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The Development of a Database for Herbal and Dietary Supplement Induced Liver Toxicity

Zhu, Jieqiang, Seo, Ji-Eun, Wang, Sanlong, Ashby, Kristin, Ballard, Rodney, Yu, Dianke, Ning, Baitang, Agarwal, Rajiv, Borlak, Jürgen, Tong, Weida, Chen, Minjun·2018·International Journal of Molecular Sciences
DOI 10.3390/ijms19102955PMC PMC6213387
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Abstract

The growing use of herbal dietary supplements (HDS) in the United States provides compelling evidence for risk of herbal-induced liver injury (HILI). Information on HDS products was retrieved from MedlinePlus of the U.S. National Library of Medicine and the herbal monograph of the European Medicines Agency. The hepatotoxic potential of HDS was ascertained by considering published case reports. Other relevant data were collected from governmental documents, public databases, web sources, and the literature. We collected information for 296 unique HDS products. Evidence of hepatotoxicity was reported for 67, that is 1 in 5, of these HDS products. The database revealed an apparent gender preponderance with women representing 61% of HILI cases. Culprit hepatotoxic HDS were mostly used for weight control, followed by pain and inflammation, mental stress, and mood disorders. Commonly discussed mechanistic events associated with HILI are reactive metabolites and oxidative stress, mitochondrial injury, as well as inhibition of transporters. HDS–drug interactions, causing both synergistic and antagonizing effects of drugs, were also reported for certain HDS. The database contains information for nearly 300 commonly used HDS products to provide a single-entry point for better comprehension of their impact on public health.

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Research works printed but not linked: 65

  1. Stickel, 2005, Herbal hepatotoxicity, J. Hepatol., 43, 901, 10.1016/j.jhep.2005.08.002 · DOI
  2. Zheng, 2015, Liver Injury from Herbal, Dietary, and Weight Loss Supplements: A Review, J. Clin. Transl. Hepatol., 3, 93, 10.14218/JCTH.2015.00006 · DOI
  3. Stickel, 2015, Hepatotoxicity of herbal and dietary supplements: An update, Arch. Toxicol., 89, 851, 10.1007/s00204-015-1471-3 · DOI
  4. Ros, 1999, A case of positive doping associated with a botanical food supplement, Pharm. World Sci., 21, 44, 10.1023/A:1008681612399 · DOI
  5. Liu, 2015, Network Pharmacology for Traditional Chinese Medicine Research: Methodologies and Applications, Chin. Herb. Med., 1, 005
  6. Bailey, 2010, Dietary supplement use in the United States, 2003–2006, J. Nutr., 141, 261, 10.3945/jn.110.133025 · DOI
  7. Lee, 2015, Evolution of traditional medicines to botanical drugs, Science, 347, S32
  8. Avigan, M.I., Mozersky, R.P., and Seeff, L.B. (2016). Scientific and regulatory perspectives in herbal and dietary supplement associated hepatotoxicity in the United States. Int. J. Mol. Sci., 17. · DOI
  9. Navarro, 2017, Liver injury from herbal and dietary supplements, Hepatology, 65, 363, 10.1002/hep.28813 · DOI
  10. Mehta, 2008, Herbal and dietary supplement disclosure to health care providers by individuals with chronic conditions, J. Alter. Complement. Med., 14, 1263, 10.1089/acm.2008.0290 · DOI · Paper page
  11. Stickel, 2011, Review of liver injury associated with dietary supplements, Liver Int., 31, 595, 10.1111/j.1478-3231.2010.02439.x · DOI
  12. Seeff, 2015, Herbal products and the liver: A review of adverse effects and mechanisms, Gastroenterology, 148, 517, 10.1053/j.gastro.2014.12.004 · DOI
  13. Chen, 2013, Liver Toxicity Knowledge Base (LTKB)—A Systems Approach to a Complex Endpoint, Clin. Pharmacol. Ther., 95, 409, 10.1038/clpt.2013.16 · DOI
  14. Chen, 2016, A Model to predict severity of drug-induced liver injury in humans, Hepatology, 64, 931, 10.1002/hep.28678 · DOI
  15. Chen, 2015, Drug-Induced liver injury: Interactions between drug properties and host factors, J. Hepatol., 63, 503, 10.1016/j.jhep.2015.04.016 · DOI
  16. Chen, 2013, High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury, Hepatology, 58, 388, 10.1002/hep.26208 · DOI · Paper page
  17. Zhang, 2012, Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?, Chem. Res. Toxicol., 25, 122, 10.1021/tx200320e · DOI
  18. Wang, 2013, A Unifying Ontology to Integrate Histological and Clinical Observations for Drug-Induced Liver Injury, Am. J. Pathol., 182, 1180, 10.1016/j.ajpath.2012.12.033 · DOI
  19. Yu, 2014, High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury, Drug Metabol. Disposition, 42, 744, 10.1124/dmd.113.056267 · DOI · Paper page
  20. Yu, K., Zhang, J., Chen, M., Xu, X., Suzuki, A., Ilic, K., and Tong, W. (2014). Mining hidden knowledge for drug safety assessment: Topic modeling of LiverTox as a case study. BMC Bioinf., 15. · DOI
  21. Wu, 2015, NETBAGs: A network based clustering approach with gene signatures for cancer subtyping analysis, Biomark Med., 9, 1053, 10.2217/bmm.15.96 · DOI
  22. Mishra, 2017, Application of “Rule-of-two” Model to Direct-Acting Antivirals for Treatment of Chronic Hepatitis C: Can it Predict Potential for Hepatotoxicity?, Gastroenterology, 152, 1270, 10.1053/j.gastro.2017.03.012 · DOI
  23. Chen, 2011, FDA-approved drug labeling for the study of drug-induced liver injury, Drug Discov. Today, 16, 697, 10.1016/j.drudis.2011.05.007 · DOI · Paper page
  24. Russmann, 2009, Current concepts of mechanisms in drug-induced hepatotoxicity, Curr. Med. Chem., 16, 3041, 10.2174/092986709788803097 · DOI
  25. Chen, M., and Will, Y. (2018). Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research. Drug-Induced Liver Toxicity, Humana Press. · DOI
  26. Copple, 2003, Liver inflammation during monocrotaline hepatotoxicity, Toxicology, 190, 155, 10.1016/S0300-483X(03)00164-1 · DOI
  27. Yao, 2014, Hepatic cytochrome P450s play a major role in monocrotaline-induced renal toxicity in mice, Acta Pharmacol. Sin., 35, 292, 10.1038/aps.2013.145 · DOI
  28. Zhou, 2010, Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways, FASEB J., 24, 4722
  29. Wang, 2015, Green tea polyphenol (-)-epigallocatechin-3-gallate triggered hepatotoxicity in mice: Responses of major antioxidant enzymes and the Nrf2 rescue pathway, Toxicol. Appl. Pharmacol., 283, 65, 10.1016/j.taap.2014.12.018 · DOI
  30. Sahu, 2012, Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture, J. Appl. Toxicol., 32, 722, 10.1002/jat.1721 · DOI
  31. Mazzanti, 2009, Chelidonium majus is not hepatotoxic in Wistar rats, in a 4 weeks feeding experiment, J. Ethnopharmacol., 126, 518, 10.1016/j.jep.2009.09.004 · DOI
  32. Sahu, 2006, Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures, Food Chem. Toxicol., 44, 1751, 10.1016/j.fct.2006.05.016 · DOI
  33. Campos, 2012, Cimicifuga racemosa impairs fatty acid beta-oxidation and induces oxidative stress in livers of ovariectomized rats with renovascular hypertension, Free Radic. Biol. Med., 53, 680, 10.1016/j.freeradbiomed.2012.05.043 · DOI
  34. Fujiwara, 1998, Dynamic recycling of ERGIC53 between the endoplasmic reticulum and the Golgi complex is disrupted by nordihydroguaiaretic acid, Biochem. Biophys. Res. Commun., 253, 869, 10.1006/bbrc.1998.9868 · DOI
  35. Fujiwara, 1998, Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum, J. Biol. Chem., 273, 3068, 10.1074/jbc.273.5.3068 · DOI
  36. Chen, 2014, The role of autophagy in usnic acid-induced toxicity in hepatic cells, Toxicol. Sci., 142, 33, 10.1093/toxsci/kfu154 · DOI
  37. Alhaddad, 2016, Khat-induced liver injuries: A report of two cases, Arab J. Gastroenterol., 17, 45, 10.1016/j.ajg.2016.02.002 · DOI
  38. Cohen, 2004, Autoimmune hepatitis associated with the use of black cohosh: A case study, Menopause, 11, 575, 10.1097/01.gme.0000142914.55849.6a · DOI
  39. Nadir, 1996, Acute hepatitis associated with the use of a Chinese herbal product, ma-huang, Am. J. Gastroenterol., 91, 1436
  40. Stedman, 2002, Herbal hepatotoxicity, Semin. Liver Dis., 22, 195, 10.1055/s-2002-30104 · DOI
  41. 2000, Herb-drug interactions, Lancet, 355, 134, 10.1016/S0140-6736(99)06457-0 · DOI
  42. Lekehal, 1996, Hepatotoxicity of the herbal medicine germander: Metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes, Hepatology, 24, 212, 10.1002/hep.510240134 · DOI
  43. Fau, 1997, Diterpenoids from germander, an herbal medicine, induce apoptosis in isolated rat hepatocytes, Gastroenterology, 113, 1334, 10.1053/gast.1997.v113.pm9322529 · DOI
  44. Loeper, 1994, Hepatotoxicity of germander in mice, Gastroenterology, 106, 464, 10.1016/0016-5085(94)90606-8 · DOI
  45. Roby, 2000, St John’s Wort: Effect on CYP3A4 activity, Clin. Pharmacol. Ther., 67, 451, 10.1067/mcp.2000.106793 · DOI
  46. Mueller, 2006, The extent of induction of CYP3A by St. John’s wort varies among products and is linked to hyperforin dose, Eur. J. Clin. Pharmacol., 62, 29, 10.1007/s00228-005-0061-3 · DOI
  47. Mathews, 2002, Inhibition of human cytochrome P450 activities by kava extract and kavalactones, Drug Metab. Dispo., 30, 1153, 10.1124/dmd.30.11.1153 · DOI
  48. Smith, 2016, MARKET REPORT. Sales of herbal dietary supplements in US increased 7.5% in 2015 consumers spent $6.92 billion on herbal supplements in 2015, marking the 12th consecutive year of growth, HerbalGram, 111, 67
  49. Teschke, 2014, Drug induced liver injury: Accuracy of diagnosis in published reports, Ann. Hepatol., 13, 248, 10.1016/S1665-2681(19)30888-9 · DOI
  50. Teschke, 2018, Drug induced liver injury with analysis of alternative causes as confounding variables, Br. J. Clin. Pharmacol., 84, 1467, 10.1111/bcp.13593 · DOI
  51. Danan, G., and Teschke, R. (2018). Drug-Induced Liver Injury: Why is the Roussel Uclaf Causality Assessment Method (RUCAM) Still Used 25 Years After Its Launch?. Drug Saf. · DOI · Paper page
  52. Lewis, 2014, Causality assessment: Which is best—Expert opinion or RUCAM?, Clin. Liver Dis., 4, 4, 10.1002/cld.365 · DOI
  53. Lucena, 2008, Evaluation of Naranjo Adverse Drug Reactions Probability Scale in causality assessment of drug-induced liver injury, Aliment. Pharmacol. Ther., 27, 780, 10.1111/j.1365-2036.2008.03655.x · DOI · Paper page
  54. Hoofnagle, 2016, Categorization of drugs implicated in causing liver injury: Critical assessment based on published case reports, Hepatology, 63, 590, 10.1002/hep.28323 · DOI · Paper page
  55. Chitturi, 2008, Hepatotoxic slimming aids and other herbal hepatotoxins, J. Gastroenterol. Hepatol., 23, 366, 10.1111/j.1440-1746.2008.05310.x · DOI
  56. Tesch, 2002, Herbs commonly used by women: An evidence-based review (Reprinted from Cln Jnl Womens Health, vol 1, pg 89-102, 2001), Dm-Dis Mon., 48, 671, 10.1053/cjwh.2001.23363 · DOI
  57. Suk, 2012, A prospective nationwide study of drug-induced liver injury in Korea, Am. J. Gastroenterol., 107, 1380, 10.1038/ajg.2012.138 · DOI · Paper page
  58. Licata, 2013, Herbal hepatotoxicity: A hidden epidemic, Intern. Emerg Med., 8, 13, 10.1007/s11739-012-0777-x · DOI
  59. Radimer, 2004, Dietary supplement use by US adults: Data from the National Health and Nutrition Examination Survey, 1999–2000, Am. J. Epidemiol., 160, 339, 10.1093/aje/kwh207 · DOI
  60. Bunchorntavakul, 2013, Review article: Herbal and dietary supplement hepatotoxicity, Aliment. Pharmacol. Ther., 37, 3, 10.1111/apt.12109 · DOI · Paper page
  61. Vuppalanchi, 2015, Herbal dietary supplement associated hepatotoxicity: An upcoming workshop and need for research, Gastroenterology, 148, 480, 10.1053/j.gastro.2015.01.004 · DOI
  62. Navarro, 2014, Hepatotoxicity induced by herbal and dietary supplements, Semin. Liver Dis., 34, 172, 10.1055/s-0034-1375958 · DOI
  63. Chalasani, 2015, Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study, Gastroenterology, 148, 1340, 10.1053/j.gastro.2015.03.006 · DOI · Paper page
  64. Gardiner, 2013, A Systematic Review of the Prevalence of Herb Usage Among Racial/Ethnic Minorities in the United States, J. Immigr. Minor. Health, 15, 817, 10.1007/s10903-012-9661-z · DOI
  65. Smith, 2017, MARKET REPORT. Herbal Supplement Sales in US Increase 7.7% in 2016 Consumer preferences shifting toward ingredients with general wellness benefits, driving growth of adaptogens and digestive health products, HerbalGram, 115, 56

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Metadata

Authors
Zhu, J., Seo, J.-E., Wang, S., Ashby, K., Ballard, R., Yu, D., Ning, B., Agarwal, R., Borlak, J., Tong, W., & Chen, M.
Affiliations
  • Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA
  • Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA
  • Center of Pharmacology and Toxicology, Hannover Medical School, 30625 Hannover, Germany
ORCID
Borlak, Jürgen
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2018-09-28
Volume
19
Issue
10
Pages
2955
ISSN
1422-0067
DOI
10.3390/ijms19102955
PMC
PMC6213387
Cited by
29
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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