Cytochrome P450 Enzymes and Drug Metabolism in Humans

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

Nelson, D. R., Koymans, L. M. H., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,946

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0637 · Cited by 2,356

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Conney, A. H. (1982) · PubMed · Cited by 1,557

Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects

Ingelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

Ingelman‐Sundberg, M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500285 · Cited by 1,111

Predicting in vivo drug interactions from in vitro drug discovery data

Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 910

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Palrasu, M., & Nagini, S. (2017) · Current Drug Targets · doi:10.2174/1389450118666170125144557 · Cited by 855

Inhibition and Induction of Cytochrome P450 and the Clinical Implications

Lin, J. H., & Lu, A. Y. H. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835050-00003 · Cited by 827

The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans

Danielson, B. S. P. P. B. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337054 · Cited by 775

Glucosinolates, isothiocyanates, and their role in the regulation of autophagy and cellular function

Maycotte, P., Illanes, M., & Moreno, D. A. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-09944-w · Cited by 10

Molecular Docking and Pharmacokinetics Analysis of Phytochemicals from Piper caninum as Dengue NS2B-NS3 Protease Inhibitors

Mustafa, N. F., Cheng, K., Razali, S. A., & Nadri, M. H. (2024) · Journal of Tropical Life Science · doi:10.11594/jtls.14.01.14 · Cited by 10

Phase 1 drug-drug interaction study to assess the effect of CYP3A4 inhibition and pan-CYP induction on the pharmacokinetics and safety of fosmanogepix in healthy participants

Hodges, M. R., van Marle, S., Kramer, W. G., Ople, E., Tawadrous, M., & Jakate, A. S. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01650-23 · Cited by 10

Exploring the structure-activity relationship (SAR) of Schiff bases as effective compounds in scavenging free radicals

Nunes, I. J., Dias, R. F. C., da Silva, A. F., Ferreira, W. V., Cunico, W. J., Couto, G. T., Bianchini, D., Casagrande, O. L., Saffi, J., & Pinheiro, A. C. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138729 · Cited by 10

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

Abdelgalil, M. H., Elhammamy, R., Ragab, H. M., Sheta, E., & Wahid, A. M. (2024) · Biological Research · doi:10.1186/s40659-024-00510-4 · Cited by 11

Uncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models

Roux, S., Cherradi, S., & Duong, H. T. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03833-z · Cited by 10

Anticoagulation in Chronic Kidney Disease

Montomoli, M., Candia, B. G., Barrios, A. A., & Pérez-Bernat, E. (2024) · Drugs · doi:10.1007/s40265-024-02077-6 · Cited by 10

IGFBP1 promotes the proliferation and migration of lung adenocarcinoma cells through the PPARα pathway

Li, Y., Yang, X., Han, T., Zhou, J., Liu, Y., Guo, J., Liu, Z., Bai, Y., Xing, Y., Ding, X., et al. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102095 · Cited by 10

Postharvest integration of prickly pear betalain-enriched gummies with different sugar substitutes for decoding diabetes type-II and skin resilience - in vitro and in silico study

Mehta, D., Kuksal, K., Sharma, A., Soni, N., Kumari, S., & Nile, S. H. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141612 · Cited by 10

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Suryanarayanan, P., Qiu, Y., Sethi, S., Mahajan, D., Li, H., Yang, Y., Eyigöz, E., Guzmán-Sáenz, A., Platt, D. E., Rumbell, T. H., et al. (2026) · Advanced Science · doi:10.1002/advs.202517840 · Cited by 13

Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity

Pratheep, T., Gayathiri, E., Prakash, P., Viswanathan, D., Rahaman, M., Pandiaraj, S., Nagarajan, S., Anantharaman, R., & Rajakumar, G. (2024) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2024.2435983 · Cited by 10

Innovative applications and future perspectives of chromatography-mass spectrometry in drug research

Cai, H., Xing, X., Su, Y., & Yang, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1529468 · Cited by 10

In-silico discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs

Ajadee, A., Mahmud, S., Ali, M. A., Mollah, M. M. H., Ahmmed, R., & Mollah, M. N. H. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf215 · Cited by 10

Computational studies on human cytochrome P450: advancing insights into drug metabolism

Hirao, H., Yue, D., Xia, S., Zhang, E., Zhang, H., Yan, J., & Xiao, Z. (2025) · Trends in Chemistry · doi:10.1016/j.trechm.2025.05.002 · Cited by 10

Coumarins at the Crossroads of Drug Development: Enzyme Modulation for Clinical Advances

Mustafa, Y. F. (2025) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-025-01331-2 · Cited by 10

Untargeted Metabolomics and in Silico Screening of Sisymbrium officinale : Identification of Flavonoid Glycosides as Potential Anti-inflammatory Agents

Kahfi, J., Rachman, D., Permatasari, D., Kusumastuti, S. A., Wulansari, M. T., Sioud, S., Manasra, R., Makharza, S. A., Kusumaningrum, S., Jaremko, M., et al. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00097 · Cited by 10

Experimental and theoretical insights into structural features of methyl (E)-3-(3,4,5-trimethoxybenzylidene)dithiocarbazate with molecular docking and ADMET studies

Mahmud, A. A., Pal, T. K., Islam, M. M., Haque, M. M., Islam, M. A., Sheikh, M. C., Miyatake, R., & Paul, S. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.135654 · Cited by 10

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase

Besskaya, V., Zhang, H., Bian, Y., Liang, J., Bi, G., Shan, G., Zhan, C., & Lin, Z. (2023) · PeerJ · doi:10.7717/peerj.15377 · Cited by 9

Computational Screening Using a Combination of Ligand-Based Machine Learning and Molecular Docking Methods for the Repurposing of Antivirals Targeting the SARS-CoV-2 Main Protease

Yuda, G. P. W. C., Hanif, N., & Hermawan, A. (2023) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-023-00484-w · Cited by 10

Interaction of mycotoxins zearalenone, α-zearalenol, and β-zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1).

Kaci, H., Dombi, Á., Gömbös, P., Szabó, A., Bakos, É., Özvegy-Laczka, C., & Poór, M. (2024) · Toxicology in Vitro · doi:10.1016/j.tiv.2024.105789 · Cited by 11

Systemic treatment and radiotherapy for patients with non-small cell lung cancer (NSCLC) and HIV infection – A systematic review

Brandão, M., Durieux, V., Auprih, M., Fozza, A., Dauby, N., Cuccia, F., Aspeslagh, S., Verhaert, M., & Giaj‐Levra, N. (2023) · Lung Cancer · doi:10.1016/j.lungcan.2023.01.010 · Cited by 9

Why drug exposure is frequently associated with T-cell mediated cutaneous hypersensitivity reactions

Line, J., Saville, E., Meng, X., & Naisbitt, D. J. (2023) · Frontiers in Toxicology · doi:10.3389/ftox.2023.1268107 · Cited by 9

Control of metalloenzyme activity using photopharmacophores

Mafy, N. N., Hudson, D. B., & Que, E. L. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215485 · Cited by 9

Effects of sex on innate immunity characteristics in the Pacific white shrimp (Litopenaeus vannamei)

Wang, Y.-X., Yan, P., Zeng, Q., Hu, J., Bao, Z., & Wang, M. (2024) · Aquaculture International · doi:10.1007/s10499-024-01501-8 · Cited by 9

An update on drug–drug interactions in older adults living with human immunodeficiency virus (HIV)

Linfield, R. Y., Nguyen, N. N., Laprade, O. H., Holodniy, M., & Chary, A. (2024) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2024.2350968 · Cited by 13

Role of Cytochrome P450 3A4 in Cancer Drug Resistance: Challenges and Opportunities

Pandey, S. K., Verma, S., Upreti, S., Mishra, A., Yadav, N., & Dwivedi‐Agnihotri, H. (2024) · Current Drug Metabolism · doi:10.2174/0113892002312369240703102215 · Cited by 9

Developing phytocompound-based new drugs against multi-drug-resistant Staphylococcus aureus

Shuvo, M. I. M., Halder, S. K., Alam, N., Himel, M. K., & Shil, A. (2024) · Royal Society Open Science · doi:10.1098/rsos.231475 · Cited by 9

Characterization and Expression of the Cytochrome P450 Genes in Daphnia magna Exposed to Cerium Oxide Nanoparticles

Kang, X., Zhou, Y., Liu, Q., Liu, M., Chen, J., Zhang, Y., Wei, J., & Wang, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910812 · Cited by 9

Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes

You, Q., Song, H., Zhu, Z., Wang, J., Wang, R., Du, M., Fu, Y., Yuan, J., & Tan, R. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00671-w · Cited by 9

Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential

Inthanon, K., Wong-a-nan, N., Dheeranupattana, S., Guerra, A. G., Davies, N. M., Kesornpun, C., Sangher, S., & Kittakoop, P. (2025) · Scientific Reports · doi:10.1038/s41598-025-87945-1 · Cited by 9

4-Hydroxycoumarin Exhibits Antinociceptive and Anti-Inflammatory Effects Through Cytokine Modulation: An Integrated In Silico and In Vivo Study

da Fonsêca, D. V., Rocha, J. S., Pereira, H. N. D. S. N., Pereira, H. N. D. S. N., de Santana, M. A. D., Alves, A. F., Pontes, A. H. O., Gomes, J. D. S., Felipe, C. F. B., da Silva, P. R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062788 · Cited by 9

Optimizing Treatment: The Role of Pharmacology, Genomics, and AI in Improving Patient Outcomes

Ahmad, F. (2025) · Drug Development Research · doi:10.1002/ddr.70093 · Cited by 10

Nepetanudoside B, a potential new food additive isolated from Nepeta aristata: antioxidant, antibacterial, DFT, ADME/T, PASS prediction and MTT analysis studies

Başar, Y., Yenigün, S., Özen, T., Demirtaş, İ., Balpınar, Ö., & Behçet, L. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04831-w · Cited by 9

Sex differences in hepatic enzymes and transporters involved in pharmacokinetics

Behal, M., McCalla, Z., & Wang, X. (2025) · Liver Research · doi:10.1016/j.livres.2025.10.003 · Cited by 9

A review of deep learning approaches for drug synergy prediction in cancer

Li, L., Zhang, H., Zheng, C., & Su, Y. (2025) · npj Drug Discovery. · doi:10.1038/s44386-025-00034-1 · Cited by 11

Recent Advances in Dual COX/LOX Inhibitor Design (2020–2024): Establishing “The Rule of Four for Inflammation”

Chatzipieris, F. P., Petsas, E., Lambrinidis, G., Vassiliou, S., & Chasapis, C. T. (2026) · Life · doi:10.3390/life16010163 · Cited by 10

An Overview of Pharmacogenomic Testing for Psychiatric Disorders

Young, C. J., & MacDougall, D. (2023) · Canadian Journal of Health Technologies · doi:10.51731/cjht.2023.664 · Cited by 10

Extracellular Vesicles as Surrogates for Drug Metabolism and Clearance: Promise vs. Reality

Gagliardi, A. M., Bajraktari‐Sylejmani, G., Barocelli, E., Weiß, J., & Rigalli, J. P. (2023) · Life · doi:10.3390/life13081745 · Cited by 9

Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population

Jan, A., Saeed, M., Mothana, R. A., Muhammad, T., Rahman, N., Alanzi, A. R., & Akbar, R. (2023) · Biomedicines · doi:10.3390/biomedicines11082282 · Cited by 9

In Vitro and In Silico Investigation of BCI Anticancer Properties and Its Potential for Chemotherapy-Combined Treatments

Marciniak, B., Kciuk, M., Mujwar, S., Rajamanikandan, S., Bukowski, K., & Gruszka, R. (2023) · Cancers · doi:10.3390/cancers15184442 · Cited by 10

Hepatic ischemia-reperfusion syndrome and its effect on the cardiovascular system: The role of treprostinil, a synthetic prostacyclin analog

Mouratidou, C., Pavlidis, T., Katsanos, G., Kotoulas, S., Mouloudi, E. K., Tsoulfas, G., Galanis, I. N., & Pavlidis, T. (2023) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v15.i9.1858 · Cited by 9

Multi-omics revealed rumen microbiota metabolism and host immune regulation in Tibetan sheep of different ages

Sha, Y., Liu, X., He, Y., Zhao, S., Hu, J., Wang, J., Li, W., Shao, P., Wang, F., Chen, X., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1339889 · Cited by 9

Electroanalysis in Pharmacogenomic Studies: Mechanisms of Drug Interaction with DNA

Shumyantseva, V. V., Pronina, V. V., Bulko, T. V., & Agafonova, L. E. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924140128 · Cited by 9

Uncovering the effective substances and mechanism of Ipomoea pes‐caprae against rheumatoid arthritis using liquid chromatography‐mass spectrometry and targeted network pharmacology

Cheng, X., Cui, N., Hou, X., Pi, Z., Deng, J., & Liu, S. (2023) · Journal of Separation Science · doi:10.1002/jssc.202200856 · Cited by 9

Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers

Li, L., Zhong, G., Li, Y., Li, T., Huo, Y., Ma, F., Li, Y., Zhang, H., Pan, J., Hu, L., et al. (2023) · BioMetals · doi:10.1007/s10534-023-00559-w · Cited by 8

Fumonisin B 1 induces endoplasmic reticulum damage and inflammation by activating the NXR response and disrupting the normal CYP450 system, leading to liver damage in juvenile quail

Zhu, L., Li, J., Yang, S., Deng, X., Wang, Z., & Cao, C. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17213 · Cited by 8

Insights into pharmacogenetics, drug-gene interactions, and drug-drug-gene interactions

Russell, L. E., Claw, K. G., Aagaard, K. M., Glass, S. M., Dasgupta, K., Nez, F. L., Haimbaugh, A. S., Maldonato, B. J., & Yadav, J. (2024) · Drug Metabolism Reviews · doi:10.1080/03602532.2024.2385928 · Cited by 8

Sodium butyrate alleviates T‐2 toxin–induced liver toxicity and renal toxicity in quails by modulating oxidative stress–related Nrf2 signaling pathway, inflammation, and CYP450 enzyme system

He, Y., Zhu, X., Song, H., Liu, Y., & Cao, C. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17400 · Cited by 8

Thyme and Oregano Oil Potential Therapeutics against Malathion Toxicity through Biochemical, Histological, and Cytochrome P450 1A2 Activities in Male Wistar Rats

Al‐Saeed, F. A., & Ali, M. E. (2024) · Animals · doi:10.3390/ani14192914 · Cited by 8

Advances in liver engineering with cell, scaffold, and vascularization

Liu, C., Wang, Y., Zhou, X., & Dong, L. (2024) · EngMedicine · doi:10.1016/j.engmed.2024.100041 · Cited by 10

Physicochemical, medicinal chemistry, and ADMET characteristics of bee antimicrobial peptides as natural bio-preservatives to extend food shelf life: a roadmap for food safety regulation

Dinata, R., Arati, C., Saeed, A.-L., Manikandan, B., Abinash, G., Pori, B., Bidanchi, R. M., Roy, V. K., & Gurusubramanian, G. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2429181 · Cited by 8

Virtual screening and molecular dynamics studies of novel small molecules targeting Schistosoma mansoni DHODH: identification of potential inhibitors

Ja’afaru, S. C., Uzairu, A., Mishra, V. K., Sallau, M. S., Ibrahim, M. T., & Dubey, A. (2024) · In Silico Pharmacology · doi:10.1007/s40203-024-00281-6 · Cited by 8

Biotransformation of anthelmintics in nematodes in relation to drug resistance

Vosála, O., Krátký, J., Matoušková, P., Rychlá, N., Štěrbová, K., Stuchlíková, L. R., Vokřál, I., & Skálová, L. (2025) · International Journal for Parasitology Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2025.100579 · Cited by 9

CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination

Ma, K., Li, Q., Zhang, Y., Wang, J., Jia, W., Liu, J., Liu, B., Li, Q., Wang, Q., & Zeng, K. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101186 · Cited by 10

Celastrol derivatives ameliorate arthritis in AIA rats via modulating calcium signaling

Huang, B., Ng, J. P. L., Zhang, D., Wang, L., Yang, J., Li, Y., Tan, C. R., Luo, G., Chen, Z., Qin, B., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157110 · Cited by 8

The Role of Pharmacogenetic Biomarkers in Pain

da Silva, I. M., Plaza‐Díaz, A., Ramos, J. R., Juanes-Borrego, A. M., & Riera, P. (2025) · Biomedicines · doi:10.3390/biomedicines13081935 · Cited by 8

Omega-3 fatty acids and chemotherapy-induced toxicities: mechanisms and emerging evidence with a pediatric focus

Maldonado-Salinas, R., Caballero-Salazar, S., Castillejos-López, M. D. J., Aquino‐Gálvez, A., Velasco-Hidalgo, L., García-Guzmán, A. D., Pliego-Villanueva, C., Alavez-Pérez, N. S., Montesinos-Correa, H., & Espíndola, L. M. T. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01044-6 · Cited by 10

The Role of Drug-Metabolizing Enzymes in Synthetic Lethality of Cancer

Zeng, Z., Zheng, W., & Hou, P. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108219 · Cited by 8

Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21

Sychterz, C. J., Gardner, I. B., Chiang, M., Ramakrishna, R., Neuhoff, S., Perera, V., Merali, S. J., Schmidt, B. J., & Gaohua, L. (2022) · Metabolites · doi:10.3390/metabo12101001 · Cited by 8

Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen

Chen, S., Guo, W., Liu, H., Zheng, J., Lu, D., Sun, J. M., Li, C., Liu, W., Wang, Y., Huang, Y., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114011 · Cited by 8

Assessment of cytochrome P450 induction in canine intestinal organoid models

Nagao, I., Nakazawa, M., Goyama, T., Court, M. H., & Ambrosini, Y. M. (2024) · Xenobiotica · doi:10.1080/00498254.2024.2326973 · Cited by 8

Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors

Kerhoas, M., Carteret, J., Huchet, L., Jouan, E., Laurence Therese, H. U. C., Vée, M. L., & Fardel, O. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116261 · Cited by 8

Spatial transcriptomics unravels palmitoylation and zonation-dependent gene regulation by AEG-1 in mouse liver

Saverino, A., Qu, X., Mendoza, R. G., Raha, S., Manna, D., Ermi, A. G., Subler, M. A., Windle, J. J., Liu, J., & Sarkar, D. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107322 · Cited by 9

Sustainable biosynthesis of silver nanoparticles from Gmelina arborea: Photocatalytic, in vitro biological implications, and in silico analysis for microbial metalloproteins

Thakar, M. S., Trivedi, P. G., & Sindhav, G. M. (2025) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2025.126966 · Cited by 8

Understanding the impact of triazoles on female fertility and embryo development: Mechanisms and implications

Sharma, S., & Pandey, G. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101948 · Cited by 9

Machine Learning in Drug Metabolism Study

Sinha, K., Ghosh, J., & Sil, P. C. (2022) · Current Drug Metabolism · doi:10.2174/1389200224666221227094144 · Cited by 8

Polymorphisms in drug-metabolizing genes and urinary bladder cancer susceptibility and prognosis: Possible impacts and future management

da Silva, I. M., Vacario, B. G. L., Okuyama, N. C. M., Barcelos, G. R. M., Fuganti, P. E., Guembarovski, R. L., Cólus, I. M. D. S., & Serpeloni, J. M. (2024) · Gene · doi:10.1016/j.gene.2024.148252 · Cited by 7

Electrical breakdown in liquid-phase processing on an enhancement of 7-hydroxymitragynine conversion from mitragynine in Mitragyna speciosa (Kratom)

Samee, W., Matra, K., Lakkham, N., Dongkaew, B., Sumkhum, P., Sangwang, W., Nupangtha, W., & Promping, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36676 · Cited by 7

Development of a high throughput cytochrome P450 ligand-binding assay

Frydendall, E. K., & Scott, E. E. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107799 · Cited by 7

Interaction of myricetin, ampelopsin (dihydromyricetin), and their sulfate metabolites with serum albumin, cytochrome P450 ( CYP2C9 , 2C19 , and 3A4 ) enzymes, and organic anion‐transporting polypeptides ( OATP1B1 and OATP2B1 )

Dombi, Á., Kaci, H., Valentová, K., Bakos, É., Özvegy‐Laczka, C., & Poór, M. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70021 · Cited by 7

Peptidomic Analysis of Potential Bioactive Peptides in Mare Milk Under Different Heat Treatment Conditions

Lou, X., Shao, W., Wu, Y., Ma, H., Chen, H., Zheng, N., & Zhao, Y. (2024) · Foods · doi:10.3390/foods13223592 · Cited by 7

Distribution Characteristics and Impacting Factors of Drug CYP Enzymes and Transporters in the Gastrointestinal Tract of Chinese Healthy Subjects

Zhang, M., Zhang, L., Suo, B., Wei, Y., Xu, Y., Jiang, M., Dong, J., Li, X., Song, Z., & Liu, D. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3497 · Cited by 7

Construction of complex three-dimensional vascularized liver tissue model in vitro based on a biphasic cell-laden embedding medium

Lv, W., Yu, H., Aazmi, A., Naren, T., Cheng, W., Yu, M., Wang, Z., Xu, X., Yang, H., & Ma, L. (2025) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ada836 · Cited by 10

Identification of the CYP gene family: insights into carotenoid metabolism associated with red shell in Meretrix meretrix

Shi, H., Fu, L., Dong, Y., Lin, Z., Xu, J., & Yao, H. (2025) · Aquaculture International · doi:10.1007/s10499-025-01934-9 · Cited by 7

Recent Advances in the Engineering of Cytochrome P450 Enzymes

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