The DOI matches its Crossref record; 143 of the 144 references it cites were found in a registry or an index.
Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
Open accessAbstract
The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.
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“Subsequent examination of this mouse has revealed significant defects in resident immune cell populations in the gut, lung, and skin as well as increased susceptibility to certain diseases including psoriasis, experiment colitis and colorectal cancer, and infections of microorganisms like Citrobacter rodentium and Toxoplasma gondii (Díaz-Díaz et al., 2016; Furue et al., 2019; H. R. Kim et al., 202”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Furue et al., 2019
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“Subsequent examination of this mouse has revealed significant defects in resident immune cell populations in the gut, lung, and skin as well as increased susceptibility to certain diseases including psoriasis, experiment colitis and colorectal cancer, and infections of microorganisms like Citrobacter rodentium and Toxoplasma gondii (Díaz-Díaz et al., 2016; Furue et al., 2019; H. R. Kim et al., 202”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Furue et al., 2019
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“AHR, a ligand-dependent transcription factor, is activated by multiple compounds that can induce either epidermal differentiation or oxidative stress (43, 44).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [44]
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Citations
Cites
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
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The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
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Functional role of AhR in the expression of toxic effects by TCDD
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Items 201–216 of 216
Rethinking Head and Neck Atopic Dermatitis: Pathogenic Axes and Emerging Therapeutic Directions
Navarro‐Triviño, F. J., Ruíz‐Villaverde, R., & Torres, T. R. (2026) · American Journal of Clinical Dermatology · doi:10.1007/s40257-026-01048-9 · Cited by 1
Wang, Z., Zhang, J., Liu, S., & Chen, H. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1834627
Li, Z., Deng, C., Lu, B., Chen, F., Cao, X., Fan, J., & Song, Y. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1840065
Ramsamooj, A., Joy, B. M., Manguerra, D. D., & Gerriets, V. A. (2026) · Clinical Drug Investigation · doi:10.1007/s40261-026-01578-4
Hasegawa, H., Watanabe, A., Katahira, Y., Mizoguchi, I., Maeda, T., Mizugami, J., Naguro, I., Ichijo, H., Harada, K., Okubo, Y., et al. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070653
Signal Transduction and Drugs that Target Signaling Pathways
Minden, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-20529-2_18
Dual zeitgeber axes in psoriasis: a chronobiological framework for immune jet lag
Lv, H., Ling, G., 莫惠霞, Lu, M., Yao, D., & Lu, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1848727 · Cited by 1
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Iino, K., Takamura, S., & Fukuda, T. (2026) · The Journal of Dermatology · doi:10.1111/1346-8138.70448
Dijkhoff, I. M., Keshavan, S., Daré, R. G., Petri‐Fink, A., Eeman, M., Tessier, A., & Rothen‐Rutishauser, B. (2026) · International Journal of Cosmetic Science · doi:10.1111/ics.70134
Jiang, T., Foster, A. R., Pournara, A. V., Steele, L., Shabbir, M., Smith, E., Evans, K., Baxter, T., Diddams, K., Wright, L., et al. (2026) · medRxiv · doi:10.64898/2026.09.02.26362057
Tsuji, G., Takemura, M., Kawamura, K., Yumine, A., Konishi, N., & Nakahara, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188032
Self-citationIgarashi, A., Tsuji, G., Murata, R., Fukasawa, S., & Yamane, S. (2026) · Journal of Cutaneous Immunology and Allergy · doi:10.3389/jcia.2026.17307
Self-citationDyszkiewicz, M., Cudowska, B., Omeljaniuk, W. J., Marcinkiewicz-Rybołowicz, S., & Lebensztejn, D. M. (2026) · Biomedicines · doi:10.3390/biomedicines14102140
The Impact of Environmental Exposures on Cystic Acne: A Narrative Review
Vaysman, A., Ulczak, M., Achterberg, C., Goetz, L., Atwood, L., Hildenbrant, R., Hallman, E., Shaughnessy, C., & Vo, K. (2026) · Biomedicines · doi:10.3390/biomedicines14102381
BindingDB Entry 50018239: Synthetic Approaches to the New Drugs Approved during 2019.
BindingDB (2024) · UC San Diego · doi:10.7270/q29p35t8
Metadata
- Authors
- Furue, M., Hashimoto-Hachiya, A., & Tsuji, G.
- Affiliations
- Kyushu University (JP)
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan
- Corresponding author
- Furue, Masutaka
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-10-31
- Volume
- 20
- Issue
- 21
- Pages
- 5424
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6862295
- OpenAlex
- W2982429666
- Cited by
- 215
- References
- 144
- Citations by year
- 2026: 35 · 2025: 23 · 2024: 42 · 2023: 37 · 2022: 27 · 2021: 27 · 2020: 20 · 2019: 2
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- The Ministry of Health, Labour, and Welfare in Japan (H30-Shokuhin-Shitei-005)
- The Leading Advanced Projects for Medical Innovation in Japan (The Leading Advanced Projects for Medical Innovation in Japan)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- aryl hydrocarbon receptor, ARNT, atopic dermatitis, psoriasis, skin barrier function, filaggrin, oxidative stress, Nrf2, tapinarof, AhR agonists, dioxins, tryptophan metabolites
- MeSH terms
- Filaggrin Proteins, Animals, Dermatitis, Atopic, T-Lymphocytes, Helper-Inducer, Humans, Psoriasis, Skin, Receptors, Aryl Hydrocarbon, Oxidative Stress, Polymorphism, Single Nucleotide, T-Lymphocytes, Regulatory
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