Peripheral Nerve Injury Treatments and Advances: One Health Perspective

Lopes, Bruna; Sousa, Patrícia; Alvites, Rui; Branquinho, Mariana; Sousa, Ana Catarina; Mendonça, Carla; Atayde, Luís Miguel; Luís, Ana Lúcia; Varejão, Artur S. P.; Maurício, Ana Colette

doi:10.3390/ijms23020918

Cited by 381Nerve injury and regenerationNerve Injury and RehabilitationTissue Engineering and Regenerative Medicine

Peripheral Nerve Injury Treatments and Advances: One Health Perspective

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Lopes, Bruna, Sousa, Patrícia, Alvites, Rui, Branquinho, Mariana, Sousa, Ana Catarina, Mendonça, Carla, Atayde, Luís Miguel, Luís, Ana Lúcia +2 more·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23020918PMC PMC8779751

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Abstract

Peripheral nerve injuries (PNI) can have several etiologies, such as trauma and iatrogenic interventions, that can lead to the loss of structure and/or function impairment. These changes can cause partial or complete loss of motor and sensory functions, physical disability, and neuropathic pain, which in turn can affect the quality of life. This review aims to revisit the concepts associated with the PNI and the anatomy of the peripheral nerve is detailed to explain the different types of injury. Then, some of the available therapeutic strategies are explained, including surgical methods, pharmacological therapies, and the use of cell-based therapies alone or in combination with biomaterials in the form of tube guides. Nevertheless, even with the various available treatments, it is difficult to achieve a perfect outcome with complete functional recovery. This review aims to enhance the importance of new therapies, especially in severe lesions, to overcome limitations and achieve better outcomes. The urge for new approaches and the understanding of the different methods to evaluate nerve regeneration is fundamental from a One Health perspective. In vitro models followed by in vivo models are very important to be able to translate the achievements to human medicine.

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Scaffold should provide suitable local microenvironment for nerve growth, such as promoting axon growth by carrying neurotrophic factors such as NGF and loading substances such as MgO to enhance anti-inflammatory ability and reduce local inflammatory response.
“the scaffold should also provide a suitable local microenvironment for nerve growth, such as promoting axon growth by carrying neurotrophic factors such as NGF and loading substances such as MgO to enhance anti-inflammatory ability and reduce local inflammatory response [181, 182].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [181]
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Gait Analysis Using Animal Models of Peripheral Nerve and Spinal Cord Injuries
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Engineered Neural Tissue Made Using Clinical-Grade Human Neural Stem Cells Supports Regeneration in a Long Gap Peripheral Nerve Injury Model
Rayner, M., Day, A. G. E., Bhangra, K. S., Sinden, J. D., & Phillips, J. B. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.030 · Cited by 30 · see citing works
Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM-MSCs): A Characterization Study
Alvites, R., Branquinho, M., Caseiro, A. R., Amorim, I., Pedrosa, S. S., Rêma, A., Faria, F., Porto, B., Oliveira, C., Teixeira, P. C. M., et al. (2020) · International Journal of Cell Biology · doi:10.1155/2020/2938258 · Cited by 28 · see citing works
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Human Muscle Progenitor Cells Overexpressing Neurotrophic Factors Improve Neuronal Regeneration in a Sciatic Nerve Injury Mouse Model
Guy, R., Grynspan, F., Ben‐Zur, T., Panski, A., Lamdan, R., Danon, U., Yaffe, D., & Offen, D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00151 · Cited by 25 · see citing works
Bone Marrow Mesenchymal Stem Cell Condition Medium Loaded on PCL Nanofibrous Scaffold Promoted Nerve Regeneration After Sciatic Nerve Transection in Male Rats
Raoofi, A., Sadeghi, Y., Piryaei, A., Sajadi, E., Aliaghaei, A., Rashidiani-Rashidabadi, A., Fatabadi, F. F., Mahdavi, B., Abdollahifar, M., & Khaneghah, A. M. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00391-5 · Cited by 25 · see citing works
Improving Outcomes in Immediate and Delayed Nerve Grafting of Peripheral Nerve Gaps Using Light-Activated Sealing of Neurorrhaphy Sites with Human Amnion Wraps
Fairbairn, N. G., Ng-Glazier, J. H., Meppelink, A. M., Randolph, M. A., Winograd, J. M., & Redmond, R. W. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000479996.04255.60 · Cited by 24 · see citing works
Regenerative potential of secretome from dental stem cells: a systematic review of preclinical studies
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Establishment of a Sheep Model for Hind Limb Peripheral Nerve Injury: Common Peroneal Nerve
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Controlled local release of PPARγ agonists from biomaterials to treat peripheral nerve injury
Rayner, M., Grillo, A., Williams, G. R., Tawfik, E. A., Zhang, T., Volitaki, C., Craig, D. Q. M., Healy, J., & Phillips, J. B. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/aba7cc · Cited by 22 · see citing works
Biomarkers of health and welfare: A One Health perspective from the laboratory side
Franco‐Martínez, L., Martı́nez-Subiela, S., Cerón, J. M. C., Tecles, F., Eckersall, P. D., Oravcová, K., & Tvarijonaviciute, A. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.12.012 · Cited by 21 · see citing works
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve
Fissel, J. A., & Farah, M. H. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02121-2 · Cited by 21 · see citing works
Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review
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Therapeutic Aspects of Mesenchymal Stem Cell-Based Cell Therapy with a Focus on Human Amniotic Epithelial Cells in Multiple Sclerosis: A Mechanistic Review
Arefnezhad, R., Motedayyen, H., & Mohammadi, A. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc21032 · Cited by 19 · see citing works
In Vitro Models for Peripheral Nerve Regeneration
Tusnim, J., Kutuzov, P., & Grasman, J. M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401605 · Cited by 19 · see citing works
Therapeutic Electrical Stimulation of Injured Peripheral Nerve Tissue Utilizing Implantable Thin-Film Wireless Nerve Stimulators
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Current Advances in Comprehending Dynamics of Regenerating Axons and Axon–Glia Interactions after Peripheral Nerve Injury in Zebrafish
González, D., & Allende, M. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052484 · Cited by 17 · see citing works
Does the combination of erythropoietin and tapered oral corticosteroids improve recovery following iatrogenic nerve injury?
Bernstein, D. T., Weiner, B. K., Tasciotti, E., & Mathis, K. B. (2016) · Injury · doi:10.1016/j.injury.2016.05.034 · Cited by 16 · see citing works
Schwann-like cell conditioned medium promotes angiogenesis and nerve regeneration
Yu, J., Ye, K., Li, J., Wei, Y., Zhou, J., Wei Min, N. I., Zhang, L., Chen, T., Tang, B., Xu, H. Y., et al. (2021) · Cell and Tissue Banking · doi:10.1007/s10561-021-09920-0 · Cited by 16 · see citing works
Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles
Hellenbrand, D. J., Haldeman, C. L., Lee, J., Gableman, A. G., Dai, E. K., Ortmann, S. D., Gotchy, J. C., Miller, K. K., Doucas, A. M., Nowak, N. C., et al. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.297786 · Cited by 13 · see citing works
Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury
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Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives
Darehbagh, R. R., Seyedoshohadaei, S. A., Ramezani, R., & Rezaei, N. (2024) · European journal of medical research · doi:10.1186/s40001-024-01987-1 · Cited by 170 · see citing works
Adipose stem cells in tissue regeneration and repair: From bench to bedside
Dong, L., Li, X., Leng, W., Guo, Z., Cai, T., Ji, X., Xu, C., Zhu, Z., & Lin, J. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.09.014 · Cited by 80 · see citing works
Exosome-mediated delivery and regulation in neurological disease progression
Singh, G., Mehra, A., Arora, S., Gugulothu, D. B., Vora, L. K., Prasad, R., & Khatri, D. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130728 · Cited by 80 · see citing works
Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration
Rahman, M., Dip, T. M., Padhye, R., & Houshyar, S. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37595 · Cited by 68 · see citing works
Piezoelectric materials for neuroregeneration: a review
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Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration
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Functional modification of silk fibroin from silkworms and its application to medical biomaterials: A review
Wang, H., Zhang, Y., Zhang, M., & Zhang, Y.-Q. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129099 · Cited by 59 · see citing works
Graphene Family Nanomaterials for Stem Cell Neurogenic Differentiation and Peripheral Nerve Regeneration
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Imaging diagnosis in peripheral nerve injury
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Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends
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Exploring the Physicochemical, Electroactive, and Biodelivery Properties of Metal Nanoparticles on Peripheral Nerve Regeneration
Sharifi, M., Kamalabadi‐Farahani, M., Salehi, M., Atashi, A., Alizadeh, M., Kheradmandi, R., & Molzemi, S. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01216 · Cited by 44 · see citing works
Optimizing Peripheral Nerve Regeneration: Surgical Techniques, Biomolecular and Regenerative Strategies—A Narrative Review
Grosu-Bularda, A., Vancea, C.-V., Hodea, F.-V., Cretu, A., Bordeanu-Diaconescu, E.-M., Dumitru, C.-Ş., Ratoiu, V.-A., Teodoreanu, R.-N., Lascăr, I., & Hariga, C.-S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083895 · Cited by 43 · see citing works
Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration
Qi, F., Liu, W., Chen, Y., Ding, F., Li, W., Peng, S., He, P., & Shuai, C. (2024) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2024.11.167 · Cited by 42 · see citing works
Hydrogels for Peripheral Nerve Repair: Emerging Materials and Therapeutic Applications
Taisescu, O., Dinescu, V. C., Rotaru-Zăvăleanu, A. D., Greșiță, A., & Hadjiargyrou, M. (2025) · Gels · doi:10.3390/gels11020126 · Cited by 42 · see citing works
Development of a VEGF-activated scaffold with enhanced angiogenic and neurogenic properties for chronic wound healing applications
Chávez, J. C. P., McGrath, M., O’Connor, C., Dervan, A. G., Dixon, J. E., Kearney, C. J., Browne, S., & O’Brien, F. J. (2025) · Biomaterials Science · doi:10.1039/d4bm01051e · Cited by 40 · see citing works
Assessment of 3D-Printed Polycaprolactone, Hydroxyapatite Nanoparticles and Diacrylate Poly(ethylene glycol) Scaffolds for Bone Regeneration
Sousa, A. C., Biscaia, S., Alvites, R., Branquinho, M., Lopes, B., Sousa, P., Valente, J. F. A., Franco, M. C., Santos, J. D., Mendonça, C., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122643 · Cited by 33 · see citing works
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Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications
Grzelak, A., Hnydka, A., Higuchi, J., Michalak, A., Tarczyńska, M., Gawęda, K., & Klimek, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031525 · Cited by 33 · see citing works
Tissue-Engineered Core–Shell Silk-Fibroin/Poly- l -Lactic Acid Nerve Guidance Conduit Containing Encapsulated Exosomes of Human Endometrial Stem Cells Promotes Peripheral Nerve Regeneration
Namini, M. S., Ebrahimi‐Barough, S., Ai, J., Jahromi, H. K., Mikaeiliagah, E., Azami, M., Bahrami, N., Lotfibakhshaiesh, N., Saremi, J., & Shirian, S. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00157 · Cited by 32 · see citing works
The Role of Micronutrients in Neurological Disorders
Brodska, H. L., Klempíř, J., Závora, J., & Kohout, P. (2023) · Nutrients · doi:10.3390/nu15194129 · Cited by 31 · see citing works
Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury: state of the art and future perspectives
Aldali, F., Deng, C., Nie, M., & Chen, H. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00235 · Cited by 31 · see citing works
Preparation of carbon-based conductive hydrogels and their potential for promoting nerve regeneration
Yang, S., Pan, J., Fu, H., Zheng, J., Chen, F., Zhang, M., Gong, Z., Liang, K., Wang, C., Lai, J., et al. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01261-w · Cited by 31 · see citing works
Unlocking nerve regeneration: electrical stimulation and bioscaffolds to enhance peripheral nerve regeneration
Thakkar, V., Mehdipour, M., & Chang, S. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1594435 · Cited by 31 · see citing works
Conductive nerve conduit with piezoelectric properties for enhanced PC12 differentiation
Javidi, H., A., A. R. S., Sadrnezhaad, S. K., & Najmoddin, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-38456-4 · Cited by 28 · see citing works
Interactions of Cells and Biomaterials for Nerve Tissue Engineering: Polymers and Fabrication
Harley‐Troxell, M. E., Steiner, R., Advíncula, R. C., Anderson, D. E., & Dhar, M. S. (2023) · Polymers · doi:10.3390/polym15183685 · Cited by 27 · see citing works
Nanoparticle-Facilitated Therapy: Advancing Tools in Peripheral Nerve Regeneration
Shi, S., Ou, X., & Cheng, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s442775 · Cited by 26 · see citing works
The potential roles of dental pulp stem cells in peripheral nerve regeneration
Fu, J., Li, X., Jin, F., Dong, Y., Zhou, H., Alhaskawi, A., Wang, Z., Lai, J., Yao, C., Ezzi, S. H. A., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1098857 · Cited by 23 · see citing works
Epidemiology and regional variance of traumatic peripheral nerve injuries in Sweden: A 15-year observational study
Magnéli, M., & Axenhus, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0310988 · Cited by 22 · see citing works
Electroacupuncture Promotes Nerve Regeneration and Functional Recovery Through Regulating lncRNA GAS5 Targeting miR-21 After Sciatic Nerve Injury
Tian, M.-Y., Yang, Y.-D., Qin, W.-T., Liu, B.-N., Mou, F.-F., Zhu, J., Guo, H.-D., & Shao, S.-J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03613-3 · Cited by 21 · see citing works
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury
Yan, Y., Ran, X., Zhou, Z., Gu, Y., Wang, R., Qiu, C., Sun, Y., Wang, J., Xiao, J., Lu, Y., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1358646 · Cited by 21 · see citing works
Programmable DNA‐Peptide Conjugated Hydrogel via Click Chemistry for Sequential Modulation of Peripheral Nerve Regeneration
Wei, Z., Li, X., Chen, Y.-C., Han, Z., Li, Y., Gan, L., Yang, Y., Chen, Y., Zhang, F., Ye, X., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202419915 · Cited by 21 · see citing works
Phytoconstituent-Loaded Nanofibrous Meshes as Wound Dressings: A Concise Review
Sharma, A., Dheer, D., Singh, I., Puri, V., & Kumar, P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041058 · Cited by 21 · see citing works
Improved Gut Microbiota Escalates Muscle Function Rehabilitation and Ameliorates Oxidative Stress Following Mechanically Induced Peripheral Nerve Injury in Mice
(2023) · Pakistan Veterinary Journal · doi:10.29261/pakvetj/2023.098 · Cited by 21 · see citing works
Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders
Pai, V., Singh, B. N., & Singh, A. K. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400150 · Cited by 20 · see citing works
Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: Behavioral and histopathological study
Elhessy, H. M., Habotta, O. A., Eldesoqui, M. B., Elsaed, W. M., Soliman, M. F. M., Sewilam, H. M., Elhassan, Y. H., & Lashine, N. H. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1090738 · Cited by 20 · see citing works
MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region
Zhang, Y., Xu, T., Xie, J., Wu, H. J., Hu, W., & Yuan, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01617-7 · Cited by 20 · see citing works
Recent advances in biomaterial design for nerve guidance conduits: a narrative review
Amalakanti, S., Mulpuri, R. P., & Avula, V. C. R. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-23-00005 · Cited by 20 · see citing works
Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration
Zhao, X., Deng, H., Feng, Y., Wang, Y., Yao, X., Ma, Y., Zhang, L., Jie, J., Yang, P., & Yang, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02557h · Cited by 19 · see citing works
Harnessing three-dimensional porous chitosan microsphere embedded with adipose-derived stem cells to promote nerve regeneration
Zhu, Y., Yi, D., Wang, J., Zhang, Y., Li, M., Ma, J., Ji, Y., Peng, J., Wang, Y., & Luo, Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03753-w · Cited by 19 · see citing works
In Vitro Models for Peripheral Nerve Regeneration
Tusnim, J., Kutuzov, P., & Grasman, J. M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401605 · Cited by 19 · see citing works
Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury—State of the Art
Gouveia, D., Cardoso, A., Carvalho, C., Oliveira, A. C., de Almeida, A. P., Gamboa, Ó., Lopes, B., Coelho, A. F., Alvites, R., Varejão, A. S. P., et al. (2024) · Animals · doi:10.3390/ani14060884 · Cited by 19 · see citing works
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Chitosan Tubes Inoculated with Dental Pulp Stem Cells and Stem Cell Factor Enhance Facial Nerve-Vascularized Regeneration in Rabbits
Mu, X., Liu, H., Yang, S., Li, Y., Xiang, L., Hu, M., & Wang, X. (2022) · ACS Omega · doi:10.1021/acsomega.2c01176 · Cited by 17 · see citing works
Metformin induces M2 polarization via AMPK/PGC-1α/PPAR-γ pathway to improve peripheral nerve regeneration.
Zhou, Z., Luo, G., Li, C., Zhang, P., Chen, W., Li, X., Tang, J., & Qing, L. (2023) · PubMed Central · Cited by 17 · see citing works
The effectiveness of photobiomodulation therapy on inferior alveolar nerve injury: A systematic review and META-analysis
Ma, Y., Yang, M., Chen, X., Qu, W., Qu, X., & He, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287833 · Cited by 17 · see citing works
Advances in nerve guidance conduits for peripheral nerve repair and regeneration.
Zheng, S., Wei, H., Cheng, H., Qi, Y., Gu, Y., Ma, X., Sun, J., Ye, F., Guo, F., & Cheng, C. (2023) · PubMed Central · Cited by 17 · see citing works
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury
Nishijima, T., Okuyama, K., Shibata, S., Kimura, H., Shinozaki, M., Ouchi, T., Mabuchi, Y., Ohno, T., Nakayama, J., Hayatsu, M., et al. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00319-4 · Cited by 17 · see citing works
Electrodiagnostic Assessment of Peri‐Procedural Iatrogenic Peripheral Nerve Injuries and Rehabilitation
Seidel, G. K., Vocelle, A. R., Ackers, I. S., Scott, K. A., Carl, C., Bradt, B. A. G., Dumitru, D., & Andary, M. T. (2025) · Muscle & Nerve · doi:10.1002/mus.28364 · Cited by 16 · see citing works
An Evaluation of the Mechanical Properties of a Hybrid Composite Containing Hydroxyapatite
Klimek, L., Kopacz, K., Śmielak, B., & Kula, Z. M. (2023) · Materials · doi:10.3390/ma16134548 · Cited by 16 · see citing works
Dual growth factor methacrylic alginate microgels combined with chitosan-based conduits facilitate peripheral nerve repair
Zhang, F., Wu, X., Li, Q., Ma, B., Zhang, M., Zhang, W., & Kou, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131594 · Cited by 16 · see citing works
Recent advances in preparation and biomedical applications of keratin based biomaterials
Shubha, A., Sharmita, G., & Rani, M. (2024) · Biotechnology for Sustainable Materials · doi:10.1186/s44316-024-00016-9 · Cited by 16 · see citing works
Endoneurial immune interplay in peripheral nerve repair: insights and implications for future therapeutic interventions
Sprenger‐Svačina, A., Svačina, M. K. R., Otlu, H. G., Gao, T., Sheikh, K. A., & Zhang, G. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1602112 · Cited by 15 · see citing works
Review of Gaps in the Clinical Indications and Use of Neural Conduits and Artificial Grafts for Nerve Repair and Reconstruction
Chan, Y. M., Judge, N. G., Hu, Y., Willits, R. K., Li, N. Y., & Becker, M. L. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c00558 · Cited by 15 · see citing works
Effects of Olfactory Mucosa Stem/Stromal Cell and Olfactory Ensheating Cells Secretome on Peripheral Nerve Regeneration
Alvites, R., Branquinho, M., Sousa, A. C., Lopes, B., Sousa, P., Prada, J., Pires, I. C. R., Ronchi, G., Raimondo, S., Luís, A. L., et al. (2022) · Biomolecules · doi:10.3390/biom12060818 · Cited by 15 · see citing works
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Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury
Amiri, F. T., Jafari, A., Ahmadi, F., Mokhtari, H., Raoofi, A., Kasmaie, F. M., Omran, M., Alimohammadi, M. A., & Nasiry, D. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.021 · Cited by 15 · see citing works
Induced Pluripotent Stem Cell-Derived Exosomes Promote Peripheral Nerve Regeneration in a Rat Sciatic Nerve Crush Injury Model: A Safety and Efficacy Study
Aldali, F., Yang, Y., Deng, C., Li, X., Cao, X., Xu, J. M., Li, Y., Ding, J., & Chen, H. (2025) · Cells · doi:10.3390/cells14070529 · Cited by 15 · see citing works
Advances in sciatic nerve regeneration: A review of contemporary techniques
Ali, S., Sun, M., Khan, M. N., & Qiang, F. (2025) · Regenerative Therapy · doi:10.1016/j.reth.2025.04.016 · Cited by 14 · see citing works
Biomaterial and Hydrogel Strategies for Regenerative Microenvironment Reconstruction in Peripheral Nerve Conduits
Zhang, W., Zhang, Y., Ma, H., Duan, L., Zhang, W., Ding, L., Kou, Y., & Jiang, B. (2025) · Gels · doi:10.3390/gels11110898 · Cited by 14 · see citing works
Ultrasound-Targeted Microbubble Destruction Assisted Delivery of Platelet-Rich Plasma-Derived Exosomes Promoting Peripheral Nerve Regeneration
Yi, D., Zhang, Y., Li, M., Chen, J., Chen, X., Wang, L., Xing, G., Chen, S., Zhu, Y., & Wang, Y. (2023) · Tissue Engineering Part A · doi:10.1089/ten.tea.2023.0133 · Cited by 14 · see citing works
Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment
Lopes, B., Coelho, A. F., Alvites, R., Sousa, A. C., Sousa, P., Moreira, A. D. S., Atayde, L. M., Salgado, A. J., Geuna, S., & Maurício, A. C. (2023) · Regenerative Medicine · doi:10.2217/rme-2023-0102 · Cited by 14 · see citing works
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The Potential Benefits of Dietary Polyphenols for Peripheral Nerve Regeneration
Muratori, L., Fregnan, F., Maurina, M., Haastert‐Talini, K., & Ronchi, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095177 · Cited by 15 · see citing works
Insights Into the Epidemiology of Peripheral Nerve Injuries in the United States: Systematic Review
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Authors: Lopes, B., Sousa, P., Alvites, R., Branquinho, M., Sousa, A. C., Mendonça, C., Atayde, L. M., Luís, A. L., Varejão, A. S. P., & Maurício, A. C.
Affiliations: Universidade do Porto (PT)
University of Trás-os-Montes and Alto Douro (PT)
Corresponding author: Maurício, Ana Colette
ORCID: Lopes, Bruna
Sousa, Patrícia
Alvites, Rui
Branquinho, Mariana
Sousa, Ana Catarina
Mendonça, Carla
Atayde, Luís Miguel
Luís, Ana Lúcia
Varejão, Artur S. P.
Maurício, Ana Colette
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-01-14
Volume: 23
Issue: 2
Pages: 918
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23020918
PMC: PMC8779751
OpenAlex: W4226082353
Cited by: 381
References: 93
Citations by year: 2026: 92 · 2025: 131 · 2024: 90 · 2023: 52 · 2022: 16
FWCI: 10.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Preprints.org (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fundação para a Ciência e Tecnologia (PEst-OE/AGR/UI0211/2011, SFRH/BD/146172/2019, SFRH/BD/146689/2019, 2021.05265.BD, SFRH/BD/116118/2016)
Agencia de Inovacao (POCI-01-0247-FEDER-017771, POCI-01-0247-FEDER-033877, POCI-01-0145-FEDER-031146)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: peripheral nerve injury, nerve regeneration, One Health, peripheral nerve anatomy, pharmacotherapy, cell therapy, biomaterials, nerve conduits, neuropathic pain, functional recovery, in vitro model, in vivo models, translational medicine
MeSH terms: Clinical Studies as Topic, Animals, Combined Modality Therapy, Disease Models, Animal, Disease Susceptibility, Humans, Peripheral Nerves, Biomarkers, Treatment Outcome, Disease Management, Peripheral Nerve Injuries

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