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Cited by 16Ion Transport and Channel RegulationRenal function and acid-base balanceDrug Transport and Resistance Mechanisms

Potential Theranostic Roles of SLC4 Molecules in Human Diseases

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Zhong, Jingwen, Dong, Jing, Ruan, Wenyan, Duan, Xiaohong·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms242015166PMC PMC10606849
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Abstract

The solute carrier family 4 (SLC4) is an important protein responsible for the transport of various ions across the cell membrane and mediating diverse physiological functions, such as the ion transporting function, protein-to-protein interactions, and molecular transduction. The deficiencies in SLC4 molecules may cause multisystem disease involving, particularly, the respiratory system, digestive, urinary, endocrine, hematopoietic, and central nervous systems. Currently, there are no effective strategies to treat these diseases. SLC4 proteins are also found to contribute to tumorigenesis and development, and some of them are regarded as therapeutic targets in quite a few clinical trials. This indicates that SLC4 proteins have potential clinical prospects. In view of their functional characteristics, there is a critical need to review the specific functions of bicarbonate transporters, their related diseases, and the involved pathological mechanisms. We summarize the diseases caused by the mutations in SLC4 family genes and briefly introduce the clinical manifestations of these diseases as well as the current treatment strategies. Additionally, we illustrate their roles in terms of the physiology and pathogenesis that has been currently researched, which might be the future therapeutic and diagnostic targets of diseases and a new direction for drug research and development.

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  • SLC4A1 regulates peripheral pH and redox buffering, and its loss has been linked to oxidative stress and neurodegeneration.

    “Of note, SLC4A1 regulates peripheral pH and redox buffering, and its loss has been linked to oxidative stress and neurodegeneration, 62 , 63 suggesting that its enrichment in APOE3Ch ‐EVs may support endothelial resilience.”

    From Plasma extracellular vesicles from <i>APOE3</i> Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease (2026) · cites this paper as [63]

    Section 4.1 says SLC4A1 regulates blood pH through chloride–bicarbonate exchange. Section 6.1 links oxidative stress to modifications of SLC4A1, but does not say SLC4A1 provides redox buffering or that its loss is linked to oxidative stress and neurodegeneration. Page numbers were not available in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Zhong, J., Dong, J., Ruan, W., & Duan, X.
Affiliations
  • State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China
  • Air Force Medical University (CN)
Corresponding author
Duan, Xiaohong
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-10-13
Volume
24
Issue
20
Pages
15166
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms242015166
PMC
PMC10606849
OpenAlex
W4387638623
Cited by
16
References
0
Citations by year
2026: 4 · 2025: 9 · 2024: 3
FWCI
0.42
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81974145, 82370907, LCC202201, LCA202013, 2021ZDLSF02-13)
  • National clinical research center for oral diseases (81974145, 82370907, LCC202201, LCA202013, 2021ZDLSF02-13)
  • Key R&amp;D plan of Shaanxi Province (81974145, 82370907, LCC202201, LCA202013, 2021ZDLSF02-13)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Health Sciences › Medicine › Nephrology › Renal function and acid-base balance
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
bicarbonate transporters, ion transport, multisystem disease, respiratory diseases, gastrointestinal diseases, urinary tract diseases, endocrine disorders, hematopoietic disorders, central nervous system disorders, carcinogenesis, therapeutic target, theranostics, drug development
MeSH terms
Humans, Mutation, Ion Transport, Precision Medicine

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