Cited by 381Nerve injury and regenerationNerve Injury and RehabilitationTissue Engineering and Regenerative Medicine

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Peripheral Nerve Injury Treatments and Advances: One Health Perspective

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Lopes, Bruna, Sousa, Patrícia, Alvites, Rui, Branquinho, Mariana, Sousa, Ana Catarina, Mendonça, Carla, Atayde, Luís Miguel, Luís, Ana Lúcia, Varejão, Artur S. P., Maurício, Ana Colette·2022·International Journal of Molecular Sciences

DOI 10.3390/ijms23020918PMC PMC8779751

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Abstract

Peripheral nerve injuries (PNI) can have several etiologies, such as trauma and iatrogenic interventions, that can lead to the loss of structure and/or function impairment. These changes can cause partial or complete loss of motor and sensory functions, physical disability, and neuropathic pain, which in turn can affect the quality of life. This review aims to revisit the concepts associated with the PNI and the anatomy of the peripheral nerve is detailed to explain the different types of injury. Then, some of the available therapeutic strategies are explained, including surgical methods, pharmacological therapies, and the use of cell-based therapies alone or in combination with biomaterials in the form of tube guides. Nevertheless, even with the various available treatments, it is difficult to achieve a perfect outcome with complete functional recovery. This review aims to enhance the importance of new therapies, especially in severe lesions, to overcome limitations and achieve better outcomes. The urge for new approaches and the understanding of the different methods to evaluate nerve regeneration is fundamental from a One Health perspective. In vitro models followed by in vivo models are very important to be able to translate the achievements to human medicine.

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Sorted by citations

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See all 381

Authors: Lopes, B., Sousa, P., Alvites, R., Branquinho, M., Sousa, A. C., Mendonça, C., Atayde, L. M., Luís, A. L., Varejão, A. S. P., & Maurício, A. C.
Affiliations: Universidade do Porto (PT)
University of Trás-os-Montes and Alto Douro (PT)
Corresponding author: Maurício, Ana Colette
ORCID: Lopes, Bruna
Sousa, Patrícia
Alvites, Rui
Branquinho, Mariana
Sousa, Ana Catarina
Mendonça, Carla
Atayde, Luís Miguel
Luís, Ana Lúcia
Varejão, Artur S. P.
Maurício, Ana Colette
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-01-14
Volume: 23
Issue: 2
Pages: 918
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23020918
PMC: PMC8779751
OpenAlex: W4226082353
Cited by: 381
References: 93
Citations by year: 2026: 92 · 2025: 131 · 2024: 90 · 2023: 52 · 2022: 16
FWCI: 10.30
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Preprints.org (acceptedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fundação para a Ciência e Tecnologia (PEst-OE/AGR/UI0211/2011, SFRH/BD/146172/2019, SFRH/BD/146689/2019, 2021.05265.BD, SFRH/BD/116118/2016)
Agencia de Inovacao (POCI-01-0247-FEDER-017771, POCI-01-0247-FEDER-033877, POCI-01-0145-FEDER-031146)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords: peripheral nerve injury, nerve regeneration, One Health, peripheral nerve anatomy, pharmacotherapy, cell therapy, biomaterials, nerve conduits, neuropathic pain, functional recovery, in vitro model, in vivo models, translational medicine
MeSH terms: Clinical Studies as Topic, Animals, Combined Modality Therapy, Disease Models, Animal, Disease Susceptibility, Humans, Peripheral Nerves, Biomarkers, Treatment Outcome, Disease Management, Peripheral Nerve Injuries

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Peripheral Nerve Injury Treatments and Advances: One Health Perspective

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