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Cited by 131Reproductive tract infections researchGut microbiota and healthGynecological conditions and treatments

The Endometrial Microbiome and Its Impact on Human Conception

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Toson, Bruno, Simon, Carlos, Moreno, Inmaculada·2022·International Journal of Molecular Sciences
DOI 10.3390/ijms23010485PMC PMC8745284
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Abstract

Changes in the female genital tract microbiome are consistently correlated to gynecological and obstetrical pathologies, and tract dysbiosis can impact reproductive outcomes during fertility treatment. Nonetheless, a consensus regarding the physiological microbiome core inside the uterine cavity has not been reached due to a myriad of study limitations, such as sample size and experimental design variations, and the influence of endometrial bacterial communities on human reproduction remains debated. Understanding the healthy endometrial microbiota and how changes in its composition affect fertility would potentially allow personalized treatment through microbiome management during assisted reproductive therapies, ultimately leading to improvement of clinical outcomes. Here, we review current knowledge regarding the uterine microbiota and how it relates to human conception.

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Cited by

Sorted by citations

Authors
Toson, B., Simon, C., & Moreno, I.
Affiliations
  • INCLIVA Health Research Institute (ES)
  • Igenomix Foundation/INCLIVA Biomedical Research Institute, Narcis Monturiol Estarriol 11B, 46980 Paterna, Spain
  • Igenomix (ES)
Corresponding author
Moreno, Inmaculada
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2022-01-01
Volume
23
Issue
1
Pages
485
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms23010485
PMC
PMC8745284
OpenAlex
W4205748116
Cited by
131
References
4
Citations by year
2026: 34 · 2025: 26 · 2024: 26 · 2023: 34 · 2022: 11
FWCI
3.19
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Generalitat Valenciana (GRISOLIAP/2021/176, PROMETEO/2018/161)
  • Instituto de Salud Carlos III (PI21/00235)
  • Ministry of Economy, Industry and Competitiveness (RTI2018-094946-B-I00)
  • European Union (H2020 - 874867)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometrial microbiota, uterine microbiota, human conception, female fertility, dysbiosis, assisted reproduction, reproductive outcomes, endometrium
MeSH terms
Endometrium, Female, Fertilization, Humans, Pregnancy, Pregnancy Outcome, Virulence, Microbiota, Dysbiosis

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