Cited by 86Probiotics and Fermented FoodsFood Quality and Safety StudiesProtein Hydrolysis and Bioactive Peptides

Probiotic Properties and Neuroprotective Effects of Lactobacillus buchneri KU200793 Isolated from Korean Fermented Foods

Open access
Cheon, Min-Jeong, Lim, Sung-Min, Lee, Na-Kyoung, Paik, Hyun-Dong·2020·International Journal of Molecular Sciences

Abstract

The purpose of this study was to evaluate the probiotic characteristics and neuroprotective effects of bacteria isolated from Korean fermented foods. Three bacterial strains (Lactobacillus fermentum KU200060, Lactobacillus delbrueckii KU200171, and Lactobacillus buchneri KU200793) showed potential probiotic properties, such as high tolerance against artificial gastric juice and bile salts, sensitivity to antibiotics, nonproduction of carcinogenic enzymes, and high adhesion to intestinal cells. Heat-killed L. fermentum KU200060 and L. buchneri KU200793 showed higher antioxidant activity than heat-killed L. delbrueckii KU200171. The conditioned medium (CM) was used to evaluate the reaction between HT-29 cells and each heat-killed strain. All CMs protected SH-SY5Y cells from 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity. The expression of brain-derived neurotropic factor (BDNF) mRNA in HT-29 cells treated with CM containing heat-killed L. buchneri KU200793 was the highest. The CM significantly reduced the Bax/Bcl-2 ratio and increased BDNF mRNA expression in SH-SY5Y cells treated with MPP+. These results indicate that L. buchneri KU200793 can be used as a prophylactic functional food, having probiotic potential and neuroprotective effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms21041227

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cheon, M.-J., Lim, S.-M., Lee, N.-K., & Paik, H.-D.
Affiliations
Konkuk University (KR)
Corresponding author
Paik, Hyun-Dong
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-02-12
Volume
21
Issue
4
Pages
1227
ISSN
1422-0067 (ISSN-L)
OpenAlex
W3006142293
Cited by
86
References
40
Citations by year
2026: 13 · 2025: 17 · 2024: 8 · 2023: 13 · 2022: 16 · 2021: 8 · 2020: 10 · 2019: 1
FWCI
7.62
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Konkuk University
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Quality and Safety Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Keywords
Lactobacillus buchneri, probiotic properties, neuroprotection, Korean fermented foods, Lactobacillus fermentum, Lactobacillus delbrueckii, heat-killed bacteria, conditioned medium, antioxidant activity, MPP+ neurotoxicity, SH-SY5Y cells, HT-29 cells, brain-derived neurotrophic factor, Bax/Bcl-2 ratio, functional foods, gut-brain axis
MeSH terms
Fermented Foods, Anti-Bacterial Agents, Antioxidants, Bile Acids and Salts, Gastric Juice, Humans, Intestines, Lactobacillus, 1-Methyl-4-phenylpyridinium, Neuroprotective Agents, HT29 Cells, Proto-Oncogene Proteins c-bcl-2, Probiotics, Limosilactobacillus fermentum, Republic of Korea

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review