Current status and future perspectives of sonodynamic therapy in glioma treatment.
Abstract
Malignant glioma is one of the most challenging central nervous system diseases to treat, and has high rates of recurrence and mortality. The current therapies include surgery, radiation therapy, and chemotherapy, although these approaches often failed to control tumor progression or improve patient survival. Sonodynamic therapy is a developing cancer treatment that uses ultrasound combined with a sonosensitizer to synergistically kill tumor cells, and has provided impressive results in both in vitro and in vivo studies. The ultrasound waves can penetrate deep tissues and reversibly open the blood-brain barrier to enhance drug delivery to the brain. Thus, sonodynamic therapy has a promising potential in glioma treatment. In this review, we summarize the studies that have confirmed the pre-clinical efficacy of sonodynamic therapy for glioma treatment, and discuss the future directions for this emerging treatment.
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The BBB may also be opened using intravenous mannitol and ultrasound, externally delivered.
“The BBB may also be opened using intravenous mannitol (an old method) and ultrasound, externally delivered (Samiotaki et al., 2017; Wang et al., 2017).”
From Human Brain/Cloud Interface (2019) · cites this paper as Wang et al., 2017
Cites
Clinical trial of blood-brain barrier disruption by pulsed ultrasound
Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6086 · Cited by 757 · see citing works
Fan, C.-H., Ting, C.-Y., Lin, H.-J., Wang, C.-H., Liu, H.-L., Yen, T.-C., & Yeh, C.-K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.099 · Cited by 225 · see citing works
Wang, P., Li, C., Wang, X., Xiong, W., Feng, X., Liu, Q., Leung, A. W., & Xu, C. (2015) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2014.10.027 · Cited by 135 · see citing works
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Yan, P., Liu, L.-H., & Wang, P. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00156 · Cited by 179 · see citing works
Self-citationApplications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms
Songca, S. P., & Adjei, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063209 · Cited by 175 · see citing works
Martins, N. R. B., Angelica, A., Chakravarthy, K., Svidinenko, Y., Boehm, F. J., Opris, I., Lebedev, M. A., Swan, M., Garan, S. A., Rosenfeld, J. V., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00112 · Cited by 91 · see citing works
- Authors
- Wang, X., Jia, Y., Wang, P., Liu, Q., & Zheng, H.
- Affiliations
- Chinese Academy of Sciences (CN)
- Shaanxi Normal University (CN)
- Corresponding author
- Zheng, Hairong
- Venue
- Ultrasonics Sonochemistry
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 37
- Pages
- 592-599
- ISSN
- 1350-4177 (ISSN-L)
- OpenAlex
- W2588144396
- Cited by
- 86
- References
- 3
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 2
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ultrasonics Sonochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Basic Research Program of China (2015CB755500, 2014CB744502)
- National Natural Science Foundation of China (81472846, 81571834)
- Postdoctoral Science Foundation (2016M600684)
- Fundamental Research Funds for the Central Universities (GK201502009)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- sonodynamic therapy, glioma, sonosensitizer, ultrasound, blood-brain barrier opening, brain drug delivery, tumor cell killing, central nervous system tumors, preclinical efficacy
- MeSH terms
- Ultrasonic Waves, Animals, Antineoplastic Agents, Blood-Brain Barrier, Brain Neoplasms, Glioma, Humans
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