The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease
Open accessAbstract
With an aging population, there is a proportional increase in the prevalence of intervertebral disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and disability. With a high prevalence of asymptomatic intervertebral disc diseases, there is a need for accurate diagnosis, which is key to management. A thorough understanding of the pathophysiology and clinical manifestation aids in understanding the natural history of these conditions. Recent developments in radiological and biomarker investigations have potential to provide noninvasive alternatives to the gold standard, invasive discogram. There is a large volume of literature on the management of intervertebral disc diseases, which we categorized into five headings: (a) Relief of pain by conservative management, (b) restorative treatment by molecular therapy, (c) reconstructive treatment by percutaneous intervertebral disc techniques, (d) relieving compression and replacement surgery, and (e) rigid fusion surgery. This review article aims to provide an overview on various current diagnostic and treatment options and discuss the interplay between each arms of these scientific and treatment advancements, hence providing an outlook of their potential future developments and collaborations in the management of intervertebral disc diseases.
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Mitophagy in degenerative joint diseases
Sun, K., Jing, X., Guo, J., Yao, X., & Guo, F. (2021) · Autophagy · doi:10.1080/15548627.2020.1822097 · Cited by 459
Mohd Isa, I. L., Teoh, S. L., Mohd Nor, N. H., & Mokhtar, S. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010208 · Cited by 365
From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration
Li, S., Du, J., Huang, Y., Gao, S., Zhao, Z., Chang, Z., Zhang, X., & He, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355503 · Cited by 32
Matrix stiffness regulates nucleus pulposus cell glycolysis by MRTF-A-dependent mechanotransduction
Xu, H., Wei, K., Ni, J., Deng, X., Wang, Y., Xiang, T., Song, F., Wang, Q., Niu, Y., Jiang, F., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00402-7 · Cited by 22
ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis
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Metadata
- Authors
- Wu, P. H., Kim, H. S., & Jang, I.-T.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-03-20
- Volume
- 21
- Issue
- 6
- Pages
- 2135
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3012168781
- Cited by
- 266
- References
- 121
- FWCI
- 17.08
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
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