The DOI matches its Crossref record; 92 of the 93 references it cites were found in a registry or an index.
Peripheral Nerve Injury Treatments and Advances: One Health Perspective
Open accessPublished version of a preprint
Abstract
Peripheral nerve injuries (PNI) can have several etiologies, such as trauma and iatrogenic interventions, that can lead to the loss of structure and/or function impairment. These changes can cause partial or complete loss of motor and sensory functions, physical disability, and neuropathic pain, which in turn can affect the quality of life. This review aims to revisit the concepts associated with the PNI and the anatomy of the peripheral nerve is detailed to explain the different types of injury. Then, some of the available therapeutic strategies are explained, including surgical methods, pharmacological therapies, and the use of cell-based therapies alone or in combination with biomaterials in the form of tube guides. Nevertheless, even with the various available treatments, it is difficult to achieve a perfect outcome with complete functional recovery. This review aims to enhance the importance of new therapies, especially in severe lesions, to overcome limitations and achieve better outcomes. The urge for new approaches and the understanding of the different methods to evaluate nerve regeneration is fundamental from a One Health perspective. In vitro models followed by in vivo models are very important to be able to translate the achievements to human medicine.
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“the scaffold should also provide a suitable local microenvironment for nerve growth, such as promoting axon growth by carrying neurotrophic factors such as NGF and loading substances such as MgO to enhance anti-inflammatory ability and reduce local inflammatory response [181, 182].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [181]
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Cites
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Praveen Kumar, L., Kandoi, S., Misra, R., Vijayalakshmi, S., Rajagopal, K., & Verma, R. S. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.04.002 · Cited by 484
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Peripheral nerve injury, scarring, and recovery
Wang, M. L., Rivlin, M. R., Graham, J. G., & Beredjiklian, P. K. (2018) · Connective Tissue Research · doi:10.1080/03008207.2018.1489381 · Cited by 304
Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit
Carvalho, C. R., Oliveira, J. M., & Reis, R. L. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00337 · Cited by 297
Peripheral nerve injury and myelination: Potential therapeutic strategies
Modrak, M., Talukder, M. A. H., Gurgenashvili, K., Noble, M., & Elfar, J. C. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24538 · Cited by 280
Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do
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Nerve grafting for peripheral nerve injuries with extended defect sizes
Kornfeld, T., Vogt, P. M., & Radtke, C. (2018) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-018-0675-6 · Cited by 237
Therapeutic Approaches for Peripheral and Central Neuropathic Pain
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Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
González-González, A., García‐Sánchez, D., Dotta, M., Rodríguez-Rey, J. C., & Pérez-Campo, F. M. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i12.1529 · Cited by 211
Research works printed but not linked: 1
- Yi, 2020, Application of stem cells in peripheral nerve regeneration, Burns Trauma, 8, tkaa002
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Darehbagh, R. R., Seyedoshohadaei, S. A., Ramezani, R., & Rezaei, N. (2024) · European journal of medical research · doi:10.1186/s40001-024-01987-1 · Cited by 188
Adipose stem cells in tissue regeneration and repair: From bench to bedside
Dong, L., Li, X., Leng, W., Guo, Z., Cai, T., Ji, X., Xu, C., Zhu, Z., & Lin, J. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.09.014 · Cited by 83
Exosome-mediated delivery and regulation in neurological disease progression
Singh, G., Mehra, A., Arora, S., Gugulothu, D. B., Vora, L. K., Prasad, R., & Khatri, D. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130728 · Cited by 81
Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration
Rahman, M., Dip, T. M., Padhye, R., & Houshyar, S. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37595 · Cited by 68
Piezoelectric materials for neuroregeneration: a review
Wu, L., Gao, H., Han, Q., Guan, W., Sun, S., Zheng, T., Liu, Y., Wang, X., Huang, R., & Li, G. (2023) · Biomaterials Science · doi:10.1039/d3bm01111a · Cited by 68
Metadata
- Authors
- Lopes, B., Sousa, P., Alvites, R., Branquinho, M., Sousa, A. C., Mendonça, C., Atayde, L. M., Luís, A. L., Varejão, A. S. P., & Maurício, A. C.
- Affiliations
- Universidade do Porto (PT)
- University of Trás-os-Montes and Alto Douro (PT)
- Corresponding author
- Maurício, Ana Colette
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-01-14
- Volume
- 23
- Issue
- 2
- Pages
- 918
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC8779751
- OpenAlex
- W4226082353
- Cited by
- 381
- References
- 93
- Citations by year
- 2026: 92 · 2025: 131 · 2024: 90 · 2023: 52 · 2022: 16
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação para a Ciência e Tecnologia (PEst-OE/AGR/UI0211/2011, SFRH/BD/146172/2019, SFRH/BD/146689/2019, 2021.05265.BD, SFRH/BD/116118/2016)
- Agencia de Inovacao (POCI-01-0247-FEDER-017771, POCI-01-0247-FEDER-033877, POCI-01-0145-FEDER-031146)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- peripheral nerve injury, nerve regeneration, One Health, peripheral nerve anatomy, pharmacotherapy, cell therapy, biomaterials, nerve conduits, neuropathic pain, functional recovery, in vitro model, in vivo models, translational medicine
- MeSH terms
- Clinical Studies as Topic, Animals, Combined Modality Therapy, Disease Models, Animal, Disease Susceptibility, Humans, Peripheral Nerves, Biomarkers, Treatment Outcome, Disease Management, Peripheral Nerve Injuries
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