Recent Formulation Advances of Mangiferin

Barakat, Sara; Nasr, Maha; Ahmed, Rania F.; Badawy, Sabry; Mortada, Nahed

doi:10.1007/s43450-022-00297-z

Cited by 29Mangiferin and Mango ExtractsDrug Solubulity and Delivery SystemsPharmacology and Nanomedicine Research

Recent Formulation Advances of Mangiferin

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Barakat, Sara, Nasr, Maha, Ahmed, Rania F., Badawy, Sabry, Mortada, Nahed·2022·Revista Brasileira de Farmacognosia

DOI 10.1007/s43450-022-00297-z

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Abstract

Nutraceuticals have recently gained interest owing to their valuable contribution in the treatment of several diseases, with high safety margin and low incidence of side effects. However, their efficacy is limited by some challenges, namely poor solubility, low permeability, and, consequently, low bioavailability. Delivery carriers have proven that they can overcome almost all the aforementioned limitations, leading to improvement in the pharmacological efficacy of nutraceuticals. Among the promising nutraceuticals that have currently evoked considerable interest is mangiferin from mango tree, which is a polyphenol exhibiting many favorable pharmacological actions, but unfortunately suffers from poor aqueous solubility and other limitations that lower its bioavailability and halter its efficacy. This review summarizes the pharmacological actions of mangiferin and provides an insight on how delivery carriers for mangiferin (lipidic, vesicular, polymeric, inorganic, and protein nanoparticles, as well as complexes) can overcome its pharmaceutical challenges, hence reflecting on its improved therapeutic effects in treatment of different diseases.

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After uptake in the proximal small intestine, extensive first-pass metabolism and gut microbiota-mediated deglycosylation reduce parent MGF levels.
“After uptake in the proximal small intestine, extensive first-pass metabolism and gut microbiota-mediated deglycosylation (yielding norathyriol and downstream conjugates) further reduce parent drug levels (21,160-162).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [161]
The Bioavailability section reports greater mangiferin absorption in the duodenum and jejunum than farther along the intestine, and intensive hepatic first-pass metabolism that reduces the dose reaching circulation in normal rats. The Metabolism section describes deglycosylation to norathyriol followed by gut-microbiome-mediated conjugation, but does not specifically attribute the deglycosylation step to the microbiota. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Material standardization is uneven, with frequent use of extracts or nanoparticles without full reporting of purity, content uniformity, or release profiles.
“Material standardization is uneven, with frequent use of extracts or nanoparticles without full reporting of purity, content uniformity or release profiles, making cross-study comparisons difficult and weakening conclusions regarding the active entity (161,181).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [161]
The Protein Nanoparticles section (page unavailable) notes poor reproducibility and batch-to-batch variation, and the review discusses mangiferin nanoparticle formulations. It does not establish that studies frequently omit purity, content-uniformity or release-profile reporting, or that such omissions impede cross-study comparisons. (LLM, conf=0.79)
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Authors: Barakat, S., Nasr, M., Ahmed, R. F., Badawy, S., & Mortada, N.
Affiliations: Misr International University (EG)
Ain Shams University (EG)
National Research Centre (EG)
Corresponding author: Nasr, Maha
ORCID: Barakat, Sara
Nasr, Maha
Ahmed, Rania F.
Badawy, Sabry
Mortada, Nahed
Venue: Revista Brasileira de Farmacognosia
Publisher: Springer Science and Business Media LLC
Published: 2022-10-04
Volume: 32
Issue: 6
Pages: 871-882
ISSN: 0102-695X (ISSN-L)
1981-528X
DOI: 10.1007/s43450-022-00297-z
OpenAlex: W4301394388
Cited by: 28
References: 113
Citations by year: 2026: 4 · 2025: 10 · 2024: 9 · 2023: 5
FWCI: 6.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Revista Brasileira de Farmacognosia (publishedVersion, cc-by)
Funders: Ain Shams University
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
Keywords: mangiferin, nutraceuticals, bioavailability enhancement, water solubility, drug carriers, nanoparticles, liposomes, polymeric nanoparticles, inorganic nanoparticles, protein nanoparticles, pharmacological activity

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