Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

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Oxyl radicals, redox-sensitive signalling cascades and antioxidants

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Diabetic Kidney Disease: Challenges, Progress, and Possibilities

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Dynamics and functions of lipid droplets

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The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease

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Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

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Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

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Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

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Mitochondrial energetics in the kidney

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Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311

Research progress on the treatment of diabetic nephropathy with leech and its active ingredients

Tian, F., Yi, X., Yang, F., Chen, Y., Zhu, W., Liu, P., & Li, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1296843 · Cited by 20

GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity

Cooper, M. E., & van Raalte, D. H. (2025) · Journal of Clinical Investigation · doi:10.1172/jci194749 · Cited by 24

Exercise as a therapeutic approach to alleviate diabetic kidney disease: mechanisms, clinical evidence and potential exercise prescriptions

Fan, R., Kong, J., Zhang, J., & Zhu, L. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1471642 · Cited by 22

Renal lipotoxicity in diabetic and obesity‐associated kidney diseases: Molecular mechanisms and therapeutic targeting

Liu, Q., Guo, S., Tong, Y., Li, Q., Baoxiang, Z., Wang, J., Wang, Y., Gao, W., & Zou, X. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70220 · Cited by 21

Biomedicine and pharmacotherapeutic effectiveness of combinatorial atorvastatin and quercetin on diabetic nephropathy: An in vitro study

Shahin, H., Sultana, R., Prabhu, A., Pavan, S. R., Mohanto, S., & Subramaniyan, V. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116533 · Cited by 19

Palmitic acid-induced insulin resistance triggers granulosa cell senescence by disruption of the UPRmt/mitophagy/lysosome axis

Tian, Y., Pan, P., Luo, X., Sun, Y., Yang, X., Gao, H., & Yang, Y. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111450 · Cited by 18

Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors

Guo, W., Li, H., Li, Y., & Kong, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115025 · Cited by 21

SIRT6’s function in controlling the metabolism of lipids and glucose in diabetic nephropathy

Wang, Y., Liu, T., Cai, Y., Liu, W., & Guo, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1244705 · Cited by 19

Central administration of Dapagliflozin alleviates a hypothalamic neuroinflammatory signature and changing tubular lipid metabolism in type 2 diabetic nephropathy by upregulating MCPIP1

Da, J., Xu, Y., Tan, Y. C. R. S., Zhang, J., Yu, J., Zhao, J., Da, Q., Yu, F., & Zha, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115840 · Cited by 18

Ferroptosis: potential targets and emerging roles in pancreatic diseases

Huang, Z., Ma, Y., Sun, Z., Cheng, L., & Wang, G. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03625-x · Cited by 19

Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues

Carpentier, A. C. (2023) · Physiology · doi:10.1152/physiol.00012.2023 · Cited by 22

Metabolic reprogramming and renal fibrosis: what role might Chinese medicine play?

Wang, W., Dai, R., Cheng, M., Chen, Y., Gao, Y., Xin, H., Zhang, W. Y., Wang, Y., & Zhang, L. (2024) · Chinese Medicine · doi:10.1186/s13020-024-01004-x · Cited by 20

Hypercaloric Diet Promotes Metabolic Disorders and Impaired Kidney Function

Meléndez-Salcido, C. G., Ramı́rez-Emiliano, J., & Pérez‐Vázquez, V. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221020162955 · Cited by 19

Global research trends and hot spots on autophagy and kidney diseases: a bibliometric analysis from 2000 to 2022

Ai, S., Li, Y., Zheng, H., Wang, Z., Liu, W., Tao, J., Li, Y., & Wang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1275792 · Cited by 17

Sirtuins as novel pharmacological targets in podocyte injury and related glomerular diseases

Liu, T., Yang, L., Mao, H., Ma, F., Wang, Y., Shen, L., Li, P., & Zhan, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113620 · Cited by 18

Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms

Zhao, Z., Zhu, Y., & Wan, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1557797 · Cited by 19

Systemic and Retinal Protective Effects of Butyrate in Early Type 2 Diabetes via Gut Microbiota–Lipid Metabolism Interaction

Gong, H., Zuo, H., Wu, K., Gao, X., Lan, Y., & Zhao, L. (2025) · Nutrients · doi:10.3390/nu17142363 · Cited by 16

Trem2+ Macrophages Alleviate Renal Tubule Lipid Accumulation and Ferroptosis in Diabetic Nephropathy by Repressing IL-1β–Mediated CD36 Expression

Wang, X., Wan, J., Wang, C., Tong, Y., Chen, Y., Wang, X., Liu, J., Li, Q., Dong, Z., Hong, Q., et al. (2025) · Diabetes · doi:10.2337/db25-0282 · Cited by 18

The impact of weight loss on renal function in individuals with obesity and type 2 diabetes: a comprehensive review

Gong, X., Zeng, X., & Fu, P. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1320627 · Cited by 21

Diabetes duration and types of diabetes treatment in data-driven clusters of patients with diabetes

Zhang, J., Deng, Y., Wan, Y., Wang, J., & Xu, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.994836 · Cited by 19

Triglyceride-glucose index is associated with the risk of chronic kidney disease progression in type 2 diabetes

Duan, S., Zhou, M., Fang, L., Chen, C., Chen, S., Geng, L., Zhang, C., Guo, H., Zeng, M., Sun, B., et al. (2023) · Endocrine · doi:10.1007/s12020-023-03357-z · Cited by 16

Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice

Opazo-Ríos, L., Tejera‐Muñoz, A., Soto‐Catalán, M., Marchant, V. A., Lavoz, C., Mas, S., Moreno, J. A., Fierro‐Fernández, M., Ramos, R., Suárez-Álvarez, B., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.778776 · Cited by 15

Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?

Zuzda, K., Grycuk, W., Małyszko, J. S., & Małyszko, J. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2161887 · Cited by 16

Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells via Hypoxia-Inducible Factor-1α/Transferrin Receptor 1 Signaling Pathway

Yang, L., Liu, Q., Lu, Q., Xiao, J., Fu, A.-Y., Wang, S., Ni, L., Hu, J., Yu, H., WU, X.-Y., et al. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0380 · Cited by 16

Astaxanthin improves lipotoxicity, lipid peroxidation and oxidative stress in kidney of sucrose-rich diet-fed rats

Joubert, M. B. V., Ingaramo, P. I., Collins, P., & D’Alessandro, M. E. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109779 · Cited by 15

GLP-1RA improves diabetic renal injury by alleviating glomerular endothelial cells pyrotosis via RXRα/circ8411/miR-23a-5p/ABCA1 pathway

Wu, W., Wang, Y., Shao, X., Huang, S., Wang, J., Zhou, S., Liu, H., Lin, Y., & Yu, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0314628 · Cited by 15

Metabolic-associated fatty liver disease increases the risk of end-stage renal disease in patients with biopsy-confirmed diabetic nephropathy: a propensity-matched cohort study

Zou, Y., Zhao, L., Zhang, J., Wang, Y., Wu, Y., Ren, H., Wang, T., Zhao, Y., Xu, H., Li, L., et al. (2022) · Acta Diabetologica · doi:10.1007/s00592-022-01978-w · Cited by 15

Potential Association Between Atherogenic Coefficient, Prognostic Nutritional Index, and Various Obesity Indices in Diabetic Nephropathy

Assani, M.-Z., Novac, M. B., Dijmărescu, A. L., Văduva, C.-C., Vladu, I. M., Clenciu, D., Mitrea, A., Ahrițculesei, R.-V., Stroe-Ionescu, A.-Ş., Assani, A.-D., et al. (2025) · Nutrients · doi:10.3390/nu17081339 · Cited by 19

Podocyte Metabolic Reprogramming and Targeted Therapy

Hu, H., Liang, W., & Ding, G. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000917 · Cited by 14

Regulation of autophagy by natural polyphenols in the treatment of diabetic kidney disease: therapeutic potential and mechanism

Liu, T., Jin, Q., Yang, L., Mao, H., Ma, F., Wang, Y., Li, P., & Zhan, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1142276 · Cited by 17

Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease

Folestad, E. B., Mehlem, A., Ning, F. C., Oosterveld, T., Palombo, I., Singh, J., Olauson, H., Witasp, A., Thorell, A., Stenvinkel, P., et al. (2024) · Kidney International · doi:10.1016/j.kint.2024.11.026 · Cited by 18

TCA Cycle and Fatty Acids Oxidation Reflect Early Cardiorenal Damage in Normoalbuminuric Subjects with Controlled Hypertension

Santiago‐Hernandez, A., Martin‐Lorenzo, M., Martín-Blázquez, A., Ruiz‐Hurtado, G., Barderas, M. G., Segura, J., Ruilope, L. M., & Álvarez‐Llamas, G. (2021) · Antioxidants · doi:10.3390/antiox10071100 · Cited by 14

Machine learning-based metabolism-related genes signature and immune infiltration landscape in diabetic nephropathy

Zhang, H., Hu, J., Zhu, J., Li, Q., & Luo, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1026938 · Cited by 14

Sodium–Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in the Lipid Metabolism and the Treatment of Chronic Kidney Disease Associated with Metabolic Syndrome

Cortés-Camacho, F., Zambrano-Vásquez, O. R., Aréchaga-Ocampo, E., Castañeda‐Sánchez, J. I., Gonzaga-Sánchez, J. G., Sánchez-Gloria, J. L., Sánchez‐Lozada, L. G., & Osorio‐Alonso, H. (2024) · Antioxidants · doi:10.3390/antiox13070768 · Cited by 14

FUNDC1 modulates mitochondrial defects and pancreatic β-cell dysfunction under lipotoxicity

Tong, B., Zhang, Z., Li, X., Liu, J., Wang, H., Song, L., Feng, J., Dai, Z., & Xu, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.06.042 · Cited by 15

Hyperglycemia and Hyperlipidemia with Kidney or Liver Transplantation: A Review

D’Elia, J. A., & Weinrauch, L. A. (2023) · Biology · doi:10.3390/biology12091185 · Cited by 14

Metabolic Differences in Diabetic Kidney Disease Patients with Normoalbuminuria versus Moderately Increased Albuminuria

Hallan, S. I., Øvrehus, M. A., Darshi, M., Montemayor, D., Langlo, K. A. R., Bruheim, P., Sharma, K., & the CRIC Study Investigators (2023) · Kidney360 · doi:10.34067/kid.0000000000000248 · Cited by 13

The Intersection of Genetic Factors, Aberrant Nutrient Metabolism and Oxidative Stress in the Progression of Cardiometabolic Disease

Butcko, A. J., Putman, A. K., & Mottillo, E. P. (2024) · Antioxidants · doi:10.3390/antiox13010087 · Cited by 12

Dapagliflozin attenuates diabetes-induced podocyte lipotoxicity via ERRα-Mediated lipid metabolism

Hu, H., Wang, J., Peng, Z., Fan, Y., Yang, Q., & Hu, J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.028 · Cited by 12

Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases

Zhang, B., Xu, S., Liu, J., Xie, Y. C., & Xiaobo, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.691824 · Cited by 12

Common gene signatures and molecular mechanisms of diabetic nephropathy and metabolic syndrome

Zhang, C., Li, H., & Wang, S. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1150122 · Cited by 14

Podocytes in health and disease: from development to regeneration

Nishimura, Y. (2025) · Human Cell · doi:10.1007/s13577-025-01296-7 · Cited by 12

Molecular pathways and emerging therapeutic targets in the pathogenesis of diabetic kidney disease

Al-Masri, S., Coelho, J. N., & Thomas, L. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1747053 · Cited by 11

Red ginseng ameliorates lipotoxicity-induced renal fibrosis in hyperuricemia mice

Zhang, Y., Chen, S.-M., Song, Y., Islam, M. A., Rao, P.-L., Zhu, M.-J., Gu, W.-Y., Yu, X., & Xu, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118014 · Cited by 11

Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy

Hu, Z., Zhu, Q., Wang, Y., Deng, X., Yang, H., Zhou, M., Zhang, J., Wang, H., Wang, H., Wang, L., et al. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2347446 · Cited by 13

Diphenyl diselenide protects against diabetic kidney disease through modulating gut microbiota dysbiosis in streptozotocin-induced diabetic rats

Wang, X., Long, D., Peng, X., Li, J., Zhou, M., Wang, Y., & Hu, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1506398 · Cited by 11

The therapeutic mechanism of PuRenDan for the treatment of diabetic nephropathy: Network pharmacology and experimental verification

Niu, H., Fan, L., Zhao, L., Yao, R., He, X., Lu, B., & Pang, Z. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115283 · Cited by 11

The correlation between the serum LDL-C/Apo B ratio and lumbar bone mineral density in young adults

Tan, A., Shu, J., Huang, H., Shao, H., & Yang, J. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06325-w · Cited by 11

Huangqi and Danshen improve the chronic nephrotoxicity of cyclosporin A by regulating lipid metabolism

Gao, R.-R., Han, C., Sui, G.-Y., Chen, Y., Zhou, L., Hu, H., Wang, Y.-C., Liu, Y., & Li, W. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156582 · Cited by 10

Structural characterization and in vitro hypolipidemic and hypoglycemic activities of a novel neutral polysaccharide from Siraitia grosvenorii (Luo Han Guo) flowers

Teng, H., Qiu, L., Huang, Z., Al‐Dalali, S., Li, C., Xu, A., & He, Z. (2025) · Chemical and Biological Technologies in Agriculture · doi:10.1186/s40538-025-00750-w · Cited by 10

Association between the atherogenic index of plasma and chronic kidney disease: an evaluation of an adult population of American patients with diabetes mellitus

Cui, M., Xiao, X., Zhao, X. Q., Wang, Y., Gang, X., & Wang, G. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2556495 · Cited by 10

C1q/tumour necrosis factor-related protein-3 alleviates high-glucose-induced lipid accumulation and necroinflammation in renal tubular cells by activating the adenosine monophosphate-activated protein kinase pathway

Du, C., Zhu, Y., Yang, Y., Mu, L., Yan, X., Wu, M. T., Zhou, C., Wu, H., Zhang, W., Wu, Y., et al. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106247 · Cited by 10

Combined Intake of Fish Oil and D-Fagomine Prevents High-Fat High-Sucrose Diet-Induced Prediabetes by Modulating Lipotoxicity and Protein Carbonylation in the Kidney

Méndez, L., Muñoz, S., Barros, L., Miralles‐Pérez, B., Romeu, M., Ramos‐Romero, S., Torres, J. L., & Medina, I. (2023) · Antioxidants · doi:10.3390/antiox12030751 · Cited by 10

Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

Jiménez-Castilla, L., Marín‐Royo, G., Orejudo, M., Opazo-Ríos, L., Caro-Ordieres, T., Artaiz, I., Suarez-Cortes, T. M., Zazpe, A., Hernández, G., Gómez‐Guerrero, C., et al. (2021) · Antioxidants · doi:10.3390/antiox10121920 · Cited by 11

In Vivo Renal Lipid Quantification by Accelerated Magnetic Resonance Spectroscopic Imaging at 3T: Feasibility and Reliability Study

Alhulail, A. A., Servati, M., Ooms, N., Akın, O., Di̇nçer, A., Thomas, M. A., Dydak, U., & Emir, U. E. (2022) · Metabolites · doi:10.3390/metabo12050386 · Cited by 9

Association between the metabolic profile of serum fatty acids and diabetic nephropathy: a study conducted in northeastern China

Liu, Y., Li, Y., Shen, H., Li, Y., Xu, Y., Zhou, M., Xia, X., & Shi, B. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221118750 · Cited by 10

Triglyceride Glucose Index and the Risk of Diabetic Nephropathy in Patients with Type 2 Diabetes: A Meta-Analysis

Deng, S., & Peng, L. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2376-6044 · Cited by 9

DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1

Hu, Y., Ye, S., Kong, J., Zhou, Q., Wang, Z., Zhang, Y., Yan, H., Wang, Y., Li, T., Xie, Y. F., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01895-1 · Cited by 11

Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src

Guo, X., Yang, L., An, X.-N., Hu, M., Shen, Y., Wang, N., Xu, Y., & Gui, D. (2025) · Chinese Medicine · doi:10.1186/s13020-024-01057-y · Cited by 12

Association of normal range of urinary albumin‐to‐creatinine ratio with all‐cause mortality among diabetic adults with preserved kidney function: National Health and Nutrition Examination Survey ( NHANES ) 2003–2018

Pang, X., Dan, W., Lin, L., Li, H., Rao, X.-R., & Li, S. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16269 · Cited by 9

Macronutrient Intake in Pregnancy and Child Cognitive and Behavioural Outcomes

Taylor, R., Blumfield, M., Ashton, L., Hure, A. J., Smith, R., Buckley, N., Drysdale, K., & Collins, C. E. (2021) · Children · doi:10.3390/children8050425 · Cited by 9

The Emerging Roles of IL-36, IL-37, and IL-38 in Diabetes Mellitus and its Complications

Huang, G., Li, M., Tian, X., Jin, Q., Mao, Y., & Li, Y. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220113142533 · Cited by 9

Exploring the pharmacological mechanisms of Tripterygium wilfordii against diabetic kidney disease using network pharmacology and molecular docking

Lu, M., Ou, J., Deng, X., Chen, Y., & Gao, Q. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17550 · Cited by 9

Estimated small dense low-density lipoprotein-cholesterol and the risk of kidney and cardiovascular outcomes in diabetic kidney disease

Yang, Q., Zou, Y., Lang, Y., Yang, J., Wu, Y., Xiao, X., Qin, C., Zhao, Y., & Liu, F. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2369701 · Cited by 10

Reprogramming Metabolism of Macrophages as a Target for Kidney Dysfunction Treatment in Autoimmune Diseases

Tian, F., Chen, H., Zhang, J., & He, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148024 · Cited by 10

Meta-analysis of the effects of palmitic acid on microglia activation and neurodegeneration

Zhou, H., & Chang, S. L. (2022) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2022-0008 · Cited by 10

The association between blood glucose levels and lipids in the general adult population: results from NHANES (2005–2016)

Yang, C., Liu, Z., Zhang, L., & Gao, J. (2024) · Journal of Health Population and Nutrition · doi:10.1186/s41043-024-00660-x · Cited by 8

Extreme temperature events, “Life’s Essential 8”, and prevalence of chronic kidney disease: A nationally representative surveillance in China

Wang, W., Zhang, X., Zhang, M., Zhang, F., Li, C., Yang, C., Zhao, Z., Wang, J., Wang, F., Li, P., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.109176 · Cited by 10

Impact of baseline and trajectory of the cardiometabolic indices on incident microvascular complications in patients with type 2 diabetes

Cao, B., Liu, K., Chen, H.-W., Xu, Z.-Y., Wang, S.-A., Zhang, C., Liu, Y.-J., Zhang, W., Li, Q.-R., Shao, Z., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120407 · Cited by 8

Mitigating Lipotoxicity: A Potential Mechanism to Delay Chronic Kidney Disease Progression Using Current Pharmacological Therapies

Anumas, S., & Inagi, R. (2025) · Nephrology · doi:10.1111/nep.70098 · Cited by 11

Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy

Chen, Y., Wang, Y., Yu, D., Zhao, H., & Li, P. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2543927 · Cited by 8

Paraoxonase 1 Ameliorates Renal Lipotoxicity by Activating Lipophagy and Inhibiting Pyroptosis

Liu, Q., Xiao, J., Wang, S., Li, Y., Yang, L.-J., Lu, Q., Wu, X., Cao, J., Hong, Y., & Zhang, B. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.07.011 · Cited by 8

Integrated analysis of potential gene crosstalk between non-alcoholic fatty liver disease and diabetic nephropathy

Yan, Q., Zhao, Z., Liu, D., Li, J., Pan, S., Duan, J., Dong, J., & Liu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1032814 · Cited by 8

Efficacy and Safety of Zhenwu Decoction in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Lv, X., Zhou, M., Liu, X., Qin, X., & Yu, R. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2133705 · Cited by 8

Variants within the LPL gene confer susceptility to diabetic kidney disease and rapid decline in kidney function in Chinese patients with type 2 diabetes

Wu, Y., Cheng, S., Gu, H., Yang, K., Xu, Z., Meng, X., Wang, Y., Jiang, Y., Li, H., Zhou, Y., et al. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15199 · Cited by 8

Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

Kang, H., Huang, D., Jing, J., Zhang, W., Zhang, L., Wang, J., Liu, Z., Lin, H., Wang, Z., Zhang, L., et al. (2024) · Nano Research · doi:10.1007/s12274-024-6610-9 · Cited by 8

KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment

Garví, E. S., van Slobbe, G. J. J., Zaal, E. A., de Baaij, J. H. F., Hoenderop, J. G. J., Masereeuw, R., Janssen, M. J., & van Genderen, A. M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03881-3 · Cited by 8

Fungus-Derived 3-Hydroxyterphenyllin and Candidusin A Ameliorate Palmitic Acid-Induced Human Podocyte Injury via Anti-Oxidative and Anti-Apoptotic Mechanisms

Kaewin, S., Changsorn, K., Sungkaworn, T., Hiranmartsuwan, P., Yaosanit, W., Rukachaisirikul, V., & Muanprasat, C. (2022) · Molecules · doi:10.3390/molecules27072109 · Cited by 8

Dyslipidemia may be a risk factor for progression in children with IgA nephropathy

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Study on the relationship between lipoprotein (a) and diabetic kidney disease

Wang, A., Zhang, S., Li, Y., Zhu, F., & Xie, B. (2022) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2022.108378 · Cited by 8

Bioinformatic analyses reveal lysosomal-associated protein transmembrane 5 as a potential therapeutic target in lipotoxicity-induced injury in diabetic kidney disease

Chen, X., Zhu, S., Huang, C., Liu, J., Wang, J., & Cui, S. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2359638 · Cited by 7

Fructooligosaccharides Ameliorate Renal Injury and Dysfunction Through the Modulation of Gut Dysbiosis, Inhibition of Renal Inflammation, Oxidative Stress, Fibrosis, and Improve Organic Anion Transporter 3 Function in an Obese Rat Model

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Molecular mechanism of ectopic lipid accumulation induced by methylglyoxal via activation of the NRF2/PI3K/AKT pathway implicates renal lipotoxicity caused by diabetes mellitus

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Diosgenin Improves Lipid Metabolism in Diabetic Nephropathy via Regulation of miR-148b-3p/DNMT1/FOXO1 Axis

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C3G improves lipid droplet accumulation in the proximal tubules of high-fat diet-induced ORG mice

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Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome

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Activation of the Lp-PLA2/LPC axis triggers endothelial ferroptosis to drive diabetic kidney disease

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[Blood Lipid Indicators and Different Clinical Classifications of Dyslipidemia and Diabetic Kidney Disease: Correlation and Predictive Value].

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Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus

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Visceral adipose tissue and risk of diabetic nephropathy: A Mendelian randomization study

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Obesidad y enfermedad renal crónica. Una mirada desde los mecanismos fisiopatológicos.

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Diosgenin alleviates the inflammatory damage and insulin resistance in high glucose‑induced podocyte cells via the AMPK/SIRT1/NF‑κB signaling pathway

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The Predictive Value of Visceral Adiposity Index and Lipid Accumulation Index for Microalbuminuria in Newly Diagnosed Type 2 Diabetes Patients

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The impact of blood lipids and statins on renal function and mortality in patients with diabetic nephropathy: A meta-analysis

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Predictive value of systemic immune-inflammation index in patients with diabetes mellitus: a systematic review and meta-analysis

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Immunomodulatory roles of quercetin in diabetic nephropathy: targeting inflammation, oxidative stress, and ferroptosis

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Inflammatory and lipotoxicity mechanisms in obesity related CKD

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Kidney lipid metabolism: impact on pediatric kidney diseases and modulation by early-life nutrition

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Diagnostic performance of hypoechoic perinephric fat as a predictor of prediabetes and diabetes

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Molecular mechanism of Gan-song Yin inhibiting the proliferation of renal tubular epithelial cells by regulating miR-21-5p in adipocyte exosomes

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Renal Lipid Metabolism and Lipotoxicity in Diabetes

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Renal Lipotoxicity: Mechanisms and Therapeutic Perspectives

Zaitoon, H., Feigin, E., Abdul‐Ghani, M. A., Clarke, G. D., Tuttle, K. R., & DeFronzo, R. A. (2026) · Diabetes Care · doi:10.2337/dci26-0036 · Cited by 4

Normal nerve conduction with an abnormal ultrasound: A separate group of CTS?

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The Role of Lipotoxicity in Diabetic Nephropathy: From Physiologic Mechanisms to Therapeutic Perspectives

范, 家. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.1541172

The Contribution of Lipotoxicity to Diabetic Kidney Disease

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