Cytochrome P450 Enzymes and Drug Metabolism in Humans

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

Nelson, D. R., Koymans, L. M. H., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,946

Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0637 · Cited by 2,356

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Conney, A. H. (1982) · PubMed · Cited by 1,557

Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects

Ingelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

Ingelman‐Sundberg, M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500285 · Cited by 1,111

Predicting in vivo drug interactions from in vitro drug discovery data

Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 910

Cytochrome P450 Structure, Function and Clinical Significance: A Review

Palrasu, M., & Nagini, S. (2017) · Current Drug Targets · doi:10.2174/1389450118666170125144557 · Cited by 855

Inhibition and Induction of Cytochrome P450 and the Clinical Implications

Lin, J. H., & Lu, A. Y. H. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835050-00003 · Cited by 827

The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans

Danielson, B. S. P. P. B. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337054 · Cited by 775

In silico studies, synthesis, and biological evaluation of novel imidazopyridine-based CYP4Z1 inhibitors targeting breast cancer stem cells

Lu, Y., Chen, K., Wang, H., Zhang, C., Huang, X., Wang, Z., Chen, H., Niu, M., Yao, H., Zheng, L., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118917 · Cited by 1

Comprehensive Review on the Toxicity of Five Main AQ Constituents from Rhubarb: Mechanisms, Challenges and Future Perspectives

Yu, L., Jiang, Y., Li, P., Wang, J., Tang, P., & Zhao, Y. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s600863 · Cited by 1

Sex-Biased Pharmacotherapeutic Disparities in Hypertension

Yaacoub, S., Bardawil, C. E., Yammine, R., Dakroub, A. H., & Eid, A. H. (2026) · Drugs · doi:10.1007/s40265-026-02326-w · Cited by 1

Integrating CRISPR functional genomics with admixture-aware psychotropic pharmacogenetics in Brazil

Rodrigues, B. B., Bittencourt, J. C., dos Santos, V. G. M., Costamilan, C. A. D. V. L.-R., & Herkenhoff, M. E. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1730641 · Cited by 2

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Prakongsup, P., & Udomsinprasert, W. (2026) · Clinical and Translational Science · doi:10.1111/cts.70628 · Cited by 1

In Silico Design of Pyrimidine Derivatives as Potential α-Glucosidase Inhibitors: QSAR, Molecular Docking, ADMET, and Molecular Dynamics Studies

Abchır, O., Rossafi, B., Bouribab, A., Es‐Sounni, B., Touti, R., Yamari, I., Samadi, A., & Chtita, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135696 · Cited by 1

Novel Inhibitors Targeting Urease Promote Fungicidal and Antivirulence Effects in Cryptococcus

Barreto, T. L., Costa, N. E. M., Freire, N. M. L., de Almeida, L. C., Miguel, R. D. A., Costa-Lotufo, L. V., Silva-Rodrigues, G., da Silva, C. M., de Aquino, T. M., Alberto, E. E., et al. (2026) · ACS Omega · doi:10.1021/acsomega.6c03740 · Cited by 1

A Critical Review of Cytochrome P450 Enzyme Inhibition by Herbal Phytochemicals: Implications for Drug Interaction Prediction and Herbal Safety

Li, Y., Gan, L., Wu, Y. J., Liu, Y., Zhang, N., Jiang, T., Chen, J., Liu, F., Peng, D., & Liu, Y. (2026) · Phytotherapy Research · doi:10.1002/ptr.70414 · Cited by 1

Interactions between cytochrome P450 enzymes and traditional Chinese herbs: A comprehensive review

Hsieh, Y.-H., & Huang, S. (2026) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000001404 · Cited by 1

Discovery of novel anti- Toxoplasma gondii agent derived from thiazolidinone–isatin hybrids: synthesis, biological assessment, and computational modeling

Sabt, A., Furlan, V., Srour, A. M., Chyb, M., Farag, H., Saleh, A., Kasai, Y., Imagawa, H., Gatkowska, J. M., Elshamy, A. I., et al. (2026) · RSC Advances · doi:10.1039/d6ra04647a · Cited by 1

Developmental neurotoxicity of atrazine: decreased synaptic spine density and miRNA-driven GluN2A downregulation in primary hippocampal neurons

Serafini, M. M., Graziosi, A., Midali, M., Ghelli, L., Grumelli, G., Sita, G., Corsini, E., Marinovich, M., Morroni, F., & Viviani, B. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04490-0 · Cited by 1

The CYP1A-HSF1 axis alleviates mitochondrial oxidative stress to limit HBO-induced lung endothelial barrier damage

Huang, J.-Q., Wang, P.-X., Zhang, X.-Y., You, Y.-T., Zhan, J., Xu, D.-H., Liu, Y., Zhu, X., & Bao, X. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104308 · Cited by 1

Endogenous biomarkers for assessing CYP3A4 and CYP2D6 activity: A critical review

Parab, S., Shaik, I. H., & Venkataramanan, R. (2026) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2026.100374 · Cited by 1

Targeting Mutant Phenylalanine Hydroxylase With Pyrimidine–Triazole Conjugates: A Primary Framework for Candidate Chaperone‐Based Strategies in Phenylketonuria

Chaturvedi, S., Mishra, S., Pandya, N., Kumar, S., Negi, R., Singh, S., Patel, Y., Tiwari, S., Patel, A., Gupta, R., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202600321r · Cited by 1

Gut Microbiota Alter Colonic Expression of Genes Encoding Drug Transporters and Drug-Metabolizing Enzymes in Mice

Nelson, D. A., Veerareddy, V., Tang, X., Kashyap, P., Kalari, K. R., & Kandimalla, K. K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177583 · Cited by 1

Drug Repurposing Potential of Natural Products: Molecular Targets, Pharmacological Profiles, and Precision Therapeutic Strategies: A Narrative Review

khaliq, M., Aftab, K., Ikhlaq, A., & Ahmed, A. (2026) · Journal of Biomolecules Pathogenesis and Therapeutics · doi:10.68041/jbpt.v2i3/09 · Cited by 1

Pharmacogenomics: an opportunity for safer and efficient pharmacotherapy

Montes, G. C., de Bem, G. F., & Fontes-Dantas, F. L. (2022) · Research Society and Development · doi:10.33448/rsd-v11i17.38884 · Cited by 1

Frequencies of Combined Dysfunction of Cytochromes P450 2C9, 2C19, and 2D6 in an Italian Cohort: Suggestions for a More Appropriate Medication Prescribing Process

Gentile, G., Luca, O. D., CASALE, A. D., Salerno, G., Simmaco, M., & Borro, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612696 · Cited by 1

Quercetin Simultaneously Inhibited Cytochrome P450 and P-Glycoprotein to Improve the Pharmacokinetics of Osthole in Rat Plasma

Huang, M., Wu, F., Zuo, X., Liu, J., Yu, W., Xie, R., Liu, G., Tan, Q., Wang, Q., & Liang, Y. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00487-3 · Cited by 1

Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis

Kawashima, A., Uramaru, N., Mikuma, T., Osabe, M., & Higuchi, T. (2023) · Fundamental Toxicological Sciences · doi:10.2131/fts.10.265 · Cited by 1

Structure–activity relationships and interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm

Thabet, R. H., Alshar, B. O. S., Alabdallah, D. H. S., Alhmoud, N. A. Z. A., Alslameen, S. T. A., & Thabet, Y. R. H. (2023) · Journal of International Medical Research · doi:10.1177/03000605231214065 · Cited by 1

Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis: A Clinical Study

Thanoon, A., & Al-Mashhadane, F. (2024) · Pharmacognosy Journal · doi:10.5530/pj.2023.15.202 · Cited by 1

Importance of genotyping and phenotyping of CYP450 isoenzymes in the treatment of psychiatric disorders

Socha, J., Kuczyńska, J., & Mierzejewski, P. (2023) · Pharmacotherapy in Psychiatry and Neurology · doi:10.5114/fpn.2023.129294 · Cited by 1

Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice

Jarrar, Y. B., Ashour, W., Madani, A., Jarrar, Q., Abulebdah, D., Jamous, Y. F., Labban, S. Y., & Tazkarji, M. (2024) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2023-0250 · Cited by 1

Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes

Iqbal, H., Ilyas, K., Akash, M. S. H., Rehman, K., Hussain, A., & Iqbal, J. (2024) · RSC Advances · doi:10.1039/d4ra00127c · Cited by 1

Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model

Muthumula, C. M. R., Khare, S., Jog, R., Wickramaratne, B., Lee, A., Chakder, S., Burgess, D. J., & Gokulan, K. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100254 · Cited by 1

Association of Pharmacogenomic Phenotypes in CYP2D6 , CYP2C9 , CYP2C19 , and CYP3A5 on Polypharmacy in Veterans

Krulikas, L. J., Bates, J. S., Chanfreau, C., Coleman, H., Dalton, S., & Voora, D. (2024) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.3297 · Cited by 1

Theoretical Investigation and Design of Bioactive Quinoline Derivatives as Inhibitors of DNA Gyrase of Salmonella typhi

Ameji, P. J., Uzairu, A., Shallangwa, G. A., & Uba, S. (2024) · Malaysian Journal of Pharmaceutical Sciences · doi:10.21315/mjps2024.22.1.1 · Cited by 1

Deciphering COPS5 influence on immune infiltration and prognosis in head and neck squamous cell carcinoma

Wan, Y., Wang, D., Yang, G. F., Liu, G., & Pan, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33553 · Cited by 1

Study on Cytochrome P450 Metabolic Profile of Paclitaxel on Rats using QTOF-MS

Meng, Z., Chen, J., Xu, L., Xiao, X., Zong, L., Han, Y., & Jiang, B. (2024) · Current Drug Metabolism · doi:10.2174/0113892002308509240711100502 · Cited by 1

Potential New Drug Targets Modulating the Environmentally-Induced Oxidative Stress in the Cardiovascular System

Đurašević, S., Zdravkovic, M. D., Nikolić, V., & Todorović, Z. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-62806-1_21 · Cited by 1

Cheminformatics approaches to predict the bioactivity and to discover the pharmacophoric traits crucial to block NF-κB

Jawarkar, R. D., Mali, S. N., Ingle, R. G., Al‐Hussain, S. A., Al‐Mutairi, A. A., Deshmukh, P., & Zaki, M. E. A. (2024) · Chemical Physics Impact · doi:10.1016/j.chphi.2024.100720 · Cited by 1

Assessment and monitoring of leather effluent discharge from Dewas and Ranipet and their computational approach

Sharma, N., & Vuppu, S. (2024) · Environmental Monitoring and Assessment · doi:10.1007/s10661-024-13074-3 · Cited by 1

Optimizing therapeutics: A novel mutual prodrug of ketoprofen and Chlorzoxazone for enhanced efficacy and safety

Salve, K. S., Bhatia, N. M., & Nadaf, D. S. (2024) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2024.101471 · Cited by 1

Effect of glucose selenol on hepatic lipid metabolism disorder induced by heavy metal cadmium in male rats

Yang, X., Huang, J., Wang, J., Sun, H., Li, J., Li, S., Tang, Y.-E., Wang, Z., & Song, Q. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2024.159589 · Cited by 1

The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients

Elderdery, A. Y., Idris, H. M. E., Alruwaili, S. N. L., Atebien, E. M., Alsrhani, A., Alenazy, F. O., Alzahrani, B., Manni, E., Elkhalifa, A. M. E., & Mills, J. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413493 · Cited by 1

The Use of Haloperidol as a Sedative During Childbirth: An Extreme Form of Obstetric Violence in Spain

Fernández, I. O., Quintela, O., & García-Martínez, A. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22010003 · Cited by 1

Identification of ketamine and norketamine in dried bloodstains on crime-scene surfaces

Nathan, R., Okeleye, B., Abdullahi, R., & Oyebode, W. (2025) · Egyptian Journal of Forensic Sciences · doi:10.1186/s41935-024-00418-w · Cited by 1

Omics Approaches to Drug and Drug-Non-Drug Interactions

Reis, Â. A. D. S., & Santos, R. D. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-80107-5_10 · Cited by 1

Development of human embryonic stem cell-derived cardiomyocytes and application of fluorescence probe substrate for characterization of cytochrome P450 enzyme 2J2

Zhu, X., Soh, Y. K., Wan, M., Pang, J. K. S., Leow, W. L., Tian, C., Soh, B.-S., & Chan, E. C. Y. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100053 · Cited by 1

Pharmacokinetics in paramedic practice

Snary, A., & Webster, C. A. (2025) · Journal of Paramedic Practice · doi:10.12968/jpar.2025.0003 · Cited by 1

Regulation of immune-mediated chemoresistance in cancer by lncRNAs: an in-depth review of signaling pathways

Jasim, S. A., Altalbawy, F. M. A., Uthirapathy, S., Bishoyi, A. K., Ballal, S., Singh, A., Devi, A., Yumashev, A. V., Mustafa, Y. F., & Abosaoda, M. K. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04081-3 · Cited by 1

In silico modeling of zerumbone as a multi-target therapeutic for lung disorders with experimental characterization of its purity and thermal stability

Elsayed, N. (2025) · Results in Chemistry · doi:10.1016/j.rechem.2025.102472 · Cited by 1

Ligand-based virtual screening and QSAR modelling for the discovery of potent SmHDAC8 inhibitors

Ja’afaru, S. C., Uzairu, A., da Costa, R. A., Sallau, M. S., & Ibrahim, M. T. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100044 · Cited by 2

Comprehensive evaluation of potential EBOV inhibitors using advanced molecular modeling techniques: implications for anti-Ebola therapeutics and rational drug design

Morais, G. C. D. F., Sena, C. P. D. S., Silva, G. V. R., Alves, G. B., Vieira, D. S., Akash, S., Aktaruzzaman, M., Al-Dies, A.-A. M., Fulco, U. L., & Oliveira, J. I. N. (2025) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-025-00902-7 · Cited by 1

Evolving Landscape of Parenteral Anticancer Therapy–Associated Lung Toxicity: Incidence, Monitoring, and Management

White, O., Burke, C. C., Jilek, B., Qi, X., Hartnett‐Quach, D., Zacholski, K., & Cuéllar, S. (2025) · JCO oncology advances. · doi:10.1200/oa-25-00105 · Cited by 2

Splice Variants of mRNA of Cytochrome P450 Genes: Analysis by the Nanopore Sequencing Method in Human Liver Tissue and HepG2 Cell Line

Deynichenko, K. A., Ptitsyn, K. G., Radko, S. P., Kurbatov, L. K., Vakhrushev, I. V., Buromski, I. V., Markin, S. S., Archakov, A. I., Lisitsa, A., & Ponomarenko, E. A. (2022) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750822040047 · Cited by 1

La escuela en el medio rural: crónica y alternativas para la reconstrucción de una identidad en crisis

Gómez, J. A. C. (1998) · Aula de innovación educativa · Cited by 1

PDB‐REDO in Computational‐Aided Drug Design ( CADD )

de Vries, I., Anastassis Perrakis, A., & Joosten, R. P. (2023) · Methods and principles in medicinal chemistry · doi:10.1002/9783527830497.ch7 · Cited by 1

Pharmacogenomics: A gateway to personalized medicine

Cacabelos, R. (2024) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2023.11.005 · Cited by 1

Profiling the organ membrane proteome dysregulation in the context of liver diseasePreprint

Antony, F., Brough, Z., Orangi, M., Aoki, H., Babu, M., & Duong, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.05.588300 · Cited by 1

Repurpose Macelignan as a Potential Drug candidate for Alzheimer’s disease: In-Silico StudyPreprint

Pradhan, R., Shrestha, A., Upadhyaya, S. R., Khatiwada, R., Chauhan, J., Poudel, P., Sharma, K. R., & Parajuli, N. (2024) · Research Square · doi:10.21203/rs.3.rs-4720869/v1 · Cited by 1

Introduction to Clinical Pharmacokinetics

Mahalakshmi, P. S., Peeriga, R., Chukka, K., & Vankadharu, N. D. S. S. (2024) · Springer eBooks · doi:10.1007/978-981-97-4283-7_1 · Cited by 1

Development of Clinically Viable Non-Muscle Myosin II Small Molecule Inhibitors with Broad Therapeutic PotentialPreprint

Radnai, L., Young, E. J., Kikuti, C. M., Hafenbreidel, M., Stremel, R. F., Li, L., Toth, K., Pasetto, P., Jin, X., Patel, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.07.617018 · Cited by 1

Therapeutic Drug Monitoring in Special Populations

Akingbasote, J. A., Szlapinski, S. K., Hilmas, E., Weston, K., Wu, Y., & Burton, A. (2025) · Wiley eBooks · doi:10.1002/9781394251315.ch4 · Cited by 1

Phytochemical and Pharmacokinetic Evaluation of Humboldtia sanjappae: LC-MS/MS Profiling, ADMET Predictions, and In Vivo Toxicity AssessmentPreprint

Sidhic, J., Singh, M. T., Sarbadhikary, P., Arunaksharan, N., T, S. C., Krishnamurthy, P. T., Abrahamse, H., George, S., & George, B. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5476342 · Cited by 1

Review article

Manwatkar, S. (2022) · International Journal of Health Sciences · doi:10.53730/ijhs.v6ns1.6880

Identification of aerobic glycolysis-related prognosis signature for predicting overall survival of patients with hepatocellular carcinomaPreprint

Deng, J., Wu, Y., Yang, B., Chen, Z. J., Xu, S., Cheng, Y., & Zhu, C. (2022) · Research Square · doi:10.21203/rs.3.rs-2255839/v1

A A Review on the Potential of Application of CRISPR/Cas9 Technology in CYP3A4 and CYP2D6 Genes: A Way to Move Forward in Identifying New Drug Targets

Hatta, F. H. M., Othman, A. A., Yusoff, R. M., Azam, S. N. N., & Hassan, A. Z. A. (2022) · ASM Science Journal · doi:10.32802/asmscj.2022.999

Genetic Polymorphism of CYP2C19 in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention (PCI) in Erbil

Jalal, R. N., & Dizaye, K. F. (2022) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2022.13.04.046

Common Approaches of Cytochrome P450 (CYP) Induction Assays

Ghosh, R., Nayan, M. I. H., Mitu, M. M., & Nandi, T. (2023) · International Blood Research & Reviews · doi:10.9734/ibrr/2023/v14i1297

Basic Aspects and the Overview on Pharmacokinetics and Studies on Drug Distribution- A Panoramic Review

Dudhat, K. R. (2022) · Bioequivalence & Bioavailability International Journal · doi:10.23880/beba-16000177

Environnement et santé publique

Noisel, N., Bonvallot, N., & Coumoul, X. (2023) · Presses de l’EHESP eBooks · doi:10.3917/ehesp.goupi.2023.01.0277 · Cited by 1

Diverse Plant-Parasitic Nematodes are Selectively Killed by Oxadiazole Thioether Pro-NematicidesPreprint

Knox, J. J., Burns, A. R., Cooke, B., Cammalleri, S. R., Kitner, M., Ching, J., Castelli, J. M. P., Puumala, E., Snider, J. D., Koury, E. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.14.557801

Managing nirmatrelvir/ritonavir (Paxlovid) interactions in general practice

Mirowska-Guzel, D. M., Niedzielko, M., & Kułakowski, R. (2023) · Family Medicine & Primary Care Review · doi:10.5114/fmpcr.2023.130097

Pyrenyl Nanocarbon Electrodes: Liver Microsomal and Cytochrome P450 Bactosomal Prodrug AssaysPreprint

Premaratne, G., Niroula, J., Moulton, J. T., & Krishnan, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4594897

Self-sufficient P450-reductase chimeras for biocatalysis

Stout, C. N., & Renata, H. (2023) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.09.010

Importance of cytochrome 3A4 and 2D6-mediated drug–drug interactions in oxycodone consumption among older adults hospitalized for hip fracture: a cross-sectional study

Decaix, T., Gautier, S., Royer, L., Laprévôte, O., Tritz, T., Siguret, V., Teillet, L., Sellier, C., & Pépin, M. (2023) · Aging Clinical and Experimental Research · doi:10.1007/s40520-023-02569-7

Distribution of Pyrethroids and Piperonyl Butoxide in Foods and Feeds Analysed with GC-MS/MS in 2022–2023

Borjan, N., Simunović, S., Stefanović, S. M., Petrović, Ž., Đinović-Stojanović, J., Jelušić, V., & Janković, S. (2023) · Meat Technology · doi:10.18485/meattech.2023.64.2.72

Special Issue of “Synthesis, Biological Evaluation and Molecular Modeling of Enzyme Inhibitors”

Mikstacka, R., Dutkiewicz, Z., & Wierzchowski, M. (2023) · Processes · doi:10.3390/pr11113128

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptationPreprint

Coleman, O. I., Sorbie, A., Riva, A., von Stern, M., Kuhls, S., Selegato, D. M., Köhler, N., Wirbel, J., Kacprowski, T., Dunkel, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.03.565267

Molecular Docking-Guided Insights into Lupeol and its Optimized Geometry's Influence on Binding Affinity to Serum Albumin (1AO6) and Mu Opioid Receptor (6DDF) for Enhanced Drug Delivery and Cancer Pain ManagementPreprint

Bako, B., Shinggu, J. P., Samuel, H. S., Ojedotun, O., & Etim, E. E. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4637582

Quit Attempts Among Smokers and its Association with CYP2A6 (rs56113850) Polymorphisms

Aldrin Joshua, A., Leelavathi, L., Vijayashree-Priyadarshini, J., Anitha, P., & Rajesh Kumar, S. (2023) · Journal of Pioneering Medical Science · doi:10.61091/jpms202312210

STATE OF THE XENOBIOTICS BIOTRANSFORMATION SYSTEM IN THE LIVER MICROSOMAL FRACTION OF RATS UNDER THE EFFECTS OF SODIUM BENZOATE AND ASCORBIC ACID

Kеtsa, О. V., & Marchenko, M. M. (2023) · Biolohichni systemy · doi:10.31861/biosystems2023.02.090

Genetic Polymorphisms in CYP2 Gene Family in Bulgarian Individuals and their Clinical Implications

Yovinska, S., Bakalov, D., Mihova, K. Y., Kamenarova, K., Kaneva, R. P., Nikolov, R. P., & Dimova, I. I. (2024) · Acta Medica Bulgarica · doi:10.2478/amb-2024-0001

Embryonic Exposure to Flubendiamide Impacts Hepatic Structure and Function in Newborn Domestic ChicksPreprint

Danes, D., Pillai, L., Singh, A., Vaishnav, J., & Balakrishnan, S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4765738

Unraveling the Genetic Interplay and Therapeutic Potentials between Major Depressive Disorder and Metabolic Syndrome: Multi-Ancestry and Multi-Trait Genome-Wide Association AnalysesPreprint

Feng, Y., Jia, N., Gu, X., Xiao, C., & Shen, J. (2024) · Research Square · doi:10.21203/rs.3.rs-4193051/v1

Transcriptome revealed the role of autophagy in nitrite oxidative stress of Penaeus vannameiPreprint

Lin, X., Liu, Z., Chen, J., Dong, B., & Liang, Q. (2024) · Research Square · doi:10.21203/rs.3.rs-4236334/v1

Exploring some substituted chalcones as DprE1 inhibitors for antitubercular activity: An integrated computational approachPreprint

Amengor, C. D. K., Biniyam, P. D., Gyan, P., Kekessie, F. K., & Harley, B. K. (2024) · Research Square · doi:10.21203/rs.3.rs-4259865/v1

Smoking may increase the usage of antidepressant: evidence from genomic perspective analysis

Qu, Y., Du, Z., Shen, Y., Zhou, Q., Zhou, Z., Jiang, Y., & Zhu, H. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01802-2

Total Synthesis Facilitates in vitro Reconstitution of SgvP, the C–S Bond Forming P450 in Griseoviridin BiosynthesisPreprint

Stout, C. N., & Renata, H. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-jt6g5

The Application of Targeted Sequencing Technology in Clinical Practice

刘, 金. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1451482

Metabolomic analysis of swainsonine poisoning in renal tubular epithelial cells

Zhang, S., Zhang, Y., Yin, H., Liu, Y., Tang, L., Zhu, Y., Sun, P., Wu, K., Zhao, B., & Lu, H. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1387853

Omics Sciences in Drug Discovery, Safety, and Pharmacokinetics

Giovanni, T., Giannese, F., & Lazarević, D. (2024) · Springer eBooks · doi:10.1007/978-3-030-73317-9_131-1

Effects of Tokishakuyakusan, Keishibukuryogan, and Kamishoyosan on the expression and activity of drug-metabolizing enzymes in the liver and small intestine

Yokoyama, K., Tabata, K., Shinozaki, Y., Saito, R., Kon, R., Sakai, H., Hosoe, T., & Ikarashi, N. (2024) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2024.100055

Avaliação da influência de variantes genéticas nos genes do citocromo P450 e ABCB1 na farmacocinética de cloridrato de trazodona

Meulman, J. (2023) · doi:10.47749/t/unicamp.2023.1373451

Pathogenesis of intracellular organisms

Phadke, K. (2023) · doi:10.31274/td-20240617-262

Identification of Praziquantel derivatives to target serpin for inhibiting Schistosoma infection in human: using molecular docking and network pharmacology approach

Al‐Malki, E. S. (2024) · Journal of Taibah University for Science · doi:10.1080/16583655.2024.2378547

Personalized pharmacoepigenomics

Peedicayil, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23802-4.00001-6

Organ-on-a-chip systems

Baranowska, P., Flont, M., Żuchowska, A., Brzózka, Z., & Jastrzębska, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15978-7.00048-5

An Overview of the Pharmacogenetics of Sulfonylurea in Type 2 Diabetes Mellitus

Aljabali, B. (2024) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2024.289503.1269

Introduction to genomics-based pharmaceutical applications

Rashwan, H. H., Dawoud, A., & El-Hadidi, M. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18866-4.00008-0

The Impact of CYP 2C9 rs1799853 and rs1057910 Polymorphism on Plasma Losartan Metabolic Ratio in a Sample of Iraqi Hypertensive Patients

Ijam, A. H., Mshimesh, B. A. R., Abdulamir, A. S., & Alsaad, S. F. (2024) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v7i1(special).985

Effect of the Impurities on Drugs, Metabolism, and the Role of the Isoenzyme CYP3A4

Dreshaj, A., Dreshaj, A., Veseli, D., Sinanaj, D., Morina, E., Dehari, S., & Dehari, D. (2024) · Acta Medica Bulgarica · doi:10.2478/amb-2024-0052

VIH et impact sur le choix thérapeutique

Brandão, M., Leprieur, E. G., & Lavolé, A. (2024) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(24)00099-5

Catalogue of Somatic Mutations in Cancer Database and Structural Modeling Analysis of CYP2D6 Mutations in Human Cancers

Kuchinski, K., King, N., Driggers, J., Lawson, K., Vo, M., Skrtic, S., Slattery, C., Lane, R., Simone, E., Mills, S. A., et al. (2024) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.124.002136

Arisarum vulgare: Bridging Tradition and Science Through Phytochemical Characterization and Exploring Therapeutic Potential via In vitro, In vivo, and In silico Biological Activities

Bouafia, Z., Boudjelal, A., Bouaziz‐Terrachet, S., Bouhenna, M. M., Bouchahdane, S., Boulila, A., Yıldız, İ., Yılmaz, S., Özen, T., & Demirtaş, İ. (2024) · ChemistrySelect · doi:10.1002/slct.202402754

Omics Sciences in Drug Discovery, Safety, and Pharmacokinetics

Tonon, G., Giannese, F., & Lazarević, D. (2024) · Springer eBooks · doi:10.1007/978-3-031-35529-5_131

The anthropic fingerprinting of chemicals in wastewater: Wastewater based-epidemiology

Kasprzyk‐Hordern, B., Byrnes, N. A., Ceolotto, N., Elliss, H., Faill, B., Hawkins, E., & Ranathunge, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85601-0.00034-5

Transcriptomic investigation of NP toxicity on HepaRG spheroids

Tüçer, M. E., Tunç, N., Tüçer, S., Acar, R., Usta, D. D., Salimi, K., Konu, Ö., & Şeker, U. Ö. Ş. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111303

Cytochrome P450 Polymorphisms

Zanger, U. M. (2012) · Encyclopedia of Drug Metabolism and Interactions · doi:10.1002/9780470921920.edm009 · Cited by 2

Cytochrome P450

Bhatia, K. S., Mahesh, A. N., & Bhatt, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00696-5 · Cited by 2

Drug Response Heterogeneity and the Genetic Variability of Cytochrome P450–Metabolizing Enzymes

Zhou, S.-F., & Sneed, K. (2014) · doi:10.1201/b15465-16 · Cited by 1

Pharmacogenetics of the Cytochrome P450 Enzyme System: Review of Current Knowledge and Clinical Significance

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Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes

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