The DOI matches its Crossref record; 112 of the 114 references it cites were found in a registry or an index.
Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome
Open accessAbstract
Human sex hormone-binding globulin (SHBG) is a glycoprotein produced by the liver that binds sex steroids with high affinity and specificity. Clinical observations and reports in the literature have suggested a negative correlation between circulating SHBG levels and markers of non-alcoholic fatty liver disease (NAFLD) and insulin resistance. Decreased SHBG levels increase the bioavailability of androgens, which in turn leads to progression of ovarian pathology, anovulation and the phenotypic characteristics of polycystic ovarian syndrome (PCOS). This review will use a case report to illustrate the inter-relationships between SHBG, NAFLD and PCOS. In particular, we will review the evidence that low hepatic SHBG production may be a key step in the pathogenesis of PCOS. Furthermore, there is emerging evidence that serum SHBG levels may be useful as a diagnostic biomarker and therapeutic target for managing women with PCOS.
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“Lower levels of the blood protein called sex hormone-binding globulin (SHBG) are advised to indicate the anomalous cholesterol measurements which are connected to inhibited insulin signaling, for instance, PCOS [112].”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [112]
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In the citing paper
“Together with free T, SHBG has recently been recognized a useful diagnostic marker and therapeutic target for managing women with PCOS [195].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [195]
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Cites
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Adolescence: A foundation for future health
Sawyer, S. M., Afifi, R. A., Bearinger, L. H., Blakemore, S.-J., Dick, B., Ezeh, A. C., & Patton, G. C. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60072-5 · Cited by 2,635
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., & the International PCOS Network (2018) · Clinical Endocrinology · doi:10.1111/cen.13795 · Cited by 1,823
Teede, H. J., Misso, M. L., Costello, M. F., Dokras, A., Laven, J., Moran, L., Piltonen, T., Norman, R. J., International PCOS Network, Andersen, M., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey256 · Cited by 1,593
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575
Teede, H., Deeks, A., & Moran, L. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-41 · Cited by 1,565
Bozdag, G., Mumusoglu, S., Zengin, D., Karabulut, E., & Yildiz, B. O. (2016) · Human Reproduction · doi:10.1093/humrep/dew218 · Cited by 1,526
DUNN, J. F., NISULA, B. C., & RODBARD, D. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-58 · Cited by 1,238
Stefan, N., Häring, H., & Cusi, K. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30154-2 · Cited by 874
Flagged first, then by citations
2 of the 114 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Johnson, T., Kaplan, L., Ouyang, P., Rizza, R., and Health, N.I.O. (2012). Evidence-Based Methodology Workshop on Polycystic Ovary Syndrome.
Cited by
Sorted by citations
Items 201–212 of 212
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Albalawi, Y. A., & Mirghani, H. O. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1809000
Coats, L., Campbell, N., Elsayed, N. S., do Carmo, J., & Alexander, B. T. (2026) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00126.2026
Li, Z., Yue, P., Zhao, J., Kang, C., & Wang, X. (2026) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2026-0012
Zheng, R., Jiao, Y., Liu, J., Yang, W., Wang, Z., Tang, W., He, Q., Wu, Z., & Xiang, L. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1909283
Kothe, U., Nair, N., Balwir, T., & Hadge, G. (2026) · Asian Pacific Journal of Reproduction · doi:10.4103/apjr.apjr_162_26
Ou, K., Zhang, D., Liao, Y., Yu, T., 刘文兴, Sun, T., & Huang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1922372
Zhao, Y., Zhang, Q., Gong, F., Duan, L., Zhang, Y., Wang, L., Zhu, H., & Xia, W. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1935187
Cooper, I. D., Petagine, L., Cooper, N., Soto-Mota, A., Edwards, K., Kraev, I., Lange, S., & Kyriakidou, Y. (2026) · Clinical bioenergetics · doi:10.3390/clinbioenerg2040016
Potential links between PCOS/PMOS and Alzheimer disease and related dementias
Amiri, M., Hamidi, A. K., Farkas, D. L., Buyalos, R. P., & Azziz, R. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag206
Zhang, X., Wang, Q., Li, S., Huang, W., Bai, H., Liu, Q., & Fan, P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1930645
Metabolic homeostasis and women’s reproductive health
Liu, X., 杨利丽, Jiang, J., Chang, H., & Mu, L. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01646-1
Metadata
- Authors
- Qu, X., & Donnelly, R.
- Affiliations
- University of Technology Sydney (AU)
- University of Nottingham (GB)
- Corresponding author
- Qu, Xianqin
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-11-01
- Volume
- 21
- Issue
- 21
- Pages
- 8191
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7663738
- OpenAlex
- W3096809272
- Cited by
- 210
- References
- 114
- Citations by year
- 2026: 40 · 2025: 46 · 2024: 47 · 2023: 35 · 2022: 29 · 2021: 13
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- sex hormone-binding globulin, polycystic ovary syndrome, non-alcoholic fatty liver disease, insulin resistance, diagnostic biomarkers, therapeutic target, PCOS pathogenesis
- MeSH terms
- Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Sensitivity and Specificity, Sex Hormone-Binding Globulin, Biomarkers, Young Adult, Molecular Targeted Therapy, Non-alcoholic Fatty Liver Disease
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