The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment
Open accessAbstract
Gold nanoparticles (AuNPs) have been widely studied and applied in the field of tumor diagnosis and treatment because of their special fundamental properties. In order to make AuNPs more suitable for tumor diagnosis and treatment, their natural properties and the interrelationships between these properties should be systematically and profoundly understood. The natural properties of AuNPs were discussed from two aspects: physical and chemical. Among the physical properties of AuNPs, localized surface plasmon resonance (LSPR), radioactivity and high X-ray absorption coefficient are widely used in the diagnosis and treatment of tumors. As an advantage over many other nanoparticles in chemicals, AuNPs can form stable chemical bonds with S-and N-containing groups. This allows AuNPs to attach to a wide variety of organic ligands or polymers with a specific function. These surface modifications endow AuNPs with outstanding biocompatibility, targeting and drug delivery capabilities. In this review, we systematically summarized the physicochemical properties of AuNPs and their intrinsic relationships. Then the latest research advancements and the developments of basic research and clinical trials using these properties are summarized. Further, the difficulties to be overcome and possible solutions in the process from basic laboratory research to clinical application are discussed. Finally, the possibility of applying the results to clinical trials was estimated. We hope to provide a reference for peer researchers to better utilize the excellent physicochemical properties of gold nanoparticles in oncotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
Nie, S., & Emory, S. R. (1997) · Science · doi:10.1126/science.275.5303.1102 · Cited by 10,238
Principles of nanoparticle design for overcoming biological barriers to drug delivery
Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002 · cited 1×
“Therefore, most AuNPs are removed from the bloodstream and primarily up-concentrated in the liver, spleen and bone marrow [107].”
BackgroundMoskovits, M. (1985) · Reviews of Modern Physics · doi:10.1103/revmodphys.57.783 · Cited by 5,466
Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods
Huang, X., El-Sayed, I. H., Qian, W., & El-Sayed, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057254a · Cited by 5,436
Plasmonics for extreme light concentration and manipulation
Schuller, J. A., Barnard, E. S., Cai, W., Jun, Y. C., White, J. S., & Brongersma, M. L. (2010) · Nature Materials · doi:10.1038/nmat2630 · Cited by 4,364
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,955
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
The golden age: gold nanoparticles for biomedicine
Dreaden, E. C., Alkilany, A. M., Huang, X., Murphy, C. J., & El-Sayed, M. A. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15237h · Cited by 3,550
Nanoparticles in Photodynamic Therapy
Lucky, S. S., Soo, K. C., & Zhang, Y. (2015) · Chemical Reviews · doi:10.1021/cr5004198 · Cited by 2,980
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
Liu, Y., Bhattarai, P., Dai, Z., & Chen, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00618k · Cited by 2,904
Cited by
Bharadwaj, K. K., Rabha, B., Pati, S., Sarkar, T., Choudhury, B. K., Barman, A., Bhattacharjya, D., Srivastava, A., Baishya, D., Edinur, H. A., et al. (2021) · Molecules · doi:10.3390/molecules26216389 · Cited by 284
Recent Formulation Advances of Mangiferin
Barakat, S., Nasr, M., Ahmed, R. F., Badawy, S., & Mortada, N. (2022) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-022-00297-z · Cited by 28
Vishwakarma, K. K., Hafeez, A., Usmani, S. A., Noor, L., & Khan, I. R. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010318524240907135527 · Cited by 4
A review on formulation and analytical aspect of mangiferin a natural phenolic xanthonoid
Shaikh, I., & Tatapudi, H. K. (2025) · Discover Chemistry · doi:10.1007/s44371-025-00193-0 · Cited by 3
Çi̇l, C., & Kılıç, A. (2026) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2026.115891 · Cited by 1
Metadata
- Authors
- Bai, X., Wang, Y., Song, Z., Feng, Y., Chen, Y., Zhang, D., & Feng, L.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-04-03
- Volume
- 21
- Issue
- 7
- Pages
- 2480
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3014719026
- Cited by
- 377
- References
- 110
- FWCI
- 34.46
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment. https://app.cochat.ai/papers/10.3390/ijms21072480
- The paper
- Bai, X., Wang, Y., Song, Z., Feng, Y., Chen, Y., Zhang, D., & Feng, L. (2020). The Basic Properties of Gold Nanoparticles and their Applications in Tumor Diagnosis and Treatment. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms21072480
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
