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Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
Open accessAbstract
Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation. The lack of successful curative therapies for neurodegenerative disorders leads to a considerable burden on society and a high economic impact. Over the past 20 years, regenerative cell therapy, also known as stem cell therapy, has provided an excellent opportunity to investigate potentially powerful innovative strategies for treating neurodegenerative diseases. This is due to stem cells’ capability to repair injured neuronal tissue by replacing the damaged or lost cells with differentiated cells, providing a conducive environment that is in favor of regeneration, or protecting the existing healthy neurons and glial cells from further damage. Thus, in this review, the various types of stem cells, the current knowledge of stem-cell-based therapies in neurodegenerative diseases, and the recent advances in this field are summarized. Indeed, a better understanding and further studies of stem cell technologies cause progress into realistic and efficacious treatments of neurodegenerative disorders.
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“Many researchers have invested considerable effort into exploring regenerative cell therapy, also known as stem cell therapy, to restore neuron loss during neurodegeneration and CNS injury [107].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [107]
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1 retracted
Salem, A. M. H., Ahmed, H. H., Atta, H. M., Ghazy, M. A., & Aglan, H. A. (2014) · Cell Biology International · doi:10.1002/cbin.10331 · Cited by 56
Retracted2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642 · cited 1×
“1 million individuals over the age of 65 [82].”
BackgroundAlzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758
Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345
Gliotransmitters Travel in Time and Space
Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308
Bang, J., Spina, S., & Miller, B. L. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00461-4 · Cited by 1,144
Cited by
Sorted by citations
Adamu, A., Li, S., Gao, F., & Xue, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1347987 · Cited by 564
Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
Tryphena, K. P., Shukla, R., Khatri, D. K., & Vora, L. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102481 · Cited by 438
Chen, Y.-A., Lu, C.-H., Ke, C.-C., Chiu, S.-J., Jeng, F.-S., Chang, C.-W., Yang, B.-H., & Liu, R.-S. (2021) · Biomedicines · doi:10.3390/biomedicines9060594 · Cited by 167
Stem Cell Therapy: From Idea to Clinical Practice
Ghasroldasht, M. M., Seok, J., Park, H.-S., Ali, F. L., & Al-Hendy, A. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052850 · Cited by 157
Designing drug delivery systems for cell therapy
Wang, L., Gao, Y., Feng, Z., Mooney, D. J., & Mitragotri, S. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00214-0 · Cited by 76
Akhtar, A., Rad, V. F., Moradi, A., Yar, M., & Bazzar, M. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.11.007 · Cited by 65
Role of histone modifications in neurogenesis and neurodegenerative disease development
Zhao, A., Xu, W., Han, R., Wei, J., Qi, Y., Wang, M., Li, H., Li, M., & Chi, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102324 · Cited by 65
An, N., Yan, X., Qiu, Q., Zhang, Z., Zhang, X., Zheng, B., Zhao, Z., Guo, J., & Liu, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02422-7 · Cited by 53
Wei, M., Yang, Z., Li, S., & Le, W. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s395010 · Cited by 57
Advances in nanotechnology versus stem cell therapy for the theranostics of Huntington's disease
Channa, G. M., Hassan, D., Zeeshan, M., Ruiz-Pulido, G., Ebrahimi, N., Mobashar, A., Pourmadadi, M., Rahdar, A., Sargazi, S., Fathi‐karkan, S., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104774 · Cited by 53
Aguirre, M., Escobar, M., Amézquita, S. F., Cubillos, D., Romero, C. A. R., Vanegas, P., Tarazona, M. P., Escobar, S., Blanco, J. C., & Celis, L. G. (2023) · Genes · doi:10.3390/genes14091697 · Cited by 57
Stem-Cell-Based Therapy: The Celestial Weapon against Neurological Disorders
Zayed, M. A., Sultan, S., Alsaab, H. O., Yousof, S. M., Alrefaei, G. I., Alsubhi, N. H., Alkarim, S., Ghamdi, K. S. A., Bagabir, S. A., Jana, A., et al. (2022) · Cells · doi:10.3390/cells11213476 · Cited by 47
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He, S., Ru, Q., Chen, L., Xu, G., & Wu, Y. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111024 · Cited by 54
Diabetes-related cognitive impairment: Mechanisms, symptoms, and treatments
Yu, X., He, H., Wen, J., Xu, X., Ruan, Z., Hu, R., Wang, F., & Ju, H. (2025) · Open Medicine · doi:10.1515/med-2024-1091 · Cited by 57
Fołta, J., Rzepka, Z., & Wrześniok, D. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115177 · Cited by 50
Rather, H., Almousa, S., Craft, S., & Deep, G. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102088 · Cited by 45
Stem Cells: Innovative Therapeutic Options for Neurodegenerative Diseases?
Bonaventura, G., Munafò, A., Bellanca, C. M., Cognata, V. L., Iemmolo, R., Attaguile, G. A., Mauro, R. D., Benedetto, G. D., Cantarella, G., Barcellona, M. L., et al. (2021) · Cells · doi:10.3390/cells10081992 · Cited by 44
Nerve regeneration using decellularized tissues: challenges and opportunities
Mahdian, M., Tabatabai, T. S., Abpeikar, Z., Rezakhani, L., & Khazaei, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1295563 · Cited by 43
Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles
D’Egidio, F., Castelli, V., d’Angelo, M., Ammannito, F., Quintiliani, M., & Cimini, A. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106663 · Cited by 41
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Boulingre, M., Lara, R. P., & Green, R. A. (2023) · Chemical Communications · doi:10.1039/d3cc05006h · Cited by 41
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease
Ahmad, F., Karan, A., Sharma, R., Sharma, N. S., Sundar, V., Jayaraj, R. L., Mukherjee, S., & DeCoster, M. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102229 · Cited by 40
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Liguori, F., Amadio, S., & Volonté, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083977 · Cited by 36
Patel, J. C., Shukla, M., & Shukla, M. (2025) · Cells · doi:10.3390/cells14120918 · Cited by 39
Khandia, R., Gurjar, P., Priyanka, Romashchenko, V. A., Al‐Hussain, S. A., & Zaki, M. E. A. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001609 · Cited by 33
Application and progress of bionic scaffolds in nerve repair: a narrative review
Fang, J., Nan, L., Song, K., Weng, Z., Shan, J., Shahin, V., Liu, J., & Qian, Y. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00004 · Cited by 29
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26
Wang, G., Zhang, D., Qin, L., Liu, Q., Tang, W., Liu, M., Xu, F., Tang, F., Cheng, L., Mo, H., et al. (2024) · Theranostics · doi:10.7150/thno.92700 · Cited by 28
Işık, S., Osman, S., Yeman-Kıyak, B., Shamshir, S. R. M., & Sanchez, N. M. E. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70577 · Cited by 34
den Bos, J. V., Ouaamari, Y. E., Wouters, K., Cools, N., & Wens, I. (2022) · Biomolecules · doi:10.3390/biom12020340 · Cited by 26
Review on the roles of specific cell-derived exosomes in Alzheimer's disease
Zou, Y., Mu, D., Ma, X., Wang, D., Zhong, J., Gao, J., Yu, S., & Qiu, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.936760 · Cited by 31
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Bakinowska, E., Kiełbowski, K., Boboryko, D., Bratborska, A. W., Olejnik-Wojciechowska, J., Rusiński, M., & Pawlik, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073901 · Cited by 26
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Villar-Gómez, N., Ojeda-Hernández, D. D., López-Muguruza, E., García-Flores, S., Bonel-García, N., Benito‐Martín, M. S., Selma-Calvo, B., Canales-Aguirre, A. A., Mateos‐Díaz, J. C., Montero‐Escribano, P., et al. (2022) · Cells · doi:10.3390/cells11193095 · Cited by 26
Therapeutic advances in neural regeneration for Huntington's disease
D’Egidio, F., Castelli, V., Lombardozzi, G., Ammannito, F., Cimini, A., & d’Angelo, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390969 · Cited by 26
Boyton, I., Valenzuela, S. M., Collins‐Praino, L. E., & Care, A. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.004 · Cited by 23
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Babu, M. A., Renuka Jyothi, S., Kaur, I., Kumar, S., Sharma, N., Kumar, M., Rajput, P., Ali, H., Gupta, G., Subramaniyan, V., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.017 · Cited by 25
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Ahmad, F., & Sachdeva, P. (2022) · Aging Medicine · doi:10.1002/agm2.12216 · Cited by 23
Lee, D. G., Kim, Y.-K., & Baek, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213936 · Cited by 25
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Wang, R., Zhu, Y., Qin, L.-F., Xu, Z., Gao, X.-R., Liu, C., Xu, G., & Chen, Y. (2023) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000528886 · Cited by 24
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Piao, X., Li, D., Liu, H., Guo, Q., & Yu, Y. (2024) · Protein & Cell · doi:10.1093/procel/pwae042 · Cited by 23
Mojaverrostami, S., Khadivi, F., Zarini, D., & Mohammadi, A. (2022) · Journal of Molecular Histology · doi:10.1007/s10735-022-10092-8 · Cited by 21
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Wiśniewska, J., Sadowska, A., Wójtowicz, A., Słyszewska, M., & Szóstek-Mioduchowska, A. Z. (2021) · Life · doi:10.3390/life11101068 · Cited by 20
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Ying, C., Zhang, J., Zhang, H., Gao, S., Guo, X., Lin, J., Wu, H., & Hong, Y. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114543 · Cited by 22
Chen, Y., Lu, C.-H., Ke, C., & Liu, R.-S. (2021) · Membranes · doi:10.3390/membranes11100796 · Cited by 23
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Deng, S., Xie, H., & Xie, B. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04285-7 · Cited by 24
Advances in stem cell and other therapies for Huntington’s disease: An update
Conner, L., Srinageshwar, B., Bakke, J., Dunbar, G. L., & Rossignol, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110673 · Cited by 23
Jin, J., Zhang, H., Lu, Q., Tian, L., Yao, S., Lai, F., Liang, Y., Liu, C., Lu, Y., Tian, S., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00303 · Cited by 20
Zhang, Y.-M., & Wang, G. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420039 · Cited by 20
Wu, Y., Liu, Y., Wang, T., Jiang, Q., Xu, F., & Liu, Z. (2022) · Engineered Regeneration · doi:10.1016/j.engreg.2022.03.001 · Cited by 20
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Vassal, M., Martins, F., Monteiro, B., Tambaro, S., Martínez‐Murillo, R., & Rebelo, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04246-w · Cited by 24
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Kalra, R. S., Dhanjal, J. K., Das, M., Singh, B., & Naithani, R. (2021) · Cells · doi:10.3390/cells10102558 · Cited by 18
Pandamooz, S., Jurek, B., Dianatpour, M., Haerteis, S., Limm, K., Oefner, P. J., Dargahi, L., Borhani‐Haghighi, A., Miyan, J. A., & Salehi, M. S. (2023) · Cell Proliferation · doi:10.1111/cpr.13397 · Cited by 18
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Yin, Z., Chen, J., Xia, M., Zhang, X., Li, Y., Chen, Z., Bao, Q.-N., Zhong, W., Yao, J., Wu, K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-39520-9 · Cited by 15
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Shen, Z., Yang, X., Lan, Y., & Chen, G. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231159 · Cited by 13
Atewologun, F. A., Okesanya, O. J., Okon, I. I., Kayode, H. H., Ukoaka, B. M., Olaleke, N. O., Ogaya, J. B., Okikiola, L. A., Manirambona, E., & Lucero‐Prisno, D. E. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03864-4 · Cited by 12
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Bargero, A., Battaglini, M., Curiale, T., Carmignani, A., Montorsi, M., Labardi, M., Pucci, C., Marino, A., & Ciofani, G. (2024) · Small Science · doi:10.1002/smsc.202400354 · Cited by 12
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Heidarzadeh, M., Amininasab, M., Rezayat, S. M., & Mousavi, S. E. (2023) · Current Drug Delivery · doi:10.2174/0115672018258030230920035222 · Cited by 11
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Kim, M. S., Kim, H., & Lee, G. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303041 · Cited by 11
Luo, Y., Hu, B., Yuan, Z., Bi, H., Yu, J., & Pan, Q. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118785 · Cited by 12
Fu, Q., Qiu, R., Tang, Q., Li, X., Li, Y., Qin, Y., Li, Q., Yao, J., Jiang, Z., Xu, H. Y., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03469-2 · Cited by 12
Harun, Z. Z., Azhar, A. A., Kim, Y. J., Ibrahim, F. W., Ng, M. H., Tan, J. K., & Lokanathan, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13122931 · Cited by 10
Jahan, S., Ansari, U. A., Srivastava, A. K., Aldosari, S., Alabdallat, N. G., Siddiqui, A. J., Khan, A., Albadrani, H. M., Sarkar, S., Khan, B., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1343569 · Cited by 10
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Metadata
- Authors
- Sivandzade, F., & Cucullo, L.
- Affiliations
- Oakland University (US)
- Corresponding author
- Cucullo, Luca
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-02-22
- Volume
- 22
- Issue
- 4
- Pages
- 2153
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7926761
- OpenAlex
- W3129268793
- Cited by
- 224
- References
- 153
- Citations by year
- 2026: 30 · 2025: 55 · 2024: 64 · 2023: 43 · 2022: 23 · 2021: 9
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Drug Abuse (2R01-DA029121, 1R01-DA049737)
- National Institute of Neurological Disorders and Stroke (1R01NS117906)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- stem cell therapy, neurodegenerative diseases, regenerative cell therapy, stem cell types, neuroprotection, glial cells, cell differentiation, paralysis, cognitive impairment
- MeSH terms
- Animals, Cell Differentiation, Humans, Neurons, Regeneration, Stem Cells, Neurodegenerative Diseases, Stem Cell Transplantation, Regenerative Medicine
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