Role of Probiotics Against Mycotoxins and Their Deleterious Effects
Open accessAbstract
Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. They commonly belong to the genera Bifidobacterium and Lactobacillus. Fermented milks haven been used as the main vehicle, so far, for their delivery to consumers. Mycotoxins are secondary toxic fungal products with a long history of responsibility for foodborne disease outbreaks. Human and animals are continuously exposed to variable levels of these contaminants (aflatoxins, ochratoxin A, fumonisins, deoxynivalenol, patulin, zearalenone, among others) that occur naturally in the diet. The long term exposure might cause tissue and genetic damage. Certain probiotic strains can bind and remove mycotoxins from liquid media. Eukaryotic cell cultures showed that the complex probiotic-mycotoxin is less adhesive to enterocytes than the probiotic alone, then favouring maybe the elimination of this complex from the gut through feces. Probiotics were also shown capable of restoring some functions of the epithelial cells after the damage produced by mycotoxin exposure. Animal trials revealed that genetic damage and tissue oxidation might be also partially avoided by the oral administration of probiotics. Finally, human clinical trials conducted in people naturally exposed to mycotoxins in food that received probiotics, showed reduced levels of mycotoxin-DNA adducts in urine and in the content of mycotoxins in feces. However, it remains to know the fate of the ingested mycotoxins that were not found in feces. In vitro to in vivo evidence is gathering in order to determine the role of probiotics on the prevention or partial remediation of the damage induced by mycotoxins.
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The effects of the synergistic action of the discussed LAB group were confirmed by a few model tests.
“The effects of the synergistic action of the discussed group of microorganisms was confirmed by few model tests (Vinderola and Ritieni 2015).”
From Trends in designing microbial silage quality by biotechnological methods using lactic acid bacteria inoculants: a minireview. (2019) · cites this paper as Vinderola and Ritieni 2015
Latest in vitro studies on the ability to bind AFB1 by lactobacilli probiotic strains showed that mycotoxin binding was fast and stable.
“The latest in vitro studies on the ability to bind AFB1 by lactobacilli probiotic strains (including commercially available L. rhamnosus GG and L. casei Shirota, P. freudenreichii ssp., shermanii JS and E. coli) showed that mycotoxin binding was fast (removal from the supernatant was already observed by time zero of contact) and stable (almost no differences in removal were observed after 72 h of”
From Trends in designing microbial silage quality by biotechnological methods using lactic acid bacteria inoculants: a minireview. (2019) · cites this paper as Vinderola and Ritieni 2015
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- Authors
- Vinderola, G., & Ritieni, A.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Journal of Food Research
- Published
- 2014-10-07
- Volume
- 4
- Issue
- 1
- Pages
- 10
- ISSN
- 1927-0887 (ISSN-L)
- 1927-0895
- OpenAlex
- W2069731042
- Cited by
- 35
- References
- 68
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Food Research (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- AgEcon Search (University of Minnesota, USA) (submittedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytase and its Applications
- Keywords
- probiotics, mycotoxins, aflatoxins, ochratoxin A, fumonisins, deoxynivalenol, patulin, zearalenone, Bifidobacterium, Lactobacillus, fermented milk, mycotoxin binding, DNA adducts, oxidative stress, mycotoxin detoxification
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