited by 214

Tau Phosphorylation and Sevoflurane Anesthesia: An Association to Postoperative Cognitive Impairment

Le Freche, H., Brouillette, J., Fernandez-Gomez, F.-J., Patin, P., Caillierez, R., Zommer, N., Sergeant, N., Buée-Scherrer, V., Lebuffe, G., Blum, D., et al. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31824be8c7 · Cited by 212

Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity

Ng, G., Clark, J. E., Coulombe, N., Éthier, N., Hébert, T. E., Sullivan, R. J., Kargman, S., Châteauneuf, A., Tsukamoto, N., McDonald, T., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7607 · Cited by 212

Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter.

López‐Corcuera, B., Liu, Q., Mandiyan, S., Nelson, H. R., & Nelson, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37067-x · Cited by 210

Immunocytochemical localization of the GABA transporter in rat brain

Radian, R., Ottersen, O. P., Storm‐Mathisen, J., Castel, M.-N., & Bi, K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01319.1990 · Cited by 208

Cortical area and species differences in dendritic spine morphology

Benavides-Piccione, R., Ballesteros-Yáñez, I., DeFelipe, J., & Yuste, R. (2002) · Journal of Neurocytology · doi:10.1023/a:1024134312173 · Cited by 207

Activation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform

Lavoie, A. M., Tingey, J., Harrison, N. L., Pritchett, D. B., & Twyman, R. E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78280-8 · Cited by 205

Distribution, prevalence, and drug binding profile of gamma-aminobutyric acid type A receptor subtypes differing in the beta-subunit variant.

Benke, D., Fritschy, J., Trzeciak, A. M., Bannwarth, W., & Möhler, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47131-1 · Cited by 204

Quantitative fine-structural analysis of olfactory cortical synapses

Schikorski, T., & Stevens, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4107 · Cited by 204

CHARACTERIZATION OF BENZODIAZEPINE BINDING SITES IN CULTURED CELLS OF NEURAL ORIGIN

Syapin, P. J., & Skolnick, P. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb04592.x · Cited by 203

Subunit Composition and Quantitative Importance of Hetero-oligomeric Receptors: GABAAReceptors Containing α6Subunits

Jechlinger, M., Pelz, R., Tretter, V. E., Klausberger, T., & Sieghart, W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02449.1998 · Cited by 201

A Single Subunit (GB2) Is Required for G-protein Activation by the Heterodimeric GABAB Receptor

Duthey, B., Caudron, S., Perroy, J., Bettler, B., Fagni, L., Pin, J., & Prézeau, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108900200 · Cited by 198

Generation of Two Forms of the γ‐Aminobutyric AcidA Receptor γ‐2‐Subunit in Mice by Alternative Splicing

Kofuji, P., Wang, J. B., Moss, S. J., Huganir, R. L., & Burt, D. R. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08209.x · Cited by 197

Alzheimer's disease: Changes in hippocampal N-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors—an autoradiographic study

Jansen, K. L. R., Faull, R. L. M., Dragunow, M., & Synek, B. J. L. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90246-z · Cited by 197

GABAAreceptors in aging and Alzheimer’s disease

Rissman, R. A., Blas, A. L. D., & Armstrong, D. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04832.x · Cited by 193

GABAergic Function in Alzheimer's Disease: Evidence for Dysfunction and Potential as a Therapeutic Target for the Treatment of Behavioural and Psychological Symptoms of Dementia

Lanctôt, K. L., Herrmann, N., Mazzotta, P., Khan, L. R., & Ingber, N. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900705 · Cited by 191

GABAA receptor modulation of memory: the role of endogenous benzodiazepines

Izquierdo, I., & Medina, J. H. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90567-c · Cited by 187

Uptake and metabolism of GABA in astrocytes cultured from dissociated mouse brain hemispheres

Schousboe, A., Hertz, L., & Svenneby, G. (1977) · Neurochemical Research · doi:10.1007/bf00964098 · Cited by 186

Effect of GABA on GnRH Neurons Switches from Depolarization to Hyperpolarization at Puberty in the Female Mouse

Han, S., Ábrahám, I. M., & Herbison, A. E. (2002) · Endocrinology · doi:10.1210/endo.143.4.8724 · Cited by 183

On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies

Faingold, C. L., Gehlbach, G., & Caspary, D. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)90326-0 · Cited by 182

Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer’s disease

Rissman, R. A., & Mobley, W. C. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07237.x · Cited by 174

Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain

Martin, D., Martin, S. B., Sj, W., & Espina, N. G. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02725.1991 · Cited by 167

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance

Lei, M., Xu, H., Li, Z., Wang, Z., O’Malley, T. T., Zhang, D., Walsh, D. M., Xu, P., Selkoe, D. J., & Li, S. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.019 · Cited by 162

Role of GABAB receptors in learning and memory and neurological disorders

Heaney, C. F., & Kinney, J. W. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.007 · Cited by 162

No Ligand Binding in the GB2 Subunit of the GABA B Receptor Is Required for Activation and Allosteric Interaction between the Subunits

Kniazeff, J., Galvez, T., Labesse, G., & Pin, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07352.2002 · Cited by 160

Glutamine as precursor for the GABA and glutamate trasmitter pools

Reubi, J. C., Berg, C. V. D., & Cuénod, M. (1978) · Neuroscience Letters · doi:10.1016/0304-3940(78)90030-7 · Cited by 157

GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors

Dalby, N. O. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00075-7 · Cited by 157

Postmortem interval effect on RNA and gene expression in human brain tissue

Birdsill, A. C., Walker, D. G., Lue, L., Sue, L. I., & Beach, T. G. (2010) · Cell and Tissue Banking · doi:10.1007/s10561-010-9210-8 · Cited by 157

Vigabatrin Induces Tonic Inhibition Via GABA Transporter Reversal Without Increasing Vesicular GABA Release

Wu, Y., Wang, W., & Richerson, G. B. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00856.2002 · Cited by 155

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

Reinikainen, K. J., Paljärvi, L., Huuskonen, M., Soininen, H. S., Laakso, M., & Riekkinen, P. J. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90179-7 · Cited by 154

Amyloid β Prevents Activation of Calcium/Calmodulin-Dependent Protein Kinase II and AMPA Receptor Phosphorylation During Hippocampal Long-Term Potentiation

Zhao, D., Watson, J. B., & Xie, C.-W. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00485.2004 · Cited by 152

Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease

Jiménez‐Jiménez, F. J., Molina, J. A., Aguilar, M. V., Meseguer, I., Mateos-Vega, C. J., González‐Muñoz, M. J., de Bustos, F., Martínez‐Salio, A., Pareja, M. O., Zurdo, M., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050073 · Cited by 151

Differences in Agonist/Antagonist Binding Affinity and Receptor Transduction Using Recombinant Human γ-Aminobutyric Acid Type A Receptors

Ebert, B., Thompson, S. A., Saounatsou, K., McKernan, R., Krogsgaard-Larsen, P., & Wafford, K. A. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.6.1150 · Cited by 145

Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord

Mackie, M., Hughes, D. I., Maxwell, D. J., Tillakaratne, N. J. K., & Todd, A. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00174-x · Cited by 144

A postmortem study of amino acid neurotransmitters in Alzheimer's disease

Ellison, D. W., Beal, M. F., Mazurek, M. F., Bird, E. D., & Martin, J. B. (1986) · Annals of Neurology · doi:10.1002/ana.410200510 · Cited by 141

Alzheimer’s disease: amino acid levels and brain metabolic status

Gueli, M. C., & Taibi, G. (2013) · Neurological Sciences · doi:10.1007/s10072-013-1289-9 · Cited by 140

A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes

Cristóvão‐Ferreira, S., Navarro, G., Brugarolas, M., Pérez‐Capote, K., Vaz, S. H., Fattorini, G., Conti, F., Lluís, C., Ribeiro, J. A., McCormick, P. J., et al. (2013) · Purinergic Signalling · doi:10.1007/s11302-013-9364-5 · Cited by 140

The amyloid pathology progresses in a neurotransmitter-specific manner

Bell, K. F. S., Ducatenzeiler, A., Ribeiro‐da‐Silva, A., Duff, K., Bennett, D. A., & Cuello, A. C. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.034 · Cited by 139

Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in gabaergic neurons: Vesicular versus non-vesicular release of GABA

Belhage, B., Hansen, G. H., & Schousboe, A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90592-4 · Cited by 138

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice

Mitew, S., Kirkcaldie, M. T. K., Dickson, T. C., & Vickers, J. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.010 · Cited by 138

Functional diversity of GABA activated Cl− currents in Purkinje versus granule neurons in rat cerebellar slices

Puia, G., Costa, E., & Vicini, S. (1994) · Neuron · doi:10.1016/0896-6273(94)90157-0 · Cited by 138

Gamma‐aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.

Dingledine, R. J., & Korn, S. J. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015804 · Cited by 137

Diminished perisomatic GABAergic terminals on cortical neurons adjacent to amyloid plaques

Garcia-Marin, V. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.028.2009 · Cited by 136

Levels of -Aminobutyric Acid in Cerebrospinal Fluid in Various Neurologic Disorders

Manyam, N. V. B., Katz, L., Hare, T. A., Gerber, J. C., & Grossman, M. H. (1980) · Archives of Neurology · doi:10.1001/archneur.1980.00500550054006 · Cited by 135

Development of GABA and glutamate signaling at the GnRH neuron in relation to puberty

Clarkson, J., & Herbison, A. E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.04.036 · Cited by 135

β and γ Frequency Synchronization by Dendritic GABAergic Synapses and Gap Junctions in a Network of Cortical Interneurons

Szabadics, J., Lörincz, A., & Tamás, G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05824.2001 · Cited by 135

Kinetics and localization of brain phosphate activated glutaminase

Kvamme, E., Torgner, I. A., & Roberg, B. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10041 · Cited by 134

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

Vellas, B., Sol, O., J. Snyder, P., Ousset, P.-J., Haddad, R., Maurin, M., Lemarie, J.-C., Desire, L., & P. Pando, M. (2011) · Current Alzheimer Research · doi:10.2174/156720511795256053 · Cited by 133

Propofol Directly Increases Tau Phosphorylation

Whittington, R. A., Virág, L., Marcouiller, F., Papon, M.-A., Khoury, N. B. E., Julien, C., Morin, F., Emala, C. W., & Planel, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016648 · Cited by 133

GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE

Lowe, S. L., Francis, P. T., PROCTER, A. W., Palmer, A. M., DAVISON, A. N., & Bowen, D. M. (1988) · Brain · doi:10.1093/brain/111.4.785 · Cited by 132

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

Levenga, J., Krishnamurthy, P., Rajamohamedsait, H. B., Wong, H., Franke, T. F., Cain, P., Sigurdsson, E. M., & Hoeffer, C. A. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-34 · Cited by 131

Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry

Ikegaki, N., Saito, N., Hashima, M., & Tanaka, C. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90072-8 · Cited by 130

The betaine-GABA transporter (BGT1, slc6a12) is predominantly expressed in the liver and at lower levels in the kidneys and at the brain surface

Zhou, Y., Holmseth, S., Hua, R., Lehre, A. C., Olofsson, A. M., Poblete-Naredo, I., Kempson, S. A., & Danbolt, N. C. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00464.2011 · Cited by 130

Utilization of Glutamine and of TCA Cycle Constituents as Precursors for Transmitter Glutamate and GABA

Peng, L., Hertz, L., Huang, R., Sonnewald, U., Petersen, S. B., Westergaard, N., Larsson, O. M., & Schousboe, A. (1994) · Developmental Neuroscience · doi:10.1159/000111357 · Cited by 128

Aberrant Expression of the Glutamate Transporter Excitatory Amino Acid Transporter 1 (EAAT1) in Alzheimer's Disease

Scott, H. L., Pow, D. V., Tannenberg, A. E. G., & Dodd, P. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-j0004.2002 · Cited by 127

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966

Pathological mechanisms and therapeutic strategies for Alzheimer’s disease

Tam, K. Y., & Ju, Y. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320970 · Cited by 422

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

Sears, S. M. S., & Hewett, S. J. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221989263 · Cited by 371

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., et al. (2021) · Brain · doi:10.1093/brain/awaa376 · Cited by 283

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?

Govindpani, K., McNamara, L. G., Smith, N. R., Vinnakota, C., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050651 · Cited by 281

The GABAergic system as a therapeutic target for Alzheimer's disease

Guzmán, B. C., Vinnakota, C., Govindpani, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14345 · Cited by 172

Recent progress on the role of GABAergic neurotransmission in the pathogenesis of Alzheimer’s disease

Abbas, G., Mahmood, W., & Kabir, N. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0062 · Cited by 18

IMPORTANT ROLE PLAYS OF GABA AND ITS TYPES IN ALZHEIMER'S DISEASE: A REVIEW

SUSMITA MANDAL, A. V. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.15771291

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

Li, Y., Sun, H., Chen, Z., Xu, H., Bu, G., & Zheng, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00031 · Cited by 282

GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s disease

Nava-Mesa, M. O., Jiménez‐Díaz, L., Yajeya, J., & Navarro‐López, J. D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00167 · Cited by 106