The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
Open accessAbstract
Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.
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Cites
Tacconelli, E., Carrara, E., Savoldi, A., Harbarth, S., Mendelson, M., Monnet, D. L., Pulcini, C., Kahlmeter, G., Kluytmans, J., Carmeli, Y., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30753-3 · Cited by 6,142
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
Nikaido, H. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.4.593-656.2003 · Cited by 4,316
Chitosan: an update on potential biomedical and pharmaceutical applications.
Cheung, R., Ng, T., Wong, J., & Chan, W. (2015) · Marine Drugs · doi:10.3390/md13085156 · Cited by 1,297
Insights into the mode of action of chitosan as an antibacterial compound.
Raafat, D., von Bargen, K., Haas, A., & Sahl, H.-G. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00453-08 · Cited by 888
New antimicrobial chitosan derivatives for wound dressing applications
Dragostin, O. M., Samal, S. K., Dash, M., Lupascu, F., Pânzariu, A., Tuchilus, C., Ghetu, N., Danciu, M., Dubruel, P., Pieptu, D., et al. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.12.078 · Cited by 194
Xing, K., Chen, X. G., Kong, M., Liu, C. S., Cha, D. S., & Park, H. J. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.09.016 · Cited by 174
Cited by
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Natural polymers in wound healing: From academic studies to commercial products
Tavakoli, M., Labbaf, S., Mirhaj, M., Salehi, S., Seifalian, A. M., & Firuzeh, M. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.53910 · Cited by 74
Deep eutectic solvents for biotechnology applications
Morozova, O. V., Vasil’eva, I. S., Shumakovich, G. P., Zaitseva, E. A., & Yaropolov, A. I. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923140092 · Cited by 41
Resource recovery of bioactive compounds from food waste and their diverse industrial applications
Chauhan, S., Pandit, N. K., Mohanty, A., & Meena, S. S. (2025) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-04967-3 · Cited by 29
Greenzaid, J. D., Chan, L. J., Chandani, B. M., Kiritsis, N. R., & Feldman, S. R. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2326625 · Cited by 17
Metadata
- Authors
- Matica, M. A., Aachmann, F. L., Tøndervik, A., Sletta, H., & Ostafe, V.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-11-24
- Volume
- 20
- Issue
- 23
- Pages
- 5889
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2990135525
- Cited by
- 818
- References
- 6
- FWCI
- 40.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Matica, M. A., Aachmann, F. L., Tøndervik, A., Sletta, H., & Ostafe, V. (2019). Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20235889
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
