CoChat
Sign Up
Cited by 104

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF

Moon, Sunhong, Chang, Mi-Sook, Koh, Seong-Ho, Choi, Yoon Kyung·2021·International Journal of Molecular Sciences
DOI 10.3390/ijms22168543PMC PMC8395233
Open this paper in CoChat — free account

Abstract

The functional neural circuits are partially repaired after an ischemic stroke in the central nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial cells, astrocytes, pericytes, microglia, and oligodendrocytes maintain homeostasis; however, these cellular networks are damaged after an ischemic stroke. The present review discusses the repair potential of stem cells (i.e., mesenchymal stem cells, endothelial precursor cells, and neural stem cells) and gaseous molecules (i.e., nitric oxide and carbon monoxide) with respect to neuroprotection in the acute phase and regeneration in the late phase after an ischemic stroke. Commonly shared molecular mechanisms in the neurovascular unit are associated with the vascular endothelial growth factor (VEGF) and its related factors. Stem cells and gaseous molecules may exert therapeutic effects by diminishing VEGF-mediated vascular leakage and facilitating VEGF-mediated regenerative capacity. This review presents an in-depth discussion of the regeneration ability by which endogenous neural stem cells and endothelial cells produce neurons and vessels capable of replacing injured neurons and vessels in the CNS.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/ijms22168543

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 151

  1. Mahar, 2018, Intrinsic mechanisms of neuronal axon regeneration, Nat. Rev. Neurosci., 19, 323, 10.1038/s41583-018-0001-8 · DOI
  2. Shibuya, 2013, VEGFR and type-V RTK activation and signaling, Cold Spring Harb. Perspect. Biol., 5, a009092, 10.1101/cshperspect.a009092 · DOI
  3. Harde, 2016, A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior, Mol. Psychiatry, 21, 1768, 10.1038/mp.2015.195 · DOI
  4. Domigan, 2015, Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy, J. Cell Sci., 128, 2236, 10.1242/jcs.163774 · DOI
  5. During, 2006, VEGF, a mediator of the effect of experience on hippocampal neurogenesis, Curr. Alzheimer Res., 3, 29, 10.2174/156720506775697133 · DOI · Paper page
  6. Eilken, 2017, Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1, Nat. Commun., 8, 1574, 10.1038/s41467-017-01738-3 · DOI
  7. Hayakawa, 2011, Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells, J. Neurosci., 31, 10666, 10.1523/JNEUROSCI.1944-11.2011 · DOI
  8. Seo, J.H., Maki, T., Miyamoto, N., Choi, Y.K., Chung, K.K., Hamanaka, G., Park, J.H., Mandeville, E.T., Takase, H., and Hayakawa, K. (2020). AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. Int. J. Mol. Sci., 21. · DOI
  9. Sandoval, 2008, Blood-brain barrier tight junction permeability and ischemic stroke, Neurobiol. Dis., 32, 200, 10.1016/j.nbd.2008.08.005 · DOI
  10. Lee, 2003, SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier, Nat. Med., 9, 900, 10.1038/nm889 · DOI
  11. Argaw, 2012, Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease, J. Clin. Investig., 122, 2454, 10.1172/JCI60842 · DOI · Paper page
  12. Strbian, 2008, The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia, Neuroscience, 153, 175, 10.1016/j.neuroscience.2008.02.012 · DOI
  13. Issa, 1999, Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke, Lab. Investig., 79, 417
  14. Pedram, 2002, Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide, J. Biol. Chem., 277, 44385, 10.1074/jbc.M202391200 · DOI
  15. Choi, 2017, Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1alpha-Independent VEGF Expression via an AMPKalpha/SIRT1-Mediated PGC-1alpha/ERRalpha Axis, Antioxid Redox Signal., 27, 21, 10.1089/ars.2016.6684 · DOI
  16. Wang, 2007, VEGF-overexpressing transgenic mice show enhanced post-ischemic neurogenesis and neuromigration, J. Neurosci. Res., 85, 740, 10.1002/jnr.21169 · DOI
  17. Li, 2014, Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression, J. Neurochem., 129, 120, 10.1111/jnc.12611 · DOI
  18. Jiang, 2018, Blood-brain barrier dysfunction and recovery after ischemic stroke, Prog. Neurobiol., 163–164, 144, 10.1016/j.pneurobio.2017.10.001 · DOI
  19. Yemisci, 2009, Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery, Nat. Med., 15, 1031, 10.1038/nm.2022 · DOI
  20. Marti, 2000, Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia, Am. J. Pathol., 156, 965, 10.1016/S0002-9440(10)64964-4 · DOI · Paper page
  21. Zhang, 2002, Correlation of VEGF and angiopoietin expression with disruption of blood-brain barrier and angiogenesis after focal cerebral ischemia, J. Cereb. Blood Flow Metab., 22, 379, 10.1097/00004647-200204000-00002 · DOI
  22. Zan, 2014, Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, Neuroscience, 262, 118, 10.1016/j.neuroscience.2013.12.060 · DOI
  23. Nilsson, 2006, Vascular endothelial growth factor (VEGF) pathway, J. Thorac. Oncol., 1, 768, 10.1097/01243894-200610000-00003 · DOI
  24. Choi, 2017, A positive circuit of VEGF increases Glut-1 expression by increasing HIF-1alpha gene expression in human retinal endothelial cells, Arch. Pharm. Res., 40, 1433, 10.1007/s12272-017-0971-5 · DOI
  25. Thibodeaux, 1999, VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain, J. Clin. Investig., 104, 1613, 10.1172/JCI8218 · DOI
  26. Kimura, 2005, Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction, Stroke, 36, 1259, 10.1161/01.STR.0000165925.20413.14 · DOI
  27. De Silva, T.M., Brait, V.H., Drummond, G.R., Sobey, C.G., and Miller, A.A. (2011). Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS ONE, 6. · DOI
  28. Lin, 2013, eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases, J. Cell Sci., 126, 5541
  29. Gavard, 2014, Endothelial permeability and VE-cadherin: A wacky comradeship, Cell Adhes. Migr., 8, 158, 10.4161/cam.29026 · DOI
  30. Liddelow, 2017, Reactive Astrocytes: Production, Function, and Therapeutic Potential, Immunity, 46, 957, 10.1016/j.immuni.2017.06.006 · DOI · Paper page
  31. Franke, 2001, P2X receptor expression on astrocytes in the nucleus accumbens of rats, Neuroscience, 108, 421, 10.1016/S0306-4522(01)00416-X · DOI
  32. Badan, 2003, Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recovery, J. Cereb. Blood Flow Metab., 23, 845, 10.1097/01.WCB.0000071883.63724.A7 · DOI
  33. Heindl, 2018, Automated Morphological Analysis of Microglia After Stroke, Front. Cell Neurosci., 12, 106, 10.3389/fncel.2018.00106 · DOI
  34. Kim, 2012, Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA, Free Radic. Biol. Med., 53, 629, 10.1016/j.freeradbiomed.2012.04.019 · DOI
  35. Choi, 2017, Carbon monoxide prevents TNF-alpha-induced eNOS downregulation by inhibiting NF-kappaB-responsive miR-155-5p biogenesis, Exp. Mol. Med., 49, e403, 10.1038/emm.2017.193 · DOI
  36. Endres, 2004, Targeting eNOS for stroke protection, Trends Neurosci., 27, 283, 10.1016/j.tins.2004.03.009 · DOI
  37. Qin, 2019, Dual Functions of Microglia in Ischemic Stroke, Neurosci. Bull., 35, 921, 10.1007/s12264-019-00388-3 · DOI
  38. Huang, 2014, Glial scar formation occurs in the human brain after ischemic stroke, Int. J. Med. Sci., 11, 344, 10.7150/ijms.8140 · DOI
  39. Silver, 2004, Regeneration beyond the glial scar, Nat. Rev. Neurosci., 5, 146, 10.1038/nrn1326 · DOI
  40. Choi, Y.K., Park, J.H., Yun, J.A., Cha, J.H., Kim, Y., Won, M.H., Kim, K.W., Ha, K.S., Kwon, Y.G., and Kim, Y.M. (2018). Heme oxygenase metabolites improve astrocytic mitochondrial function via a Ca2+-dependent HIF-1alpha/ERRalpha circuit. PLoS ONE, 13. · DOI
  41. Nasyrov, 2019, The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain, FASEB J., 33, 12812, 10.1096/fj.201901385RR · DOI
  42. Dong, 2016, Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats’ stroke model, J. Ethnopharmacol., 191, 169, 10.1016/j.jep.2016.06.030 · DOI
  43. Qin, 2017, Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway, Stroke, 48, 3336, 10.1161/STROKEAHA.117.018505 · DOI
  44. Schwab, 2014, Nogo limits neural plasticity and recovery from injury, Curr. Opin. Neurobiol., 27, 53, 10.1016/j.conb.2014.02.011 · DOI
  45. Tedeschi, 2017, Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration, Curr. Opin. Neurobiol., 42, 118, 10.1016/j.conb.2016.12.005 · DOI
  46. Jung, E., Koh, S.H., Yoo, M., and Choi, Y.K. (2020). Regenerative Potential of Carbon Monoxide in Adult Neural Circuits of the Central Nervous System. Int. J. Mol. Sci., 21. · DOI
  47. Licht, 2011, Reversible modulations of neuronal plasticity by VEGF, Proc. Natl. Acad. Sci. USA, 108, 5081, 10.1073/pnas.1007640108 · DOI
  48. Lee, 2007, Autocrine VEGF signaling is required for vascular homeostasis, Cell, 130, 691, 10.1016/j.cell.2007.06.054 · DOI
  49. Domingues, I., Rino, J., Demmers, J.A., de Lanerolle, P., and Santos, S.C. (2011). VEGFR2 translocates to the nucleus to regulate its own transcription. PLoS ONE, 6. · DOI
  50. Mistry, 2017, Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis, Free Radic. Biol. Med., 108, 500, 10.1016/j.freeradbiomed.2017.04.025 · DOI
  51. Dalkara, 1994, Blood flow-dependent functional recovery in a rat model of focal cerebral ischemia, Am. J. Physiol., 267, H678
  52. Murohara, 1998, Nitric oxide synthase modulates angiogenesis in response to tissue ischemia, J. Clin. Investig., 101, 2567, 10.1172/JCI1560 · DOI
  53. Aicher, 2003, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells, Nat. Med., 9, 1370, 10.1038/nm948 · DOI
  54. 2017, Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective, Front. Mol. Neurosci., 10, 427, 10.3389/fnmol.2017.00427 · DOI
  55. Hettiarachchi, 2017, Heme oxygenase-1 derived carbon monoxide suppresses Abeta1-42 toxicity in astrocytes, Cell Death Dis., 8, e2884, 10.1038/cddis.2017.276 · DOI
  56. Dirnagl, 2009, Preconditioning and tolerance against cerebral ischaemia: From experimental strategies to clinical use, Lancet Neurol., 8, 398, 10.1016/S1474-4422(09)70054-7 · DOI
  57. Jackson, 2016, Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes, J. Neurosci., 36, 7109, 10.1523/JNEUROSCI.4518-15.2016 · DOI
  58. Kim, 2020, The Role of a Neurovascular Signaling Pathway Involving Hypoxia-Inducible Factor and Notch in the Function of the Central Nervous System, Biomol. Ther., 28, 45, 10.4062/biomolther.2019.119 · DOI
  59. Choi, 2016, Carbon monoxide stimulates astrocytic mitochondrial biogenesis via L-type Ca2+ channel-mediated PGC-1alpha/ERRalpha activation, Biochem. Biophys. Res. Commun., 479, 297, 10.1016/j.bbrc.2016.09.063 · DOI
  60. Choi, 2010, Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein, J. Biol. Chem., 285, 32116, 10.1074/jbc.M110.131284 · DOI
  61. Ramamoorthy, 2019, Expression of Hypoxia Inducible Factor 1alpha Is Protein Kinase A-dependent in Primary Cortical Astrocytes Exposed to Severe Hypoxia, Neurochem. Res., 44, 258, 10.1007/s11064-018-2516-9 · DOI
  62. Bulnes, S., Argandona, E.G., Bengoetxea, H., Leis, O., Ortuzar, N., and Lafuente, J.V. (2010). The role of eNOS in vascular permeability in ENU-induced gliomas. Brain Edema XIV, Springer. · DOI
  63. Zhu, 2016, Endothelial nitric oxide synthase: A potential therapeutic target for cerebrovascular diseases, Mol. Brain, 9, 30, 10.1186/s13041-016-0211-9 · DOI · Paper page
  64. Shepro, 1993, Pericyte physiology, FASEB J., 7, 1031, 10.1096/fasebj.7.11.8370472 · DOI
  65. Gautam, 2018, Roles of Pericytes in Stroke Pathogenesis, Cell Transplant., 27, 1798, 10.1177/0963689718768455 · DOI
  66. Liu, 2012, The role of pericytes in blood-brain barrier function and stroke, Curr. Pharm. Des., 18, 3653, 10.2174/138161212802002706 · DOI
  67. Peppiatt, 2006, Bidirectional control of CNS capillary diameter by pericytes, Nature, 443, 700, 10.1038/nature05193 · DOI · Paper page
  68. Hori, 2004, A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro, J. Neurochem., 89, 503, 10.1111/j.1471-4159.2004.02343.x · DOI
  69. Augustin, 2009, Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system, Nat. Rev. Mol. Cell Biol., 10, 165, 10.1038/nrm2639 · DOI
  70. Hsuan, 2016, Mesenchymal stem cell-based treatments for stroke, neural trauma, and heat stroke, Brain Behav., 6, e00526, 10.1002/brb3.526 · DOI
  71. Han, 2020, The role of peripheral monocytes and macrophages in ischemic stroke, Neurol. Sci., 41, 3589, 10.1007/s10072-020-04777-9 · DOI
  72. Sheikh, 2011, Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: Contribution of fractalkine and IL-5, Neurobiol. Dis., 41, 717, 10.1016/j.nbd.2010.12.009 · DOI
  73. Hiratsuka, 1998, Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice, Proc. Natl. Acad. Sci. USA, 95, 9349, 10.1073/pnas.95.16.9349 · DOI
  74. Maki, 2018, A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter, Stem Cells, 36, 751, 10.1002/stem.2771 · DOI
  75. Maki, 2018, Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion, Stroke, 49, 1003, 10.1161/STROKEAHA.117.019346 · DOI
  76. Hayakawa, 2012, Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro, Neurosci. Lett., 513, 42, 10.1016/j.neulet.2012.02.004 · DOI
  77. Esposito, 2018, Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia, J. Neurochem., 146, 160, 10.1111/jnc.14337 · DOI
  78. Liao, 2017, Endothelial Progenitor Cells for Ischemic Stroke: Update on Basic Research and Application, Stem Cells Int., 2017, 2193432, 10.1155/2017/2193432 · DOI
  79. Choi, 2021, Regulation of Endothelial and Vascular Functions by Carbon Monoxide via Crosstalk with Nitric Oxide, Front. Cardiovasc. Med., 8, 649630, 10.3389/fcvm.2021.649630 · DOI
  80. Choi, 2016, Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury, Nat. Med., 22, 1335, 10.1038/nm.4188 · DOI
  81. Wang, 2018, Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke, Cell Transplant., 27, 1825, 10.1177/0963689718795424 · DOI · Paper page
  82. Chelluboina, 2017, Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases, Cell Physiol. Biochem., 44, 1360, 10.1159/000485533 · DOI
  83. Sheikh, 2019, A Mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model, Exp. Neurol., 311, 182, 10.1016/j.expneurol.2018.10.001 · DOI
  84. Semenza, 2007, Vasculogenesis, angiogenesis, and arteriogenesis: Mechanisms of blood vessel formation and remodeling, J. Cell Biochem., 102, 840, 10.1002/jcb.21523 · DOI
  85. Ryu, 2019, Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model, J. Neurosurg., 132, 442, 10.3171/2018.11.JNS182331 · DOI
  86. Liu, 2019, Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke, Microvasc. Res., 123, 74, 10.1016/j.mvr.2019.01.001 · DOI
  87. Hiasa, 2004, Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: Next-generation chemokine therapy for therapeutic neovascularization, Circulation, 109, 2454, 10.1161/01.CIR.0000128213.96779.61 · DOI
  88. Tobin, 2020, Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis, J. Am. Heart Assoc., 9, e013583, 10.1161/JAHA.119.013583 · DOI
  89. Yuan, 2019, Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment, Cytotherapy, 21, 1033, 10.1016/j.jcyt.2019.04.055 · DOI
  90. Terai, 2016, ERK activation in endothelial cells is a novel marker during neovasculogenesis, Genes Cells, 21, 1164, 10.1111/gtc.12438 · DOI
  91. Gao, 2019, Protective effects of mesenchymal stem cells overexpressing extracellular regulating kinase 1/2 against stroke in rats, Brain Res. Bull., 149, 42, 10.1016/j.brainresbull.2019.04.006 · DOI
  92. Son, 2019, Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4, Mol. Neurobiol., 56, 7617, 10.1007/s12035-019-1629-8 · DOI
  93. Park, 2010, Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury, Glia, 58, 1118, 10.1002/glia.20992 · DOI
  94. Xia, 2020, Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke, Stem Cell Res. Ther., 11, 313, 10.1186/s13287-020-01834-0 · DOI
  95. Bang, 2005, Autologous mesenchymal stem cell transplantation in stroke patients, Ann. Neurol., 57, 874, 10.1002/ana.20501 · DOI
  96. Jaillard, 2020, Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: A Randomized Clinical Trial, Transl. Stroke Res., 11, 910, 10.1007/s12975-020-00787-z · DOI
  97. Honmou, 2011, Intravenous administration of auto serum-expanded autologous mesenchymal stem cells in stroke, Brain, 134, 1790, 10.1093/brain/awr063 · DOI
  98. Levy, 2019, Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke, Stroke, 50, 2835, 10.1161/STROKEAHA.119.026318 · DOI
  99. Asahara, 1997, Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275, 964, 10.1126/science.275.5302.964 · DOI · Paper page
  100. Gill, 2001, Vascular trauma induces rapid but transient mobilization of VEGFR2(+)AC133(+) endothelial precursor cells, Circ. Res., 88, 167, 10.1161/01.RES.88.2.167 · DOI
  101. Powell, 2005, Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease, Arterioscler. Thromb. Vasc. Biol., 25, 296, 10.1161/01.ATV.0000151690.43777.e4 · DOI
  102. Askari, 2003, Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy, Lancet, 362, 697, 10.1016/S0140-6736(03)14232-8 · DOI
  103. Liu, 2011, SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion, Protein. Cell, 2, 845, 10.1007/s13238-011-1097-z · DOI
  104. Cheng, 2017, The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia, Front. Neurosci., 11, 590, 10.3389/fnins.2017.00590 · DOI
  105. Fan, 2010, Endothelial progenitor cell transplantation improves long-term stroke outcome in mice, Ann. Neurol., 67, 488, 10.1002/ana.21919 · DOI
  106. Bai, 2015, Bone Marrow Endothelial Progenitor Cell Transplantation After Ischemic Stroke: An Investigation Into Its Possible Mechanism, CNS Neurosci. Ther., 21, 877, 10.1111/cns.12447 · DOI
  107. Rosell, A., Morancho, A., Navarro-Sobrino, M., Martinez-Saez, E., Hernandez-Guillamon, M., Lope-Piedrafita, S., Barcelo, V., Borras, F., Penalba, A., and Garcia-Bonilla, L. (2013). Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice. PLoS ONE, 8. · DOI
  108. Sebastia, 2009, Angiogenin protects motoneurons against hypoxic injury, Cell Death Differ., 16, 1238, 10.1038/cdd.2009.52 · DOI
  109. Man, 2016, Neurogenic potential of engineered mesenchymal stem cells overexpressing VEGF, Cell Mol. Bioeng., 9, 96, 10.1007/s12195-015-0425-4 · DOI
  110. Akita, 2003, Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization, Lab. Investig., 83, 65, 10.1097/01.LAB.0000050761.67879.E4 · DOI
  111. Banerjee, 2014, Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke, Stem Cells Transl. Med., 3, 1322, 10.5966/sctm.2013-0178 · DOI
  112. Lin, 2016, Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice, Cell Death Dis., 7, e2273, 10.1038/cddis.2015.284 · DOI
  113. Wang, 2015, NAMPT as a Therapeutic Target against Stroke, Trends Pharmacol. Sci., 36, 891, 10.1016/j.tips.2015.08.012 · DOI
  114. Wang, 2019, Targeting NAMPT as a therapeutic strategy against stroke, Stroke Vasc. Neurol., 4, 83, 10.1136/svn-2018-000199 · DOI
  115. Wang, 2008, Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: Role of enhanced DNA repair, Stroke, 39, 2587, 10.1161/STROKEAHA.107.509158 · DOI
  116. Wang, 2011, Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway, Ann. Neurol., 69, 360, 10.1002/ana.22236 · DOI
  117. Kang, 2011, Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway, Neurosci. Lett., 504, 121, 10.1016/j.neulet.2011.09.014 · DOI
  118. Kim, 2007, Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2, Biochem. Biophys. Res. Commun., 357, 150, 10.1016/j.bbrc.2007.03.105 · DOI
  119. Wang, 2014, Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors, Cardiovasc. Res., 104, 477, 10.1093/cvr/cvu220 · DOI
  120. Prabhakar, 2015, Oxygen Sensing and Homeostasis, Physiology, 30, 340, 10.1152/physiol.00022.2015 · DOI
  121. Kim, 2011, Heme oxygenase in the regulation of vascular biology: From molecular mechanisms to therapeutic opportunities, Antioxid. Redox Signal., 14, 137, 10.1089/ars.2010.3153 · DOI
  122. Lee, 2013, Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling for recovery of ischemic retinopathy, Sci. Transl. Med., 5, 203ra127, 10.1126/scitranslmed.3006666 · DOI
  123. Semenza, 2003, Targeting HIF-1 for cancer therapy, Nat. Rev. Cancer, 3, 721, 10.1038/nrc1187 · DOI · Paper page
  124. Brune, 2007, Hypoxia-inducible factor-1alpha under the control of nitric oxide, Methods Enzymol., 435, 463, 10.1016/S0076-6879(07)35024-6 · DOI
  125. Liu, 1998, Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer, J. Biol. Chem., 273, 15257, 10.1074/jbc.273.24.15257 · DOI
  126. Cheng, 2003, Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain, Dev. Biol., 258, 319, 10.1016/S0012-1606(03)00120-9 · DOI
  127. Chung, 2008, Icariin stimulates angiogenesis by activating the MEK/ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells, Biochem. Biophys. Res. Commun., 376, 404, 10.1016/j.bbrc.2008.09.001 · DOI
  128. Dimmeler, 1999, Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation, Nature, 399, 601, 10.1038/21224 · DOI · Paper page
  129. Li, 2013, Neuroprotection by inhaled nitric oxide in a murine stroke model is concentration and duration dependent, Brain Res., 1507, 134, 10.1016/j.brainres.2013.02.031 · DOI
  130. Terpolilli, 2012, Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles, Circ. Res., 110, 727, 10.1161/CIRCRESAHA.111.253419 · DOI
  131. Choi, 2012, Regulation of ROS production and vascular function by carbon monoxide, Oxid. Med. Cell Longev., 2012, 794237, 10.1155/2012/794237 · DOI
  132. Scheiblich, 2015, Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO-1/CO signaling, Dev. Neurobiol., 75, 854, 10.1002/dneu.22253 · DOI
  133. Mancuso, 2008, Bilirubin as an endogenous modulator of neurotrophin redox signaling, J. Neurosci. Res., 86, 2235, 10.1002/jnr.21665 · DOI
  134. Dore, 1999, Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury, Proc. Natl. Acad. Sci. USA, 96, 2445, 10.1073/pnas.96.5.2445 · DOI
  135. Imuta, 2007, Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis, Antioxid. Redox Signal., 9, 543, 10.1089/ars.2006.1519 · DOI
  136. Nada, 2014, Heme oxygenase 1-mediated neurogenesis is enhanced by Ginkgo biloba (EGb 761(R)) after permanent ischemic stroke in mice, Mol. Neurobiol., 49, 945, 10.1007/s12035-013-8572-x · DOI
  137. Parfenova, 2012, Antioxidant roles of heme oxygenase, carbon monoxide, and bilirubin in cerebral circulation during seizures, J. Cereb. Blood Flow Metab., 32, 1024, 10.1038/jcbfm.2012.13 · DOI
  138. Boehning, 2003, Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2, Neuron, 40, 129, 10.1016/S0896-6273(03)00596-8 · DOI
  139. Motterlini, 2010, The therapeutic potential of carbon monoxide, Nat. Rev. Drug Discov., 9, 728, 10.1038/nrd3228 · DOI
  140. Dulak, 2008, Heme oxygenase-1 and carbon monoxide in vascular pathobiology: Focus on angiogenesis, Circulation, 117, 231, 10.1161/CIRCULATIONAHA.107.698316 · DOI
  141. Cudmore, 2007, Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1, Circulation, 115, 1789, 10.1161/CIRCULATIONAHA.106.660134 · DOI
  142. Lin, 2008, Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1, J. Mol. Cell Cardiol., 45, 44, 10.1016/j.yjmcc.2008.04.011 · DOI
  143. Lin, 2011, Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1, J. Biol. Chem., 286, 3829, 10.1074/jbc.M110.168831 · DOI
  144. Yang, 2016, Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism, Vasc. Pharmacol., 87, 209, 10.1016/j.vph.2016.09.010 · DOI
  145. Wang, 2018, Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption, J. Neuroinflammation, 15, 188, 10.1186/s12974-018-1226-1 · DOI
  146. Lin, 2017, Heme Oxygenase-1 Induction by Carbon Monoxide Releasing Molecule-3 Suppresses Interleukin-1beta-Mediated Neuroinflammation, Front. Mol. Neurosci., 10, 387, 10.3389/fnmol.2017.00387 · DOI
  147. Kim, Y., Park, J., and Choi, Y.K. (2019). The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review. Antioxidants, 8. · DOI
  148. Nitti, M., Piras, S., Brondolo, L., Marinari, U.M., Pronzato, M.A., and Furfaro, A.L. (2018). Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?. Int. J. Mol. Sci., 19. · DOI
  149. Stifter, J., Ulbrich, F., Goebel, U., Bohringer, D., Lagreze, W.A., and Biermann, J. (2017). Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release. PLoS ONE, 12. · DOI
  150. Weinstock, 2001, Neuroprotective effects of novel cholinesterase inhibitors derived from rasagiline as potential anti-Alzheimer drugs, Ann. N. Y. Acad. Sci., 939, 148, 10.1111/j.1749-6632.2001.tb03622.x · DOI
  151. Sugaya, 2012, Neuroprotection and neuroregeneration in Alzheimer’s disease, Int. J. Alzheimer’s Dis., 2012, 864138

Cited by

Sorted by citations

Metadata

Authors
Moon, S., Chang, M.-S., Koh, S.-H., & Choi, Y. K.
Affiliations
  • Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul 05029, Korea
  • Department of Oral Anatomy, Seoul National University School of Dentistry, Seoul 03080, Korea
  • Department of Neurology, Hanyang University Guri Hospital, Guri 11923, Korea
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2021-08-09
Volume
22
Issue
16
Pages
8543
ISSN
1422-0067
DOI
10.3390/ijms22168543
PMC
PMC8395233
Cited by
104
References
17
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Korea Health Industry Development Institute (HI20C0253)
  • National Research Foundation of Korea (2020R1A2C1004397)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review