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Cited by 2,306

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Open access
Pang, Zheng, Raudonis, Renee, Glick, Bernard R., Lin, Tong-Jun, Cheng, Zhenyu·2019·Biotechnology Advances
DOI 10.1016/j.biotechadv.2018.11.013
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Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of P. aeruginosa has become increasingly difficult due to its remarkable capacity to resist antibiotics. Strains of Pseudomonas aeruginosa are known to utilize their high levels of intrinsic and acquired resistance mechanisms to counter most antibiotics. In addition, adaptive antibiotic resistance of P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections. The discovery and development of alternative therapeutic strategies that present novel avenues against P. aeruginosa infections are increasingly demanded and gaining more and more attention. Although mostly at the preclinical stages, many recent studies have reported several innovative therapeutic technologies that have demonstrated pronounced effectiveness in fighting against drug-resistant P. aeruginosa strains. This review highlights the mechanisms of antibiotic resistance in P. aeruginosa and discusses the current state of some novel therapeutic approaches for treatment of P. aeruginosa infections that can be further explored in clinical practice.

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Metadata

Authors
Pang, Z., Raudonis, R., Glick, B. R., Lin, T.-J., & Cheng, Z.
Venue
Biotechnology Advances
Publisher
Elsevier BV
Published
2019-01
Volume
37
Issue
1
Pages
177-192
ISSN
0734-9750 (ISSN-L)
DOI
10.1016/j.biotechadv.2018.11.013
OpenAlex
W2903381708
Cited by
2,306
References
12
FWCI
36.10
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. https://app.cochat.ai/papers/10.1016/j.biotechadv.2018.11.013
The paper
Pang, Z., Raudonis, R., Glick, B. R., Lin, T.-J., & Cheng, Z. (2019). Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies. Biotechnology Advances. https://doi.org/10.1016/j.biotechadv.2018.11.013

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.