Cited by 1,070Pharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsMetal-Catalyzed Oxygenation Mechanisms

The DOI matches its Crossref record; 119 of the 124 references it cites were found in a registry or an index.

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Open access

Zhao, Mingzhe, Ma, Jingsong, Li, Mo, Zhang, Yingtian, Jiang, Bixuan, Zhao, Xianglong, Huai, Cong, Shen, Lu, Zhang, Na, He, Lin, Qin, Shengying·2021·International Journal of Molecular Sciences

DOI 10.3390/ijms222312808PMC PMC8657965

Open this paper in CoChat — free account Open PDF

Abstract

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to one or more of the various CYPs, from the CYP families 1–3. In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism, in both metabolic organs and local sites of action. Structures of CYPs have recently provided new insights into both understanding the mechanisms of drug metabolism and exploiting CYPs as drug targets. Genetic polymorphisms and epigenetic changes in CYP genes and environmental factors may be responsible for interethnic and interindividual variations in the therapeutic efficacy of drugs. In this review, we summarize and highlight the structural knowledge about CYPs and the major CYPs in drug metabolism. Additionally, genetic and epigenetic factors, as well as several intrinsic and extrinsic factors that contribute to interindividual variation in drug response are also reviewed, to reveal the multifarious and important roles of CYP-mediated metabolism and elimination in drug therapy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms222312808

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
Zanger, U. M., & Schwab, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.007 · Cited by 4,169
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
Nelson, D. R., Koymans, L. M. H., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,946
Reduced Expression of the let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival
Takamizawa, J., Konishi, H., Yanagisawa, K., Tomida, S., Osada, H., Endoh, H., Harano, T., Yatabe, Y., Nagino, M., Nimura, Y., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0637 · Cited by 2,356
Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.
Conney, A. H. (1982) · PubMed · Cited by 1,557
Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
Ingelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
Ingelman‐Sundberg, M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500285 · Cited by 1,111
Predicting in vivo drug interactions from in vitro drug discovery data
Wienkers, L. C., & Heath, T. G. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1851 · Cited by 910
Cytochrome P450 Structure, Function and Clinical Significance: A Review
Palrasu, M., & Nagini, S. (2017) · Current Drug Targets · doi:10.2174/1389450118666170125144557 · Cited by 855
Inhibition and Induction of Cytochrome P450 and the Clinical Implications
Lin, J. H., & Lu, A. Y. H. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199835050-00003 · Cited by 827
The Cytochrome P450 Superfamily: Biochemistry, Evolution and Drug Metabolism in Humans
Danielson, B. S. P. P. B. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337054 · Cited by 775

Flagged first, then by citations

Show all 124 references

5 of the 124 references couldn’t be matched to a known paper.

Sorted by citations

Items 601–700 of 999

Molecular insights into steroid resistance in childhood nephrotic syndrome: Gene expression and prognostic miRNA signatures
Suresh, P. K., Venkatachalapathy, Y., Doss, C. G. P., Geminiganesan, S., Ekambaram, S., & MohanaPriya, C. D. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108584 · Cited by 2
Evaluating Allium lycaonicum Phytochemicals as CCR5 Inhibitors for HIV Therapy: A Computational Study
Munir, M., Khan, M. U., Shan, M. A., Shah, M. U., Rehman, R., Shabbir, C. A., & Alkahtani, H. M. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500980 · Cited by 2
In Vitro Inhibitory Effects and Molecular Mechanism of Four Theaflavins on Isozymes of CYP450 and UGTs
Hu, L., Hu, Z., Peng, J., Hou, A., Hao, Z., Wu, Z., Li, Y., Li, K., Li, Z., Liu, Z., et al. (2025) · Foods · doi:10.3390/foods14162822 · Cited by 2
Antidermatophytic activity of Curcuma longa against Trichophyton spp.: compound identification and molecular docking to lanosterol 14α-demethylase
Rahman, A., Patwary, M. F., Ahmed, S., Hossen, M., Hossain, M. H., Islam, M. S., Rahman, R., Dutta, S., Sultana, K. F., Hossain, M. S., et al. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05049-9 · Cited by 4
Investigating the Antimicrobial Efficacy of Cannabinoids and Their Derivatives Against Neisseria Gonorrhoeae by Computational Analysis
Omeershffudin, U. N. M., Abidin, Z. Z., Hein, Z. M., Nassir, C. M. N. C. M., Cheriya, E. N. K., Kumar, S., & Ramli, M. D. C. (2025) · Biology · doi:10.3390/biology14091272 · Cited by 2
From Tears to Toxins: Mapping Antibiotic Passage Through the Eye–Liver Axis
Šoša, I. (2025) · Antibiotics · doi:10.3390/antibiotics14111069 · Cited by 2
A Patient With Sepsis-Induced Multiorgan Failure and Increasing Serum Methadone Concentration: A Case Study
Dale, G. H., Holmaas, G., Berg, J. A., Riedel, B., Schjøtt, J., & Bjånes, T. K. (2022) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000963 · Cited by 2
Splice variants of mRNA of cytochrome P450 genes: analysis by the nanopore sequencing method in human liver tissue and HepG2 cell line
Deynichenko, K. A., Ptitsyn, K. G., Radko, S. P., Kurbatov, L. K., Vakhrushev, I. V., Buromski, I. V., Markin, S. S., Archakov, A. I., Lisitsa, A. V., & Ponomarenko, E. A. (2022) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20226802117 · Cited by 2
In Vivo Metabolite Profiling of DMU-212 in ApcMin/+ Mice Using UHPLC-Q/Orbitrap/LTQ MS
Li, J., Li, X., Zhou, X., Yang, L., Sun, H. J., Kong, L. D., Yan, G., Han, Y., & Wang, X. (2023) · Molecules · doi:10.3390/molecules28093828 · Cited by 2
Artificial Intelligence in anesthesia: Biotechnology applications for optimal patient outcomes
Banerjee, S., Abhishek, H. N., Gupta, P., Patel, A. P., Kant, K., & Shetti, A. N. (2023) · Journal of Cellular Biotechnology · doi:10.3233/jcb-230092 · Cited by 2
Inhibitory effects of herbal medicines with claimed anticancer indications on cytochrome P450—An evaluation of drug-herb interactions risk
Mudyiwa, M., Sharma, M., Ray, S. K., Masimirembwa, C. M., & Thelingwani, R. S. (2023) · Scientific African · doi:10.1016/j.sciaf.2023.e01835 · Cited by 2
Bioengineered MSC GFPCxcr2-Mmp13 Transplantation Alleviates Hepatic Fibrosis by Regulating Mammalian Target of Rapamycin Signaling
Chawla, S., Choudhury, S., & Das, A. (2024) · Antioxidants & Redox Signaling · doi:10.1089/ars.2023.0390 · Cited by 2
Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents
Mazzone, F., Klischan, M. K. T., Greb, J., Smits, S. H. J., Pietruszka, J., & Pfeffer, K. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1406307 · Cited by 2
Exploration of phytoconstituents of Medhya Rasayana herbs to identify potential inhibitors for cerebroside sulfotransferase through high-throughput screening
Singh, N., & Singh, A. K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1476482 · Cited by 2
Cytochrome P450
Bhatia, K. S., Mahesh, A. N., & Bhatt, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00696-5 · Cited by 2
Genetic Polymorphisms of very Important Pharmacogene Variants in the Chinese Lisu Population
Lu, H., Zhang, Z., Wang, Y., Wang, L., Yuan, D., He, Y., & Jin, T. (2023) · Personalized Medicine · doi:10.2217/pme-2022-0117 · Cited by 1
Transition of stability of putidaredoxin reductase by introducing proline
Okamura, T., Aritomi, R., Matsumoto, T., Yamada, R., Hirakawa, H., & Ogino, H. (2023) · Biochemical Engineering Journal · doi:10.1016/j.bej.2023.109139 · Cited by 1
Breaking down resistance: Verapamil analogues augment the efficacy of antibiotics against Streptococcus pneumoniae via MATE transporter interference
Ahmed, N., Biswas, P., Mogal, M. R., Sarker, M. R., Tareq, M. M. I., Ahmed, S., Akter, M., Miah, M. T., Kundo, N. K., Hasan, M. N., et al. (2024) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2024.101493 · Cited by 1
Metabolomics: An Approach to Decode the Insight of Organism Functioning in Polluted Environments
Piliposyan, G., Merhi, C., Abdulkarim, S., Tawalbeh, M., Halalsheh, N., & Al–Othman, A. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781837673131-00458 · Cited by 1
Structure, Function, and Genetic Variation of CYP2D6, a Cytochrome Metabolizing Drugs
Parietti, R., Bernardoni, B. L., D’Agostino, I., Campisi, L., & Motta, C. L. (2024) · Biochemistry · doi:10.5772/intechopen.115466 · Cited by 1
Integrating structure-guided and fragment-based inhibitor design to combat bedaquiline resistant Mycobacterium tuberculosis : a molecular dynamics study
Roy, A., Banerjee, P., Paul, I., Ghosh, R., & Ray, S. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2441426 · Cited by 1
Machine learning-based pan-cancer study of classification and mechanism of BRAF inhibitor resistance
Zhao, Y., Yang, K., Chen, Y., Lv, Z., Wang, Q., Zhong, Y., & Chen, X. M. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-961 · Cited by 1
Pharmacogenomics for Nurses
Cheek, D. J., & Walker, T. K. (2025) · Nursing Clinics of North America · doi:10.1016/j.cnur.2025.01.006 · Cited by 1
The Use of Pharmacogenomics in Cardiovascular Care
Spahn, C., Walker, T. K., Byurat, S., & Palaniappan, L. P. (2025) · Nursing Clinics of North America · doi:10.1016/j.cnur.2024.12.007 · Cited by 1
Prediction of Drug Metabolism with In Silico Models: A Case Study of Doping Detection
Maltarollo, V. G., & Fernandes, J. P. S. (2024) · Computer-aided drug discovery and design · doi:10.1007/978-3-031-76718-0_19 · Cited by 1
Analysis of in silico and in vivo pharmacokinetic and toxicological parameters of dillapiole n -butyl ether
Cruz, D. L. V., Pinto, A. C. D. S., Ferreira, M. S. L., de Souza, D. E. M., Acho, L. D. R., Barcellos, J. F. M., Lima, É. S., Guilhon‐Simplicio, F., & Rafael, M. S. (2025) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2025.2473557 · Cited by 1
CYP2D6 polymorphism rs1065852 significantly increases the risk of type 2 diabetes
Wei, H., & Zhao, Q. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2470956 · Cited by 3
Modulating the Gut Microbiota to Combat Drug-Induced Liver Injury: A New Frontier in Hepatic Health
Ye, Y., & Chu, H. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1009178 · Cited by 1
Computational insights into drug discovery from Vernonia amygdalina: a narrative review
Agu, P. C., Ogbu, C. O., Ale, B. A., Ebenyi, L. N., Fasogbon, I. V., Mitaki, N. B., Eze, E. D., & Aja, P. M. (2025) · Discover Plants. · doi:10.1007/s44372-025-00165-9 · Cited by 1
Pharmacokinetics of lipid drug conjugates
Roy, P. K., Debbarma, A., Tarai, M., Kalita, P., Das, M. K., & Pachuau, L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33382-8.00006-6 · Cited by 1
Cytochrome P450 Mediated Cyclohexane Ring Formation in Forazoline Biosynthesis
Chen, X., Zhang, Y., Li, S., Liao, W., Tao, W., Deng, Z., Bugni, T. S., Su, H., & Zhang, F. (2025) · Angewandte Chemie · doi:10.1002/ange.202504925 · Cited by 1
Self-citation
Cytochrome P450 Mediated Cyclohexane Ring Formation in Forazoline Biosynthesis
Chen, X., Zhang, Y., Li, S., Liao, W., Tao, W., Deng, Z., Bugni, T. S., Su, H., & Zhang, F. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202504925 · Cited by 1
Self-citation
Exploring the pharmacokinetic, toxicity and anti-arthritic activity of bioactive polyphenols to mitigate the HIF-regulated angiogenic-pannus growth in rheumatoid arthritis
Kalidass, B., Nazeer, A. A., Mahalingam, M., Raja, R. K., & Lakshmanan, D. K. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114851 · Cited by 1
CYP450 gene polymorphisms and the risk of taxane-induced neurotoxicity in breast cancer patients: a systematic review and meta-analysis
Moretti, N. R., Moreira, B. D. M., Braz, I. P., Barretto, I. C. D. O., Chiba, A. L. A. Z., Dominato, A. A. G., & de Moraes, F. C. A. (2025) · Biomarkers · doi:10.1080/1354750x.2025.2522892 · Cited by 1
Exploring Plant‐Derived Natural Products Against Plasmodium falciparum Malaria Causative Agent by Targeting Protein Kinase 5: Insights Into Computational Approaches
Umar, H. I., Baammi, S., Ishabiyi, F. O., Aborode, A. T., Omoboyede, V., Awoyemi, B. O., Michael, I. F., Tiamiyu, B. B., Makinde, I. A., Nweze, C. C., et al. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402991 · Cited by 2
The brain-eye-liver axis during spaceflight: implications of hepatic dysfunction in spaceflight associated neuro-ocular syndrome
Helvacıoğlu, S., Cools, B., Ong, J., Waisberg, E., Lee, R. S., Lee, A. G., & Vinken, M. (2025) · Life Sciences in Space Research · doi:10.1016/j.lssr.2025.07.001 · Cited by 1
Integrative network toxicology, molecular dynamics and transcriptional analysis elucidate DEHP-induced cardiovascular dysfunction
Guo, Y., Song, P., Liu, Y., Zhou, Y., Cheng, D., Zhu, M., Xu, W., & Qiao, P. (2025) · Toxicology Research · doi:10.1093/toxres/tfaf090 · Cited by 1
Adverse Drug–Drug Interaction Between Phenobarbital and Fluconazole in Two Dogs
Jaramillo, M., Mondino, A., Court, M. H., Lewis, M. J., Olby, N. J., & Muñana, K. R. (2025) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.70190 · Cited by 1
Analytical Methods for Fimasartan: A Comprehensive Review of Chromatographic and Spectroscopic Techniques
Patel, S. T., Patil, H. K., Patil, H., Pawar, M. S., Dhankani, A. R., Dhankani, M. A., & Pawar, S. P. (2025) · Asian Journal of Pharmaceutical Analysis · doi:10.52711/2231-5675.2025.00035 · Cited by 1
Cannabis sativa Phytochemicals as Potent Regulators of Aquaporin-4 in Alzheimer’s Disease: A Cheminformatics and Machine Learning Approach
Shyamal, S. S., MohanaSundaram, A., Singla, R. K., Shanmugarajan, T. S., Ajagbe͓, A. O., Christy, J., & Anand, D. A. (2025) · Chemistry Africa · doi:10.1007/s42250-025-01404-y · Cited by 1
Optimization of In Vitro CYP3A4 TDI Assay Conditions and Use of Derived Parameters for Clinical DDI Risk Assessment Using Static and Dynamic Models
Pugliano, A., Ekiciler, A., Preiss, L. C., Parrott, N. J., Annaert, P., & Umehara, K. (2025) · The AAPS Journal · doi:10.1208/s12248-025-01114-w · Cited by 1
In Silico Identification of Six Mushroom-Derived Sterol and Triterpenoid Compounds as Potential P-Glycoprotein Modulators in Multidrug Resistance
Fonsêca, J., Shiraishi, C. S. H., Abreu, R. M. V., Ricardo, S. A. V., & Vaz, J. A. (2025) · Applied Sciences · doi:10.3390/app15168772 · Cited by 1
Computational Identification of Phytochemical Inhibitors Against White Spot Syndrome Virus dUTPase: A Potential Antiviral Approach
Alharbi, M. G., Algothmi, K. M., Alhazmi, S., Al-Hindi, R. R., & Alhamad, J. A. (2025) · Jundishapur Journal of Microbiology · doi:10.5812/jjm-161457 · Cited by 1
A privacy-preserving HLA imputation method with homomorphic encryption
Kim, H., Hwang, I., Song, Y., & Han, B. (2025) · iScience · doi:10.1016/j.isci.2025.113442 · Cited by 1
Anti‐Obesity Effects of Peucedanum Japonicum Thunb Root Extract With Induction of Hepatic Cyp2b10 Gene Expression in Mice
Aisyah, R., Vatanapahu, R., Mihara, M., Tagawa, T., Kanazawa, M., Kuwahara, H., Chen, S., Bono, H. U., Kumrungsee, T., & Yanaka, N. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70524 · Cited by 1
Nephroprotective Effect of Sansevieria trifasciata
Islas, J. R., Lomelí, M. L.-C., González-Martínez, B. E., Islas, I. R. R., Gutiérrez-López, M., Sáenz, A., Vázquez-Rodríguez, J. A., Méndez-López, L. F., Verde‐Star, M. J., García‐Ponce, R., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178619 · Cited by 1
Unique electron transfer system of cytochrome P450 monooxygenase includes a mechanism of fatty acid β-oxidation
Kojima, S., Shinji, K., Namiki, H., Suzuki, K., Shimizu, M., Kadooka, C., Katsuki, N., Masuo, S., Amahisa, M., Doi, Y., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08791-5 · Cited by 1
Benzoxazine–Purine Hybrids as Antiproliferative Agents: Rational Design and Divergent Mechanisms of Action
Boulaiz, H., Jiménez-Martínez, Y., Franco-Montalbán, F., Peña-Martín, J., Conejo‐García, A., & Carriòn, M. D. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17101260 · Cited by 1
Herb-drug interaction of Astragali Radix based on in vitro incubation and pharmacokinetic assessment
Wang, T., Zhang, T., Chen, X., Huang, C., Tu, P., Wang, K., & Qiu, F. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05085-5 · Cited by 1
Pharmacogenomics in Orofacial Clefts Care: Insights from Whole-Genome Sequencing of Case-Parents Trios
Poku-Adusei, E., Mensah, G. O., Asamoah, C. O., Tsri, B., Akeeya, H., Danbaki, A. S., Obiri‐Yeboah, S., Busch, T. D., Borquaye, L. S., Donkor, P., et al. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15100456 · Cited by 1
Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population
Ohmori, Y., Hishinuma, E., Suzuki, Y., Ueda, A., Kijogi, C., Nakayoshi, T., Oda, A., Saito, S., Tadaka, S., Kinoshita, K., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117396 · Cited by 1
Biochemical, Toxicological, and In Silico Aspects of Holm Oak ( Quercus baloot Griff.): A Rich Source of Natural Bioactive Compounds
Ahmad, F. J., Hanif, A., Ali, S., Iqbal, M. A., Kanwal, R., Hussain, I., Khalid, M., Nadeem, H., Ling, C. K., Mahmood, S., et al. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202501107 · Cited by 1
Curcumin as a modulator of drug metabolism and gene expression: Implications for pharmacogenomics
Dimeji, I. Y., Jabba, H. L., Murtala, N., & Ayodeji, A. S. (2025) · Pharmacological Research - Reports · doi:10.1016/j.prerep.2025.100067 · Cited by 1
The Hepatoprotective Properties of the Revised Formulation of Dahuang Xiaoshi Tang, an Ancient Chinese Herbal Decoction, Are Probed by Integrated Metabolomics and Network Pharmacology
Kong, X., Wang, X., Ren, H., Yao, Y., Zhang, H., Li, H., Li, H., Cheng, Y., Song, Z., Pei, M., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18101534 · Cited by 1
Structure-Based Molecular Screening and Simulation Approaches To Inhibit Marburg Virus VP35 Protein Using Medicinal Phytocompounds for Restoring Host Immune Response
Alshehri, M. A., Alissa, M., & Suleman, M. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10127-z · Cited by 1
Regulation of P450-derived epoxy fatty acids in cardiovascular diseases
Edin, M. L., Graves, J. P., & Zeldin, D. C. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100064 · Cited by 1
DFT and Molecular Docking Studies of N‐(7‐Indazolyl)benzenesulfonamides as Potential Drugs Targeting EGFR‐Tyrosine Kinase Inhibitors
Moumad, A., Bouhaoui, A., Alaqarbeh, M., Faris, A., Domingo, L. R., & Bouissane, L. (2025) · ChemistrySelect · doi:10.1002/slct.202503419 · Cited by 1
Secondary metabolites for improvement of human health
Shahnawaz, M. D., & Sharma, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33959-2.00015-0 · Cited by 1
Inhibitory Effects and Characteristics of Byakangelicol on the Activity of Multiple Cytochrome P450 Isoforms
Lin, T. C., He, X. B., Lin, P., & Chang, Y. (2025) · International Journal of Toxicology · doi:10.1177/10915818251382082 · Cited by 1
Effects of High Concentrations of Flumequine on CYP Gene Expression and Histopathology in Olive Flounder, Paralichthys olivaceus
Lee, G. B., Na, H. J., Jeong, J.-M., Kwon, M., Hwang, S. D., & Seo, J. S. (2025) · Animals · doi:10.3390/ani15213125 · Cited by 1
Current insights on cardiovascular and neurodegenerative relations of direct oral anticoagulants and their biotransformation
Todorova, N., Mateeva, A., Savova, A., & Kondeva-Burdina, M. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e165858 · Cited by 1
Identification and clinical assessment of novel biomarkers for sepsis-induced liver injury
Xia, T., Shen, Q., Yu, J., Huang, J., Yuan, M., Wang, C., & Li, R. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115764 · Cited by 1
Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD
Orlowska, K., Nault, R., & Zacharewski, T. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210853 · Cited by 1
Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing
Li, Z., Liu, B., Wang, Y., Cheng, J., Aguilera, R., Deng, X., Chen, Q., & Chen, P. (2025) · Drug Testing and Analysis · doi:10.1002/dta.3969 · Cited by 1
Dose-dependent impacts of antimicrobial parachlorometaxylenol on bioreactor functional stability: linking microbial ecological succession to metabolic pathway remodeling in sludge floc reconstruction and system resilience
Luo, J., Chen, J., Luo, Y., Du, W., Wang, F., Cao, J., & Zhang, Q. (2025) · Environmental Research · doi:10.1016/j.envres.2025.123340 · Cited by 1
Systems Biology Approach to Berberine Metabolomics and Toxicity: An In Silico Investigation of Bioactive Pathways and Risk Assessment
Sarkar, S., Sharma, D., Manna, S., Saha, N. C., & Banerjee, P. (2025) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.70096 · Cited by 1
Developmental reprogramming of cytochrome P450 enzymes in offspring by adverse maternal factors exposure: Implications for long-term metabolic disease susceptibility
Xia, X., Chen, Y., & Sun, X. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119444 · Cited by 1
In vitro inhibition of mouse liver microsomal cytochrome P450 (CYP) subfamilies by the diterpenes synagrantol A and G isolated from the latex of Euphorbia umbellata
Rolim, T. D. S., Tostes, J. B. D. F., Ramos, C. G., de Oliveira, A. C. A. X., Paumgartten, F. J. R., Moreira, D. D. L., & Siani, A. C. (2025) · Rodriguésia · doi:10.1590/2175-7860202576046 · Cited by 1
Pyrazolopyrimidine derivatives as potent peroxidase inhibitors: In silico study and experimental validation
Smaoui, S., Messaâd, M., Dhouib, I., Gargouri, B., & Khemakhem, B. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144912 · Cited by 1
Identification and in silico evaluation of natural compounds from Annona muricata (soursop) leaves for colon cancer treatment
Ali, M. Y., Asha, A. J., Riti, F. A., Nayeem, S. M. A., Rudro, R. H., Sarkar, N. K., Ali, M. M., Ahmmed, T., Jamal, M. A. H. M., Haque, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-30151-w · Cited by 1
Toxicity of key secondary metabolites and essential oils used in cancer
Rolim, H. M. L., Ramalho, T. C., Franco, L. O., de Medeiros, M. D. G. F., & de Lima, M. A. B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-40511-2.00009-7 · Cited by 1
Real‐World Applications of Pharmacogenomics in Paediatrics
Newbound, C. N., Roberts, B., Cooper, Z., Rodger, J., Hood, S. D., Hryniewicki, J., Homberg, K., Conyers, R. K., Moore, C., Mateos, M. K., et al. (2025) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.70239 · Cited by 1
Interactions of neocryptotanshinone and human cytochrome P450 in silico and in vitro
Chen, X., Pan, X., Zhao, J., Jin, H., Zhang, H., Song, Y., Zhou, H., Yao, J., & Jiang, H. (2025) · Toxicology in Vitro · doi:10.1016/j.tiv.2025.106191 · Cited by 1
3D liver model for assessing immune-mediated hepatotoxicity from biopharmaceutical risks
견, 미., Park, D., Jung, H., Ryu, J. H., Kim, I., Jeong, S. Y., Kim, J., Jo, M., Kwon, J.-I., Kim, J.-K., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168419 · Cited by 1
A Microfibrous Extracellular Matrix Platform for In Vitro Hepatotoxicity Screening: A Next-Generation Model for Humanized Liver Research
Kaur, N., Savitsky, M. J., Lipscomb, M., Yang, D., & Ali, J. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00567 · Cited by 1
In silico and in vivo anti-hyperuricemic and anti-gouty arthritic effects of Adhatoda vasica extract: Forecasting drug candidates and mechanistic insights into urate transporter 1 and xanthine oxidase inhibition
Chowdhury, R. T., Pathan, S. I., Akhter, H., Uddin, M. N., Sultana, M., Adhikery, D., Rahman, M. T., Akhter, S., Lyzu, C., & Abdurrahim, M. (2025) · Phytomedicine Plus · doi:10.1016/j.phyplu.2025.100952 · Cited by 1
Donepezil‐Induced Severe Anorexia and T‐Wave Inversion in Early‐Onset Alzheimer's Disease: A Case Report
Takahashi, N., Kuroda, T., Yoshioka, T., Murakami, H., & TANAKA, H. (2025) · Clinical Case Reports · doi:10.1002/ccr3.71660 · Cited by 1
Understanding pharmacokinetic variability in women across different life stages
Campesi, I., Capobianco, G., Virdis, G., & Franconi, F. (2025) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2025.2608753 · Cited by 1
Evaluating the Safety of Ashwagandha as a Food Additive: A Focus on Reproductive, Thyroid, and Immune System Effects
Li, L., Zhang, X., Hao, J., Tian, X., Zhu, Y., Yang, Y., Qiu, B., & Wen, J. (2025) · Phytotherapy Research · doi:10.1002/ptr.70157 · Cited by 2
Gastroprotection and gastric healing activity potential of a fixed oil extract from Syagrus coronata (Mart.) Becc almonds
Ribeiro, K. A., Vieira, Â. M., Bezerra, I. C., da Silva, A. J., de Lima, J. S., Fernandes, P. H. E., do Nascimento, J. W., Gubert, P., Lopes, P. R. S., da Silva, M. V., et al. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100522 · Cited by 1
In silico identification of alkaloids and repurposed drugs as potential small-molecule inhibitors of GOLPH3 in cancer using molecular docking, molecular dynamics, and MM-PBSA analysis
Oresanya, Z. O., Eleanya, G. C., Akande, T., Jesugbemi, T. M., & Kanmodi, R. (2026) · Discover Chemistry. · doi:10.1007/s44371-026-00478-y · Cited by 1
Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals
Wang, H., Wang, M., Fan, C., Sun, Y., Feng, J., He, M., Li, N., Shang, F., & Liu, B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1734644 · Cited by 1
Identification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population
Lin, Q., Xu, W., Zhang, Q., Lu, Z., Geng, P., Chen, C., Ma, Y., Han, A., Liu, R., Wu, S. S., et al. (2025) · Pharmacogenomics · doi:10.1080/14622416.2026.2624546 · Cited by 1
Ocimum Gratissimum L. Leaves Extract Protects Osteoblast‐Like Cells From Glucose‐Induced Stress by Antioxidant Mechanisms and RUNX2 Signaling: A Combined Experimental and Computational Study
Masroor, H., Shukla, S., Pandey, S., Israr, J., Arshad, M., & Gupta, M. (2026) · ChemistrySelect · doi:10.1002/slct.202505053 · Cited by 1
Silver Nanoparticles Specially Amplify the Anticancer Effects of Platinum-Based Drugs by Disrupting Cellular Nucleotide and Sulfur Homeostasis
Li, Y., Wang, Q., Xia, H., Wang, F., Jiao, P., Song, M., & Jiang, G. (2026) · Nano Letters · doi:10.1021/acs.nanolett.5c06237 · Cited by 1
In silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1α/VEGFA/BACE1 pathway against Alzheimer’s disease
Rai, S., Ray, S. K., & Mukherjee, S. (2026) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2025-0278 · Cited by 2
Using an integrative multi-omics and in vitro approach to investigate the role of tris(2-butoxyethyl) phosphate in promoting hepatic steatosis
Zhou, G., Gu, X., Zhou, X., Chen, S., Liu, H., & Wang, J. (2026) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2025-002123 · Cited by 1
Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population
Chen, C., Geng, P., Liu, R., Lu, Z., Lin, Q., Ma, Y., Han, A., Zhang, Q., Wu, S., Jin, P., et al. (2026) · Gene · doi:10.1016/j.gene.2026.150094 · Cited by 1
A herbal formulation inhibits growth and survival of lung cancer cells through DNA damage and apoptosis - in vitro and in vivo studies
Ali, M., Punia, R., Singh, N., Shamsi, Y., & Singh, R. P. (2026) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2025.101313 · Cited by 1
Molecular modeling studies of novel breast cancer inhibitors using molecular docking, molecular dynamics, MEP, bioisosteric replacement, and ADME-Tox prediction
Hasni, F., Daoud, I., Melkemi, N., Kenouche, S., Alorini, T., & Al‐Shuhaib, M. B. S. (2026) · Monatshefte für Chemie - Chemical Monthly · doi:10.1007/s00706-026-03436-7 · Cited by 1
Beyond the Very Important Pharmacogenes (VIPs): Uncovering Shadow Pharmacogenes in the Human Drug Response Network
de Melo, N. C., Accioli, G. S., Sánchez-Luquez, K., Gomes, M. F. D. F., Felicio, A. C., & de Carvalho, L. M. (2026) · ACS Omega · doi:10.1021/acsomega.5c12757 · Cited by 1
Synthesis and biological evaluation of novel fused pyridopyrimidine derivatives as topoisomerase I inhibitors and as potential antitumor agents: promising results in lung, ovary and gastric cancer
Lopez-Aguileta, L., Martín‐Encinas, E., Knudsen, B. R., Tesauro, C., Schirizzi, A., Montanaro, R., D’Alessandro, R., Perrone, M. G., Stefanachi, A., Contino, M., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118782 · Cited by 1
From emission to toxicity: Unraveling the overlooked challenge of polycyclic aromatic hydrocarbons from vehicle exhaust
Yao, J., Yang, X., Wu, T., Zhang, X., Chen, H., Song, W., Tong, X., Wang, Y., Li, X., & Ding, Y. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.128016 · Cited by 1
Effects of music on hepatic cytochrome P450 1A enzymes in Sprague Dawley rats
Shalaby, A. H., Adhiya, J., Al-Dajani, A. R., El-Mahrouk, S. R., Olympus, C., Seubert, J. M., Ahonen, H., El‐Kadi, A. O. S., & Kiang, T. K. L. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.117805 · Cited by 1
Novel EP2 Antagonist Attenuates Microgliosis and Memory Deficits in Pilocarpine-Induced Status Epilepticus Mice
Ganesh, T., Pourkhodadad, S., Heman-Bozadas, P., Dingledine, R. J., Wang, W., Rawat, V., Varvel, N. H., Herr, R. J., Jiang, Q., & Johnson, G. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00172 · Cited by 1
Development of machine learning models to predict acetylcholinesterase inhibitory activity and UDP-glucuronosyltransferase affinity and design of new acetylcholinesterase inhibitors
Ando, R., & Kaneko, H. (2026) · Results in Chemistry · doi:10.1016/j.rechem.2026.103321 · Cited by 1
Computational bioprospecting for novel Plasmodium falciparum lactate dehydrogenase inhibitors toward malaria treatment
Ibrahim, S. O., Ayipo, Y. O., Mordi, M. N., Lukman, H. Y., Abubakar, F. A., Usman, S. O., Abdulkadir, F. R., Zubair, M. F., & Atolanı, O. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100335 · Cited by 1
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Okunlola, G. A., & Aleku, G. A. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.202526152 · Cited by 1
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Okunlola, G. A., & Aleku, G. A. (2026) · Angewandte Chemie · doi:10.1002/ange.202526152 · Cited by 1
Bisphenol S induces lipid metabolic disruption associated with SREBP signaling in Caenorhabditis elegans
Zhang, J., Wang, Y., Yumin, S. H. A. N., Che, Z., Farag, M. A., Hou, X., Liu, Y., Zhang, H., Cao, H., Simal‐Gándara, J., et al. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120128 · Cited by 1

Authors: Zhao, M., Ma, J., Li, M., Zhang, Y., Jiang, B., Zhao, X., Huai, C., Shen, L., Zhang, N., He, L., & Qin, S.
Affiliations: Shanghai Jiao Tong University (CN)
Institutes for Shanghai Pudong Decoding Life, Shanghai 200135, China
Corresponding author: Qin, Shengying
ORCID: Zhao, Mingzhe
Li, Mo
Zhang, Yingtian
Zhao, Xianglong
Huai, Cong
Shen, Lu
Zhang, Na
He, Lin
Qin, Shengying
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2021-11-26
Volume: 22
Issue: 23
Pages: 12808
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms222312808
PMC: PMC8657965
OpenAlex: W3216238012
Cited by: 1,070
References: 124
Citations by year: 2026: 255 · 2025: 349 · 2024: 301 · 2023: 134 · 2022: 30
FWCI: 20.56
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Nature Science Foundation of China (81773818, 81273596, 30900799, 81671326)
National key research and development program (2016YFC0905000, 2016YFC0905002, 2016YFC1200200, 2016YFC0906400)
111 project, Shanghai Pujiang Program (17PJD020)
Shanghai Key Laboratory of Psychotic Disorders (13dz2260500)
Shanghai Science and Technology Innovation Fund (20DZ2202000, 21002411100)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: cytochrome P450, drug metabolism, human drug metabolism, CYP1A2, CYP2C9, CYP2C19, CYP3A4, CYP2D6, CYP2B6, CYP2A6, CYP2E1, CYP1B1, CYP1A1
MeSH terms: Animals, Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Humans, Metabolic Clearance Rate, Inactivation, Metabolic, Polymorphism, Genetic, Xenobiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks