Cytochrome P450 Enzymes and Drug Metabolism in Humans

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

Nelson, D. R., Koymans, L. M. H., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,946

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0637 · Cited by 2,356

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Conney, A. H. (1982) · PubMed · Cited by 1,557

Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects

Ingelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

Ingelman‐Sundberg, M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500285 · Cited by 1,111

Predicting in vivo drug interactions from in vitro drug discovery data

Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 910

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Palrasu, M., & Nagini, S. (2017) · Current Drug Targets · doi:10.2174/1389450118666170125144557 · Cited by 855

Inhibition and Induction of Cytochrome P450 and the Clinical Implications

Lin, J. H., & Lu, A. Y. H. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835050-00003 · Cited by 827

The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans

Danielson, B. S. P. P. B. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337054 · Cited by 775

Pharmacogenetics in Child and Adolescent Psychiatry: Background and Evidence-Based Clinical Applications

Malik, S., Verma, P., Ruaño, G., Siaghy, A. A., Dilawar, A., Bishop, J. R., Strawn, J. R., & Namerow, L. B. (2024) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2023.0074 · Cited by 4

Ethnic Aspects of Valproic Acid P-Oxidation

Shnayder, N. A., Владимировна, Г. В., Trefilova, V. V., Kissin, M. Y., Narodova, E. A., Петрова, М. М., Al-Zamil, M., Garganeeva, N. P., & Nasyrova, R. F. (2024) · Biomedicines · doi:10.3390/biomedicines12051036 · Cited by 4

Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes

Nkoy, F. L., Stone, B. L., Deering‐Rice, C. E., Zhu, A. W., Lamb, J. G., Rower, J. E., & Reilly, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126548 · Cited by 4

Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases

Shanbhag, A. P., & Bhowmik, P. (2024) · The Yale Journal of Biology and Medicine · doi:10.59249/vtbv6559 · Cited by 4

Comparative gene expression responses to Babesia infection and oil contamination in a seabird

Esperanza, C. W., Quock, R. C., Duerr, R. S., Roy, S. W., & Sehgal, R. N. M. (2024) · Frontiers in Conservation Science · doi:10.3389/fcosc.2024.1425484 · Cited by 4

Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells

Zhou, G., Shimura, T., Yoneima, T., Nagamachi, A., Kanai, A., Doi, K., & Sasatani, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810213 · Cited by 4

Responses in organs, sperm, steroid hormones and CYP450 enzyme in male mice treated by quinestrol only or in conjunction with clarithromycin

Ji, Y., Wang, Y., Liu, Y., Liu, Y., Qin, J., Yuan, D., & Liu, Q. (2024) · Scientific Reports · doi:10.1038/s41598-024-78752-1 · Cited by 4

Efficacy and in vitro pharmacological assessment of novel N -hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors

Woodson, M. E., Walden, H. F., Mottaleb, M. A., Makri, M., Prifti, G., Moianos, D., Pardali, V., Zoidis, G., & Tavis, J. E. (2024) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01455-24 · Cited by 4

Amino Acid Hepatotoxicity Biomarkers in Human Hepatic Organoids: Promising Standardization of Drug Toxicity Evaluation

Noh, H., Choi, S., Park, K. W., Lee, S., Seok, D. W., Kim, Y. E., Kwon, H., Kim, H., Park, H., Kim, T., et al. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00612 · Cited by 6

Pharmacokinetic Boosting of Calcineurin Inhibitors in Transplantation: Pros, Cons, and Perspectives

Pattanaik, S., & Monchaud, C. (2024) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000001288 · Cited by 4

Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer’s disease

Feng, X., & Zhao, S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1530046 · Cited by 4

Nanocomposite treatment of hospital wastewater; Prophylaxis toxicity in the freshwater crayfish muscles and hepatopancreas

Sabry, H. A., Salaah, S. M., El-Naggar, M. M., Ali, E. H. A., Khalil, T. M., Ibrahim, A. A. E.-M., & Mostafa, A. B. (2025) · Scientific African · doi:10.1016/j.sciaf.2025.e02567 · Cited by 4

Hepatic endoplasmic reticulum-derived nanodiscs for broad-spectrum drug detoxification

Sun, L., Feng, K., Bai, D., Yu, Y., Shen, W., Zhang, J. A., Fang, R. H., Gao, W., & Zhang, L. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123188 · Cited by 4

Role of Cytochromes P450 in Intestinal Barrier Function: Possible Involvement in the Pathogenesis of Leaky Gut Syndrome

Makaro, A., Kasprzak, Z., Jaczynska, M., Świerczyński, M., & Sałaga, M. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-08873-8 · Cited by 4

Oxidation of α-hydroxy acids by D-2-hydroxyglutarate dehydrogenase enzymes

Quaye, J. A., Moni, B. M., Kugblenu, J. E., & Gadda, G. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110355 · Cited by 4

Advancements in SGLT2 inhibitors: pharmacokinetics, pharmacodynamics, and clinical efficacy with a focus on pharmacogenomics

Bhagya, G., Namini, M. T., Girish, B. S., & Srinivasan, R. (2025) · Prospects in Pharmaceutical Sciences · doi:10.56782/pps.274 · Cited by 4

Association between CYP17A1 rs743572 polymorphism and cancer risk: A meta-analysis

Wang, B., Cao, Z., Li, Y., & Zou, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326843 · Cited by 4

Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor

Alsharidah, A. R., Alehaideb, Z., Alghamdi, S. S., Suliman, R. S., Althenayyan, S., Almourfi, F. M., Hazazi, B., Almogren, A., Tuwaijri, A. A., Boudjelal, M., et al. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04998-5 · Cited by 4

Analysis of immune characteristics and inflammatory mechanisms in COPD patients: a multi-layered study combining bulk and single-cell transcriptome analysis and machine learning

Wei, C., Zhu, Y., Chen, C., Li, F., & Li, Z. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1592802 · Cited by 4

Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism

Yuan, L., Li, X.-Y., Ni, J., Wang, J., Xu, X., Luo, J.-C., Zhou, Q., Hu, G., Cai, J., & Qian, J. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116653 · Cited by 4

Preparation and characterization of inclusion complexes of Nigella sativa seed oil with β-cyclodextrin: in vitro biological applications and in silico assessment

Amara, F. B., Jemli, S., Marques, H. M., Akermi, S., Ennouri, M., Smaoui, S., Mansour, R. B., & Béjar, S. (2024) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-024-06069-0 · Cited by 4

EpiMed Coronabank Chemical Collection: Compound selection, ADMET analysis, and utilisation in the context of potential SARS-CoV-2 antivirals

Pitsillou, E., Beh, R. C., Liang, J. J., Tang, T. S., Zhou, X. C., Siow, Y. Y., Ma, Y., Hu, Z., Wu, Z., Hung, A., et al. (2023) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2023.108602 · Cited by 4

Protein fusion strategies for a multi-component Rieske oxygenasePreprint

Runda, M. E., Miao, H., & Schmidt, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.09.598105 · Cited by 4

Considerations for drug–drug interactions between long-acting antiretrovirals and immunosuppressants for solid organ transplantation

Coppinger, C., & Anderson, P. L. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2448970 · Cited by 4

Novel Coumarin–Hydrazone Hybrids as Potential Antiplatelet Agents: Microwave‐Assisted Synthesis, Characterization, In Vitro and In Silico Biological Evaluations and Toxicity Assessment

Khdhiri, E., Haffouz, A., HadjKacem, B., Dhouib, I., Amor, I. B., Jerbi, A., Gargouri, J., Sahli, E., Abid, M., Allouche, N., et al. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500101 · Cited by 3

Review of pharmacology of medications during pregnancy

Pratt, C. L., & Hahn, N. M. (2025) · Seminars in Perinatology · doi:10.1016/j.semperi.2025.152073 · Cited by 3

Potential inhibitors of metalloproteinases (MMPs) and phospholipases from Nemopilema nomurai jellyfish peptides: An in-silico pharmacokinetics and molecular docking studies

Danso, B., Fengling, Y., Hua, X., Zhang, J., Chen, J., Yao, Y., Pozzolini, M., Wang, F., Liang, X., & Ruixue, H. (2025) · Toxicon · doi:10.1016/j.toxicon.2025.108421 · Cited by 3

Mechanism of Mn (II) oxidation by Bacillus altitudinis BYD19 under ofloxacin exposure: Insights from transcriptome and metabolomics

Yu, J., Xu, J., & Wang, H. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.117394 · Cited by 3

A reliable prognostic model for hepatocellular carcinoma using neutrophil extracellular traps and immune related genes

Yuan, D., Zhang, F., Lv, P., Zhu, J. W., Zhang, H., & Zhang, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-01335-1 · Cited by 3

General Approach To Access Aldehyde Oxidase Metabolites of Drug Molecules via N-Oxidation/Reissert–Henze-Type Reaction

Hanneman, C. M., Song, S., Onuska, N. P. R., Ruble, J. C., & Stahl, S. S. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c02063 · Cited by 3

Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function

Hüsken, S., Röder, A., Ptok, J., Meyer, A. E., Georg, M., Schwarz, Y., Roos, C., Mätz‐Rensing, K., Hutter, M. C., Floss, D. M., et al. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011750 · Cited by 4

Identification of key biomarkers and potential therapeutic drugs in nasopharyngeal carcinoma based on comprehensive bioinformatics analysis

Fu, C., Sun, L., Zhang, L., Zhou, T., & Bi, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-03047-4 · Cited by 3

Toward Precision Medicine: Molecular Biomarkers of Response to Tofacitinib in Inflammatory Bowel Disease

Bizjak, A., Gole, B., Jezernik, G., Potočnik, U., & Gorenjak, M. (2025) · Genes · doi:10.3390/genes16080908 · Cited by 3

Temporal changes of hepatic drug-metabolizing enzymes mediated by hepatic ischemia-reperfusion injury and the protective effect of Oridonin

Gu, T., Dai, F., Cai, M., Zhang, F., Xie, D., Jiang, H., Tian, L., Yan, L., Lan, W., Lv, H., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-06179-3 · Cited by 3

Relieving effect of an Maren-Zhizhu emulsion on loperamide hydrochloride-induced constipation in mice and its effects on the gut microbiota

Han, X., Chai, Y., Li, N., Li, C., Yao, F., Huang, Q., Weng, L., Qiu, Z., & Jia, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1641367 · Cited by 3

Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions using RNAscope combined with immunofluorescence

Jin, J., Tawfik, S. M., Nguyen, L. T. G., Armanios, B., & Zhong, X. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100123 · Cited by 3

GenoStaR : An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes

Coulter, A. J., Thamilselvan, M., Kennedy, J. L., Zai, C. C. H., & Tiwari, A. K. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.70059 · Cited by 3

Design of Novel PI3Kα Inhibitors by Combining 3D-QSAR, ADMET Screening, Molecular Docking, and Molecular Dynamics Simulations

Wang, M., Liu, X., Chen, X., Li, J., Liu, R., Zou, L., Yang, W., He, Y., & Shu, M. (2025) · Chemistry Africa · doi:10.1007/s42250-025-01398-7 · Cited by 3

Proteome mining of Yersinia Enterocolitica for drug targets and computational inhibitor identification with ADMET, anti-inflammation potential and formulation characteristics

Basharat, Z., Alghamdi, Y. S., Mashraqi, M. M., Ogaly, H. A., Al‐Zahrani, F. A. M., Wei, C. R., Ahmed, I., & Kim, S. (2025) · BioData Mining · doi:10.1186/s13040-025-00482-5 · Cited by 3

Changes in cultivation parameters impact cytochrome P450 gene transcription in HepaRG cells: implications for in vitro toxicological assessments

Jochum, K., Städele, V., & Marx‐Stoelting, P. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1690384 · Cited by 3

Unraveling the Role of CYP2E1 in Antitubercular Drug–Induced Hepatotoxicity: From Molecular Mechanisms to Clinical Implications

Bishnu, D., Santra, S., Purkait, S., & Santra, A. K. (2025) · International Journal of Hepatology · doi:10.1155/ijh/9980298 · Cited by 5

Dicarboxylate and dicarboxylic acid appended supramolecular self-associating amphiphiles as antimicrobial agents against high priority bacterial pathogens

White, L. J., Streather, B. R., Sutton, J. M., Rankin, J., Baker, J., Bennett, C., Wilson, H. B., Hind, C. K., & Hiscock, J. R. (2025) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob01615k · Cited by 3

Identification of potential novel aromatase inhibitors as therapeutic strategies against breast cancer: insight into molecular docking, MD simulations and ADMET profiling

Ojedele, O. A., Hamdi, N., Mughram, M. H. A., Alyami, E. M., Dauelbait, M., & Almohammed, O. A. (2025) · BMC Cancer · doi:10.1186/s12885-025-15321-3 · Cited by 3

Mass spectrometry footprinting reveals microsomal CYP2A6 structural changes induced by interaction with its reductase flavin mononucleotide domain

Chai, M., Burris‐Hiday, S. D., Rempel, D. L., Gross, M. L., & Scott, E. E. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100210 · Cited by 3

Anesthetic-induced epigenetic alterations: mechanisms and long-term clinical implications

Delshad, E. S., Shamsi, A., Mohseni, M. M., Abak, N., & Saberian, M. (2025) · Epigenetics · doi:10.1080/15592294.2025.2599650 · Cited by 4

Computational identification of Azadirachta indica compounds targeting trypanothione reductase in Leishmania infantum

Onile, O. S., Samuel, O., Ignatius, F. A., Onile, T. A., Abdul, M., Oladipo, E. K., Esther, A. T., Omotara, R., Nour, H., & Chtita, S. (2025) · Bioinformatics Advances · doi:10.1093/bioadv/vbaf318 · Cited by 3

Human CYP2C9 Metabolism of Organophosphorus Pesticides and Nerve Agent Surrogates

Shriwas, P., Noonchester, A., Revnew, A., Lane, T. R., Hadad, C. M., Ekins, S., & McElroy, C. A. (2025) · Journal of Xenobiotics · doi:10.3390/jox16010001 · Cited by 3

Pyrimidine Derivative as Anti-Liver Cancer Agent against EGFR Kinase Mutant T790M/L858R: A Comprehensive In-silico Approach

Roney, M., Issahaku, A. R., Uddin, M. N., Akter, M., Anke, W., & Aluwi, M. F. F. M. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10258-3 · Cited by 3

Clinical Study to Evaluate Drug Interactions of Cannabidiol with Citalopram and Morphine in Healthy Adults

Salcedo, P. A., Volpe, D. A., Chaturbedi, A., Shah, A., Krishna, A., Hyland, P. L., Vegesna, G., Hsiao, C., Palma, R. M. D., Fein, M., et al. (2026) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.70219 · Cited by 3

Cancer Comorbidities: Clinical Impacts, Mechanistic Insights, and Management Strategies

Peng, T., Chen, S., He, X., Yang, Y., Ren, Y., Sun, Y., Shi, F., Lv, Y., Wen, X., Wen, Y., et al. (2026) · MedComm – Oncology · doi:10.1002/mog2.70052 · Cited by 3

PDA in Prematurity: Rethinking a Decades-Old Debate in 2026

Plessas-Azurduy, P., Lapointe, A., Spénard, S., Shalish, W., Beltempo, M., SantʼAnna, G., & Altit, G. (2026) · Biomedicines · doi:10.3390/biomedicines14030576 · Cited by 3

Integrative Molecular Insights Into Epidemiological, Genetic, and Metabolic Risk Factors of Gallbladder Cancer: Implications for Biomarkers, Therapeutic Targeting, and Future Perspectives

Jaiswar, D., Jeeyar, V., Choudhury, S., & Dixit, M. (2026) · Cancer Control · doi:10.1177/10732748261433619 · Cited by 4

Multitarget mechanisms and clinical integration of traditional Chinese medicine in breast cancer

Wang, Y., Liu, H., Dai, S., Sun, W., & Ren, N. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158090 · Cited by 3

Enhancing Therapeutic Efficacy Through Tailored Pharmacokinetics: A Review of Mesoporous Silica Nanoparticle-Based Delivery Systems

Aulifa, D. L., Maharani, A., Purnomo, K., Salsabilla, R., Fahlevi, Z., Pramudita, F. W., Wibisono, T., Amaliah, S., Subra, L., & Budiman, A. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s604271 · Cited by 3

Enantiomer-specific burden of metalaxyl and myclobutanil in non-occupationally exposed population with evidence from dietary intake and urinary excretion

Ding, J., Sun, Y., Mortimer, M., Guo, L., & Yang, F. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115623 · Cited by 3

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

Ferreira, M. C., Crispim, A. D. E., Aguiar, A., Lopes, A. J. S. B., & Corrêa-Barbosa, J. (2024) · Research Society and Development · doi:10.33448/rsd-v13i5.45556 · Cited by 3

Production of 17α-hydroxyprogesterone using an engineered biocatalyst with efficient electron transfer and improved 5-aminolevulinic acid synthesis coupled with a P450 hydroxylase

Li, J., Gao, J., Ai, J., Yin, Z., Lu, F., Qin, H., & Mao, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132831 · Cited by 3

Drug Disposition in Neonatal Göttingen Minipigs: Exploring Effects of Perinatal Asphyxia and Therapeutic Hypothermia

Stroe, M., Huang, M., Annaert, P., Leys, K., Smits, A., Allegaert, K., Bockstal, L. V., Valenzuela, A., Ayuso, M., Ginneken, C. J. V., et al. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001677 · Cited by 3

Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia

Herqash, R. N., Alanzi, A. R., Ahamad, S. R., Rehman, M. T., Alharbi, M. S., Alsufyani, S. A., Al-Mishari, A. A., & Alqahtani, A. S. (2024) · Open Chemistry · doi:10.1515/chem-2024-0063 · Cited by 3

Electrochemical Probing of Human Liver Subcellular S9 Fractions for Drug Metabolite Synthesis

Medina, D., Omanakuttan, B., Nguyen, R., Alwarsh, E., & Walgama, C. T. (2024) · Metabolites · doi:10.3390/metabo14080429 · Cited by 3

Computational exploration and molecular dynamic simulation for the discovery of antiviral agents targeting Newcastle disease virus

Ali, I. F. M., Haq, I. U., Akbar, N. I., Iqbal, M. N., Rahim, K., Khan, A. A., Alanazi, A. M., & Rasheed, M. A. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106884 · Cited by 3

Mitigating CYP3A4-mediated aflatoxin toxicity with algal-derived Sodium Copper Chlorophyllin: Production and In-silico insights

Mishra, M., Gupta, D., Preeti, & Deb, D. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135594 · Cited by 3

Bioefficacy, chromatographic profiling and drug-likeness analysis of flavonoids and terpenoids as potential inhibitors of H1N1 influenza viral proteins

Libin, K. V., Debnath, M., Sisodiya, S., Rathod, S. B., Prajapati, P. B., Lisina, K. V., Bhuyan, R., & Evanjelene, V. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136125 · Cited by 3

Notable drug-drug interaction between omeprazole and voriconazole in CYP2C19 *1 and *2 (rs4244285, 681G>A) alleles in vitro

Li, X. (2024) · Xenobiotica · doi:10.1080/00498254.2024.2421513 · Cited by 3

The regulatory role of mitotic catastrophe in hepatocellular carcinoma drug resistance mechanisms and its therapeutic potential

Li, J., Cheng, X., Huang, D., & Cui, R. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117598 · Cited by 3

Cytochrome P450-mediated carbon-carbon bond formation in drug metabolism

Liu, J., & Zhang, D. (2025) · Drug Metabolism Reviews · doi:10.1080/03602532.2025.2451847 · Cited by 3

Strategies to Enhance Protein Delivery

Zhu, Y., Zhuang, W., & Cheng, H. (2025) · Langmuir · doi:10.1021/acs.langmuir.4c04636 · Cited by 4

Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation

Ngan, D. K., Sakamuru, S., Zhao, J., Xia, M., Ferguson, S., Reif, D. M., Simeonov, A. M., & Huang, R. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117315 · Cited by 3

Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults

Buelow, A. A., Matney, J., Skillett, S. M., Ashley, J., Song, J., Mixon, C., Fakhrabadi, A. A., Stanford, M. D., Bemben, D. A., Larson, D. J., et al. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00173.2024 · Cited by 3

Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practices

Zhou, W., Zeng, J., Zhang, L., Zhang, J., Deng, Y., Zhang, Q., Deng, H., Wang, J., Zhao, H., Zhang, C., et al. (2025) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2025-0186 · Cited by 3

Synthesis of new imidazolidine derivatives: Characterization, anti-cancer potential and molecular docking

Slimani, I., Karcı, H., Dündar, M., Üstün, E., Özdemir, İ., Gürbüz, N., Koç, A., & Özdemir, İ. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.142887 · Cited by 3

Molecular docking study and pharmacokinetic insights of rifampicin in pure and capsule dosage forms

Alassaf, N. A., Hamody, A. S., Jabir, M. S., Ghotekar, S. K., & Swelum, A. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-06720-4 · Cited by 3

Substituted 1,4-naphthoquinones for potential anticancer therapeutics: In vitro cytotoxic effects and QSAR-guided design of new analogs

Prachayasittikul, V., Mandi, P., Pingaew, R., Prachayasittikul, S., Ruchirawat, S., & Prachayasittikul, V. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.07.040 · Cited by 4

CYP2S1 Knockout Promotes Intestinal Tumor Growth in APCMin/+ Mice and Its Clinical Significance

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Aluri, K. C., Slavsky, M., Tan, Y., Whitcher‐Johnstone, A., Zhang, Z., Hariparsad, N., & Ramsden, D. (2024) · Clinical and Translational Science · doi:10.1111/cts.13746 · Cited by 3

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Rajan, R. K., Maida Engels, S. E., & Ramanathan, M. (2024) · In Silico Pharmacology · doi:10.1007/s40203-024-00228-x · Cited by 3

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Shumyantseva, V. V., Berezhnova, A. V., Agafonova, L. E., Bulko, T. V., & Veselovsky, A. V. (2024) · Journal of Analytical Chemistry · doi:10.1134/s1061934824700254 · Cited by 3

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Shahbar, A. N., Katlan, D. A., Almutairy, R., & Alnoamy, Y. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-0675-8.ch003 · Cited by 3

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Reyes, E. R., Herrera, J., Cuétara-Lugo, E., Shkedy, Z., Valkenborg, D., Perez-Novo, C. A., Fernández, G., Pérez, I. G., Fernández-Pérez, M. D., Vandenberghe, W., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1467036 · Cited by 3

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Song, Y., Li, C., Liu, G., Liu, R., Chen, Y., Li, W., Cao, Z., Zhao, B., Lu, C. C., & Liu, Y. (2021) · Clinical Pharmacokinetics · doi:10.1007/s40262-021-01001-5 · Cited by 115