Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
Abstract
Innate lymphoid cells (ILC) expressing the transcription factor RORγt induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. RORγt(+) ILC express the aryl hydrocarbon receptor (AhR), a highly conserved, ligand-inducible transcription factor believed to control adaptation of multicellular organisms to environmental challenges. We show that AhR is required for the postnatal expansion of intestinal RORγt(+) ILC and the formation of intestinal lymphoid follicles. AhR activity within RORγt(+) ILC could be induced by dietary ligands such as those contained in vegetables of the family Brassicaceae. AhR-deficient mice were highly susceptible to infection with Citrobacter rodentium, a mouse model for attaching and effacing infections. Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections.
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AhR is required for postnatal maintenance of IL-22-producing ILC3s and for formation of isolated lymphoid follicles.
“the AhR is in fact required for postnatal maintenance of IL-22-producing ILC3s, as well as the formation of isolated lymphoid follicles (Kiss et al., 2011; Lee et al., 2011; Y. Li et al., 2011; J. Qiu et al., 2012).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Kiss et al., 2011
Ahr−/− mice have multiple immunological deficits, including reduced resistance to Listeria monocytogenes, Citrobacter rodentium, and Candida albicans, exacerbated DSS-induced colitis, and altered susceptibility to EAE.
“Ahr−/− mice suffer from multiple immunological deficits, including reduced resistance to infection with the bacteria Listeria monocytogenes or Citrobacter rodentium, as well as the fungus Candida albicans; exacerbated DSS-induced colitis; and even altered susceptibility to experimental autoimmune encephalomyelitis (EAE)”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Kiss et al., 2011
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Background
- Authors
- Kiss, E. A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., & Diefenbach, A.
- Affiliations
- University of Freiburg (DE)
- Institute of Medical Microbiology and Hygiene (IMMH), University of Freiburg Medical Center, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.
- University of Basel (CH)
- Leibniz Institute of Environmental Medicine (DE)
- Corresponding author
- Diefenbach, Andreas
- Venue
- Science
- Published
- 2011-12-16
- Volume
- 334
- Issue
- 6062
- Pages
- 1561-1565
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2069677284
- Cited by
- 801
- References
- 46
- Citations by year
- 2026: 26 · 2025: 39 · 2024: 33 · 2023: 48 · 2022: 41 · 2021: 61 · 2020: 58 · 2019: 54 · 2018: 53 · 2017: 65 · 2016: 67 · 2015: 80 · 2014: 63 · 2013: 63 · 2012: 49
- FWCI
- 24.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- aryl hydrocarbon receptor, RORγt, innate lymphoid cells, Brassicaceae, Citrobacter rodentium infection, intestinal homeostasis
- MeSH terms
- Animals, Diet, Enterobacteriaceae Infections, Intestine, Small, Ligands, Lymphocytes, Mice, Inbred C57BL, Receptors, Aryl Hydrocarbon, Organogenesis, Citrobacter rodentium, Cell Line, Tumor, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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