The Potential Role of Irisin in Vascular Function and Atherosclerosis: A Review
Open accessAbstract
Exercise is an effective intervention for both the prevention and the treatment of obesity and insulin resistance because skeletal muscle secretes many bioactive proteins that contribute to the beneficial effect of exercise. It has been revealed that irisin plays an important role in metabolic homeostasis and both acute and chronic exercises increase circulating irisin in experimental animal models and in humans. Although previous studies have reported that the irisin-related signaling mechanism may play a beneficial role in the treatment of metabolic diseases including obesity, metabolic syndrome, insulin resistance, and diabetes mellitus, studies on whether irisin plays a key role in vascular function and vascular complications are still insufficient. Therefore, the current review aims to summarize the accumulating evidence showing the potential role of irisin, especially in vascular reactivity and vascular abnormalities such as atherosclerosis.
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These cytokines appear to exhibit a protective effect on the endothelium and vascular smooth muscle, preventing atherosclerosis.
“Beyond that, these cytokines appear to exhibit a protective effect on the endothelium and vascular smooth muscle, preventing atherosclerosis [103].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [103]
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Shatova, O. P., Appolonova, S. A., Roumiantsev, S. A., & Shestopalov, A. (2023) · Problems of Biological Medical and Pharmaceutical Chemistry · doi:10.29296/25877313-2023-03-05
Romaniuk, O., Sklyarova, H., Tiutiunnyk, О. О., Fomenko, I., Sklyarov, E., Коbylinska, L. I., & Vari, S. G. (2024) · Medical Science of Ukraine (MSU) · doi:10.32345/2664-4738.3.2024.04
Suveică, L., Loghin-Oprea, N., Schipor, S. V., Cumpătă, V., Carşote, M., Gheorghe, A.-M., Sima, O.-C., Costăchescu, M., Petrova, E., Trandafir, A.-I., et al. (2025) · Balneo and PRM Research Journal · doi:10.12680/balneo.2025.884
Associations of skeletal muscle mass and strength with arterial stiffness in type 2 diabetes
Koike, N., Irie, Y., Doi, Y., Kemmotsu, R., Kusushita, M., Sakai, Y., Okita, T., Sho, H., Inui, R., Tabuchi, Y., et al. (2026) · Journal of Diabetes Investigation · doi:10.1111/jdi.70376
Reduced serum Irisin levels in systemic sclerosis: a cross-sectional case–control study
Okyar, B., Yıldırım, A., Eyı, B., Dılek, O., Alışkan, H. E., Sümbül, H. E., & Ersözlü, E. D. (2026) · Clinical Rheumatology · doi:10.1007/s10067-026-08457-5
- Authors
- Byun, K., & Lee, S.
- Affiliations
- Incheon National University (KR)
- Corresponding author
- Lee, Sewon
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-09-29
- Volume
- 21
- Issue
- 19
- Pages
- 7184
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7583934
- OpenAlex
- W3090941167
- Cited by
- 38
- References
- 56
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 11
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Incheon National University (Incheon National University Research grant in 2018)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- irisin, vascular function, atherosclerosis, physical activity, skeletal muscle, insulin resistance, obesity, metabolic syndrome, diabetes mellitus, vascular reactivity, metabolic homeostasis
- MeSH terms
- Diabetes Mellitus, Type 2, Exercise Therapy, Fibronectins, Humans, Insulin Resistance, Metabolic Diseases, Obesity, Muscle, Skeletal, Atherosclerosis
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