Cited by 170Mycotoxins in Agriculture and FoodMicrobial Natural Products and BiosynthesisPhytase and its Applications

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Biological Detoxification of Mycotoxins: Current Status and Future Advances

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Liu, Lu, Xie, Mei, Wei, Dong·2022·International Journal of Molecular Sciences

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Abstract

Mycotoxins are highly toxic metabolites produced by fungi that pose a huge threat to human and animal health. Contamination of food and feed with mycotoxins is a worldwide issue, which leads to huge financial losses, annually. Decades of research have developed various approaches to degrade mycotoxins, among which the biological methods have been proved to have great potential and advantages. This review provides an overview on the important advances in the biological removal of mycotoxins over the last decade. Here, we provided further insight into the chemical structures and the toxicity of the main mycotoxins. The innovative strategies including mycotoxin degradation by novel probiotics are summarized in an in-depth discussion on potentialities and limitations. We prospected the promising future for the development of multifunctional approaches using recombinant enzymes and microbial consortia for the simultaneous removal of multiple mycotoxins.

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Authors: Liu, L., Xie, M., & Wei, D.
Affiliations: Guangdong Academy of Sciences (CN)
Beijing Normal-Hong Kong Baptist University (CN)
Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety (CN)
Corresponding author: Wei, Dong
ORCID: Liu, Lu
Xie, Mei
Wei, Dong
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2022-01-19
Volume: 23
Issue: 3
Pages: 1064
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms23031064
PMC: PMC8835436
OpenAlex: W4205944514
Cited by: 162
References: 117
Citations by year: 2026: 29 · 2025: 56 · 2024: 34 · 2023: 32 · 2022: 11
FWCI: 3.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: GDAS' Project of Science and Technology Development (2020GDASYL-20200103026)
National Natural Science Foundation of China (32001812)
Guangdong Basic and Applied Basic Research Foundation (2019B1515120002)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytase and its Applications
Keywords: mycotoxins, detoxification, mycotoxin degradation, probiotics, recombinant enzyme, microbial consortia, food and feed contamination, mycotoxin toxicity
MeSH terms: Animals, Food, Food Contamination, Fungi, Inactivation, Metabolic, Mycotoxins

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Biological Detoxification of Mycotoxins: Current Status and Future Advances

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