Rho-kinase as a target for cancer therapy and its immunotherapeutic potential

Oncology meets immunology: the cancer-immunity cycle.

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Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,365 · see citing works

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296 · see citing works

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Plasticity of cell migration: a multiscale tuning model

Friedl, P., & Wolf, K. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200909003 · Cited by 1,356 · see citing works

The nuts and bolts of AGC protein kinases

Pearce, L. R., Komander, D., & Alessi, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2822 · Cited by 1,294 · see citing works

Kinase-targeted cancer therapies: progress, challenges and future directions

Bhullar, K. S., Orrego-Lagarón, N., McGowan, E. M., Parmar, I., Jha, A., Hubbard, B. P., & Rupasinghe, H. P. V. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0804-2 · Cited by 1,260 · see citing works

Rho GTPases and cell migration

Ridley, A. J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.15.2713 · Cited by 1,194 · see citing works

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Henke, E., Nandigama, R., & Ergün, S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00160 · Cited by 1,142 · see citing works

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.

Bhowmick, N., Ghiassi, M., Bakin, A. V., Aakre, M., Lundquist, C., Engel, M., Arteaga, C., & Moses, H. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.27 · Cited by 1,087 · see citing works

Rho‐associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

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Rho‐kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

Amano, M., Nakayama, M., & Kaibuchi, K. (2010) · Cytoskeleton · doi:10.1002/cm.20472 · Cited by 994 · see citing works

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

Sebbagh, M., Renvoizé, C., Hamelin, J., Riché, N., Bertoglio, J., & Bréard, J. (2001) · Nature Cell Biology · doi:10.1038/35070019 · Cited by 915 · see citing works

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

LEUNG, T. K. C., Chen, X., Manser, E. J., & Lim, L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5313 · Cited by 902 · see citing works

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K., & Narumiya, S. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00811-3 · Cited by 807 · see citing works

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

Fukata, Y., Kaibuchi, K., Amano, M., & Kaibuchi, K. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01596-0 · Cited by 748 · see citing works

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

LEUNG, T. K. C., Manser, E. J., Tan, L. H.-P., & Lim, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29051 · Cited by 720 · see citing works

DNA Damage and Repair Biomarkers of Immunotherapy Response

Mouw, K. W., Goldberg, M. S., Konstantinopoulos, P. A., & D’Andrea, A. D. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0226 · Cited by 652 · see citing works

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Wang, G., Lü, X., Dey, P., Deng, P., Wu, C.-C., Jiang, S., Fang, Z., Zhao, K., Konaparthi, R., Hua, S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0224 · Cited by 556 · see citing works

Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions

Julian, L., & Olson, M. F. (2014) · Small GTPases · doi:10.4161/sgtp.29846 · Cited by 550 · see citing works

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

Samuel, M. S., Lopez, J. I., McGhee, E. J., Croft, D. R., Strachan, D., Timpson, P., Munro, J., Schröder, E., Zhou, J., Brunton, V. G., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.008 · Cited by 538 · see citing works

p160ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

Ishizaki, T., Naito, M., Fujisawa, K., Maekawa, M., Watanabe, N., Saito, Y., & Narumiya, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00107-5 · Cited by 515 · see citing works

Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility

Wheeler, A. P., & Ridley, A. J. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.08.012 · Cited by 479 · see citing works

Glucocorticoids promote breast cancer metastasis

Obradović, M. M. S., Hamelin, B., Manevski, N., Couto, J. P., Sethi, A., Coissieux, M.-M., Münst, S., Okamoto, R., Kohler, H., Schmidt, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1019-4 · Cited by 462 · see citing works

ROCK- and Myosin-Dependent Matrix Deformation Enables Protease-Independent Tumor-Cell Invasion In Vivo

Wyckoff, J. B., Pinner, S. E., Gschmeissner, S., Condeelis, J. S., & Sahai, E. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.065 · Cited by 435 · see citing works

NK cell–mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-J., Sanchez-Rivera, F. J., Feucht, J., et al. (2018) · Science · doi:10.1126/science.aas9090 · Cited by 415 · see citing works

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

Madaule, P., Eda, M., Watanabe, N., Fujisawa, K., Matsuoka, T., Bito, H., Ishizaki, T., & Narumiya, S. (1998) · Nature · doi:10.1038/28873 · Cited by 402 · see citing works

DNA Damage and Cancer Immunotherapy: A STING in the Tale

Reisländer, T., Groelly, F. J., & Tarsounas, M. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.026 · Cited by 318 · see citing works

Analysis of the role of the Hippo pathway in cancer

Han, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1869-4 · Cited by 290 · see citing works

The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity

Amano, M., Chihara, K., Nakamura, N., Kaneko, T., Matsuura, Y., & Kaibuchi, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32418 · Cited by 272 · see citing works

NK cells mediate clearance of CD8 ⁺ T cell–resistant tumors in response to STING agonists

Nicolai, C. J., Wolf, N., Chang, I.-C., Kirn, G., Marcus, A., Ndubaku, C. O., McWhirter, S. M., & Raulet, D. H. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz2738 · Cited by 268 · see citing works

Inhibition of Rho-Associated Kinase Signaling Prevents Breast Cancer Metastasis to Human Bone

Liu, S., Goldstein, R. H., Scepansky, E. M., & Rosenblatt, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1541 · Cited by 264 · see citing works

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

Vennin, C., Chin, V. T., Warren, S. C., Lucas, M. C., Herrmann, D., Magenau, A., Mélénec, P., Walters, S. N., del Monte‐Nieto, G., Conway, J. R. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8504 · Cited by 264 · see citing works

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414189111 · Cited by 262 · see citing works

Rho kinase in the regulation of cell death and survival

Shi, J., & Wei, L. (2007) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-007-0009-7 · Cited by 254 · see citing works

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

Smith, A. M., Bracke, M., Leitinger, B., Porter, J. C., & Hogg, N. (2003) · Journal of Cell Science · doi:10.1242/jcs.00606 · Cited by 245 · see citing works

Rho-Kinase Inhibitor Retards Migration and in Vivo Dissemination of Human Prostate Cancer Cells

Somlyo, A. V., Bradshaw, D., Ramos, S. I., Murphy, C. E., Myers, C. E., & Somlyo, A. P. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2343 · Cited by 241 · see citing works

YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma

Kim, M. H., Kim, C. G., Kim, S.-K., Shin, S. J., Choe, E. A., Park, S.-H., Shin, E.-C., & Kim, J. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0320 · Cited by 241 · see citing works

Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow

Kosako, H., Yoshida, T., Matsumura, F., Ishizaki, T., Narumiya, S., & Inagaki, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203987 · Cited by 240 · see citing works

YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity

Ni, X., Tao, J., Barbi, J. J., Chen, Q., Park, B. V., Li, Z., Zhang, N., Lebid, A., Ramaswamy, A., Wei, P., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1124 · Cited by 235 · see citing works

Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2

Sapet, C., Simoncini, S., Loriod, B., Puthier, D., Sampol, J., Nguyen, C., Dignat‐George, F., & Anfosso, F. J. (2006) · Blood · doi:10.1182/blood-2006-04-014175 · Cited by 232 · see citing works

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

Shi, J., Wu, X., Surma, M. L., Vemula, S., Zhang, L., Yu, Y., Kapur, R., & Wei, L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.10 · Cited by 231 · see citing works

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R. P., Paz, K. G., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis‐Mortari, A., Vulic, A., Luznik, L., MacDonald, K. P. A., Hill, G. R., et al. (2016) · Blood · doi:10.1182/blood-2015-10-678706 · Cited by 231 · see citing works

Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner

Sebbagh, M., Hamelin, J., Bertoglio, J. H., Solary, É., & Bréard, J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20031877 · Cited by 212 · see citing works

Novel Insights into the Roles of Rho Kinase in Cancer

Wei, L., Surma, M. L., Shi, S., Lambert-Cheatham, N. A., & Shi, J. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0382-6 · Cited by 205 · see citing works

ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-versus-host disease

Jagasia, M., Lazaryan, A., Bachier, C. R., Salhotra, A., Weisdorf, D. J., Zoghi, B., Essell, J., Green, L., Schueller, O., Patel, J., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.02754 · Cited by 198 · see citing works

Yes-Associated Protein Mediates Immune Reprogramming in Pancreatic Ductal Adenocarcinoma

Murakami, S., Shahbazian, D., Surana, R., Zhang, W.-Y., Chen, H., Graham, G., White, S. M., Weiner, L., & Yi, C.-L. (2016) · Oncogene · doi:10.1038/onc.2016.288 · Cited by 197 · see citing works

ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration

Zandi, S., Nakao, S., Chun, K., Fiorina, P., Sun, D., Arita, R., Zhao, M., Kim, E., Schueller, O. J. A., Campbell, A. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.050 · Cited by 196 · see citing works

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Kümper, S., Mardakheh, F. K., McCarthy, A., Yeo, M., Stamp, G., Paul, A., Worboys, J. D., Sadok, A., Jørgensen, C., Guichard, S., et al. (2016) · eLife · doi:10.7554/elife.12203 · Cited by 188 · see citing works

Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis

Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184 · see citing works

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

Ying, H., Biroc, S. L., Li, W., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0440 · Cited by 182 · see citing works

Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination

Herráiz, C., Calvo, F., Pandya, P., Cantelli, G., Rodríguez‐Hernández, I., Orgaz, J. L., Kang, N., Chu, T., Sahai, E. A., & Sanz‐Moreno, V. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv289 · Cited by 180 · see citing works

Targeting Rho GTPase Signaling Networks in Cancer

Clayton, N. S., & Ridley, A. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00222 · Cited by 179 · see citing works

MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation, and a Neoplastic State

Li, Y., Choi, P. S., Casey, S. C., Dill, D. L., & Felsher, D. W. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.06.014 · Cited by 174 · see citing works

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

Ohgushi, M., Minaguchi, M., & Sasai, Y. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.07.009 · Cited by 173 · see citing works

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

Georgouli, M., Herráiz, C., Crosas‐Molist, E., Fanshawe, B., Maiques, Ó., Perdrix-Rosell, A., Pandya, P., Rodríguez‐Hernández, I., Ilieva, K. M., Cantelli, G., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.038 · Cited by 170 · see citing works

Paving the Rho in cancer metastasis: Rho GTPases and beyond

Jansen, S. R., Gosens, R., Wieland, T., & Schmidt, M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.09.002 · Cited by 169 · see citing works

Hippo effector YAP directly regulates the expression of PD-L1 transcripts in EGFR-TKI-resistant lung adenocarcinoma

Lee, B. S., Park, D. I., Lee, D. H., Lee, J. E., Yeo, M., Park, Y., Lim, D., Choi, W., Lee, D. H., Yoo, G., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.07.007 · Cited by 166 · see citing works

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

Genda, T., Sakamoto, M., Ichida, T., et al. (1999) · Hepatology · doi:10.1002/hep.510300420 · Cited by 157 · see citing works

Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling

Tosello‐Trampont, A., Nakada‐Tsukui, K., & Ravichandran, K. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306079200 · Cited by 153 · see citing works

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y., Yang, C.-K., Wei, P., Huynh, T.-T., Whang‐Peng, J., Meng, T., Hsiao, M., Tzeng, Y., Wu, A. T. H., & Yen, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0421-3 · Cited by 152 · see citing works

Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

Orgaz, J. L., Crosas-Molist, E., Sadok, A., Perdrix-Rosell, A., Maiques, O., Rodriguez-Hernandez, I., Monger, J., Mele, S., Georgouli, M., Bridgeman, V., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2019.12.003 · Cited by 151 · see citing works

Rho‐kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration

Niggli, V. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00098-8 · Cited by 148 · see citing works

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion #

Wong, C. C., Wong, C., Tung, E. K., et al. (2009) · Hepatology · doi:10.1002/hep.22836 · Cited by 141 · see citing works

Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis

Sadok, A., McCarthy, A., Caldwell, J., Collins, I., Garrett, M. D., Yeo, M., Hooper, S., Sahai, E. A., Kuemper, S., Mardakheh, F. K., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2156 · Cited by 137 · see citing works

Fibronectin Matrix Assembly Requires Distinct Contributions from Rho Kinases I and -II

Yoneda, A., Ushakov, D., Multhaupt, H. A. B., & Couchman, J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0684 · Cited by 135 · see citing works

Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility

Hanley, P. J., Xu, Y., Kronlage, M., Grobe, K., Schön, P. M., Song, J., Sorokin, L. M., Schwab, A., & Bähler, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911986107 · Cited by 130 · see citing works

YAP regulates PD-L1 expression in human NSCLC cells

Miao, J., Hsu, P., Yang, Y., Xu, Z., Dai, Y., Wang, Y., Chan, G., Huang, Z., Hu, B., Li, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23051 · Cited by 130 · see citing works

The role of small GTPases of the Rho/Rac family in TGF‐β‐induced EMT and cell motility in cancer

Ungefroren, H., Witte, D. P., & Lehnert, H. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24505 · Cited by 128 · see citing works

Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells

Chircop, M. (2014) · Small GTPases · doi:10.4161/sgtp.29770 · Cited by 125 · see citing works

Control of adhesion and protrusion in cell migration by Rho GTPases

Warner, H. M., Wilson, B. J., & Caswell, P. T. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.09.003 · Cited by 121 · see citing works

Effect of Fasudil Hydrochloride, a Protein Kinase Inhibitor, on Cerebral Vasospasm and Delayed Cerebral Ischemic Symptoms After Aneurysmal Subarachnoid Hemorrhage-Results of a Randomized Trial of Fasudil Hydrochloride Versus Nimodipine-

ZHAO, J., ZHOU, D., GUO, J., REN, Z., ZHOU, L., WANG, S., XU, B., & WANG, R. (2006) · Neurologia medico-chirurgica · doi:10.2176/nmc.46.421 · Cited by 117 · see citing works

Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis.

Street, C. A., & Bryan, B. A. (2011) · PubMed · Cited by 114 · see citing works

Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer

Nam, G., Lee, E. J., Kim, Y. K., Hong, Y., Choi, Y., Ryu, M., Woo, J., Cho, Y., Ahn, D. J., Yang, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04607-9 · Cited by 113 · see citing works

RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma

Azab, A. K., Azab, F., Blotta, S., Pitsillides, C. M., Thompson, B. D., Runnels, J. M., Roccaro, A. M., Ngo, H. T., Melhem, M. R., Sacco, A., et al. (2009) · Blood · doi:10.1182/blood-2009-01-199281 · Cited by 111 · see citing works

Mechanisms of Tumor Cell–Intrinsic Immune Evasion

Spranger, S., & Gajewski, T. F. (2017) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030617-050606 · Cited by 107 · see citing works

Yap suppresses T-cell function and infiltration in the tumor microenvironment

Stampouloglou, E., Cheng, N., Federico, A. N., Slaby, E. M., Monti, S., Szeto, G. L., & Varelas, X. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000591 · Cited by 106 · see citing works

Targeting ROCK/LIMK/cofilin signaling pathway in cancer

Lee, M., Kundu, J. K., Chae, J., & Shim, J. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01153-w · Cited by 104 · see citing works

IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling

Little, A., Pathanjeli, P., Wu, Z.-F., Bao, L., Goo, L., Yates, J., Oliver, C., Soellner, M., & Merajver, S. D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00456 · Cited by 97 · see citing works

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Wang, J., Hu, K., Guo, J., Cheng, F., Lv, J., Jiang, W., Lü, W., Liu, J., Pang, X., & Liu, M. (2016) · Nature Communications · doi:10.1038/ncomms11363 · Cited by 96 · see citing works

A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes

Kumar, V. V., Dasoveanu, D., Chyou, S., Tzeng, T.-C. J., Rozo, C. T., Liang, Y., Stohl, W., Fu, Y., Ruddle, N. H., & Lu, T. T. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.015 · Cited by 93 · see citing works

Cytoskeletal adaptivity regulates T cell receptor signaling

Thauland, T. J., Hu, K. H., Bruce, M. A., & Butte, M. J. (2017) · Science Signaling · doi:10.1126/scisignal.aah3737 · Cited by 89 · see citing works

Rho–Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways

Ai, S., Kuzuya, M., Koike, T., et al. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00585-2 · Cited by 88 · see citing works

Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8 + T cell

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CD44v10 interaction with Rho‐kinase (ROK) activates inositol 1,4,5‐triphosphate (IP 3 ) receptor‐mediated Ca 2+ signaling during hyaluronan (HA)‐induced endothelial cell migration

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ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

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Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2

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Pharmacological inhibition of Rho-kinase signaling with Y-27632 blocks melanoma tumor growth

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Cell cycle regulation of Rho signaling pathways

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ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc

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Rho-kinase mediates TNF-α-induced MCP-1 expression via p38 MAPK signaling pathway in mesangial cells

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Rho kinase inhibitors: a patent review (2014 – 2016)

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Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

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Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma

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Rho Kinase Phosphorylation Promotes Ezrin-Mediated Metastasis in Hepatocellular Carcinoma

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Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo

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A Pivotal Role of Rho GTPase in the Regulation of Morphology and Function of Dendritic Cells

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Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma

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First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors

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MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β

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The right Timing, right combination, right sequence, and right delivery for Cancer immunotherapy

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BRCA2 and Nucleophosmin Coregulate Centrosome Amplification and Form a Complex with the Rho Effector Kinase ROCK2

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Rho-associated kinase is a therapeutic target in neuroblastoma

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Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway

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In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis

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Dendritic Cell Motility and T Cell Activation Requires Regulation of Rho-Cofilin Signaling by the Rho-GTPase Activating Protein Myosin IXb

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YAP-1 Promotes Tregs Differentiation in Hepatocellular Carcinoma by Enhancing TGFBR2 Transcription

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ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

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ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity

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Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite

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ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells

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YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response

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Immunotherapy for Merkel cell carcinoma: a turning point in patient care

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A Role for a RhoA/ROCK/LIM-Kinase Pathway in the Regulation of Cytotoxic Lymphocytes

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Regulators of Rho GTPases in the Nervous System: Molecular Implication in Axon Guidance and Neurological Disorders

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Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy

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Clinical Development of PD-1 in Advanced Melanoma

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Rho Kinases in Autoimmune Diseases

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The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

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Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling

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Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK

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RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer

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Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling

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Safety and Efficacy of Ripasudil in Japanese Patients with Glaucoma or Ocular Hypertension: 3-month Interim Analysis of ROCK-J, a Post-Marketing Surveillance Study

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Intrinsic cancer vaccination

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Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection

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Rho‐associated protein kinase‐dependent moesin phosphorylation is required for PD‐L1 stabilization in breast cancer

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Immunoexpression of ROCK-1 and MMP-9 as prognostic markers in breast cancer

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Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine

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Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma

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Status of Rho kinase inhibitors in glaucoma therapeutics—an overview

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Diosgenin and GSK126 Produce Synergistic Effects on Epithelial–Mesenchymal Transition in Gastric Cancer Cells by Mediating EZH2 via the Rho/ROCK Signaling Pathway

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Role of Small GTPase RhoA in DNA Damage Response

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GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms

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ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1

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Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells

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Epithelial–mesenchymal transition of rat peritoneal mesothelial cells via Rhoa/Rock pathway

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RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: Suppression by cilostazol

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ROCK-Driven Actomyosin Contractility Induces Tissue Stiffness and Tumor Growth

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Role of Rho-Kinase Gene Polymorphisms and Protein Expressions in Colorectal Cancer Development

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Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis

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Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy

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Rho Kinase Regulates Induction of T-Cell Immune Dysfunction in Abdominal Sepsis

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Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA–NF-κB

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In vivo Effects in Melanoma of ROCK Inhibition-Induced FasL Overexpression

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Combination treatment with fasudil and clioquinol produces synergistic anti-tumor effects in U87 glioblastoma cells by activating apoptosis and autophagy

He, M., Luo, M., Liu, Q., Chen, J., Li, K., Zheng, M., Weng, Y., Ouyang, L., & Liu, A. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-2044-2 · Cited by 19 · see citing works

Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo

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RhoA-Dependent HGF and c-Met Mediate Gas6-Induced Inhibition of Epithelial–Mesenchymal Transition, Migration, and Invasion of Lung Alveolar Epithelial Cells

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PD-1 Blockade in Classic Hodgkin Lymphoma

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Rho kinase proteins display aberrant upregulation in vascular tumors and contribute to vascular tumor growth

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Autophagy Inhibition Stimulates Apoptosis in Oesophageal Squamous Cell Carcinoma Treated with Fasudil

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Rho-kinase inhibition by Fasudil promotes tumor maturation and apoptosis in small-cell lung cancer.

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Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

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Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth

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Small Molecule Screening Identifies Rho-Associate Protein Kinase (ROCK) As a Regulator of NK Cell Cytotoxicity Against Cancer

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What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation

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Roles of Rho/ROCK in Cancer Signaling

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Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Mukhopadhyay, S., Huang, H.-Y., Lin, Z., Ranieri, M., Li, S., Sahu, S., Liu, Y., Ban, Y., Guidry, K., Hu, H., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2729 · Cited by 105 · see citing works

Protein kinase inhibitors as therapeutics in neurodegenerative and psychiatric disorders

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Role of the tumor immune microenvironment in tumor immunotherapy (Review)

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Immunotherapy and tumor microenvironment

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Modeling The Metastasis Promoting Tumor Microenvironment Using Extracellular Matrix Three Dimensional Culture

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Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review)

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Radiotherapy-induced tumor physical microenvironment remodeling to overcome immunotherapy resistance

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