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Cited by 998Proteoglycans and glycosaminoglycans researchOsteoarthritis Treatment and MechanismsHydrogels: synthesis, properties, applications

Hyaluronic acid (hyaluronan): A review

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Necas, J., Bartosikova, L., Brauner, P., Kolar, J.·2008·Veterinární medicína
DOI 10.17221/1930-vetmed
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Abstract

Hyaluronic acid (HA) is a high molecular weight biopolysacharide, discovered in 1934, by Karl Meyer and his assistant, John Palmer in the vitreous of bovine eyes. Hyaluronic acid is a naturally occurring biopolymer, which has important biological functions in bacteria and higher animals including humans. It is found in most connective tissues and is particularly concentrated in synovial fluid, the vitreous fluid of the eye, umbilical cords and chicken combs. It is naturally synthesized by a class of integral membrane proteins called hyaluronan synthases, and degraded by a family of enzymes called hyaluronidases. This review describes metabolisms, different physiological and pathological functions, basic pharmacological properties, and the clinical use of hyaluronic acid.

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  • HA is a linear polyanionic polysaccharide that occurs naturally in all living organisms and maintains an appropriate level of tissue hydration.

    “HA is a linear polyanionic polysaccharide, with the structure of glucuronic acid and N-acetylglucosamine repeating units linked via alternating β-1,4 and β-1,3 glycosidic bonds, which occurs naturally in all living organisms and maintains an appropriate level of tissue hydration [57].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [57]

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Authors
Necas, J., Bartosikova, L., Brauner, P., & Kolar, J.
Affiliations
University of Veterinary Sciences Brno (CZ)
Venue
Veterinární medicína
Publisher
Czech Academy of Agricultural Sciences
Published
2008-08-31
Volume
53
Issue
8
Pages
397-411
ISSN
  • 0375-8427 (ISSN-L)
  • 1805-9392
DOI
10.17221/1930-vetmed
OpenAlex
W2099935411
Cited by
998
References
0
Citations by year
2026: 45 · 2025: 68 · 2024: 78 · 2023: 68 · 2022: 100 · 2021: 94 · 2020: 94 · 2019: 100 · 2018: 73 · 2017: 72 · 2016: 60 · 2015: 53 · 2014: 48 · 2013: 23 · 2012: 15
FWCI
0.19
Type
journal article
Language
cs
Open access
Licence
Locations
  • Veterinární Medicína (publishedVersion, cc-by-nc)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
hyaluronic acid, hyaluronan synthase, hyaluronidase, hyaluronic acid metabolism, connective tissue, synovial fluid, vitreous humor, clinical application, pathological functions

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